Kun Qian

About me
Publications
Public outreach and news

About me

I am a scientist at Chemical Biology Consortium Sweden, a Swedish national infrastructure core facility located in SciLifeLab. I specialized in assay development and screening and my role is to help other researchers to design and develop high throughput
screening assays to idendify novel small molecule modulators from chemical libraries.
I obtained my PhD in Pharmaceutical Sciences from the University of Georgia College of Pharmacy, then I was a postdoc at Emory University School of Medicine, working at the Emory Chemical Biology Discovery Center. In 2023, I joind CBCS at Karolinska Institute.

Research

My PhD research was mainly in identifying small molecule inhibitors for
Protein Methyltransferases in epigenetic regulation. During my postdoctoral
research, I was focused on high throughput screening and discovery of
chemical disruptors for protein-protein interactions of novel protein targets
in cancer and Alzheimer’s Disease.

Articles

Journal article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2025;392(3):100664
Targeting the SFRP1 Interaction with ADAM10 for Therapeutic Discovery in Alzheimer's Disease
Lee H; Qian K; Li Q; Cary G; Carter G; Wiley J; Nwkamma R; Zoeller E; Betarbet R; Wen Z; Levey A; Du Y; Fu H
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(12):105382
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease
Du Y; Bradshaw WJ; Leisner TM; Annor-Gyamfi JK; Qian K; Bashore FM; Sikdar A; Nwogbo FO; Ivanov AA; Frye SV; Gileadi O; Brennan PE; Levey AI; Axtman AD; Pearce KH; Fu H; Katis VL
Journal article: JOURNAL OF MOLECULAR CELL BIOLOGY. 2023;15(3):mjad017
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
Cicka D; Niu Q; Qui M; Qian K; Miller E; Fan D; Mo X; Ivanov AA; Sarafianos SG; Du Y; Fu H
Journal article: ACTA PHARMACOLOGICA SINICA. 2022;43(9):2419-2428
Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells.
Shu C; Zheng X; Wuhafu A; Cicka D; Doyle S; Niu Q; Fan D; Qian K; Ivanov AA; Du Y; Mo X; Fu H
Journal article: CELL. 2022;185(11):1974-1985.e12
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mo X; Niu Q; Ivanov AA; Tsang YH; Tang C; Shu C; Li Q; Qian K; Wahafu A; Doyle SP; Cicka D; Yang X; Fan D; Reyna MA; Cooper LAD; Moreno CS; Zhou W; Owonikoko TK; Lonial S; Khuri FR; Du Y; Ramalingam SS; Mills GB; Fu H
Journal article: BIOORGANIC & MEDICINAL CHEMISTRY. 2021;45:116324
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
Yang X; Fan D; Troha AH; Ahn HM; Qian K; Liang B; Du Y; Fu H; Ivanov AA
Journal article: RSC MEDICINAL CHEMISTRY. 2021;12(1):95-102
Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases.
Qian K; Yan C; Su H; Dang T; Zhou B; Wang Z; Zhao X; Ivanov I; Ho M-C; Zheng YG
Journal article: ELIFE. 2019;8:e45403
The dynamic conformational landscape of the protein methyltransferase SETD8.
Chen S; Wiewiora RP; Meng F; Babault N; Ma A; Yu W; Qian K; Hu H; Zou H; Wang J; Fan S; Blum G; Pittella-Silva F; Beauchamp KA; Tempel W; Jiang H; Chen K; Skene RJ; Zheng YG; Brown PJ; Jin J; Luo C; Chodera JD; Luo M
Journal article: SCIENTIFIC REPORTS. 2019;9(1):1771
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.
Lee Y-J; Chang W-W; Chang C-P; Liu T-Y; Chuang C-Y; Qian K; Zheng YG; Li C
Journal article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2018;3:6
Detection of PRMT1 inhibitors with stopped flow fluorescence.
Qian K; Hu H; Xu H; Zheng YG
Journal article: RSC MEDICINAL CHEMISTRY. 2017;8(2):440-444
Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
Zhang J; Qian K; Yan C; He M; Jassim BA; Ivanov I; Zheng YG
Journal article: ONCOTARGET. 2016;7(39):63629-63639
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma.
Eberhardt A; Hansen JN; Koster J; Lotta LT; Wang S; Livingstone E; Qian K; Valentijn LJ; Zheng YG; Schor NF; Li X
Journal article: EXPERT OPINION ON INVESTIGATIONAL DRUGS. 2016;25(3):335-358
Small Molecule Inhibitors of Protein Arginine Methyltransferases.
Hu H; Qian K; Ho M-C; Zheng YG
Journal article: ELIFE. 2015;4:e07938
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Zhang L; Tran N-T; Su H; Wang R; Lu Y; Tang H; Aoyagi S; Guo A; Khodadadi-Jamayran A; Zhou D; Qian K; Hricik T; Côté J; Han X; Zhou W; Laha S; Abdel-Wahab O; Levine RL; Raffel G; Liu Y; Chen D; Li H; Townes T; Wang H; Deng H; Zheng YG; Leslie C; Luo M; Zhao X
Journal article: NATURE CHEMICAL BIOLOGY. 2014;10(5):328-330
Labeling: palladium brings proteins to life.
Qian K; Zheng YG
Journal article: JOURNAL OF MEDICINAL CHEMISTRY. 2014;57(6):2611-2622
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Yan L; Yan C; Qian K; Su H; Kofsky-Wofford SA; Lee W-C; Zhao X; Ho M-C; Ivanov I; Zheng YG

All other publications

Book chapter: HIGH CONTENT IMAGING IN DRUG DISCOVERY. 2025;p. 168-208
High Content Imaging Applications of Advanced and Translational Disease Models in Drug Discovery and Development
Cui W; Haffa M; Massai F; Qian K; Vallin M; Axelsson H; Seashore-Ludlow B
Preprint: BIORXIV. 2023;BIORXIV
Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.
Du Y; Bradshaw WJ; Leisner TM; Annor-Gyamfi JK; Qian K; Bashore FM; Sikdar A; Nwogbo FO; Ivanov AA; Frye SV; Gileadi O; Brennan PE; Levey AI; Emory-Sage-SGC TREAT-AD Center; Axtman AD; Pearce KH; Fu H; Katis VL
Book chapter: EPI-INFORMATICS. 2016;p. 231-256
Current Development of Protein Arginine Methyltransferase Inhibitors
Qian K; George Zheng Y

About me

Research

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