Kristina Viktorsson

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Articles

Article: CYTOPATHOLOGY. 2023;34(4):286-294
Multiplex protein analysis and ensemble machine learning methods of fine needle aspirates from prostate cancer patients reveal potential diagnostic signatures associated with tumour grade
Robeck P; Franzen B; Cantera-Ahlman R; Dragomir A; Auer G; Jorulf H; Jacobsson SP; Viktorsson K; Lewensohn R; Haggman M; Ladjevardi S
Article: TALANTA. 2023;259:124553
Analyses of single extracellular vesicles from non-small lung cancer cells to reveal effects of epidermal growth factor receptor inhibitor treatments
Stridfeldt F; Cavallaro S; Haag P; Lewensohn R; Linnros J; Viktorsson K; Dev A
Article: BIOSENSORS & BIOELECTRONICS. 2023;227:115142
Multi-marker profiling of extracellular vesicles using streaming current and sequential electrostatic labeling
Sahu SS; Gevari MT; Nagy A; Gestin M; Haag P; Lewensohn R; Viktorsson K; Karlstrom AE; Dev A
Article: CELL DEATH DISCOVERY. 2022;8(1):464
Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells
Alkasalias T; Zhang J; Madapura H; Dalarun B; Reina OB; Lewensohn R; Viktorsson K; Salihi A; Darekar S; Lain S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(11):e12277
Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis
Banijamali M; Hojer P; Nagy A; Haag P; Paz Gomero E; Stiller C; Kaminskyy VO; Ekman S; Lewensohn R; Karlstrom AE; Viktorsson K; Ahmadian A
Article: MOLECULAR ONCOLOGY. 2022;16(20):3620-3641
Profiling of extracellular vesicles of metastatic urothelial cancer patients to discover protein signatures related to treatment outcome
Viktorsson K; Haag P; Shah C-H; Franzen B; Arapi V; Holmsten K; Sandstrom P; Lewensohn R; Ullen A
Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(10):2064-2078
Plasma RNA profiling unveils transcriptional signatures associated with resistance to osimertinib in EGFR T790M positive non-small cell lung cancer patients
Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Article: CELL DEATH DISCOVERY. 2022;8(1):284
Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia
Haag P; Olsson M; Forsberg J; Lindberg ML; Stenerlow B; Zong D; Kanter L; Lewensohn R; Viktorsson K; Zhivotovsky B; Stenke L
Article: MARINE DRUGS. 2022;20(4):265
Cytotoxic Alkylynols of the Sponge Cribrochalina vasculum: Structure, Synthetic Analogs and SAR Studies
Kovalerchik D; Zovko A; Haag P; Sierakowiak A; Viktorsson K; Lewensohn R; Ilan M; Carmeli S
Article: BIOSENSORS & BIOELECTRONICS. 2021;193:113568
Multiplexed electrokinetic sensor for detection and therapy monitoring of extracellular vesicles from liquid biopsies of non-small-cell lung cancer patients
Cavallaro S; Haag P; Sahu SS; Berisha L; Kaminskyy VO; Ekman S; Lewensohn R; Linnros J; Viktorsson K; Dev A
Article: MOLECULAR ONCOLOGY. 2021;15(11):2941-2957
Multiplex immune protein profiling of fine-needle aspirates from patients with non-small-cell lung cancer reveals signatures associated with PD-L1 expression and tumor stage
Franzen B; Viktorsson K; Kamali C; Darai-Ramqvist E; Grozman V; Arapi V; Haag P; Kaminskyy VO; Hydbring P; Kanter L; Nyren S; Ekman S; De Petris L; Lewensohn R
Article: ACS APPLIED MATERIALS & INTERFACES. 2021;13(36):42513-42521
Exploiting Electrostatic Interaction for Highly Sensitive Detection of Tumor-Derived Extracellular Vesicles by an Electrokinetic Sensor
Sahu SS; Cavallaro S; Haag P; Nagy A; Karlstrom AE; Lewensohn R; Viktorsson K; Linnros J; Dev A
Article: NANOSCALE ADVANCES. 2021;3(11):3053-3063
Comparison and optimization of nanoscale extracellular vesicle imaging by scanning electron microscopy for accurate size-based profiling and morphological analysis
Cavallaro S; Haag P; Viktorsson K; Krozer A; Fogel K; Lewensohn R; Linnros J; Dev A
Article: CANCERS. 2021;13(5):1010
EPHA2 Interacts with DNA-PK_cs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells
Kaminskyy VO; Haag P; Novak M; Vegvari A; Arapi V; Lewensohn R; Viktorsson K
Article: CANCERS. 2021;13(4):922
Detection of Tumor-Associated Membrane Receptors on Extracellular Vesicles from Non-Small Cell Lung Cancer Patients via Immuno-PCR
Stiller C; Viktorsson K; Paz Gomero E; Haag P; Arapi V; Kaminskyy VO; Kamali C; De Petris L; Ekman S; Lewensohn R; Karlstrom AE
Article: ACTA ONCOLOGICA. 2020;59(4):388-394
Treatment patterns and survival outcomes for small-cell lung cancer patients - a Swedish single center cohort study
Tendler S; Zhan Y; Pettersson A; Lewensohn R; Viktorsson K; Fang F; De Petris L
Article: PLOS ONE. 2020;15(10):e0240973
The prognostic implications of Notch1, Hes1, Ascl1, and DLL3 protein expression in SCLC patients receiving platinum-based chemotherapy
Tendler S; Kanter L; Lewensohn R; Ortiz-Villalon C; Viktorsson K; De Petris L
Article: ACS SENSORS. 2019;4(5):1399-1408
Label-Free Surface Protein Profiling of Extracellular Vesicles by an Electrokinetic Sensor
Cavallaro S; Horak J; Haag P; Gupta D; Stiller C; Sahu SS; Gorgens A; Gatty HK; Viktorsson K; El Andaloussi S; Lewensohn R; Karlstrom AE; Linnros J; Dev A
Article: LUNG CANCER. 2018;124:45-52
Exosomal RNA-profiling of pleural effusions identifies adenocarcinoma patients through elevated miR-200 and LCN2 expression
Hydbring P; De Petris L; Zhang Y; Branden E; Koyi H; Novak M; Kanter L; Haag P; Hurley J; Tadigotla V; Zhu B; Skog J; Viktorsson K; Ekman S; Lewensohn R
Article: LUNG CANCER. 2018;120:75-81
Validation of the 8th TNM classification for small-cell lung cancer in a retrospective material from Sweden
Tendler S; Grozman V; Lewensohn R; Tsakonas G; Viktorsson K; De Petris L
Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2018;100(1):174-187
Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment
Eriksson M; Haag P; Brzozowska B; Lipka M; Lisowska H; Lewensohn R; Wojcik A; Viktorsson K; Lundholm L
Article: RADIATION ONCOLOGY. 2017;12(1):206
Tumor treating fields (TTFields) delay DNA damage repair following radiation treatment of glioma cells
Giladi M; Munster M; Schneiderman RS; Voloshin T; Porat Y; Blat R; Zielinska-Chomej K; Haag P; Bomzon Z; Kirson ED; Weinberg U; Viktorsson K; Lewensohn R; Palti Y
Article: ONCOTARGET. 2016;7(37):60332-60347
Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer
Efazat G; Novak M; Kaminskyy VO; De Petris L; Kanter L; Juntti T; Bergman P; Zhivotovsky B; Lewensohn R; Haag P; Viktorsson K
Article: ONCOTARGET. 2016;7(37):59322-59335
Preclinical activity of melflufen (J1) in ovarian cancer
Carlier C; Strese S; Viktorsson K; Velander E; Nygren P; Uustalu M; Juntti T; Lewensohn R; Larsson R; Spira J; De Vlieghere E; Ceelen WP; Gullbo J
Article: ONCOTARGET. 2016;7(31):50258-50276
Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells
Zovko A; Novak M; Haag P; Kovalerchick D; Holmlund T; Farnegardh K; Ilan M; Carmeli S; Lewensohn R; Viktorsson K
Article: MOLECULAR ONCOLOGY. 2016;10(5):719-734
Melphalan-flufenamide is cytotoxic and potentiates treatment with chemotherapy and the Src inhibitor dasatinib in urothelial carcinoma
Viktorsson K; Shah C-H; Juntti T; Haag P; Zielinska-Chomej K; Sierakowiak A; Holmsten K; Tu J; Spira J; Kanter L; Lewensohn R; Ullen A
Article: BMC CANCER. 2015;15:628
DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines
Salim H; Zong D; Haag P; Novak M; Mork B; Lewensohn R; Lundholm L; Viktorsson K
Article: MOLECULAR CANCER THERAPEUTICS. 2014;13(12):2941-2954
Marine Sponge Cribrochalina vasculum Compounds Activate Intrinsic Apoptotic Signaling and Inhibit Growth Factor Signaling Cascades in Non-Small Cell Lung Carcinoma
Zovko A; Viktorsson K; Haag P; Kovalerchick D; Farnegardh K; Alimonti A; Ilan M; Carmeli S; Lewensohn R
Article: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 2014;32(8):1215-1224
Vascular endothelial growth factor receptor 2, but not S100A4 or S100A6 correlates with prolonged survival in advanced urothelial carcinoma
Shah C-H; Viktorsson K; Kanter L; Sherif A; Asmundsson J; Rosenblatt R; Lewensohn R; Ullen A
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2014;90(8):718-726
Phosphoprotein analysis reveals MEK inhibition as a way to target non-small cell lung cancer tumor initiating cells
Lundholm L; Haag P; Juntti T; Lewensohn R; Viktorsson K
Article: CELL DEATH & DISEASE. 2014;5(3):e1111
Harnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer
Zong D; Zielinska-Chomej K; Juntti T; Mork B; Lewensohn R; Haag P; Viktorsson K
Article: GENES CHROMOSOMES & CANCER. 2013;52(10):895-911
miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression
Salim H; Arvanitis A; de Petris L; Kanter L; Haag P; Zovko A; Ozata DM; Lui W-O; Lundholm L; Zhivotovsky B; Lewensohn R; Viktorsson K
Article: CANCER. 2013;119(16):3076-3083
Multidrug resistance in relapsed acute myeloid leukemia: Evidence of biological heterogeneity
Patel C; Stenke L; Varma S; Lindberg ML; Bjorkholm M; Sjoberg J; Viktorsson K; Lewensohn R; Landgren O; Gottesman MM; Gillet J-P
Article: MARINE DRUGS. 2013;11(7):2574-2594
APS8, a Polymeric Alkylpyridinium Salt Blocks α7 nAChR and Induces Apoptosis in Non-Small Cell Lung Carcinoma
Zovko A; Viktorsson K; Lewensohn R; Kolosa K; Filipic M; Xing H; Kem WR; Paleari L; Turk T
Article: ANTI-CANCER DRUGS. 2013;24(6):648-652
Clinical activity of sorafenib in a previously treated advanced urothelial cancer patient
Shah C-H; Viktorsson K; Sherif A; Kanter L; Gryback P; Lewensohn R; Sandstrom P; Nilsson S; Ullen A
Article: CLINICAL CANCER RESEARCH. 2013;19(11):3019-3031
In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells
Chauhan D; Ray A; Viktorsson K; Spira J; Paba-Prada C; Munshi N; Richardson P; Lewensohn R; Anderson KC
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2013;54(5):327-337
A role for Myh1 in DNA repair after treatment with strand-breaking and crosslinking chemotherapeutic agents
Jansson K; Alao JP; Viktorsson K; Warringer J; Lewensohn R; Sunnerhagen P
Article: CELL DEATH & DISEASE. 2013;4(1):e478
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest
Lundholm L; Haag P; Zong D; Juntti T; Mork B; Lewensohn R; Viktorsson K
Article: CELL DEATH & DISEASE. 2013;4(1):e454
Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412
Stahl S; Kaminskyy VO; Efazat G; Vaculova AH; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B
Article: BRITISH JOURNAL OF CANCER. 2012;107(8):1361-1373
miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence
Salim H; Akbar NS; Zong D; Vaculova AH; Lewensohn R; Moshfegh A; Viktorsson K; Zhivotovsky B
Article: GENES & DEVELOPMENT. 2011;25(19):2031-2040
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair
Malewicz M; Kadkhodaei B; Kee N; Volakakis N; Hellman U; Viktorsson K; Leung CY; Chen B; Lewensohn R; van Gent DC; Chen DJ; Perlmann T
Article: CELL DEATH & DISEASE. 2011;2(7):e181
Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation
Zong D; Haag P; Yakymovych I; Lewensohn R; Viktorsson K
Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(5):2566-2578
Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor
Stahl S; Branca RM; Efazat G; Ruzzene M; Zhivotovsky B; Lewensohn R; Viktorsson K; Lehtio J
Article: BIOCHEMICAL PHARMACOLOGY. 2010;79(9):1281-1290
The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan
Wickstrom M; Viktorsson K; Lundholm L; Aesoy R; Nygren H; Sooman L; Fryknas M; Vogel LK; Lewensohn R; Larsson R; Gullbo J
Article: BRITISH JOURNAL OF CANCER. 2009;101(5):816-821
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86
Beskow C; Skikuniene J; Holgersson A; Nilsson B; Lewensohn R; Kanter L; Viktorsson K
Article: EXPERIMENTAL HEMATOLOGY. 2009;37(6):755-766
Deficient activation of Bak and Bax confers resistance to gemtuzumab ozogamicin-induced apoptotic cell death in AML
Haag P; Viktorsson K; Lindberg ML; Kanter L; Lewensohn R; Stenke L
Article: MOLECULAR & CELLULAR PROTEOMICS. 2009;8(5):1117-1129
Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced Apoptosis in Non-small Lung Cancer Cells
Stahl S; Fung E; Adams C; Lengqvist J; Mork B; Stenerlow B; Lewensohn R; Lehtio J; Zubarev R; Viktorsson K
Article: MOLECULAR CANCER RESEARCH. 2008;6(10):1630-1638
An Autocrine VEGF/VEGFR2 and p38 Signaling Loop Confers Resistance to 4-Hydroxytamoxifen in MCF-7 Breast Cancer Cells
Aesoy R; Sanchez BC; Norum JH; Lewensohn R; Viktorsson K; Linderholm B
Article: MOLECULAR CANCER THERAPEUTICS. 2007;6(9):2409-2417
The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo
Wickstrom M; Johnsen JI; Ponthan F; Segerstrom L; Sveinbjornsson B; Lindskog M; Lovborg H; Viktorsson K; Lewensohn R; Kogner P; Larsson R; Gullbo J
Article: MOLECULAR CANCER THERAPEUTICS. 2007;6(8):2303-2309
The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non-small cell lung carcinoma cells to DNA double-strand break-induced cell death
Polischouk AG; Holgersson A; Zong D; Stenerlow B; Karlsson HL; Moller L; Viktorsson K; Lewensohn R
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1581-1589
Two distinct steps of Bak regulation during apoptotic stress signaling: Different roles of MEKK1 and JNK1
Ihrlund LS; Hernlund E; Viktorsson K; Panaretakis T; Barna G; Sabapathy K; Linder S; Shoshan MC
Article: EXPERIMENTAL CELL RESEARCH. 2003;289(2):256-264
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line
Viktorsson K; Ekedahl J; Lindebro MC; Lewensohn R; Zhivotovsky B; Linder S; Shoshan MC
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(9):3003-3013
Calpain-mediated bid cleavage and calpain-independent Bak modulation: Two separate pathways in cisplatin-induced apoptosis
Mandic A; Viktorsson K; Strandberg L; Heiden T; Hansson J; Linder S; Shoshan MC
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(11):3684-3691
Cisplatin induces the proapoptotic conformation of Bak in a ΔMEKK1-dependent manner
Mandic A; Viktorsson K; Molin M; Akusjärvi G; Eguchi H; Hayashi SI; Toi M; Hansson J; Linder S; Shoshan MC
Article: MELANOMA RESEARCH. 2001;11(1):11-19
The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis
Mandic A; Viktorsson K; Heiden T; Hansson J; Shoshan MC
Article: APOPTOSIS. 2000;5(4):355-367
Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin
Viktorsson K; Heiden T; Molin M; Akusjärvi G; Linder S; Shoshan MC
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Review: STRAHLENTHERAPIE UND ONKOLOGIE. 2023;199(12):1091-1109
Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy
Viktorsson K; Rieckmann T; Fleischmann M; Diefenhardt M; Hehlgans S; Roedel F
Corrigendum: CELL DEATH DISCOVERY. 2022;8(1):472
Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells (vol 15, pg 548, 2022)
Alkasalias T; Zhang J; Madapura H; Dalarun B; Reina OB; Lewensohn R; Viktorsson K; Salihi A; Darekar S; Lain S
Letter: ACTA ONCOLOGICA. 2022;61(7):869-873
Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial
Backlund E; Yang M; Grozman V; Masucci G; Falkenius J; Eriksson H; Jovanovic B; Hammarlund K; Isacsson U; Radu C; Abel E; Karlsson K; Palanco Zamora R; Wersall P; Edback U; Wickstrom S; Darai Ramqvist E; Egyhazi Brage S; Kiessling R; Viktorsson K; Franzen B; Lewensohn R; Olofsson Bagge R; Ullenhag GJ; Ny L; Lindberg K; Helgadottir H
Corrigendum: LUNG CANCER. 2018;123:178-179
Validation of the 8th TNM classification for small-cell lung cancer in a retrospective material from Sweden (vol 120, pg 75, 2018)
Tendler S; Grozman V; Lewensohn R; Tsakonas G; Viktorsson K; De Petris L
Review: CELL DEATH & DISEASE. 2014;5(5):e1260
Systems biology approaches to develop innovative strategies for lung cancer therapy
Viktorsson K; Lewensohn R; Zhivotovsky B
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):134
Global gene analysis reveals ephrin B3 as a potential radio sensitizing target in non small cell lung cancer cells
Stahl S; Vaculova A; Kaminskyy V; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):113
miRNA and cancer stem cell analysis of NSCLC to explain the sensitizing effect of trifluoperazine on cisplatin-induced cell death signaling
Lundholm L; Zong D; Haag P; Salim H; Lewensohn R; Viktorsson K
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):134-135
The DNA glycosylase Myh1 is stabilized by cisplatin and inhibition of Myh1 expression increases cisplatin-induced apoptotic signaling in lung carcinoma cells
Viktorsson K; Efazat G; Haag P; Zong D; Stenke L; Sunnerhagen P; Lewensohn R
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):57
Cytotoxicity and cell death signaling in stem cell like AML cells
Haag P; Lindberg ML; Zong D; Kanter L; Lewensohn R; Stenke L; Viktorsson K
Editorial comment: JOURNAL OF THORACIC ONCOLOGY. 2007;2(3):175-179
Apoptotic signaling pathways in lung cancer
Viktorsson K; Lewensohn RF
Review: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;331(3):868-880
The role of p53 in treatment responses of lung cancer
Viktorsson K; De Petris L; Lewensohn R
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2005;94:143-196
Apoptotic pathways and therapy resistance in human malignancies
Viktorsson K; Lewensohn R; Zhivotovsky B
Thesis / dissertation: 2003
On the role of SAP kinase pathways in cellular responses to cancer treatment
Viktorsson, Kristina

Employments

Senior Research Specialist, Department of Oncology-Pathology, Karolinska Institutet, 2022-

Degrees and Education

Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2003

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