Klas Pekkari

Publications
CV
Public outreach and news

Articles

Article: ANNALS OF SURGERY. 2023;277(1):30-37
A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery
Pieniowski EHA; Bergstroem CM; Nordenvall CAM; Westberg KS; Johar AM; Tumlin Ekelund SF; Larsson KR; Pekkari KJ; Jansson Palmer GC; Lagergren P; Abraham-Nordling M
Article: GASTROINTESTINAL ENDOSCOPY. 2022;96(1):101-107
Endoscopic submucosal dissection for removal of large colorectal neoplasias in an outpatient setting: a single-center series of 660 procedures in Sweden
Tidehag V; Tornqvist B; Pekkari K; Marsk R
Article: BJS OPEN. 2022;6(1):zrab140
Comparison of four surgical approaches for rectal prolapse: multicentre randomized clinical trial
Smedberg J; Graf W; Pekkari K; Hjern F
Article: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 2020;35(10):1895-1901
Computed tomography diagnosed first time diverticulitis and colorectal cancer
Fogelstrom A; Hallen F; Pekkari K
Article: DIGESTIVE SURGERY. 2020;37(6):456-462
Long-Term Results after Anastomotic Leakage following Rectal Cancer Surgery: A Comparison of Treatment with Endo-Sponge and Transanal Irrigation
Wereen A; Dahlberg M; Heinius G; Pieniowski E; Saraste D; Eklov K; Nygren J; Pekkari K; Everhov AH
Article: COLORECTAL DISEASE. 2019;21(2):191-199
Robotic vs laparoscopic rectal tumour surgery: a cohort study
Asklid D; Gerjy R; Hjern F; Pekkari K; Gustafsson UO
Article: SURGICAL ENDOSCOPY. 2017;31(9):3690-3695
Colorectal ESD in day surgery
Ohya T; Marsk R; Pekkari K
Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2017;43(8):1433-1439
The impact of perioperative fluid therapy on short-term outcomes and 5-year survival among patients undergoing colorectal cancer surgery - A prospective cohort study within an ERAS protocol
Asklid D; Segelman J; Gedda C; Hjern F; Pekkari K; Gustafsson UO
Article: WORLD JOURNAL OF SURGICAL ONCOLOGY. 2016;14(1):232
Emergency management with resection versus proximal stoma or stent treatment and planned resection in malignant left-sided colon obstruction
Oistamo E; Hjern F; Blomqvist L; Falken Y; Pekkari K; Abraham-Nordling M
Article: WOUNDS. 2010;22(4):88-93
The Thioredoxin and Glutaredoxin Systems in Smoking Cessation and the Possible Relation to Postoperative Wound Complications
Lindstrom D; Wladis A; Pekkari K
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2005;7(9-10):1189-1194
Requirements for the different cysteines in the chemotactic and desensitizing activity of human thioredoxin
Bizzarri C; Holmgren A; Pekkari K; Chang G; Colotta F; Ghezzi P; Bertini R
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2005;29(3):281-286
Elevated thioredoxin after angioplasty in peripheral arterial disease
Wahlgren CM; Pekkari K
Article: BLOOD. 2005;105(4):1598-1605
Truncated thioredoxin (Trx80) induces differentiation of human CD14⁺ monocytes into a novel cell type (TAMs) via activation of the MAP kinases p38, ERK, and JNK
Pekkari K; Goodarzi MT; Scheynius A; Holmgren A; Avila-Cariño J
Article: FEBS LETTERS. 2003;539(1-3):143-148
Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido-reductase activity
Pekkari K; Avila-Cariño H; Gurunath R; Bengtsson Å; Scheynius A; Holmgren A
Article: BLOOD. 2001;97(10):3184-3190
Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes
Pekkari K; Avila-Cariño J; Bengtsson Å; Gurunath R; Scheynius A; Holmgren A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(48):37474-37480
Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma
Pekkari K; Gurunath R; Arnér ESJ; Holmgren A
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1999;189(11):1783-1789
Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells
Bertini R; Howard OMZ; Dong HF; Oppenheim JJ; Bizzarri C; Sergi R; Caselli G; Pagliei S; Romines B; Wilshire JA; Mengozzi M; Nakamura H; Yodoi J; Pekkari K; Gurunath R; Holmgren A; Herzenberg LA; Herzenberg LA; Ghezzi P
Article: EXPERIMENTAL CELL RESEARCH. 1997;236(1):181-192
Thioredoxin expression and localization in human cell lines: Detection of full-length and truncated species
Sahaf B; Soderberg A; Spyrou G; Barral AM; Pekkari K; Holmgren A; Rosen A

All other publications

Letter: BJS OPEN. 2022;6(2):zrac043
Author response to: Comparison of four surgical approaches for rectal prolapse: multicentre randomized clinical trial
Smedberg J; Graf W; Pekkari K; Hjern F
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2004;6(1):53-61
Truncated thioredoxin: Physiological functions and mechanism
Pekkari K; Holmgren A
Thesis / dissertation: 2001
Human truncated thioredoxin (Trx80) as a novel mitogenic cytokine for white blood cells
Pekkari, Klas

Employments

Affiliated to Research, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2022
Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2001
University Medical Degree, Karolinska Institutet, 1997

Supervisor

Jannica Smedberg, Rectal prolapse - aspects of incidence, etiology and results after surgical treatment, 2022

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