Klas Kärre

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2017;8:15627
Expression of CD226 is associated to but not required for NK cell education
Wagner AK; Kadri N; Snall J; Brodin P; Gilfillan S; Colonna M; Bernhardt GN; Hoglund P; Karre K; Chambers BJ
Article: SEXUALLY TRANSMITTED INFECTIONS. 2017;93(3):169-174
Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences
Franzen-Rohl E; Schepis D; Atterfelt F; Franck K; Wikstrom A; Liljeqvist J-A; Bergstrom T; Aurelius E; Karre K; Berg L; Gaines H
Article: ONCOIMMUNOLOGY. 2017;6(3):e1284718
NK cells control breast cancer and related cancer stem cell hematological spread
Tallerico R; Conti L; Lanzardo S; Sottile R; Garofalo C; Wagner AK; Johansson MH; Cristiani CM; Karre K; Carbone E; Cavallo F
Article: ONCOIMMUNOLOGY. 2017;6(2):e1261242
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
Tallerico RA; Cristiani CMA; Staaf EB; Garofalo CA; Sottile RA; Capone MC; de Coana YPD; Madonna GC; Palella EA; Wolodarski MD; Carannante VB; Mallardo DC; Simeone EC; Grimaldi AMC; Johansson SB; Frumento PE; Gulletta EF; Anichini AG; Colucci FH; Ciliberto GI; Kiessling RD; Kaerre KB; Ascierto PAC; Carbone EA
Article: SCIENTIFIC REPORTS. 2016;6:37996
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+dendritic cells
Thuy TL; Ganesan S; Wagner AK; Sarhan D; Meinke S; Garbi N; Haemmerling G; Alici E; Karre K; Chambers BJ; Hoglund P; Kadri N
Article: SCIENTIFIC REPORTS. 2016;6:30636
IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo
Kritikou JS; Dahlberg CIM; Baptista MAP; Wagner AK; Banerjee PP; Gwalani LA; Poli C; Panda SK; Karre K; Kaech SM; Wermeling F; Andersson J; Orange JS; Brauner H; Westerberg LS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(7):1758-1769
In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation
Lakshmikanth T; Heuts F; Muvva SSVJR; Wallin RPA; Persson A-K; Fauriat C; Applequist SE; Ljunggren H-G; Hoglund P; Karre K; Svensson M; Juarez JG
Article: IMMUNOLOGY AND CELL BIOLOGY. 2016;94(2):177-184
Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice
Brauner H; Hall HT; Flodstrom-Tullberg M; Karre K; Hoglund P; Johansson S
Article: CANCER IMMUNOLOGY RESEARCH. 2016;4(2):113-123
Retuning of Mouse NK Cells after Interference with MHC Class I Sensing Adjusts Self-Tolerance but Preserves Anticancer Response
Wagner AK; Wickstrom SL; Tallerico R; Salam S; Lakshmikanth T; Brauner H; Hoglund P; Carbone E; Johansson MH; Karre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(2):409-419
HLA class I downregulation is associated with enhanced NK-cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors
Sottile R; Pangigadde PN; Tan T; Anichini A; Sabbatino F; Trecroci F; Favoino E; Orgiano L; Roberts J; Ferrone S; Kaerre K; Colucci F; Carbone E
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:119
Microchip screening Platform for single cell assessment of NK cell cytotoxicity
Guldevall K; Brandt L; Forslund E; Olofsson K; Frisk TW; Olofsson PE; Gustafsson K; Manneberg O; Vanherberghen B; Brismar H; Karre K; Uhlin M; Onfelt B
Article: NATURE COMMUNICATIONS. 2014;5:5639
Enrichment of CD56^dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients
Ali TH; Pisanti S; Ciaglia E; Mortarini R; Anichini A; Garofalo C; Tallerico R; Santinami M; Gulletta E; Ietto C; Galgani M; Matarese G; Bifulco M; Ferrone S; Colucci F; Moretta A; Karre K; Carbone E
Article: JOURNAL OF IMMUNOLOGY. 2014;192(4):1577-1586
A Genetic Defect in Mice That Impairs Missing Self Recognition Despite Evidence for Normal Maturation and MHC Class I-Dependent Education of NK Cells
Wickstrom SL; Oberg L; Karre K; Johansson MH
Article: PLOS ONE. 2014;9(12):e111758
Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane
La Rocca R; Tallerico R; Hassan AT; Das G; Tadepally L; Matteucci M; Liberale C; Mesuraca M; Scumaci D; Gentile F; Cojoc G; Perozziello G; Ammendolia A; Gallo A; Karre K; Cuda G; Candeloro P; Di Fabrizio E; Carbone E
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2381-2390
Human NK Cells Selective Targeting of Colon Cancer-Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules
Tallerico R; Todaro M; Di Franco S; Maccalli C; Garofalo C; Sottile R; Palmieri C; Tirinato L; Pangigadde PN; La Rocca R; Mandelboim O; Stassi G; Di Fabrizio E; Parmiani G; Moretta A; Dieli F; Kaerre K; Carbone E
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Karre K; Malmberg K-J; Hoglund P; Mehr R
Article: CARCINOGENESIS. 2012;33(6):1231-1238
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC^Min/+ mice
Li Y; Kundu P; Seow SW; de Matos CT; Aronsson L; Chin KC; Karre K; Pettersson S; Greicius G
Article: CLINICAL IMMUNOLOGY. 2012;143(2):134-144
Expansion of T-cells from the cord blood graft as a predictive tool for complications and outcome of cord blood transplantation
Gertow J; Berglund S; Okas M; Karre K; Remberger M; Mattsson J; Uhlin M
Article: JOURNAL OF IMMUNOLOGY. 2012;188(5):2218-2226
Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets
Brodin P; Lakshmikanth T; Karre K; Hoglund P
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(1):129-141
Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules
Dabrazhynetskaya A; Ma J; Guerreiro-Cacais AO; Arany Z; Rudd E; Henter J-I; Karre K; Levitskaya J; Levitsky V
Article: CELL CYCLE. 2011;10(19):3346-3358
Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2
Li H; Lakshmikanth T; Garofalo C; Enge M; Spinnler C; Anichini A; Szekely L; Karre K; Carbone E; Selivanova G
Article: VIRAL IMMUNOLOGY. 2011;24(5):359-368
NK Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients
Johansson SE; Rollman E; Chung AW; Center RJ; Hejdeman B; Stratov I; Hinkula J; Wahren B; Kaerre K; Kent SJ; Berg L
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2011;18(4):655-660
Increased Cell-Mediated Immune Responses in Patients with Recurrent Herpes Simplex Virus Type 2 Meningitis
Franzen-Rohl E; Schepis D; Lagrelius M; Franck K; Jones P; Liljeqvist J-A; Bergstrom T; Aurelius E; Karre K; Berg L; Gaines H
Article: PLOS ONE. 2010;5(10):e13174
Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice
Brodin P; Lakshmikanth T; Mehr R; Johansson MH; Duru AD; Achour A; Salmon-Divon M; Karre K; Hoglund P; Johansson S
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2010;162(1):146-155
Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation
Gertow J; Berglund S; Okas M; Uzunel M; Berg L; Karre K; Mattsson J; Uhlin M
Article: JOURNAL OF IMMUNOLOGY. 2010;184(5):2272-2280
Distinct Phenotype and Function of NK Cells in the Pancreas of Nonobese Diabetic Mice
Brauner H; Elemans M; Lemos S; Broberger C; Holmberg D; Flodstrom-Tullberg M; Karre K; Hoglund P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(3):813-823
In vivo tumor cell rejection induced by NK cell inhibitory receptor blockade: Maintained tolerance to normal cells even in the presence of IL-2
Vahlne G; Lindholm K; Meier A; Wickstrom S; Lakshmikanth T; Brennan F; Wilken M; Nielsen R; Romagne F; Wagtmann NR; Karre K; Johansson MH
Article: CLINICAL IMMUNOLOGY. 2010;134(2):158-168
NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients
Johansson SE; Hejdeman B; Hinkula J; Johansson MH; Romagne F; Wahren B; Wagtmann NR; Karre K; Berg L
Article: JOURNAL OF IMMUNOTHERAPY. 2010;33(1):96-105
Clinical Expansion of Cord Blood-derived T Cells for Use as Donor Lymphocyte Infusion After Cord Blood Transplantation
Okas M; Gertow J; Uzunel M; Karlsson H; Westgren M; Karre K; Ringden O; Mattsson J; Uhlin M
Article: JOURNAL OF NEUROSCIENCE. 2009;29(43):13503-13515
Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction
Thams S; Brodin P; Plantman S; Saxelin R; Karre K; Cullheim S
Article: PLOS ONE. 2009;4(6):e6046
Probing Natural Killer Cell Education by Ly49 Receptor Expression Analysis and Computational Modelling in Single MHC Class I Mice
Johansson S; Salmon-Divon M; Johansson MH; Pickman Y; Brodin P; Karre K; Mehr R; Hoglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;69(5):429-436
Herpes Simplex Virus Infection Downmodulates NKG2D Ligand Expression
Schepis D; D'Amato M; Studahl M; Bergstrom T; Karre K; Berg L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(5):1251-1263
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo
Lakshmikanth T; Burke S; Ali TH; Kimpfler S; Ursini F; Ruggeri L; Capanni M; Umansky V; Paschen A; Sucker A; Pende D; Groh V; Biassoni R; Hoglund P; Kato M; Shibuya K; Schadendorf D; Anichini A; Ferrone S; Velardi A; Karre K; Shibuya A; Carbone E; Colucci F
Article: BLOOD. 2009;113(11):2434-2441
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
Brodin P; Lakshmikanth T; Johansson S; Karre K; Hoglund P
Article: TRANSPLANTATION. 2009;87(4):467-472
Increased Frequency and Responsiveness of PSA-Specific T Cells After Allogeneic Hematopoetic Stem-Cell Transplantation
Uhlin M; Okas M; Karlsson H; Gertow J; Henningsohn L; Ringden O; Karre K; Levitsky V; Mattsson J
Article: IMMUNOLOGY. 2009;126(1):140-146
Increased proportion of CD56^bright natural killer cells in active and inactive systemic lupus erythematosus
Schepis D; Gunnarsson I; Eloranta M-L; Lampa J; Jacobson SH; Karre K; Berg L
Article: IMMUNOLOGY. 2008;123(2):164-170
Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
Titanji K; Sammicheli S; De Milito A; Mantegani P; Fortis C; Berg L; Karre K; Travi G; Tassandin C; Lopalco L; Rethi B; Tambussi G; Chiodi F
Article: IMMUNOLOGY. 2007;122(2):291-301
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients:: role of CD94/NKG2A in control of cytokine secretion
de Matos CT; Berg L; Michaelsson J; Fellander-Tsai L; Kaerre K; Soederstroem K
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2007;66(2-3):335-344
The expression of human natural killer cell receptors in early life
Sundstrom Y; Nilsson C; Lilja G; Karre K; Troye-Blomberg M; Berg L
Article: JOURNAL OF IMMUNOLOGY. 2007;178(6):3536-3543
Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection
Wagner CS; Riise GC; Bergstrom T; Karre K; Carbone E; Berg L
Article: JOURNAL OF IMMUNOLOGY. 2006;177(8):4981-4990
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections
French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM
Article: JOURNAL OF IMMUNOLOGY. 2006;177(5):2908-2916
DAP12 signalling regulates plasmacytoid ddendritic cell homeostasis and down-modulates their function during viral infection
Sjolin H; Robbins SH; Bessou G; Hidmark A; Tomasello E; Johansson M; Hall H; Charifi F; Hedestam GBK; Biron CA; Karre K; Hoglund P; Vivier E; Dalod M
Article: NATURE MEDICINE. 2006;12(4):417-424
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants
van Hall T; Wolpert EZ; van Veelen P; Laban S; van der Veer M; Roseboom M; Bres S; Grufman P; de Ru A; Meiring H; de Jong A; Franken K; Teixeira A; Valentijn R; Drijfhout JW; Koning F; Camps M; Ossendorp F; Kärre K; Ljunggren HG; Melief CJM; Offringa R
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2006;36(3):732-741
Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1/ILT2/CD85j
Cerboni C; Achour A; Wärnmark A; Mousavi-Jazi M; Sandalova T; Hsu ML; Cosman D; Kärre K; Carbone E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396
Structural basis of the differential stability and receptor specificity of H-2D^b in complex with murine versus human β₂-microglobulin
Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093
Expression, refolding and crystallization of murine MHC class IH-2D^b in complex with human β₂-microglobulin
Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075
A structural basis for CD8⁺ T cell-dependent recognition of non-homologous peptide ligands -: Implications for molecular mimicry in autoreactivity
Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärres K; Achour A
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;201(7):1145-1155
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules
Johansson S; Johansson M; Rosmaraki E; Vahlne G; Mehr R; Salmon-Divon M; Lemonnier F; Kärre K; Höglund P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(51):17843-17848
A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy
Oliveira ALR; Thams S; Lidman O; Piehl F; Hökfelt T; Kärre K; Lindä H; Cullheim S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1646-1653
Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo -: role of KARAP/DAP12-dependent and -independent pathways
Öberg L; Johansson S; Michaëlsson J; Tomasello E; Vivier E; Kärre K; Höglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(2):159-167
Proliferative and cytotoxic response of human natural killer cells exposed to transporter associated with antigen-processing-deficient cells
Cerboni C; Öberg L; Terrazzano G; Zappacosta S; Carbone E; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2003;171(2):902-908
Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells:: Up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein
Rölle A; Mousavi-Jazi M; Eriksson M; Odeberg J; Söderberg-Nauclér C; Cosman D; Kärre K; Cerboni C
Article: CANCER IMMUNITY. 2003;3:6
The uterine cervix--a new member of the family of immunologically exceptional sites?
Höglund P; Kärre K; Klein G
Article: THE LANCET. 2003;361(9363):1099-1101
LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients
Berg L; Riise GC; Cosman D; Bergström T; Olofsson S; Kärre W; Carbone E
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2002;196(11):1403-1414
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition
Michaëlsson J; de Matos CT; Achour A; Lanier LL; Kärre K; Söderström K
Article: IMMUNITY. 2002;17(6):757-768
A structural basis for LCMV immune evasion:: Subversion of H-2D^b and H-2K^b presentation of gp33 revealed by comparative crystal structure analyses
Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2002;195(7):825-834
Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection
Sjölin H; Tomasello E; Mousavi-Jazi M; Bartolazzi A; Kärre K; Vivier E; Cerboni C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):149-161
Human cytomegalovirus (HCMV)-infected endothelial cells and macrophages are less susceptible to natural killer lysis independent of the downregulation of classical HLA class I molecules or expression of the HCMV class I homologue, UL18
Odeberg J; Cerboni C; Browne H; Kärre K; Möller E; Carbone E; Söderberg-Nauclér C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139
The role of an exposed loop in the α₂ domain in the mouse MHC class IH-2D_d molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A
Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800
NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding
Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2001;194(10):1519-1530
Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors
Sjöström A; Eriksson M; Cerboni C; Johansson MH; Sentman CL; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334
MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the β₂-microglobulin subunit
Michaëlsson J; Achour A; Rölle A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro
Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: VIROLOGY. 2000;273(1):112-119
Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization
Sandberg JK; Leandersson AC; Devito C; Kohleisen B; Erfle V; Achour A; Levi M; Schwartz S; Kärre K; Wahren B; Hinkula J
Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity
Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RPA; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2000;164(12):6130-6137
Inhibition of human NK cell-mediated killing by CD1 molecules
Carbone E; Terrazzano G; Melián A; Zanzi D; Moretta L; Porcelli S; Kärre K; Zappacosta S
Article: NATURE. 2000;405(6786):527-528
Immunology -: The footprint of a killer
Kärre K; Schneider G
Article: JOURNAL OF IMMUNOLOGY. 2000;164(9):4775-4782
Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts
Cerboni C; Mousavi-Jazi M; Linde A; Söderström K; Brytting M; Wahren B; Kärre K; Carbone E
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(4):1088-1093
Innate and adaptive immunity to tumors:: IL-12 is required for optimal responses
Grufman P; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(2):525-533
Differential effects on T cell and NK cell development by tissue-specific expression of H-2D^d transgene
Johansson MH; Bieberich C; Kåse-Sjöström A; Yoshioka T; Höglund E; Christy BA; Scangos G; Kärre K; Jay G; Höglund P
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2000;191(1):129-138
Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype:: An adaptive component of NK cell-mediated responses
Glas R; Franksson L; Une C; Eloranta ML; Öhlén C; Örn A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers
Michaëlsson J; Achour A; Salcedo M; Kåse-Sjöström A; Sundbäck J; Harris RA; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(12):4022-4029
Recognition of autologous dendritic cells by human NK cells
Carbone E; Terrazzano G; Ruggiero G; Zanzi D; Ottaiano A; Manzo C; Kärre K; Zappacosta S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(9):2748-2758
Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C
Franksson L; Sundbäck J; Achour A; Bernlind J; Glas R; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(7):2197-2204
T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens
Grufman P; Wolpert EZ; Sandberg JK; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1999;162(12):7010-7014
The MHC class I molecule H-2D^P inhibits murine NK cells via the inhibitory receptor Ly49A
Olsson-Alheim MY; Sundbäck J; Kärre K; Sentman CL
Article: JOURNAL OF IMMUNOLOGY. 1999;162(10):5910-5916
Triggering of murine NK cells by CD40 and CD86 (B7-2)
Martín-Fontecha A; Assarsson E; Carbone E; Kärre K; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1999;189(6):883-894
Recognition of the major histocompatibility complex restriction element modulates CD8⁺ T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide
Sandberg JK; Kärre K; Glas R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1999;55(Pt 1):260-262
Murine class I major histocompatibility complex H-2D^d:: expression, refolding and crystallization
Achour A; Harris RA; Persson K; Sundbäck J; Sentman CL; Schneider G; Lindqvist Y; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;161(9):4499-4505
Immunodominance in the CTL response against minor histocompatibility antigens:: Interference between responding T cells, rather than with presentation of epitopes
Wolpert EZ; Grufman P; Sandberg JK; Tegnesjö A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(9):2872-2881
Impaired MHC class I (H-2D^d)-mediated protection against Ly-49A⁺ NK cells after amino acid substitutions in the antigen binding cleft
Waldenström M; Sundbäck J; Olsson-Alheim MY; Achour A; Kärre K
Article: IMMUNITY. 1998;9(2):199-208
The crystal structure of H-2D^d MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 Å resolution:: Implications for T cell and NK cell recognition
Achour A; Persson K; Harris RA; Sundbäck J; Sentman CL; Lindqvist Y; Schneider G; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;160(12):5971-5978
The α₂ domain of H-2D^d restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A
Sundbäck J; Nakamura MC; Waldenström M; Niemi EC; Seaman WE; Ryan JC; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;160(7):3163-3169
Superdominance among immunodominant H-2K^b-restricted epitopes and reversal by dendritic cell-mediated antigen delivery
Sandberg JK; Grufman P; Wolpert EZ; Franksson L; Chambers BJ; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(1):370-378
β2-Microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2K^b and D^b heavy chains
Höglund P; Glas R; Ménard C; Kåse A; Johansson MH; Franksson L; Lemmonier F; Kärre K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(21):11496-11501
Generation of CD8(+) T cells specific for transporter associated with antigen processing deficient cells
Wolpert EZ; Petersson M; Chambers BJ; Sandberg JK; Kiessling R; Ljunggren HG; Karre K
Article: CANCER RESEARCH. 1997;57(19):4348-4355
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells
SalazarOnfray F; Nakazawa T; Chhajlani V; Petersson M; Karre K; Masucci G; Celis E; Sette A; Southwood S; Appella E; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 1997;159(7):3189-3194
NK cell receptor calibration - Effects of MHC class I induction on killing by Ly49A(high) and Ly49A(low) NK cells
OlssonAlheim MY; Salcedo M; Ljunggren HG; Karre K; Sentman CL
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1997;186(3):353-364
Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene
Johansson MH; Bieberich C; Jay G; Karre K; Hoglund P
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1997;185(12):2053-2060
A new mechanism of NK cell cytotoxicity activation: The CD40-CD40 ligand interaction
Carbone E; Ruggiero G; Terrazzano G; Palomba C; Manzo C; Fontana S; Spits H; Karre K; Zappacosta S
Article: JOURNAL OF IMMUNOLOGY. 1997;158(7):3174-3180
Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice
Salcedo M; Diehl AD; OlssonAlheim MY; Sundback J; VanKaer L; Karre K; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(1):342-345
Lack of F-1 anti-parental resistance in H-2(b/d) F-1 hybrids devoid of beta(2)-microglobulin
Hoglund P; OlssonAlheim MY; Johansson M; Karre K; Sentman CL
Article: UGESKRIFT FOR LAEGER. 1996;158(51):7379-7383
[Nobel Prize for discovery of the cell-mediated immune defence].
Klareskog L; Kärre K; Möller E; Wigzell H
Article: JOURNAL OF IMMUNOLOGY. 1996;157(9):3936-3942
Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes
Sundback J; Karre K; Sentman CL
Article: LAKARTIDNINGEN. 1996;93(42):3714-3717
[The Nobel Prize for discovery of the cell-mediated immune defense. Significance for clinical medicine].
Klareskog L; Kärre K; Möller E; Wigzell H
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(9):2127-2132
Influence of glycosylphosphatidylinositol-linked H-2D(d) molecules on target cell protection and natural killer cell specificity in transgenic mice
Sentman CL; OlssonAlheim MY; Lendahl U; Karre K
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;67(3):365-371
Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression
Yamasaki T; Akiyama Y; Fukuda M; Kimura Y; Moritake K; Kikuchi H; Ljunggren HG; Karre K; Klein G
Article: JOURNAL OF IMMUNOLOGY. 1996;156(7):2423-2429
H-2D(p) transgene alters natural killer cell specificity at the target and effector cell levels - Comparison with an H-2D(d) transgene
Sentman CL; OlssonAlheim MY; Lendahl U; Karre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(3):683-689
Natural killer clones recognize specific soluble HLA class I molecules
Carbone E; Terrazzano G; Colonna M; Tuosto L; Piccolella E; Franksson L; Palazzolo G; PerezVillar JJ; Fontana S; Karre K; Zappacosta S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):288-293
TAP1-deficient mice select a CD8(+) T cell repertoire that displays both diversity and peptide specificity
Sandberg JK; Chambers BJ; VanKaer L; Karre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1995;154(12):6291-6298
IL-10 CONVERTS MOUSE LYMPHOMA-CELLS TO A CTL-RESISTANT, NK-SENSITIVE PHENOTYPE WITH LOW BUT PEPTIDE-INDUCIBLE MHC CLASS-I EXPRESSION
SALAZARONFRAY F; PETERSSON M; FRANKSSON L; MATSUDA M; BLANKENSTEIN T; KARRE K; KIESSLING R
Article: INTERNATIONAL IMMUNOLOGY. 1995;7(6):919-928
DOMINANT AND CRYPTIC ANTIGENS IN THE MHC CLASS-I RESTRICTED T-CELL RESPONSE ACROSS A COMPLEX MINOR HISTOCOMPATIBILITY BARRIER - ANALYSIS AND MAPPING BY ELUTION OF CELLULAR PEPTIDES
WOLPERT E; FRANKSSON L; KARRE K
Article: CANCER RESEARCH. 1995;55(9):1911-1916
REJECTION OF TUMORS IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY SYNDROME DETERMINED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I EXPRESSION ON THE GRAFT
GLAS R; WALDENSTROM M; HOGLUND P; KLEIN G; KARRE K; LJUNGGREN HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1995;25(5):1286-1291
INHIBITION OF NATURAL-KILLER CELL-MEDIATED BONE-MARROW GRAFT-REJECTION BY ALLOGENEIC MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I, BUT NOT CLASS-II MOLECULES
OHLEN C; HOGLUND P; SENTMAN CL; CARBONE E; LJUNGGREN HG; KOLLER B; KARRE K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(5):1649-1653
ALTERED PHENOTYPE AND FUNCTION OF NATURAL-KILLER-CELLS EXPRESSING THE MAJOR HISTOCOMPATIBILITY COMPLEX RECEPTOR LY-49 IN MICE TRANSGENIC FOR ITS LIGAND
OLSSON MY; KARRE K; SENTMAN CL
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Other: NATURE. 2017;542(7641):296
George Klein (1925-2016) A pioneering cancer biologist and Renaissance man OBITUARY
Ernberg I; Karre K; Wigzell H
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2016;395:95-114
Dynamic Regulation of NK Cell Responsiveness
Kadri N; Wagner AK; Ganesan S; Karre K; Wickstrom S; Johansson MH; Hoglund P
Review: ONCOTARGET. 2014;5(24):12472-12508
Classification of current anticancer immunotherapies
Galluzzi L; Vacchelli E; Bravo-San Pedro J-M; Buque A; Senovilla L; Baracco EE; Bloy N; Castoldi F; Abastado J-P; Agostinis P; Apte RN; Aranda F; Ayyoub M; Beckhove P; Blay J-Y; Bracci L; Caignard A; Castelli C; Cavallo F; Celis E; Cerundolo V; Clayton A; Colombo MP; Coussens L; Dhodapkar MV; Eggermont AM; Fearon DT; Fridman WH; Fucikova J; Gabrilovich DI; Galon J; Garg A; Ghiringhelli F; Giaccone G; Gilboa E; Gnjatic S; Hoos A; Hosmalin A; Jaeger D; Kalinski P; Kaerre K; Kepp O; Kiessling R; Kirkwood JM; Klein E; Knuth A; Lewis CE; Liblau R; Lotze MT; Lugli E; Mach J-P; Mattei F; Mavilio D; Melero I; Melief CJ; Mittendorf EA; Moretta L; Odunsi A; Okada H; Palucka AK; Peter ME; Pienta KJ; Porgador A; Prendergast GC; Rabinovich GA; Restifo NP; Rizvi N; Sautes-Fridman C; Schreiber H; Seliger B; Shiku H; Silva-Santos B; Smyth MJ; Speiser DE; Spisek R; Srivastava PK; Talmadge JE; Tartour E; Van der Burg SH; Van den Eynde BJ; Vile R; Wagner H; Weber JS; Whiteside TL; Wolchok JD; Zitvogel L; Zou W; Kroemer G
Other: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2012;61(4):587-591
First International Meeting of the Thematic Centre for Immune Modulatory Therapies for Autoimmunity and Cancer (IMTAC) 13-14 June 2011, Ljusterö, Sweden.
Choudhury A; Höglund P; Kiessling R; Kärre K; Lundqvist A; Malmberg K; Mellstedt H; Scheynius A; Winqvist O; Osterborg A
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2012;18(2):S267
EXPANSION OF T-CELLS FROM THE CORD BLOOD GRAFT AS A PREDICTIVE TOOL FOR COMPLICATIONS AND OUTCOME OF CORD BLOOD TRANSPLANTATION
Gertow J; Berglund S; Okas M; Karre K; Remberger M; Mattsson J; Uhlin M
Review: TRENDS IN IMMUNOLOGY. 2009;30(4):143-149
NK cell education: not an on-off switch but a tunable rheostat
Brodin P; Karre K; Hoglund P
Editorial comment: NATURE IMMUNOLOGY. 2008;9(5):477-480
Natural killer cell recognition of missing self
Karre K
Other: JOURNAL OF IMMUNOLOGY. 2007;179(7):4301-4306
Association of class I major histocompatibility heavy and light chains induced by viral peptides (Reprinted from Nature, vol 340, pg 443-448, 1989)
Townsend A; Ohlen C; Bastin J; Ljunggren H-G; Foster L; Karre K
Other: JOURNAL OF IMMUNOLOGY. 2005;174(11):6566-6569
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy (Reprinted from Nature 319: 675-678 (1986))
Kärre K; Ljunggren HG; Piontek G; Kiessling R
Editorial comment: NATURE IMMUNOLOGY. 2002;3(6):505-506
Clever, cleverer, cleverest
Kärre K
Editorial comment: SCIENCE. 2002;295(5562):2029-2031
Immunology -: A perfect mismatch
Kärre K
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(3):221-228
NK cells, MHC class I molecules and the missing self
Kärre K
Published conference paper: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(10):2926-2935
Synergistic effect of IFN-γ and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity
Cerboni C; Mousavi-Jazi M; Wakiguchi H; Carbone E; Kärre K; Söderström K
Published conference paper: JOURNAL OF LEUKOCYTE BIOLOGY. 1999;66(2):268-271
Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens
Grufman P; Sandberg JK; Wolpert EZ; Kärre K
Review: LAKARTIDNINGEN. 1997;94(17):1595-1600
[A scientist's day-dream or future reality? Specific immunotherapy against cancer].
Kiessling R; Kärre K
Editorial comment: NATURE. 1997;386(6624):446-447
Immunology - Viral decoy vetoes killer cell
Karre K; Welsh RM
Review: IMMUNOLOGICAL REVIEWS. 1997;155:11-28
Host MHC class I gene control of NK-cell specificity in the mouse
Hoglund P; Sundback J; OlssonAlheim MY; Johansson M; Salcedo M; Ohlen C; Ljunggren HG; Sentman CL; Karre K
Review: IMMUNOLOGICAL REVIEWS. 1997;155:5-9
How to recognize a foreign submarine
Karre K
Review: IMMUNOLOGICAL REVIEWS. 1996;151:123-148
Reactivity and specificity of CD8(+) T cells in mice with defects in the MHC class I antigen-presenting pathway
Ljunggren HG; Glas R; Sandberg JK; Karre K
Review: SEMINARS IN IMMUNOLOGY. 1995;7(2):109-119
Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self.
Sentman CL; Olsson MY; Kärre K
Editorial comment: SCIENCE. 1995;267(5200):978-979
EXPRESS YOURSELF OR DIE - PEPTIDES, MHC MOLECULES, AND NK CELLS
KARRE K
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