Kayoko Hosaka

Publications
Public outreach and news

Articles

Article: ADVANCED SCIENCE. 2023;10(24):e2301505
Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism
Wu J; Jing X; Du Q; Sun X; Holgersson K; Gao J; He X; Hosaka K; Zhao C; Tao W; FitzGerald GA; Yang Y; Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(29):e2303740120
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas
Hosaka K; Andersson P; Wu J; He X; Du Q; Jing X; Seki T; Gao J; Zhang Y; Sun X; Huang P; Yang Y; Ge M; Cao Y
Article: CANCER COMMUNICATIONS. 2023;43(6):637-660
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors
Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
Article: NATURE METABOLISM. 2022;4(12):1674-1683
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119
Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo
Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
Article: CELL DEATH AND DISEASE. 2022;13(8):724
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma
Sun Q; Wang Y; Ji H; Sun X; Xie S; Chen L; Li S; Zeng W; Chen R; Tang Q; Zuo J; Hou L; Hosaka K; Lu Y; Liu Y; Ye Y; Yang Y
Article: NATURE. 2022;608(7922):421-428
Brown-fat-mediated tumour suppression by cold-altered global metabolism
Seki T; Yang Y; Sun X; Lim S; Xie S; Guo Z; Xiong W; Kuroda M; Sakaue H; Hosaka K; Jing X; Yoshihara M; Qu L; Li X; Chen Y; Cao Y
Article: JCI INSIGHT. 2022;7(10):e157874
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis
Wang Y; Sun Q; Ye Y; Sun X; Xie S; Zhan Y; Song J; Fan X; Zhang B; Yang M; Lv L; Hosaka K; Yang Y; Nie G
Article: GUT. 2022;71(1):129-147
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Sun X; He X; Zhang Y; Hosaka K; Andersson P; Wu J; Wu J; Jing X; Du Q; Hui X; Ding B; Guo Z; Hong A; Liu X; Wang Y; Ji Q; Beyaert R; Yang Y; Li Q; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(37):22910-22919
Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo
He X; Yin X; Wu J; Wickstrom SL; Duo Y; Du Q; Qin S; Yao S; Jing X; Hosaka K; Wu J; Jensen LD; Lundqvist A; Salter AI; Brautigam L; Tao W; Chen Y; Kiessling R; Cao Y
Article: NATURE COMMUNICATIONS. 2020;11(1):3704
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors
Hosaka K; Yang Y; Seki T; Du Q; Jing X; He X; Wu J; Zhang Y; Morikawa H; Nakamura M; Scherzer M; Sun X; Xu Y; Cheng T; Li X; Liu X; Li Q; Liu Y; Hong A; Chen Y; Cao Y
Article: JOURNAL OF PATHOLOGY. 2018;246(4):447-458
Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth
Thijssen VLJL; Paulis YWJ; Nowak-Sliwinska P; Deumelandt KL; Hosaka K; Soetekouw PMMB; Cimpean AM; Raica M; Pauwels P; van den Oord JJ; Tjan-Heijnen VCG; Hendrix MJ; Heldin C-H; Cao Y; Griffioen AW
Article: JCI INSIGHT. 2018;3(20):e122375
Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis
Andersson P; Yang Y; Hosaka K; Zhang Y; Fischer C; Braun H; Liu S; Yu G; Liu S; Beyaert R; Chang M; Li Q; Cao Y
Article: CELL METABOLISM. 2018;28(1):104-117.e5
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
Iwamoto H; Abe M; Yang Y; Cui D; Seki T; Nakamura M; Hosaka K; Lim S; Wu J; He X; Sun X; Lu Y; Zhou Q; Shi W; Torimura T; Nie G; Li Q; Cao Y
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2018;215(2):611-626
Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning
Seki T; Hosaka K; Fischer C; Lim S; Andersson P; Abe M; Iwamoto H; Gao Y; Wang X; Fong G-H; Cao Y
Article: CELL DISCOVERY. 2018;4:3
Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling
Hosaka K; Yang Y; Nakamura M; Andersson P; Yang X; Zhang Y; Seki T; Scherzer M; Dubey O; Wang X; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9635-E9644
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
Article: CLINICAL CANCER RESEARCH. 2017;23(16):4769-4779
A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Liu C; Zhang Y; Lim S; Hosaka K; Yang Y; Pavlova T; Alkasalias T; Hartman J; Jensen L; Xing X; Wang X; Lu Y; Nie G; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627
Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12680
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Yang Y; Zhang Y; Iwamoto H; Hosaka K; Seki T; Andersson P; Lim S; Fischer C; Nakamura M; Abe M; Cao R; Skov PV; Chen F; Chen X; Lu Y; Nie G; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12152
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T; Hosaka K; Lim S; Fischer C; Honek J; Yang Y; Andersson P; Nakamura M; Naslund E; Yla-Herttuala S; Sun M; Iwamoto H; Li X; Liu Y; Samani NJ; Cao Y
Article: ONCOTARGET. 2016;7(25):38282-38291
Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis
Lim S; Hosaka K; Nakamura M; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:11385
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
Yang Y; Andersson P; Hosaka K; Zhang Y; Cao R; Iwamoto H; Yang X; Nakamura M; Wang J; Zhuang R; Morikawa H; Xue Y; Braun H; Beyaert R; Samani N; Nakae S; Hams E; Dissing S; Fallon PG; Langer R; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(15):4158-4163
Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy
Zhang Y; Yang Y; Hosaka K; Huang G; Zang J; Chen F; Zhang Y; Samani NJ; Cao Y
Article: ONCOGENE. 2015;34(37):4867-4878
MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes
Keklikoglou I; Hosaka K; Bender C; Bott A; Koerner C; Mitra D; Will R; Woerner A; Muenstermann E; Wilhelm H; Cao Y; Wiemann S
Article: SCIENTIFIC REPORTS. 2015;5:10351
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model
Chen X; Wang J; Cao Z; Hosaka K; Jensen L; Yang H; Sun Y; Zhuang R; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(22):E2900-E2909
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
Yang X; Zhang Y; Hosaka K; Andersson P; Wang J; Tholander F; Cao Z; Morikawa H; Tegner J; Yang Y; Iwamoto H; Lim S; Cao Y
Article: CELL REPORTS. 2014;9(2):569-580
VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization
Lim S; Zhang Y; Zhang D; Chen F; Hosaka K; Feng N; Seki T; Andersson P; Li J; Zang J; Sun B; Cao Y
Article: CELL METABOLISM. 2013;18(1):118-129
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong M; Yang X; Lim S; Cao Z; Honek J; Lu H; Zhang C; Seki T; Hosaka K; Wahlberg E; Yang J; Zhang L; Lanne T; Sun B; Li X; Liu Y; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):654-659
Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs
Hedlund E-ME; Yang X; Zhang Y; Yang Y; Shibuya M; Zhong W; Sun B; Liu Y; Hosaka K; Cao Y
Article: NATURE COMMUNICATIONS. 2013;4:2129
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
Article: CELL REPORTS. 2012;2(2):231-241
Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish
Jensen LD; Cao Z; Nakamura M; Yang Y; Brautigam L; Andersson P; Zhang Y; Wahlberg E; Lanne T; Hosaka K; Cao Y
Article: NATURE PROTOCOLS. 2012;7(3):606-615
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
Lim S; Honek J; Xue Y; Seki T; Cao Z; Andersson P; Yang X; Hosaka K; Cao Y
Article: NATURE MEDICINE. 2011;18(1):100-110
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Gao R; Hosaka K; Cao Y
Article: NATURE PROTOCOLS. 2010;5(12):1911-1918
Hypoxia-induced metastasis model in embryonic zebrafish
Rouhi P; Jensen LD; Cao Z; Hosaka K; Lanne T; Wahlberg E; Steffensen JF; Cao Y
Article: NATURE PROTOCOLS. 2010;5(12):1903-1910
Hypoxia-induced retinopathy model in adult zebrafish
Cao Z; Jensen LD; Rouhi P; Hosaka K; Lanne T; Steffensen JF; Wahlberg E; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(41):17505-17510
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
Hedlund E-M; Hosaka K; Zhong Z; Cao R; Cao Y
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