Karolina Kauppi
Principal Researcher
E-mail: karolina.kauppi@ki.se
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Lichtenstein, 171 77 Stockholm
About me
- I am a senior researcher (docent in neuroscience) with interest in
neurogenetics related to cognitive aging and dementia, but also cognitive
symptoms in psychotic diseases.
*Currently looking for a PhD student (May 2023) - please contact me for more
information!*
Group members:
* Lovisa Larsson, Bachelor student, 2023
* Adil Supiyev, postdoc, 2020-2023
* Elise Koch, PhD-student (main supervisor), 2018-2022
* Sofia Håglin, postdoc, 2018-2020
Other:
I am also affiliated with Umeå University, department of Integrative Medical
Biology.
I am a member of the Young Academy of Sweden:
https://www.sverigesungaakademi.se/ledamoter.html [1]
*Grants from: *
Swedish Research council - international postdoc grant (2015), start-up grant
(2018), project grant (2022)
Karolinska Institutet - Faculty funded assistant professor (2019) and senior
researcher (2023) position
Kempe foundation (2020)
Umeå University - strategic grants (2021)
PhD in physiology (on genetics, memory and brain functioning), Umeå
University. 2013.
MSc in Biomedicine, Umeå University 2009.
*Postdoc: *
Oslo University (Prof. Ole Andreassen) 2013-2015
University of California San Diego (Prof's Anders Dale and Chi-Hua Chen)
2015-2018
[1] https://www.sverigesungaakademi.se/ledamoter.html
Research
- I am currently working on a primary research project, funded by VR, Umeå
University, and Karolinska Institutet, which focuses on the interplay between
inherited risk factors and inflammatory factors in the development of
cognitive impairment and dementia in aging.
Normal aging is associated with changes in the brain that cause many
cognitive abilities, such as memory, to decline in most people, but there is
a large degree of individual variation! While some maintain very good
cognitive ability in old age, others experience more severe declines. Both
individual variations within the framework of normal aging and the risk of
developing dementia, or pathological aging, have a significant genetic
component with a complex inheritance pattern. The project aims to identify
the mechanisms through which genes act and how they interact with other
factors such as gender and environmental factors.
In my research, I analyze data from the Betula project (Umeå University),
where people's cognitive abilities, health, and brain structure have been
followed for a long time, as well as from the Swedish Twin Registry at the
Karolinska Institutet, and the international open database UK Biobank. In
this project, I link genetic factors for Alzheimer's disease with results
from cognitive tests, biomarkers for inflammation, and measures of brain
structure and function that have been developed using functional magnetic
resonance imaging.
Increased understanding of the biological processes underlying how our brains
age can be used to develop better drugs and treatments.
I am also interested in psychiatric genetics and previous studies include
work on the genetic relationship between schizophrenia and cognition.
Teaching
- I am a teacher in physiology for Biomedical student at Umeå University
Articles
-
Article: JOURNAL OF ALZHEIMERS DISEASE. 2023;94(4):1443-1464
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Article: NEUROBIOLOGY OF AGING. 2023;126:103-112
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Article: SCIENTIFIC REPORTS. 2023;13(1):8433
-
Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2023;32(4):446-454
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Article: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2023;120:110637
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Article: GENES. 2022;13(3):412
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Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):520
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Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):130
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Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2021;76(6):955-963
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Article: SCHIZOPHRENIA RESEARCH. 2020;222:167-174
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Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):250
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Article: NEUROBIOLOGY OF AGING. 2019;84:243.e1-243.e9
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Article: BRAIN. 2019;142(2):460-470
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Article: BIOINFORMATICS. 2019;35(1):1-11
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Article: AMERICAN JOURNAL OF PSYCHIATRY. 2018;175(7):674-682
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Article: FRONTIERS IN NEUROSCIENCE. 2018;12:260
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Article: ACTA NEUROPATHOLOGICA. 2018;135(1):85-93
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Article: SCIENTIFIC REPORTS. 2017;7(1):15736
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Article: HUMAN MOLECULAR GENETICS. 2017;26(22):4530-4539
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Article: JAMA PSYCHIATRY. 2017;74(10):1065-1075
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Article: ANNALS OF NEUROLOGY. 2017;82(3):484-488
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Article: PLOS MEDICINE. 2017;14(3):e1002258
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Article: BRAIN BEHAVIOR AND IMMUNITY. 2017;61:209-216
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Article: PSYCHOLOGICAL MEDICINE. 2017;47(4):669-679
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Article: NEUROIMAGE. 2017;147:243-252
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Article: NATURE GENETICS. 2017;49(1):152-156
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Article: SCHIZOPHRENIA BULLETIN. 2015;41(3):736-743
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Article: PLOS ONE. 2015;10(7):e0134202
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Article: PSYCHIATRY RESEARCH. 2014;222(1-2):60-66
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Article: JOURNAL OF COGNITIVE NEUROSCIENCE. 2014;26(4):746-754
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Article: NEUROIMAGE. 2014;89:306-313
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Article: NEUROPSYCHOLOGIA. 2013;51(12):2462-2468
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Article: CEREBRAL CORTEX. 2012;22(10):2297-2304
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Article: JOURNAL OF NEUROSCIENCE. 2011;31(40):14218-14222
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(52):22682-22686
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Article: NEUROIMAGE. 2010;52(2):686-698
- Show more
All other publications
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Corrigendum: ALZHEIMERS RESEARCH & THERAPY. 2024;16(1):39
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Review: AGEING RESEARCH REVIEWS. 2020;64:101184