Karine Chemin

Karine Chemin is Associate Professor (docent, Immunology) at the Rheumatology Division at the Karolinska Institute and team leader at the Center for Molecular Medicine (CMM). She is coordinator for the Allergy immunology inflammation (Aii) doctoral school, Karolinska Institute.

2018-: Senior researcher, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
2014-2018: Assistant Professor, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
2011-2014: Postdoc, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
2006-2010: Postdoc, Curie Institute, Paris, France. 
2002-2006: PhD student, Hematology, Hôpital Saint Louis Paris, France. 
2001-2002: Master student, Hôpital Saint Louis Paris, France
2000: Bachelor degree, Cell Biology, University Rennes 1, France
1999: ERASMUS exchange, Center of Immunology Turku, Finland

Tissue-resident memory T cells in rheumatic diseases

In my team, we are interested in the function of tissue-resident memory T cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) and idiopathic inflammatory myopathies (IIM). Using single-cell approaches in clinically well-characterised patient samples, we aim to understand the molecular and metabolic programs that drive the differentiation and persistence of TRM T cells across different inflammatory sites. Despite advances in immunosuppressive therapies, up to 30% of patients still experience inadequate responses, resulting in persistent active disease.

Our research relies on strong collaborations with the Rheumatology Clinic and experts in bioinformatics, with the overall goal to improve the understanding of the mechanisms driving rheumatic diseases and to contribute to the development of more specific diagnostic and therapeutic strategies.

Research Support:

KI-fond
Vetenskapsrådet (Swedish Research Council)
Stiftelsen Konung Gustaf V:s 80‑årsfond
Reumatikerfonden
Nanna Svartz Fond