Karine Chemin
Senior Research Specialist | Docent
E-mail: karine.chemin@ki.se
Visiting address: CMM L8:04 Karolinska universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Malmström V, 171 77 Stockholm
About me
Karine Chemin is Associate Professor (docent, Immunology) at the Rheumatology Division at the Karolinska Institute and team leader at the Center for Molecular Medicine (CMM). She is coordinator for the Allergy immunology inflammation (Aii) doctoral school, Karolinska Institute.
2018-: Senior researcher, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
2014-2018: Assistant Professor, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
2011-2014: Postdoc, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
2006-2010: Postdoc, Curie Institute, Paris, France.
2002-2006: PhD student, Hematology, Hôpital Saint Louis Paris, France.
2001-2002: Master student, Hôpital Saint Louis Paris, France
2000: Bachelor degree, Cell Biology, University Rennes 1, France
1999: ERASMUS exchange, Center of Immunology Turku, Finland
Research
- Tissue-resident memory T cells in rheumatic diseases
Although the etiology of autoimmune diseases is unknown, a complex interplay between genetics, environment and epigenetics is proposed to be the cause of self-tolerance failure. In my team, we are interested in the function of tissue-resident memory T cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) and idiopathic inflammatory myopathies (IIM). In these two inflammatory disorders, the strongest genetic risk factor is the major histocompatibility complex (MHC) locus highlighting the importance of T cells in the pathogenesis. T cells are vital for defending the body against pathogens such as viruses and bacteria whereas, in autoimmune diseases, T cells mistakenly attack our own body. We believe that, by studying T cells at the site of inflammation, we can understand their pathogenic effector function, their antigen specificity and the mechanisms implicated in their migration and retention in the tissue. We also have a specific interest in the subset of cytotoxic CD4+ T cells sharing common effector functions with CD8+ T cells. We use single cell technologies (SmartSeq2 and 10X genomics) in association with conventional cell biology/molecular biology techniques on clinical samples to investigate the diversity of T-cell populations. Our translational research relies on strong collaborations with the Rheumatology Clinic, KS (Prof Ingrid Lundberg´s team) as well as with geneticist/bioinformatics expert (Dr. Lina Diaz-Gallo). Our ambition is to provide a better understanding of the mechanisms driving rheumatic diseases to improve diagnosis and treatment approaches.
Research Support:
Vetenskapsrådet (Swedish Research Council)
Stiftelsen Konung Gustaf V:s 80‑årsfond
Reumatikerfonden
Nanna Svartz Fond
Teaching
- 2013-: Teaching at PhD courses KI: Basic immunology, #2302, Basic inflammation, #2705, Cell signaling #3049, Cytokines in Inflammation #1626, Translational medicine in the Field of Autoimmunity #2760, Clinical and Experimental NeuroImmunology #3200
2019- : Teaching at the Rheumatology Clinic (medical students in rotation)
2021-2022: Teaching at the Medical Research and Innovative Medicine, Uppsala
2013-2020: Teaching at the Biomedicine Master Programme, KI
2017 and 2019: Organisation of the PhD course Cytokines in Inflammation, #1626, KI
2019 and 2020: Organisation of the PhD course Basic Immunology, #5229, KI
Articles
- Journal article: RMD OPEN. 2024;10(4):e004510
- Article: RHEUMATOLOGY. 2024;63(5):1466-1473
- Article: EMBO MOLECULAR MEDICINE. 2023;15(10):e17240
- Article: CLINICAL RHEUMATOLOGY. 2023;42(10):2889-2895
- Article: KIDNEY INTERNATIONAL. 2023;103(5):973-985
- Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(5):673-684
- Article: SCIENTIFIC REPORTS. 2022;12(1):11876
- Article: NATURE COMMUNICATIONS. 2022;13(1):4046
- Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:826152
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2021;205(1):44-52
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(2):194-202
- Article: BMC IMMUNOLOGY. 2020;21(1):27
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(10):1454-1462
- Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):188
- Article: JOURNAL OF AUTOIMMUNITY. 2018;90:28-38
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;192(3):259-270
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(4):655-669
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033
- Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(5):1124-1135
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(12):4612-4624
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(10):2979-2989
- Article: NATURE IMMUNOLOGY. 2013;14(7):723-731
- Article: JOURNAL OF IMMUNOLOGY. 2012;189(5):2159-2168
- Article: BLOOD. 2012;119(18):4174-4181
- Article: CRITICAL REVIEWS IN IMMUNOLOGY. 2012;32(2):139-155
- Article: PLOS ONE. 2011;6(5):e19680
- Article: JOURNAL OF IMMUNOLOGY. 2010;185(11):6809-6818
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(10):2113-2125
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(7):1966-1976
- Article: BLOOD. 2008;111(7):3579-3590
- Article: BRITISH JOURNAL OF HAEMATOLOGY. 2007;136(4):609-614
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(44):15712-15717
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(11):3187-3196
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All other publications
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:292.1-29292
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:575.1-57575
- Editorial comment: NATURE REVIEWS. RHEUMATOLOGY. 2023;19(5):259-260
- Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):442-443
- Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):428
- Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):458-459
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2023;75:3468-3469
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2023;75:4891-4892
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:751.2-75752
- Letter: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2019;195(3):305-309
- Review: FRONTIERS IN IMMUNOLOGY. 2019;10:353
- Letter: ARTHRITIS & RHEUMATOLOGY. 2016;68(8):2053-2054
- Review: CURRENT OPINION IN RHEUMATOLOGY. 2016;28(2):181-188
- Review: SEMINARS IN IMMUNOPATHOLOGY. 2010;32(2):107-116
Employments
- Senior Research Specialist, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2021