Juulia Jylhävä

About me
Publications
CV
Public outreach and news

About me

My main research interest is the aging-related frailty syndrome and
epigenetics and genetics of aging. I’m also conducting research into aging
biomarkers, such as the epigenetic clock, cell-free DNA and inflammatory
markers, and interested in studying how they operate at different stages of
human aging.
For a more detailed description of my current research please visit my
project page: Molecular epidemiological studies into frailty and aging
biomarkers [1]
• PhD in Molecular Immunology (Biology of aging), University of Tampere,
Finland 2013
• MSc in Molecular Biology, University of Jyväskylä Finland, 2006
[1] https://ki.se/en/meb/molecular-epidemiological-studies-into-frailty-and-aging-biomarkers

Research

Current projects:
• Examining the longitudinal relationship between DNA methylation and
development of the frailty syndrome
• Analyzing the genetic and epigenetic determinants and heritability of
frailty
• Assessing the predictive role of frailty on health span, mortality and
morbidity
For a list of my publications, please visit my ResearchGate page:
https://www.researchgate.net/profile/Juulia_Jylhaevae/publications [1]
[1] https://www.researchgate.net/profile/Juulia_Jylhaevae/publications

Articles

Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255

Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population.

Li X; Ploner A; Wang Y; Mak JKL; Lu Y; Magnusson PKE; Jylhävä J; Hägg S
Article: AGING CELL. 2023;22(8):e13868

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.

Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jääskeläinen T; Koskinen S; Lu Y; Magnusson PKE; Hägg S; Jylhävä J
Article: BRITISH JOURNAL OF CANCER. 2023;129(1):94-103

Clinical biomarker-based biological aging and risk of cancer in the UK Biobank.

Mak JKL; McMurran CE; Kuja-Halkola R; Hall P; Czene K; Jylhävä J; Hägg S
Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2023;51(4):587-594

Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA).

Wennberg AM; Yin W; Fang F; Pedersen NL; Hägg S; Jylhävä J; Modig K
Article: GEROSCIENCE. 2023;45(3):2051-2064

Can frailty scores predict the incidence of cancer? Results from two large population-based studies.

Mak JKL; Kuja-Halkola R; Wang Y; Hägg S; Jylhävä J
Journal article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(6):980-987

Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study.

Haapanen MJ; Mikkola TM; Kortelainen L; Jylhävä J; Wasenius NS; Kajantie E; Eriksson JG; von Bonsdorff MB
Article: GEROSCIENCE. 2023;45(3):2065-2078

Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging.

Tang B; Li X; Wang Y; Sjölander A; Johnell K; Thambisetty M; Ferrucci L; Reynolds CA; Finkel D; Jylhävä J; Pedersen NL; Hägg S
Article: ECLINICALMEDICINE. 2023;58:101943

Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study.

Ojalehto E; Zhan Y; Jylhävä J; Reynolds CA; Dahl Aslan AK; Karlsson IK
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(2):333-341

Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age.

Mak JKL; Kuja-Halkola R; Bai G; Hassing LB; Pedersen NL; Hägg S; Jylhävä J; Reynolds CA
Article: GEROSCIENCE. 2023;45(1):85-103

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics.

Kananen L; Hurme M; Bürkle A; Moreno-Villanueva M; Bernhardt J; Debacq-Chainiaux F; Grubeck-Loebenstein B; Malavolta M; Basso A; Piacenza F; Collino S; Gonos ES; Sikora E; Gradinaru D; Jansen EHJM; Dollé MET; Salmon M; Stuetz W; Weber D; Grune T; Breusing N; Simm A; Capri M; Franceschi C; Slagboom E; Talbot D; Libert C; Raitanen J; Koskinen S; Härkänen T; Stenholm S; Ala-Korpela M; Lehtimäki T; Raitakari OT; Ukkola O; Kähönen M; Jylhä M; Jylhävä J
Article: GERONTOLOGY. 2023;69(4):396-405

Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study.

Mak JKL; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Bäck Jerlardtz V; Engström M; Johnson P; Lundberg LG; Åkesson E; Sühl Öberg C; Olsson M; Cederholm T; Hägg S; Religa D; Jylhävä J
Article: PLOS ONE. 2023;18(3):e0283344

Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden.

Kananen L; Hong X; Annetorp M; Mak JKL; Jylhävä J; Eriksdotter M; Hägg S; Religa D
Article: GERONTOLOGY. 2023;69(12):1385-1393

Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK.

Bai G; Wang Y; Mak JKL; Ericsson M; Hägg S; Jylhävä J
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2022;37(12):1261-1271

Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels.

Karlsson IK; Zhan Y; Wang Y; Li X; Jylhävä J; Hägg S; Dahl Aslan AK; Gatz M; Pedersen NL; Reynolds CA
Article: CLINICAL NUTRITION. 2022;41(12):2973-2979

Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19.

Kananen L; Eriksdotter M; Boström AM; Kivipelto M; Annetorp M; Metzner C; Bäck Jerlardtz V; Engström M; Johnson P; Lundberg LG; Åkesson E; Sühl Öberg C; Hägg S; Religa D; Jylhävä J; Cederholm T
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2281-2287

Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age.

Haapanen MJ; Jylhävä J; Kortelainen L; Mikkola TM; Salonen M; Wasenius NS; Kajantie E; Eriksson JG; von Bonsdorff MB
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2311-2319

Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden.

Mak JKL; Hägg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Bäck Jerlardtz V; Engström M; Johnson P; Lundberg LG; Åkesson E; Sühl Öberg C; Olsson M; Cederholm T; Jylhävä J; Religa D
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2022;20(10):2358-2365.e11

Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases: A Nationwide Cohort Study.

Kochar B; Jylhävä J; Söderling J; Ritchie CS; SWIBREG Study Group; Ludvigsson JF; Khalili H; Olén O
Article: EPIGENOMICS. 2022;14(18):1105-1124

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.

Marttila S; Tamminen H; Rajić S; Mishra PP; Lehtimäki T; Raitakari O; Kähönen M; Kananen L; Jylhävä J; Hägg S; Delerue T; Peters A; Waldenberger M; Kleber ME; März W; Luoto R; Raitanen J; Sillanpää E; Laakkonen EK; Heikkinen A; Ollikainen M; Raitoharju E
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2022;37(3):227-234

COVID-19 prevalence and mortality in longer-term care facilities.

Levin AT; Jylhävä J; Religa D; Shallcross L
Journal article: NPJ PARKINSONS DISEASE. 2022;8(1):14

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients.

Meoni G; Tenori L; Schade S; Licari C; Pirazzini C; Bacalini MG; Garagnani P; Turano P; PROPAG-AGEING Consortium; Trenkwalder C; Franceschi C; Mollenhauer B; Luchinat C
Article: SCIENTIFIC REPORTS. 2022;12(1):1330

Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients.

Zago E; Dal Molin A; Dimitri GM; Xumerle L; Pirazzini C; Bacalini MG; Maturo MG; Azevedo T; Spasov S; Gómez-Garre P; Periñán MT; Jesús S; Baldelli L; Sambati L; Calandra-Buonaura G; Garagnani P; Provini F; Cortelli P; Mir P; Trenkwalder C; Mollenhauer B; Franceschi C; Liò P; Nardini C; PROPAG-AGEING Consortium
Article: JOURNAL OF NUTRITION. 2022;152(1):269-275

Protein Nutritional Status and Frailty: A Mendelian Randomization Study.

Tomata Y; Wang Y; Hägg S; Jylhävä J
Article: AGE AND AGEING. 2021;50(6):2174-2182

Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?

Bai G; Szwajda A; Wang Y; Li X; Bower H; Karlsson IK; Johansson B; Dahl Aslan AK; Pedersen NL; Hägg S; Jylhävä J
Article: BMC MEDICINE. 2021;19(1):248

Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?

Bai G; Wang Y; Kuja-Halkola R; Li X; Tomata Y; Karlsson IK; Pedersen NL; Hägg S; Jylhävä J
Article: NUTRIENTS. 2021;13(10):3539

Fatty Acids and Frailty: A Mendelian Randomization Study.

Tomata Y; Wang Y; Hägg S; Jylhävä J
Journal article: NPJ PARKINSONS DISEASE. 2021;7(1):78

Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients.

Baldelli L; Schade S; Jesús S; Schreglmann SR; Sambati L; Gómez-Garre P; Halsband C; Calandra-Buonaura G; Adarmes-Gómez AD; Sixel-Döring F; Zenesini C; Pirazzini C; Garagnani P; Bacalini MG; Bhatia KP; Cortelli P; Mollenhauer B; Franceschi C; PROPAG-AGEING consortium; Mir P; Trenkwalder C; Provini F
Article: AGING CELL. 2021;20(9):e13459

A genome-wide association study of the frailty index highlights brain pathways in ageing.

Atkins JL; Jylhävä J; Pedersen NL; Magnusson PK; Lu Y; Wang Y; Hägg S; Melzer D; Williams DM; Pilling LC
Article: AGING-US. 2021;13(13):16990-17023

Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education.

Mak JKL; Reynolds CA; Hägg S; Li X; Ericsson M; Pedersen NL; Jylhävä J; Kuja-Halkola R
Article: MOLECULAR PSYCHIATRY. 2021;26(6):2148-2162

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.

van Dongen J; Hagenbeek FA; Suderman M; Roetman PJ; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty JD; Adams MJ; Walker RM; Morris SW; Lahti J; Küpers LK; Escaramis G; Alemany S; Jan Bonder M; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send TS; Frank J; Jylhävä J; Wang Y; Mishra PP; Colins OF; Corcoran DL; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix JF; Bakermans-Kranenburg MJ; Campbell A; Czamara D; Binder E; Corpeleijn E; Gonzalez JR; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; BIOS Consortium; Kluft C; Davies GE; Hakulinen C; Keltikangas-Järvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernández-Rivas A; Vetro A; Raitakari O; Lehtimäki T; Vermeiren R; Strandberg T; Räikkönen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hägg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van IJzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma DI
Article: HUMAN GENETICS. 2021;140(6):849-861

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(5):1128-1139

Frailty and comorbidity in predicting community COVID-19 mortality in the U.K. Biobank: The effect of sampling.

Mak JKL; Kuja-Halkola R; Wang Y; Hägg S; Jylhävä J
Article: CLINICAL EPIGENETICS. 2021;13(1):85

Epigenome-wide association study of level and change in cognitive abilities from midlife through late life.

Karlsson IK; Ericsson M; Wang Y; Jylhävä J; Hägg S; Dahl Aslan AK; Reynolds CA; Pedersen NL
Article: EBIOMEDICINE. 2021;66:103318

Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data.

Li X; Ploner A; Wang Y; Zhan Y; Pedersen NL; Magnusson PK; Jylhävä J; Hägg S
Article: SCIENTIFIC REPORTS. 2021;11(1):6139

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Kananen L; Enroth L; Raitanen J; Jylhävä J; Bürkle A; Moreno-Villanueva M; Bernhardt J; Toussaint O; Grubeck-Loebenstein B; Malavolta M; Basso A; Piacenza F; Collino S; Gonos ES; Sikora E; Gradinaru D; Jansen EHJM; Dollé MET; Salmon M; Stuetz W; Weber D; Grune T; Breusing N; Simm A; Capri M; Franceschi C; Slagboom PE; Talbot DCS; Libert C; Koskinen S; Bruunsgaard H; Hansen ÅM; Lund R; Hurme M; Jylhä M
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2021;194:111426

A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project.

Pirazzini C; Azevedo T; Baldelli L; Bartoletti-Stella A; Calandra-Buonaura G; Dal Molin A; Dimitri GM; Doykov I; Gómez-Garre P; Hägg S; Hällqvist J; Halsband C; Heywood W; Jesús S; Jylhävä J; Kwiatkowska KM; Labrador-Espinosa MA; Licari C; Maturo MG; Mengozzi G; Meoni G; Milazzo M; Periñán-Tocino MT; Ravaioli F; Sala C; Sambati L; Schade S; Schreglmann S; Spasov S; Tenori L; Williams D; Xumerle L; Zago E; Bhatia KP; Capellari S; Cortelli P; Garagnani P; Houlden H; Liò P; Luchinat C; Delledonne M; Mills K; Mir P; Mollenhauer B; Nardini C; Pedersen NL; Provini F; Strom S; Trenkwalder C; Turano P; Bacalini MG; Franceschi C; PROPAG-AGEING Consortium
Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(11):1555-1559.e2

Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.

Hägg S; Jylhävä J; Wang Y; Xu H; Metzner C; Annetorp M; Garcia-Ptacek S; Khedri M; Boström A-M; Kadir A; Johansson A; Kivipelto M; Eriksdotter M; Cederholm T; Religa D
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(10):1943-1950

Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden.

Raymond E; Reynolds CA; Dahl Aslan AK; Finkel D; Ericsson M; Hägg S; Pedersen NL; Jylhävä J
Article: SCIENTIFIC REPORTS. 2020;10(1):13809

Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey.

Kananen L; Hurme M; Jylhä M; Härkänen T; Koskinen S; Stenholm S; Kähönen M; Lehtimäki T; Ukkola O; Jylhävä J
Article: AGING CELL. 2020;19(8):e13197

A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation.

Reynolds CA; Tan Q; Munoz E; Jylhävä J; Hjelmborg J; Christiansen L; Hägg S; Pedersen NL
Article: BMC PULMONARY MEDICINE. 2020;20(1):206

Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis.

Nyberg A; Larsson A; Jylhävä J; Hurme M; Sperber J; Lipcsey M; Castegren M
Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(6):1397-1405

Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins.

Karlsson IK; Ericsson M; Wang Y; Jylhävä J; Hägg S; Pedersen NL; Reynolds CA; Dahl Aslan AK
Article: EJSO. 2020;46(3):316-320

Should we invest in biological age predictors to treat colorectal cancer in older adults?

Hägg S; Jylhävä J
Article: ELIFE. 2020;9:e51507

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up.

Li X; Ploner A; Wang Y; Magnusson PK; Reynolds C; Finkel D; Pedersen NL; Jylhävä J; Hägg S
Article: CLINICAL EPIGENETICS. 2019;11(1):187

Comprehensive longitudinal study of epigenetic mutations in aging.

Wang Y; Karlsson R; Jylhävä J; Hedman ÅK; Almqvist C; Karlsson IK; Pedersen NL; Almgren M; Hägg S
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(12):1980-1986

Functional Aging Index Complements Frailty in Prediction of Entry Into Care and Mortality.

Finkel D; Sternäng O; Jylhävä J; Bai G; Pedersen NL
Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s222

CAUSES OF FRAILTY: GENETIC ANALYSIS IN 164,000 UK BIOBANK PARTICIPANTS

Atkins J; Pilling LC; Williams D; Jylhävä J; Melzer D
Article: PSYCHOSOMATIC MEDICINE. 2019;81(9):799-807

Neuroticism as a Predictor of Frailty in Old Age: A Genetically Informative Approach.

Daníelsdóttir HB; Jylhävä J; Hägg S; Lu Y; Colodro-Conde L; Martin NG; Pedersen NL; Mosing MA; Lehto K
Article: BIOGERONTOLOGY. 2019;20(3):321-329

Can markers of biological age predict dependency in old age?

Jylhävä J; Jiang M; Foebel AD; Pedersen NL; Hägg S
Article: BMC MEDICINE. 2019;17(1):94

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study.

Li X; Ploner A; Karlsson IK; Liu X; Magnusson PKE; Pedersen NL; Hägg S; Jylhävä J
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(4):582-587

A Frailty Index for UK Biobank Participants.

Williams DM; Jylhävä J; Pedersen NL; Hägg S
Article: CELL REPORTS. 2019;26(10):2681-2691.e5

Fcμ receptor as a Costimulatory Molecule for T Cells.

Meryk A; Pangrazzi L; Hagen M; Hatzmann F; Jenewein B; Jakic B; Hermann-Kleiter N; Baier G; Jylhävä J; Hurme M; Trieb K; Grubeck-Loebenstein B
Article: EBIOMEDICINE. 2019;40:710-716

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts.

Jylhävä J; Hjelmborg J; Soerensen M; Munoz E; Tan Q; Kuja-Halkola R; Mengel-From J; Christensen K; Christiansen L; Hägg S; Pedersen NL; Reynolds CA
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):418-426

Plasma cell-free DNA and qSOFA score predict 7-day mortality in 481 emergency department bacteraemia patients.

Rannikko J; Seiskari T; Huttunen R; Tarkiainen I; Jylhävä J; Hurme M; Syrjänen J; Aittoniemi J
Article: GENES. 2018;9(2):E78-78

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins.

Svane AM; Soerensen M; Lund J; Tan Q; Jylhävä J; Wang Y; Pedersen NL; Hägg S; Debrabant B; Deary IJ; Christensen K; Christiansen L; Hjelmborg JB
Article: AGING-US. 2017;9(12):2629-2646

Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort.

Jiang M; Foebel AD; Kuja-Halkola R; Karlsson I; Pedersen NL; Hägg S; Jylhävä J
Article: EXPERIMENTAL GERONTOLOGY. 2017;97:60-63

Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence.

Marttila S; Nevalainen T; Jylhävä J; Kananen L; Jylhä M; Hervonen A; Hurme M
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(11):1569-1574

Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study.

Lisko I; Tiainen K; Raitanen J; Jylhävä J; Hurme M; Hervonen A; Jylhä M; Stenholm S
Article: CLINICAL EPIGENETICS. 2017;9:20

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals.

Nevalainen T; Kananen L; Marttila S; Jylhävä J; Mononen N; Kähönen M; Raitakari OT; Hervonen A; Jylhä M; Lehtimäki T; Hurme M
Article: NEUROLOGY. 2016;87(22):2290-2299

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders.

Lehtonen JM; Forsström S; Bottani E; Viscomi C; Baris OR; Isoniemi H; Höckerstedt K; Österlund P; Hurme M; Jylhävä J; Leppä S; Markkula R; Heliö T; Mombelli G; Uusimaa J; Laaksonen R; Laaksovirta H; Auranen M; Zeviani M; Smeitink J; Wiesner RJ; Nakada K; Isohanni P; Suomalainen A
Article: AGE. 2016;38(3):65

The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies.

Kananen L; Marttila S; Nevalainen T; Kummola L; Junttila I; Mononen N; Kähönen M; Raitakari OT; Hervonen A; Jylhä M; Lehtimäki T; Hurme M; Jylhävä J
Article: ONCOTARGET. 2016;7(15):19228-19241

Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift.

Jylhävä J; Kananen L; Raitanen J; Marttila S; Nevalainen T; Hervonen A; Jylhä M; Hurme M
Journal article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2016;71(3):412-419

Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years.

Enroth L; Raitanen J; Hervonen A; Lehtimäki T; Jylhävä J; Hurme M; Jylhä M
Article: BMC GENOMICS. 2016;17:103

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study.

Kananen L; Marttila S; Nevalainen T; Jylhävä J; Mononen N; Kähönen M; Raitakari OT; Lehtimäki T; Hurme M
Journal article: NEUROLOGICAL RESEARCH. 2016;38(1):45-50

The concentration of cell-free DNA in video-EEG patients is dependent on the epilepsy syndrome and duration of epilepsy.

Alapirtti T; Jylhävä J; Raitanen J; Mäkinen R; Peltola J; Hurme MA; Liimatainen S
Article: PLOS ONE. 2016;11(11):e0167028

Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals.

Nevalainen T; Kananen L; Marttila S; Jylhävä J; Jylhä M; Hervonen A; Hurme M
Article: EXPERIMENTAL GERONTOLOGY. 2015;72:227-229

Cytomegalovirus infection accelerates epigenetic aging.

Kananen L; Nevalainen T; Jylhävä J; Marttila S; Hervonen A; Jylhä M; Hurme M
Article: ONCOTARGET. 2015;6(31):30557-30567

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny.

Marttila S; Kananen L; Jylhävä J; Nevalainen T; Hervonen A; Jylhä M; Hurme M
Journal article: MITOCHONDRION. 2015;24:s45-s46

Mitochondrial myopathy biomarker Fibroblast growth factor 21 is induced by muscle mtDNA instability and translation defects

Lehtonen JM; Forsström S; Viscomi C; Zeviani M; Moraes C; Nakada K; Smeitink J; Wiesner RJ; Baris O; Isoniemi H; Höckerstedt K; Österlund P; Hurme M; Jylhävä J; Leppä S; Markkula R; Heliö T; Mombelli G; Suomalainen A
Article: AGE. 2015;37(4):9814

Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study.

Nevalainen T; Kananen L; Marttila S; Jylhä M; Hervonen A; Hurme M; Jylhävä J
Article: BMC GENOMICS. 2015;16(1):179

Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression.

Marttila S; Kananen L; Häyrynen S; Jylhävä J; Nevalainen T; Hervonen A; Jylhä M; Nykter M; Hurme M
Article: SCIENTIFIC REPORTS. 2015;5:8631

Number of sons contributes to ageing-associated inflammation.

Marttila S; Nevalainen T; Kananen L; Jylhävä J; Jylhä M; Hervonen A; Ilonen J; Hurme M
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2014;143-144:1-8

Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy--a study with monozygotic twin pairs.

Kangas R; Pöllänen E; Rippo MR; Lanzarini C; Prattichizzo F; Niskala P; Jylhävä J; Sipilä S; Kaprio J; Procopio AD; Capri M; Franceschi C; Olivieri F; Kovanen V
Article: BMC MEDICAL GENOMICS. 2014;7:54

Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+ Study.

Jylhävä J; Raitanen J; Marttila S; Hervonen A; Jylhä M; Hurme M
Article: BLOOD COAGULATION & FIBRINOLYSIS. 2014;25(6):612-617

Plasma pentraxin-3 and coagulation and fibrinolysis variables during acute Puumala hantavirus infection and associated thrombocytopenia.

Laine OK; Koskela SM; Outinen TK; Joutsi-Korhonen L; Huhtala H; Vaheri A; Hurme MA; Jylhävä J; Mäkelä SM; Mustonen JT
Article: CURRENT PHARMACEUTICAL DESIGN. 2014;20(38):6058-6070

Determinants of longevity: genetics, biomarkers and therapeutic approaches.

Jylhävä J
Article: ATHEROSCLEROSIS. 2014;233(1):268-271

Circulating cell-free DNA is associated with cardiometabolic risk factors: the Health 2000 Survey.

Jylhävä J; Lehtimäki T; Jula A; Moilanen L; Kesäniemi YA; Nieminen MS; Kähönen M; Hurme M
Article: IMMUNITY & AGEING. 2014;11(1):2

Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians.

Marttila S; Jylhävä J; Kananen L; Hervonen A; Jylhä M; Hurme M
Journal article: CRITICAL CARE. 2014;18(Suppl 1):p292

Lung-protective ventilation suppresses plasma levels of cell-free DNA in porcine experimental postoperative sepsis

Nyberg A; Sperber J; Lipcsey M; Jylhävä J; hurme M; Castegren M
Article: PLOS ONE. 2014;9(2):e87741

High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment.

Forsblom E; Aittoniemi J; Ruotsalainen E; Helmijoki V; Huttunen R; Jylhävä J; Hurme M; Järvinen A
Article: EPILEPSY RESEARCH. 2013;105(3):292-298

The concentration of cell-free DNA in focal epilepsy.

Liimatainen SP; Jylhävä J; Raitanen J; Peltola JT; Hurme MA
Article: AGING CELL. 2013;12(3):388-397

Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty.

Jylhävä J; Nevalainen T; Marttila S; Jylhä M; Hervonen A; Hurme M
Article: EXPERIMENTAL GERONTOLOGY. 2013;48(3):305-312

Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis.

Kuparinen T; Marttila S; Jylhävä J; Tserel L; Peterson P; Jylhä M; Hervonen A; Hurme M
Article: PLOS ONE. 2013;8(6):e66229

Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.

Marttila S; Jylhävä J; Nevalainen T; Nykter M; Jylhä M; Hervonen A; Tserel L; Peterson P; Hurme M
Article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2012;12(5):363-365

Indoleamine 2,3-dioxygenase activity and expression in patients with chronic lymphocytic leukemia.

Lindström V; Aittoniemi J; Jylhävä J; Eklund C; Hurme M; Paavonen T; Oja SS; Itälä-Remes M; Sinisalo M
Article: EXPERIMENTAL GERONTOLOGY. 2012;47(5):372-378

Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study.

Jylhävä J; Jylhä M; Lehtimäki T; Hervonen A; Hurme M
Article: GENES AND IMMUNITY. 2012;13(2):184-190

Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response.

Kuparinen T; Seppälä I; Jylhävä J; Marttila S; Aittoniemi J; Kettunen J; Viikari J; Kähönen M; Raitakari O; Lehtimäki T; Hurme M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;167(2):309-316

Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study.

Haarala A; Kähönen M; Lehtimäki T; Aittoniemi J; Jylhävä J; Hutri-Kähönen N; Taittonen L; Laitinen T; Juonala M; Viikari J; Raitakari OT; Hurme M
Article: PLOS ONE. 2012;7(2):e31455

Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection.

Outinen TK; Kuparinen T; Jylhävä J; Leppänen S; Mustonen J; Mäkelä S; Pörsti I; Syrjänen J; Vaheri A; Hurme M
Article: PLOS ONE. 2012;7(4):e35426

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

Jylhävä J; Lyytikäinen L-P; Kähönen M; Hutri-Kähönen N; Kettunen J; Viikari J; Raitakari OT; Lehtimäki T; Hurme M
Article: EXPERIMENTAL GERONTOLOGY. 2011;46(12):1000-1002

IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence.

Marttila S; Jylhävä J; Pesu M; Hämäläinen S; Jylhä M; Hervonen A; Hurme M
Article: IMMUNITY & AGEING. 2011;8:9

Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells.

Marttila S; Jylhävä J; Eklund C; Hervonen A; Jylhä M; Hurme M
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2011;41(9):951-957

Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study.

Haarala A; Kähönen M; Eklund C; Jylhävä J; Koskinen T; Taittonen L; Huupponen R; Lehtimäki T; Viikari J; Raitakari OT; Hurme M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2011;164(2):211-217

Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey.

Jylhävä J; Haarala A; Kähönen M; Lehtimäki T; Jula A; Moilanen L; Kesäniemi YA; Nieminen MS; Hurme M
Article: PLOS ONE. 2011;6(3):e17653

High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort study.

Huttunen R; Hurme M; Aittoniemi J; Huhtala H; Vuento R; Laine J; Jylhävä J; Syrjänen J
Article: PLOS ONE. 2011;6(7):e21700

Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort study.

Huttunen R; Kuparinen T; Jylhävä J; Aittoniemi J; Vuento R; Huhtala H; Laine J; Syrjänen J; Hurme M
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2011;132(1-2):20-26

Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the Vitality 90+ study.

Jylhävä J; Kotipelto T; Raitala A; Jylhä M; Hervonen A; Hurme M
Article: BIOGERONTOLOGY. 2010;11(6):671-677

Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study.

Jylhävä J; Eklund C; Jylhä M; Hervonen A; Hurme M
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2010;459(2):239-246

Gene variants as determinants of longevity: focus on the inflammatory factors.

Jylhävä J; Hurme M
Article: JOURNAL OF RHEUMATOLOGY. 2009;36(11):2487-2490

Serum amyloid A and C-reactive protein concentrations are differently associated with markers of autoimmunity in patients with primary Sjögren's syndrome.

Pertovaara M; Jylhävä J; Uusitalo H; Pukander J; Helin H; Hurme M
Article: JOURNAL OF INTERNAL MEDICINE. 2009;266(3):286-295

Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study.

Jylhävä J; Haarala A; Eklund C; Pertovaara M; Kähönen M; Hutri-Kähönen N; Levula M; Lehtimäki T; Huupponen R; Jula A; Juonala M; Viikari J; Raitakari O; Hurme M
Article: PLOS ONE. 2009;4(6):e5948

Parvovirus induced alterations in nuclear architecture and dynamics.

Ihalainen TO; Niskanen EA; Jylhävä J; Paloheimo O; Dross N; Smolander H; Langowski J; Timonen J; Vihinen-Ranta M
Article: EXPERIMENTAL GERONTOLOGY. 2009;44(4):297-299

Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study.

Jylhävä J; Eklund C; Jylhä M; Hervonen A; Lehtimäki T; Karhunen P; Hurme M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;155(1):53-58

Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

Jylhävä J; Eklund C; Pessi T; Raitakari OT; Juonala M; Kähönen M; Viikari JSA; Lehtimäki T; Hurme M
Article: CELLULAR MICROBIOLOGY. 2007;9(8):1946-1959

Dynamics and interactions of parvoviral NS1 protein in the nucleus.

Ihalainen TO; Niskanen EA; Jylhävä J; Turpeinen T; Rinne J; Timonen J; Vihinen-Ranta M
Article: BMC BIOTECHNOLOGY. 2007;7:1

Internalization of novel non-viral vector TAT-streptavidin into human cells.

Rinne J; Albarran B; Jylhävä J; Ihalainen TO; Kankaanpää P; Hytönen VP; Stayton PS; Kulomaa MS; Vihinen-Ranta M
Journal article: MOLECULAR THERAPY. 2006;13:s73

188. Internalization of Novel Delivery Vector TAT-Streptavidin into Human Cells

Rinne J; Albarran B; Jylhävä J; Ihalainen TO; Kankaanpää P; Hytönen VP; Stayton PS; Kulomaa MS; Vihinen-Ranta M
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All other publications

Review: AGEING RESEARCH REVIEWS. 2023;91:102082

Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology.

Dent E; Hanlon P; Sim M; Jylhävä J; Liu Z; Vetrano DL; Stolz E; Pérez-Zepeda MU; Crabtree DR; Nicholson C; Job J; Ambagtsheer RC; Ward PR; Shi SM; Huynh Q; Hoogendijk EO; EPI-FRAIL consortium
Review: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;:glad251

Temporal dynamics of epigenetic aging and frailty from midlife to old age.

Mak JKL; Karlsson IK; Tang B; Wang Y; Pedersen NL; Hägg S; Jylhävä J; Reynolds CA
Editorial comment: AGING-US. 2023;15(11):4571-4573

Automated frailty scores: towards clinical implementation.

Mak JKL; Religa D; Jylhävä J
Preprint: BIORXIV. 2022

Methylation status of VTRNA2-1/nc886 is stable across human populations, monozygotic twin pairs and in majority of somatic tissues

Marttila S; Tamminen H; Rajić S; Mishra P; Lehtimäki T; Raitakari O; Kähönen M; Kananen L; Jylhävä J; Hägg S; Delerue T; Peters A; Waldenberger M; Kleber M; März W; Luoto R; Raitanen J; Sillanpää E; Laakkonen E; Heikkinen A; Ollikainen M; Raitoharju E
Preprint: MEDRXIV. 2021

Using an electronic frailty index to predict adverse outcomes in geriatric COVID-19 patients: data from the Stockholm GeroCovid study

Mak J; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Hägg S; Religa D; Jylhävä J
Preprint: MEDRXIV. 2021

Development of an electronic frailty index for hospitalized geriatric patients in Sweden

Mak J; Hägg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Jylhävä J; Religa D
Corrigendum: HUMAN GENETICS. 2021;140(6):863

Correction to: Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Review: ELIFE. 2021;10:e63425

Sex differences in biological aging with a focus on human studies.

Hägg S; Jylhävä J
Preprint: RESEARCH SQUARE. 2021

Epigenome-wide association study of level and change in cognitive abilities from midlife through late-life

Karlsson I; Ericsson M; Wang Y; Jylhävä J; Hägg S; Aslan AD; Reynolds C; Pedersen N
Preprint: MEDRXIV. 2020

Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education

Mak J; Reynolds C; Hägg S; Li X; Ericsson M; Pedersen N; Jylhävä J; Kuja-Halkola R
Preprint: MEDRXIV. 2020

Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling

Mak J; Kuja-Halkola R; Wang Y; Hägg S; Jylhävä J
Preprint: BIORXIV. 2020

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance

Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Preprint: BIORXIV. 2020

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

van Dongen J; Hagenbeek F; Suderman M; Roetman P; Sugden K; Chiocchetti A; Ismail K; Mulder R; Hafferty J; Adams M; Walker R; Morris S; Lahti J; Küpers L; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip H; Jansen R; Baselmans B; Parmar P; Lowry E; Streit F; Sirignano L; Send T; Frank J; Jylhävä J; Wang Y; Mishra PP; Colins O; Corcoran D; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix J; Bakermans-Kranenburg M; Campbell A; Czamara D; Binder E; Corpeleijn E; González JR; Grazuleviciene R; Gutzkow K; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies G; Hakulinen C; Keltikangas-Järvinen L; Franke B; Freitag C; Konrad K; Hervas A; Fernández-Rivas A; Vetro A; Raitakari O; Lehtimäki T; Vermeiren R; Strandberg T; Räikkönen K; Snieder H; Witt S; Deuschle M; Pedersen N; Hägg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt T; Tiemeier H; van Ijzendoorn M; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans K; McIntosh A; Bartels M; Boomsma D; BIOS Consortium
Conference publication: BEHAVIOR GENETICS. 2020;50(6):485-487

DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan

van Dongen J; Hagenbeek FA; Suderman M; Roetman P; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty J; Adams MJ; Walker RM; Morris SW; Lahti J; Kupers LK; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send T; Frank J; Jylhava J; Wang Y; Mishra PP; Colins OF; Corcoran D; Poulton R; Mill J; Hannon EJ; Arseneault L; Korhonen T; Vuoksimaa E; Felix J; Bakermans-Kranenburg M; Campbell A; Czamara D; Binder E; Corpeleijn E; Ramon Gonzalez J; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies GE; Hakulinen C; Keltikangas-Jarvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernandez-Rivas A; Vetro A; Raitakari O; Lehtimaki T; Vermeiren R; Strandberg T; Raikkonen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hagg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van Ijzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma D
Preprint: RESEARCH SQUARE. 2019

Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis

Nyberg A; Larsson A; Jylhävä J; Hurme M; Sperber J; Lipcsey M; Castegren M
Preprint: MEDRXIV. 2019

Drivers of Frailty from Adulthood into Old Age: Results from a 27-year Longitudinal Population-Based Study in Sweden

Raymond E; Reynolds C; Dahl Aslan A; Finkel D; Ericsson M; Hägg S; Pedersen N; Jylhävä J
Preprint: BIORXIV. 2019

A decade of epigenetic change in aging twins: genetic and environmental contributions to longitudinal DNA methylation

Reynolds C; Tan Q; Munoz E; Jylhävä J; Hjelmborg J; Christiansen L; Hägg S; Pedersen N
Preprint: MEDRXIV. 2019

A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in Aging

Atkins J; Jylhävä J; Pedersen N; Magnusson P; Lu Y; Wang Y; Hägg S; Melzer D; Williams D; Pilling L
Preprint: BIORXIV. 2019

Comprehensive longitudinal study of epigenetic mutations in aging

Wang Y; Karlsson R; Jylhävä J; Hedman Å; Almqvist C; Karlsson I; Pedersen N; Almgren M; Hägg S
Preprint: BIORXIV. 2019

Neuroticism as a predictor of frailty in old age: a genetically informative approach

Danielsdottir HB; Jylhävä J; Hägg S; Lu Y; Colodro-Conde L; Martin N; Pedersen N; Mosing M; Lehto K
Conference publication: BEHAVIOR GENETICS. 2019;49(6):516

Genome-wide association study of a frailty Index in UK Biobank and TwinGene

Jylhava J; Pilling L; Williams D; Lu Y; Pedersen NL; Melzer D; Atkins J
Conference publication: BEHAVIOR GENETICS. 2019;49(6):515

Neuroticism as a predictor of frailty in old age: a genetically informative approach

Bjork H; Jylhava J; Hagg S; Lu Y; Colodro-Conde L; Martin N; Pedersen NL; Mosing M; Lehto K
Conference publication: BEHAVIOR GENETICS. 2019;49(6):527

10-year epigenetic change: age-associated CpGs are differentially heritable

Reynolds C; Tan Q; Munoz E; Jylhava J; Hjelmborg J; Christiansen L; Hagg S; Pedersen NL
Conference publication: BEHAVIOR GENETICS. 2019;49(6):503

DNA methylation and change in late-life cognitive abilities

Karlsson I; Ericsson M; Wang Y; Jylhava J; Hagg S; Aslan AD; Reynolds C; Pedersen NL
Conference publication: BEHAVIOR GENETICS. 2019;49(6):523

Frailty and mortality: sex differences and socioeconomic influences in Swedish twins

Ericsson M; Pedersen NL; Fors S; Kuja-Halkola R; Mosing M; Jylhava J; Aslan AD
Preprint: BIORXIV. 2018

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards

Li X; Ploner A; Karlsson I; Liu X; Magnusson PKE; Pedersen N; Hägg S; Jylhävä J
Preprint: BIORXIV. 2017

A frailty index for UK Biobank participants

Williams D; Jylhävä J; Pedersen N; Hägg S
Preprint: BIORXIV. 2017

The frailty index is associated with the need for care in an aging Swedish population

Jylhävä J; Jiang M; Foebel AD; Pedersen NL; Hägg S
Preprint: BIORXIV. 2017

Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort

Jiang M; Foebel AD; Kuja-Halkola R; Karlsson I; Pedersen NL; Hägg S; Jylhävä J
Review: EBIOMEDICINE. 2017;21:29-36

Biological Age Predictors.

Jylhävä J; Pedersen NL; Hägg S
Conference publication: BEHAVIOR GENETICS. 2017;47(6):706

Longitudinal variance components of the Horvath clock and its contributing CpGs

Jylhava J; Reynolds C; Hjelmborg J; Munoz E; Tan Q; Christiansen L; Hagg S; Pedersen NL
Review: ANTIVIRAL RESEARCH. 2013;100(3):589-604

The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions.

Mustonen J; Mäkelä S; Outinen T; Laine O; Jylhävä J; Arstila PT; Hurme M; Vaheri A
Meeting abstract: EXPERIMENTAL GERONTOLOGY. 2013;48(7):689

The quantity of cell-free mitochondrial DNA in plasma as an indicator of frailty in nonagenarians

Nevalainen T; Jylhava J; Marttila S; Jylha M; Hervonen A; Hurme M
Book chapter: ENCYCLOPEDIA OF LIFE SCIENCES. 2012;p.

Genetic Determinants of Human Life‐Span

Jylhävä J; Hurme M
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Employments

Principal Researcher, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2021

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