Julie Lasselin

Julie Lasselin

Principal Researcher | Docent
Visiting address: Nobels väg 9, 17165 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 Psykologi Lekander, 171 77 Stockholm
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About me

  • I am a Psychoneuroimmunologist aiming at better understanding how inflammation influences behavior and what factors underlie the inter-individual differences in the vulnerability to the behavioral effects of cytokines.

    My work includes basic science research using clinical and experimental models in humans, which characterize in details the overt and subjective behavioral changes induced by inflammation in humans, investigate the adaptive relevance of sickness behavior, analyze the psychological and biological factors that interact with cytokines to affect the brain and behavior, and the underlying mechanisms.

    My research highlights the complex motivational changes that occur during inflammation by demonstrating that sickness behavior is not only driven by immune signals, but that top-down processes can shape the behavioral effects of pro-inflammatory cytokines. I also investigate how overt changes in behavior during inflammatory sickness affect the relationship with others and the care one receives, and how this in turn modulates health outcomes.

    I am part of the steering committee and webmaster of the newly developed European Psychoneuroimmunology Network (https://pnieurope.se). I obtained the PNIRS Ader New Investigator Award in 2021. This prestigious award is presented to an outstanding new research scientist who has made exciting basic science or clinical contributions to the field of Psychoneuroimmunology. The award honors Dr. Ader’s innovation and creativity as a scientist and recognizes his contributions to the instantiation of PNI as a meaningful endeavor dedicated to the betterment of health and the prevention of disease. (https://pnirs.memberclicks.net/awards-lectures#Ader)

Teaching

  • I am leading two online doctoral courses (co-leader: Mats Lekander): "Psychoneuroimmunology" and "Stress, Sleep, and Health".
    I am also a co-leader of the doctoral course "The science of the placebo effect" (leader: Karin Jensen).

Articles

All other publications

Grants

  • Riksbankens Jubileumsfond
    1 January 2024 - 31 January 2026
    The question of how emotions are triggered remains obscure. A recent influential theory is built on predicting coding, which states that the brain makes predictions and constantly compares these predictions with the actual incoming sensory information. The active inference theory of emotions posits that emotions arise when there is a mismatch between the bodily (interoceptive) sensations and what was predicted by the brain, i.e. when interoceptive prediction errors occur. This theory is extremely relevant for emotional disorders linked with infections (e.g. post-COVID), since infections can trigger various and intense interoceptive signals that can be difficult to predict by the brain. In this project, we will apply the active inference theory of emotions in an ecologically relevant model of infection, using an innovative experimental approach. We will go beyond the existing correlational designs by applying a causal intervention eliciting real sickness symptoms, and manipulating interoceptive prediction errors directly, in 240 participants. We hypothesize that emotional responses will arise during sickness when interoceptive prediction errors occur, i.e. when interoceptive sensations violate predictions. This project will therefore provide critical information to understand how individuals' predictions shape sickness behavior, and how emotions are generated in infection-related conditions, which could open new therapies for mood disorders associated with immune activation.
  • Swedish Research Council
    1 December 2021 - 30 November 2025
    Infectious diseases have always been and still are a major cause of human death, causing fatal epidemics worldwide. This project aims to resolve the paradox that while the most effective defense strategy would be to avoid every sick individual, humans do not
    instead, some sick individuals are approached for caregiving purposes. In fact, most care needs are met by family members, suggesting that kin selection strongly affects human responses to sickness cues. This interdisciplinary project will be the first to address whether early facial cues of sickness influence humans’ decisions to avoid or approach (i.e. care for) sick individuals and to what degree kinship moderates such decisions. In study 1, we will establish whether facial photographs of sick individuals induce spatial and social avoidance by using novel methods from experimental psychology and economics. In study 2, we will use cutting-edge digital morphing techniques to experimentally increase facial resemblance, and establish whether this cue of kinship suppresses avoidance of sick kin or even induces an approach behavior. In study 3, we will investigate whether the mere sight of early sickness cues activates the immune system, a mechanism that may enable approach, especially caregiving, by preparing the human body for an infectious attack. This project will answer fundamental questions of human behavioral immunity, a field that will benefit a world whose inhabitants are increasingly at risk from pandemics.
  • Swedish Research Council
    1 January 2021 - 31 December 2024

Employments

  • Principal Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2023

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