Jonas Muhr

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About me

I am a Professor of Eukaryotic Molecular Biology at the Department of Cell and Molecular Biology. The main interest of my research group is to understand how brain stem cells are regulated during cortical development and how mitotically active human brain stem cells are prevented from malignant transformation.

Articles

Article: OPEN BIOLOGY. 2024;14(4):230383
Mapping combinatorial expression of non-clustered protocadherins in the developing brain identifies novel PCDH19-mediated cell adhesion properties
Mincheva-Tasheva S; Pfitzner C; Kumar R; Kurtsdotter I; Scherer M; Ritchie T; Muhr J; Gecz J; Thomas PQ
Article: ISCIENCE. 2022;25(11):105317
Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer
Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
Article: DEVELOPMENT. 2022;149(14):dev200547
SOX2 transcription factor binding and function
Hagey DW; Bergsland M; Muhr J
Article: BIOESSAYS. 2021;43(7):e2000285
The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance
Muhr J; Hagey DW
Article: NATURE COMMUNICATIONS. 2020;11(1):2898
CYCLIN-B1/2 and-D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
Hagey DW; Topcic D; Kee N; Reynaud F; Bergsland M; Perlmann T; Muhr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
Article: EMBO REPORTS. 2018;19(11):e46635
Sequentially acting SOX proteins orchestrate astrocyte- and oligodendrocyte-specific gene expression
Klum S; Zaouter C; Alekseenko Z; Bjorklund AK; Hagey DW; Ericson J; Muhr J; Bergsland M
Article: PLOS GENETICS. 2018;14(2):e1007224
SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs
Hagey DW; Klum S; Kurtsdotter I; Zaouter C; Topcic D; Andersson O; Bergsland M; Muhr J
Article: CANCER RESEARCH. 2017;77(18):4985-4997
SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells
Kurtsdotter I; Topcic D; Karlen A; Singla B; Hagey DW; Bergsland M; Siesjo P; Nister M; Carlson JW; Lefebvre V; Persson O; Holmberg J; Muhr J
Article: CELL REPORTS. 2016;17(2):469-483
MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis
Vasconcelos FF; Sessa A; Laranjeira C; Raposo AASF; Teixeira V; Hagey DW; Tomaz DM; Muhr J; Broccoli V; Castro DS
Article: GENOME RESEARCH. 2016;26(7):908-917
Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells
Hagey DW; Zaouter C; Combeau G; Lendahl MA; Andersson O; Huss M; Muhr J
Article: CELL REPORTS. 2014;9(5):1908-1920
Sox2 Acts in a Dose-Dependent Fashion to Regulate Proliferation of Cortical Progenitors
Hagey DW; Muhr J
Article: CELL REPORTS. 2014;8(4):1018-1025
Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons
Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2794-2799
Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system
Lee KE; Seo J; Shin J; Ji EH; Roh J; Kim JY; Sun W; Muhr J; Lee S; Kim J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(18):7330-7335
SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals
Oosterveen T; Kurdija S; Enstero M; Uhde CW; Bergsland M; Sandberg M; Sandberg R; Muhr J; Ericson J
Article: DEVELOPMENTAL CELL. 2012;23(5):1006-1019
Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling
Oosterveen T; Kurdija S; Alekseenko Z; Uhde CW; Bergsland M; Sandberg M; Andersson E; Dias JM; Muhr J; Ericson J
Article: GENES & DEVELOPMENT. 2011;25(23):2453-2464
Sequentially acting Sox transcription factors in neural lineage development
Bergsland M; Ramskold D; Zaouter C; Klum S; Sandberg R; Muhr J
Article: EXPERIMENTAL NEUROLOGY. 2011;229(1):65-71
Olfactory ensheathing cells promote neurite outgrowth from co-cultured brain stem slice
Jiao Y; Novozhilova E; Karlen A; Muhr J; Olivius P
Article: PLOS ONE. 2011;6(3):e18454
Activation of Neural and Pluripotent Stem Cell Signatures Correlates with Increased Malignancy in Human Glioma
Holmberg J; He X; Peredo I; Orrego A; Hesselager G; Ericsson C; Hovatta O; Oba-Shinjo SM; Nagahashi Marie SK; Nister M; Muhr J
Article: DEVELOPMENT. 2010;137(3):437-445
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression
Marklund U; Hansson EM; Sundstrom E; de Angelis MH; Przemeck GKH; Lendahl U; Muhr J; Ericson J
Article: DEVELOPMENT. 2008;135(10):1843-1851
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: GENES & DEVELOPMENT. 2006;20(24):3475-3486
The establishment of neuronal properties is controlled by Sox4 and Sox11
Bergsland M; Werme M; Malewicz M; Perlmann T; Muhr J
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(16):3108-3119
A global genomic transcriptional code associated with CNS-expressed genes
Bailey PJ; Klos JM; Andersson E; Karlen M; Kallstrom M; Ponjavic J; Muhr J; Lenhard B; Sandelin A; Ericson J
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127
Recording Notch signaling in real time
Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: NATURE NEUROSCIENCE. 2005;8(8):995-1001
Sox21 promotes the progression of vertebrate neurogenesis
Sandberg M; Källström M; Muhr J
Article: NATURE NEUROSCIENCE. 2003;6(11):1162-1168
Vertebrate neurogenesis is counteracted by Sox1-3 activity
Bylund M; Andersson E; Novitch BG; Muhr J
Article: NEURON. 2001;31(5):743-755
Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification
Vallstedt A; Muhr J; Pattyn A; Pierani A; Mendelsohn M; Sander M; Jessell TM; Ericson J
Article: CELL. 2001;104(6):861-873
Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
Muhr J; Andersson E; Persson M; Jessell TM; Ericson J
Article: NEURON. 1999;23(4):689-702
Convergent inductive signals specify midbrain, hindbrain, and spinal cord identity in gastrula stage chick embryos.
Muhr J; Graziano E; Wilson S; Jessell TM; Edlund T
Article: NEURON. 1997;19(3):487-502
Assignment of early caudal identity to neural plate cells by a signal from caudal paraxial mesoderm.
Muhr J; Jessell TM; Edlund T
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):809-816
Sonic hedgehog: a common signal for ventral patterning along the rostrocaudal axis of the neural tube.
Ericson J; Muhr J; Jessell TM; Edlund T
Article: CELL. 1995;81(5):747-756
Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube.
Ericson J; Muhr J; Placzek M; Lints T; Jessell TM; Edlund T
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Employments

Professor, Department of Cell and Molecular Biology, Karolinska Institutet, 2012-

Degrees and Education

Docent, Karolinska Institutet, 2012

About me

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Employments

Degrees and Education

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