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About me

Clinical pathologist at dept of Pathology/Cytology, Karolinska University Laboratory at the Southern Hospital (Södersjukhuset).

Research team leader, Karolinska Institutet

Associate Professor of Pathology

 

 

 

 

 

 

Education

2016                     Board certified surgical pathologist 

2015                     Docent/Associate Professor in experimental pathology

2011                     Licensed physician (Karolinska Hospital/SLL)

2008                     PhD, molecular biology (Prof Jan-Åke Gustafsson research group)

2008                     University medical degree (MD), Karolinska Institutet

2001                     BSc in molecular biology and biochemistry, Stockholm University

Research description

The main research focus of Dr Hartmans team is breast cancer therapy prediction for precision oncology. This includes digital image analysis in histopathology and computer-aided diagnosis, cancer genomics/transcriptomics and patient derived tumor cell cultures (organotypic cultures). The team is also providing core center pathology service to several clincal trials.

Teaching portfolio

  • Past main-supervisor for 4 PhD-students (Ran Ma, Gustaf Rosin, Karthik Gowindasamy and Gustav Stålhammar), ongoing main-supervisor for 1 PhD-student.
  • Lecturer at Karolinska Institutet (annual courses for medical students, biomedicine students and PhD-students)

Academic honours, awards and prizes

  • Cancerfonden Clinical Investigator Award (2016-2022) 
  • Alvarengas prize (best scientific manuscript 2013), Swedish Society of Medicine.
  • Asklepios award for best scientific paper by junior physicians and medical students 2009, Swedish Society of Medicine (www.sls.se)
  • The 2006-year Anders Wall award for junior researchers (www.wallumni.com)
  • The McKinsey Award 2007 at Karolinska Institutet (www.mckinsey.com) for “combining exceptional academic results and medical research”

Publications

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Kim C, Gao R, Sei E, Brandt R, Hartman J, Hatschek T, et al
Cell 2018;173(4):879-893.e13

Digital image analysis in breast pathology-from image processing techniques to artificial intelligence
Robertson S, Azizpour H, Smith K, Hartman J
Translational research : the journal of laboratory and clinical medicine 2018;194():19-35

Digital image analysis of Ki67 in hot spots is superior to both manual Ki67 and mitotic counts in breast cancer
Stålhammar G, Robertson S, Wedlund L, Lippert M, Rantalainen M, Bergh J, et al
Histopathology 2018;72(6):974-989

Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes
Ullah I, Karthik Gm, Alkodsi A, Kjällquist U, Stålhammar G, Lövrot J, et al
The Journal of clinical investigation 2018;128(4):1355-1370

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)
Kjällquist U, Erlandsson R, Tobin Np, Alkodsi A, Ullah I, Stålhammar G, et al
BMC cancer 2018;18(1):174-

Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer
Robertson S, Stålhammar G, Darai-ramqvist E, Rantalainen M, Tobin Np, Bergh J, et al
Journal of clinical pathology 2018;():-

A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Liu C, Zhang Y, Lim S, Hosaka K, Yang Y, Pavlova T, et al
Clinical cancer research : an official journal of the American Association for Cancer Research 2017;23(16):4769-4779

Differential expression of sex hormone receptors in abdominal aortic aneurysms
Villard C, Eriksson P, Kronqvist M, Lengquist M, Jorns C, Hartman J, et al
Maturitas 2017;96():39-44

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells
Ma R, Karthik Gm, Lövrot J, Haglund F, Rosin G, Katchy A, et al
Journal of the National Cancer Institute 2017;109(3):1-14

Intra-tumor heterogeneity in breast cancer has limited impact on transcriptomic-based molecular profiling
Karthik Gm, Rantalainen M, Stålhammar G, Lövrot J, Ullah I, Alkodsi A, et al
BMC cancer 2017;17(1):802-

Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Li J, Ivansson E, Klevebring D, Tobin Np, Lindström Ls, Holm J, et al
Clinical cancer research : an official journal of the American Association for Cancer Research 2017;23(10):2584-2592

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity
Tanaka N, Kanatani S, Tomer R, Sahlgren C, Kronqvist P, Kaczynska D, et al
NATURE BIOMEDICAL ENGINEERING 2017;1(10):796-806

Digital image analysis outperforms manual biomarker assessment in breast cancer
Stålhammar G, Fuentes Martinez N, Lippert M, Tobin Np, Mølholm I, Kis L, et al
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016;29(4):318-29

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin Np, et al
Cancer research 2016;76(11):3166-78

Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, et al
Proceedings of the National Academy of Sciences of the United States of America 2016;113(38):E5618-27

Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers
Rantalainen M, Klevebring D, Lindberg J, Ivansson E, Rosin G, Kis L, et al
Scientific reports 2016;6():38037-

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
Pellegrini P, Dyczynski M, Sbrana Fv, Karlgren M, Buoncervello M, Hägg-olofsson M, et al
Oncotarget 2016;7(24):35703-35723

Gene protein detection platform--a comparison of a new human epidermal growth factor receptor 2 assay with conventional immunohistochemistry and fluorescence in situ hybridization platforms
Stålhammar G, Farrajota P, Olsson A, Silva C, Hartman J, Elmberger G
Annals of diagnostic pathology 2015;19(4):203-10

mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells
Karthik Gm, Ma R, Lövrot J, Kis Ll, Lindh C, Blomquist L, et al
Cancer letters 2015;367(1):76-87

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development
Wang J, Cao Z, Zhang Xm, Nakamura M, Sun M, Hartman J, et al
Cancer research 2015;75(2):306-15

Response to correspondence on 'low concordance of biomarkers in histopathological and cytological material from breast cancer'
Stålhammar G, Hartman J
Histopathology 2015;66(5):756-8

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J, Tobin Np, Rundqvist H, Li T, Lavergne M, García-ibáñez Y, et al
Journal of the National Cancer Institute 2015;107(10):-

Tumour nuclear oestrogen receptor beta 1 correlates inversely with parathyroid tumour weight
Haglund F, Rosin G, Nilsson Il, Juhlin Cc, Pernow Y, Norenstedt S, et al
Endocrine connections 2015;4(1):76-85

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion
Mojallal M, Zheng Yj, Hultin S, Audebert S, Van Harn T, Johnsson P, et al
NATURE COMMUNICATIONS 2014;:4557-

Low concordance of biomarkers in histopathological and cytological material from breast cancer
Stålhammar G, Rosin G, Fredriksson I, Bergh J, Hartman J
Histopathology 2014;64(7):971-80

miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer
Wang J, Tsouko E, Jonsson P, Bergh J, Hartman J, Aydogdu E, et al
Molecular oncology 2014;8(8):1690-702

Oestrogen receptors β1 and βcx have divergent roles in breast cancer survival and lymph node metastasis
Rosin G, De Boniface J, Karthik Gm, Frisell J, Bergh J, Hartman J
British journal of cancer 2014;111(5):918-26

Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo
Klevebring D, Rosin G, Ma R, Lindberg J, Czene K, Kere J, et al
BREAST CANCER RESEARCH 2014;16(4):R72-

Superficial scrapings from breast tumors is a source for biobanking and research purposes
Ma R, Fredriksson I, Karthik Gm, Winn G, Darai-ramqvist E, Bergh J, et al
Laboratory investigation; a journal of technical methods and pathology 2014;94(7):796-805

High prevalence of human cytomegalovirus proteins and nucleic acids in primary breast cancer and metastatic sentinel lymph nodes
Taher C, De Boniface J, Mohammad Aa, Religa P, Hartman J, Yaiw Kc, et al
PloS one 2013;8(2):e56795-

Lymphoid aggregates in Crohn's colitis and mucosal immunity
Rubio Ca, Ásmundsson J, Silva P, Illies C, Hartman J, Kis L
Virchows Archiv : an international journal of pathology 2013;463(5):637-42

Clinically Used Breast Cancer Markers Such As Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression
Lindstrom Ls, Karlsson E, Wilking Um, Johansson U, Hartman J, Lidbrink Ek, et al
JOURNAL OF CLINICAL ONCOLOGY 2012;30(21):2601-8

Current concepts and significance of estrogen receptor β in prostate cancer
Hartman J, Ström A, Gustafsson JÅ
Steroids 2012;77(12):1262-6

Estrogen Receptors beta 1 and beta 2 Have Opposing Roles in Regulating Proliferation and Bone Metastasis Genes in the Prostate Cancer Cell Line PC3
Dey P, Jonsson P, Hartman J, Williams C, Strom A, Gustafsson Ja
MOLECULAR ENDOCRINOLOGY 2012;26(12):1991-2003

Evidence of a functional estrogen receptor in parathyroid adenomas
Haglund F, Ma R, Huss M, Sulaiman L, Lu M, Nilsson Il, et al
The Journal of clinical endocrinology and metabolism 2012;97(12):4631-9

The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer
Rosin G, Hannelius U, Lindström L, Hall P, Bergh J, Hartman J, et al
BMC cancer 2012;12():79-

ER beta 1 Represses FOXM1 Expression through Targeting ER alpha to Control Cell Proliferation in Breast Cancer
Horimoto Y, Hartman J, Millour J, Pollock S, Olmos Y, Ho Kk, et al
AMERICAN JOURNAL OF PATHOLOGY 2011;179(3):1148-56

Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders?
Hartman J, Gustafsson Ja
CANCER PREVENTION RESEARCH 2010;3(8):897-9

FOXM1 is a transcriptional target of ER alpha and has a critical role in breast cancer endocrine sensitivity and resistance
Millour J, Constantinidou D, Stavropoulou Av, Wilson Msc, Myatt Ss, Kwok Jmm, et al
ONCOGENE 2010;29(20):2983-95

Targeting of estrogen receptor beta as a future cancer treatment
Gustafsson Ja, Warner M, Strom A, Hartman J
ENDOCRINE JOURNAL 2010;:S321-S321

Estrogen receptor beta in breast cancer-Diagnostic and therapeutic implications
Hartman J, Strom A, Gustafsson Ja
STEROIDS 2009;74(8):635-41

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer
Francis Re, Myatt Ss, Krol J, Hartman J, Peck B, Mcgovern Ub, et al
INTERNATIONAL JOURNAL OF ONCOLOGY 2009;35(1):57-68

Function of HES6 an Inhibitor of HES1, in the Breast Cancer Cell Lines T47D and MCF-7 Is to Up-Regulate E2F-1 and Increased Proliferation
Strom Am, Hartman J, Lam Ewf, Lin Cy, Gustafsson Ja
CANCER RESEARCH 2009;69(24):642S-642S

Hes-6, an inhibitor of Hes-1, is regulated by 17 beta-estradiol and promotes breast cancer cell proliferation
Hartman J, Lam Ewf, Gustafsson Ja, Strom A
BREAST CANCER RESEARCH 2009;11(6):R79-

Tumor Repressive Functions of Estrogen Receptor beta in SW480 Colon Cancer Cells
Hartman J, Edvardsson K, Lindberg K, Zhao Cy, Williams C, Strom A, et al
CANCER RESEARCH 2009;69(15):6100-6

Estrogen receptors: How do they signal and what are their targets
Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, et al
PHYSIOLOGICAL REVIEWS 2007;87(3):905-31

Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts
Hartman J, Lindberg K, Morani A, Inzunza J, Strom A, Gustafsson Ja
CANCER RESEARCH 2006;66(23):11207-13

Estrogen receptor beta represses breast tumor growth and angiogenesis in vivo.
Hartman J, Lindberg K, Inzunza J, Wan J, Strom A, Gustafsson J
JOURNAL OF CLINICAL ONCOLOGY 2006;24(18):565S-565S

Estrogen receptor beta inhibits 17 beta-estradiol-stimulated proliferation of the breast cancer cell line T47D
Strom A, Hartman J, Foster Js, Kietz S, Wimalasena J, Gustafsson Ja
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004;101(6):1566-71

HES-1 inhibits 17 beta-estradiol and heregulin-beta 1-mediated upregulation of E2F-1
Hartman J, Muller P, Foster Js, Wimalasena J, Gustafsson Ja, Strom A
ONCOGENE 2004;23(54):8826-33

Lithium chloride inhibits the expression and secretion of insulin-like growth factor-binding protein-1
Lewitt Ms, Brismar K, Ohlson J, Hartman J
JOURNAL OF ENDOCRINOLOGY 2001;171(3):R11-5

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