Johan Frostegård

About me
Publications
Public outreach and news

About me

Professor of Medicine at the Institute of Environmental Medicine and Head of Unit of Immunology and Chronic Disease. Main research interest is how different types of lipids, mainly phospholipids, activate immune reactions and how these affect atherosclerosis, cardiovascular disease, and inflammation in general. The research is both experimental and clinically oriented.

Articles

Article: SCIENTIFIC REPORTS. 2023;13(1):15011

Antibodies against malondialdehyde among 60-year-olds: prediction of cardiovascular disease.

Samal SK; Leander K; Vikström M; Griesbaum L; de Faire U; Frostegård J
Journal article: JOURNAL OF LIPID RESEARCH. 2023;64(8):100412

Antibodies against oxidation-specific epitopes and risk of acute myocardial infarction.

Frostegård J
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:809007

Antibodies Against Phosphorylcholine Among 60-Year-Olds: Clinical Role and Simulated Interactions.

Samal SK; Panda PK; Vikström M; Leander K; de Faire U; Ahuja R; Frostegård J
Article: SCIENTIFIC REPORTS. 2021;11(1):20246

Antibodies against phosphorylcholine in hospitalized versus non-hospitalized obese subjects.

Jujić A; Korduner J; Holm H; Engström G; Bachus E; Bhattacharya P; Nilsson PM; Frostegård J; Magnusson M
Article: ACR OPEN RHEUMATOLOGY. 2021;3(9):642-653

Effects of Atorvastatin on T-Cell Activation and Apoptosis in Systemic Lupus Erythematosus and Novel Simulated Interactions With C-Reactive Protein and Interleukin 6.

Sun J; Kumar Panda P; Kumar Samal S; Ahuja R; Ajeganova S; Hafström I; Liu A; Frostegård J
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):201

Higher levels of anti-phosphorylcholine autoantibodies in early rheumatoid arthritis indicate lower risk of incident cardiovascular events.

Ajeganova S; Andersson MLE; Frostegård J; Hafström I
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(1):141-156

Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases.

de Vries MR; Ewing MM; de Jong RCM; MacArthur MR; Karper JC; Peters EAB; Nordzell M; Karabina SAP; Sexton D; Dahlbom I; Bergman A; Mitchell JR; Frostegård J; Kuiper J; Ninio E; Jukema JW; Pettersson K; Quax PHA
Article: SCIENTIFIC REPORTS. 2021;11(1):12120

Potential natural immunization against atherosclerosis in hibernating bears.

Samal SK; Fröbert O; Kindberg J; Stenvinkel P; Frostegård J
Article: ARTHRITIS & RHEUMATOLOGY. 2021;73(6):1073-1085

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases.

Barturen G; Babaei S; Català-Moll F; Martínez-Bueno M; Makowska Z; Martorell-Marugán J; Carmona-Sáez P; Toro-Domínguez D; Carnero-Montoro E; Teruel M; Kerick M; Acosta-Herrera M; Le Lann L; Jamin C; Rodríguez-Ubreva J; García-Gómez A; Kageyama J; Buttgereit A; Hayat S; Mueller J; Lesche R; Hernandez-Fuentes M; Juarez M; Rowley T; White I; Marañón C; Gomes Anjos T; Varela N; Aguilar-Quesada R; Garrancho FJ; López-Berrio A; Rodriguez Maresca M; Navarro-Linares H; Almeida I; Azevedo N; Brandão M; Campar A; Faria R; Farinha F; Marinho A; Neves E; Tavares A; Vasconcelos C; Trombetta E; Montanelli G; Vigone B; Alvarez-Errico D; Li T; Thiagaran D; Blanco Alonso R; Corrales Martínez A; Genre F; López Mejías R; Gonzalez-Gay MA; Remuzgo S; Ubilla Garcia B; Cervera R; Espinosa G; Rodríguez-Pintó I; De Langhe E; Cremer J; Lories R; Belz D; Hunzelmann N; Baerlecken N; Kniesch K; Witte T; Lehner M; Stummvoll G; Zauner M; Aguirre-Zamorano MA; Barbarroja N; Castro-Villegas MC; Collantes-Estevez E; de Ramon E; Díaz Quintero I; Escudero-Contreras A; Fernández Roldán MC; Jiménez Gómez Y; Jiménez Moleón I; Lopez-Pedrera R; Ortega-Castro R; Ortego N; Raya E; Artusi C; Gerosa M; Meroni PL; Schioppo T; De Groof A; Ducreux J; Lauwerys B; Maudoux A-L; Cornec D; Devauchelle-Pensec V; Jousse-Joulin S; Jouve P-E; Rouvière B; Saraux A; Simon Q; Alvarez M; Chizzolini C; Dufour A; Wynar D; Balog A; Bocskai M; Deák M; Dulic S; Kádár G; Kovács L; Cheng Q; Gerl V; Hiepe F; Khodadadi L; Thiel S; de Rinaldis E; Rao S; Benschop RJ; Chamberlain C; Dow ER; Ioannou Y; Laigle L; Marovac J; Wojcik J; Renaudineau Y; Borghi MO; Frostegård J; Martín J; Beretta L; Ballestar E; McDonald F; Pers J-O; Alarcón-Riquelme ME
Article: LUPUS SCIENCE & MEDICINE. 2021;8(1):e000454

Patients with SLE have higher risk of cardiovascular events and mortality in comparison with controls with the same levels of traditional risk factors and intima-media measures, which is related to accumulated disease damage and antiphospholipid syndrome: a case-control study over 10 years.

Ajeganova S; Hafström I; Frostegård J
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):32

Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms.

Frostegård J; Ahmed S; Hafström I; Ajeganova S; Rahman M
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100090

An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases.

Bettacchioli E; Le Gaffric C; Mazeas M; Borghi MO; Frostegard J; Barturen G; Makowska Z; Babei S; Lesche R; PRECISESADS Clinical Consortium; Meroni PL; Alarcon-Riquelme ME; Renaudineau Y
Article: BMC CARDIOVASCULAR DISORDERS. 2020;20(1):524

C-reactive protein in traditional melanesians on Kitava.

Carrera-Bastos P; Fontes-Villalba M; Gurven M; Muskiet FAJ; Åkerfeldt T; Lindblad U; Råstam L; Frostegård J; Shapira Y; Shoenfeld Y; Granfeldt Y; Sundquist K; Jönsson T
Article: JOURNAL OF AUTOIMMUNITY. 2020;115:102524

Antiphospholipid autoantibody detection is important in all patients with systemic autoimmune diseases.

Marziale A; Bettacchioli E; Picart G; Nafai S; Galinat H; Meroni PL; Frostegard J; PRECISESADS Clinical Consortium; Alarcon-Riquelme ME; Renaudineau Y
Article: JOURNAL OF IMMUNOLOGY. 2020;205(8):2109-2116

Antibodies against Phosphorylcholine and Malondialdehyde during the First Two Years of Life.

Thiagarajan D; Lundström SL; Pershagen G; Almqvist C; Andolf E; Hedman A; Berg O; Oparina N; Frostegård J
Article: SCIENTIFIC REPORTS. 2020;10(1):11010

IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases.

Thiagarajan D; Oparina N; Lundström S; Zubarev R; Sun J; PRECISESADS Clinical Consortium; Alarcon-Riquelme M; Frostegård J
Article: LUPUS. 2020;29(8):825-835

Proprotein convertase subtilisin kexin 9 is associated with disease activity and is implicated in immune activation in systemic lupus erythematosus.

Liu A; Rahman M; Hafström I; Ajeganova S; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2020;201(1):94-104

Different subclasses and isotypes of antibodies against phosphorylcholine in haemodialysis patients: association with mortality.

Samal SK; Qureshi AR; Rahman M; Stenvinkel P; Frostegård J
Article: ACR OPEN RHEUMATOLOGY. 2020;2(6):344-356

Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms.

Thiagarajan D; Fiskesund R; Frostegård A; Steen J; Rahman M; Vikström M; Lundström S; Frostegård J
Article: JOURNAL OF INTERNAL MEDICINE. 2020;287(4):422-434

Phenotypic features of vascular calcification in chronic kidney disease.

Dai L; Debowska M; Lukaszuk T; Bobrowski L; Barany P; Söderberg M; Thiagarajan D; Frostegård J; Wennberg L; Lindholm B; Qureshi AR; Waniewski J; Stenvinkel P
Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(3):E753-753

Antibodies against Malondialdehyde in Haemodialysis Patients and Its Association with Clinical Outcomes: Differences between Subclasses and Isotypes.

Samal SK; Qureshi AR; Rahman M; Stenvinkel P; Frostegård J
Article: LUPUS SCIENCE & MEDICINE. 2020;7(1):e000362

Similar progression of carotid intima-media thickness in 7-year surveillance of patients with mild SLE and controls, but this progression is still promoted by dyslipidaemia, lower HDL levels, hypertension, history of lupus nephritis and a higher prednisolone usage in patients.

Ajeganova S; Gustafsson T; Lindberg L; Hafström I; Frostegård J
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(4):480-494

Malondialdehyde Conjugated With Albumin Induces Pro-Inflammatory Activation of T Cells Isolated From Human Atherosclerotic Plaques Both Directly and Via Dendritic Cell-Mediated Mechanism.

Rahman M; Steuer J; Gillgren P; Végvári Á; Liu A; Frostegård J
Article: LUPUS. 2018;27(10):1670-1678

Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus.

Frostegård J; Hellström C; Nilsson P; Frostegård AG; Ajeganova S
Article: CLINICAL RHEUMATOLOGY. 2018;37(7):1825-1834

Variation in pain related to systemic lupus erythematosus (SLE): a 7-year follow-up study.

Waldheim E; Ajeganova S; Bergman S; Frostegård J; Welin E
Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.

Chen X; Gustafsson S; Whitington T; Borné Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hägg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engström G; Lind L; Karlsson MCI; Pedersen NL; Frostegård J; Magnusson PKE
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):428-433

Association between dietary and metabolic factors and IgM antibodies to phosphorylcholine and malondialdehyde in patients with systemic lupus erythematosus and population-based matched controls.

Lourdudoss C; Ajeganova S; Frostegård J
Article: JOURNAL OF INTERNAL MEDICINE. 2018;:193-210

PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque.

Liu A; Frostegård J
Article: ATHEROSCLEROSIS. 2018;268:36-48

IgM antibodies against phosphorylcholine promote polarization of T regulatory cells from patients with atherosclerotic plaques, systemic lupus erythematosus and healthy donors.

Sun J; Lundström SL; Zhang B; Zubarev RA; Steuer J; Gillgren P; Rahman M; Ajeganova S; Liu A; Frostegård J
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2017;6(11):e006778

Induction of Dendritic Cell-Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60.

Rahman M; Steuer J; Gillgren P; Hayderi A; Liu A; Frostegård J
Article: NATURE COMMUNICATIONS. 2017;8:16021

Transancestral mapping and genetic load in systemic lupus erythematosus.

Langefeld CD; Ainsworth HC; Cunninghame Graham DS; Kelly JA; Comeau ME; Marion MC; Howard TD; Ramos PS; Croker JA; Morris DL; Sandling JK; Almlöf JC; Acevedo-Vásquez EM; Alarcón GS; Babini AM; Baca V; Bengtsson AA; Berbotto GA; Bijl M; Brown EE; Brunner HI; Cardiel MH; Catoggio L; Cervera R; Cucho-Venegas JM; Dahlqvist SR; D'Alfonso S; Da Silva BM; de la Rúa Figueroa I; Doria A; Edberg JC; Endreffy E; Esquivel-Valerio JA; Fortin PR; Freedman BI; Frostegård J; García MA; de la Torre IG; Gilkeson GS; Gladman DD; Gunnarsson I; Guthridge JM; Huggins JL; James JA; Kallenberg CGM; Kamen DL; Karp DR; Kaufman KM; Kottyan LC; Kovács L; Laustrup H; Lauwerys BR; Li Q-Z; Maradiaga-Ceceña MA; Martín J; McCune JM; McWilliams DR; Merrill JT; Miranda P; Moctezuma JF; Nath SK; Niewold TB; Orozco L; Ortego-Centeno N; Petri M; Pineau CA; Pons-Estel BA; Pope J; Raj P; Ramsey-Goldman R; Reveille JD; Russell LP; Sabio JM; Aguilar-Salinas CA; Scherbarth HR; Scorza R; Seldin MF; Sjöwall C; Svenungsson E; Thompson SD; Toloza SMA; Truedsson L; Tusié-Luna T; Vasconcelos C; Vilá LM; Wallace DJ; Weisman MH; Wither JE; Bhangale T; Oksenberg JR; Rioux JD; Gregersen PK; Syvänen A-C; Rönnblom L; Criswell LA; Jacob CO; Sivils KL; Tsao BP; Schanberg LE; Behrens TW; Silverman ED; Alarcón-Riquelme ME; Kimberly RP; Harley JB; Wakeland EK; Graham RR; Gaffney PM; Vyse TJ
Article: LAKARTIDNINGEN. 2017;114:EH7W

[Small fatty substances may be of great importance in the development of atherosclerosis].

Frostegård J
Article: IMMUNOLOGICAL INVESTIGATIONS. 2017;46(1):59-69

Antibodies against Phosphorylcholine among New Guineans Compared to Swedes: An Aspect of the Hygiene/Missing Old Friends Hypothesis.

Frostegård J; Tao W; Råstam L; Lindblad U; Lindeberg S
Article: PLOS ONE. 2017;12(4):e0171195

IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds.

Frostegård J; Su J; Sing S; Hua X; Vikström M; Leander K; Gigante B; de Faire U; Frostegård AG
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(1):131-142

Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus.

An J; Briggs TA; Dumax-Vorzet A; Alarcón-Riquelme ME; Belot A; Beresford M; Bruce IN; Carvalho C; Chaperot L; Frostegård J; Plumas J; Rice GI; Vyse TJ; Wiedeman A; Crow YJ; Elkon KB
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(12):e004415

Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60-Year-Olds.

Thiagarajan D; Frostegård AG; Singh S; Rahman M; Liu A; Vikström M; Leander K; Gigante B; Hellenius M-L; Zhang B; Zubarev RA; de Faire U; Lundström SL; Frostegård J
Article: LUPUS. 2016;25(14):1602-1609

Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus.

Lourdudoss C; Elkan A-C; Hafström I; Jogestrand T; Gustafsson T; van Vollenhoven R; Frostegård J
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(9):e003976

Oxidized Low-Density Lipoprotein (OxLDL)-Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let-7c Is Integral to the Effect.

Frostegård J; Zhang Y; Sun J; Yan K; Liu A
Article: CLINICAL IMMUNOLOGY. 2016;166-167:27-37

IgM antibodies against malondialdehyde and phosphorylcholine are together strong protection markers for atherosclerosis in systemic lupus erythematosus: Regulation and underlying mechanisms.

Rahman M; Sing S; Golabkesh Z; Fiskesund R; Gustafsson T; Jogestrand T; Frostegård AG; Hafström I; Liu A; Frostegård J
Article: LUPUS SCIENCE & MEDICINE. 2016;3(1):e000135

The association between diet and glucocorticoid treatment in patients with SLE.

Lourdudoss C; Hafström I; Frostegård J; van Vollenhoven R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(1):242-252

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

Zhao J; Giles BM; Taylor RL; Yette GA; Lough KM; Ng HL; Abraham LJ; Wu H; Kelly JA; Glenn SB; Adler AJ; Williams AH; Comeau ME; Ziegler JT; Marion M; Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks; Alarcón GS; Anaya J-M; Bae S-C; Kim D; Lee H-S; Criswell LA; Freedman BI; Gilkeson GS; Guthridge JM; Jacob CO; James JA; Kamen DL; Merrill JT; Sivils KM; Niewold TB; Petri MA; Ramsey-Goldman R; Reveille JD; Scofield RH; Stevens AM; Vilá LM; Vyse TJ; Kaufman KM; Harley JB; Langefeld CD; Gaffney PM; Brown EE; Edberg JC; Kimberly RP; Ulgiati D; Tsao BP; Boackle SA
Article: CLINICAL IMMUNOLOGY. 2015;161(2):157-162

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus.

Zhao J; Wu H; Langefeld CD; Kaufman KM; Kelly JA; Bae S-C; Marta E. Alarcón-Riquelme for the BIOLUPUS and GEN; Alarcón GS; Anaya J-M; Criswell LA; Freedman BI; Kamen DL; Gilkeson GS; Jacob CO; James JA; Merrill JT; Gaffney PM; Sivils KM; Niewold TB; Petri MA; Song ST; Jeong H-J; Ramsey-Goldman R; Reveille JD; Scofield RH; Stevens AM; Boackle SA; Vilá LM; Chang D-M; Song YW; Vyse TJ; Harley JB; Brown EE; Edberg JC; Kimberly RP; Hahn BH; Grossman JM; Tsao BP; La Cava A
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2015;29(8):1152-1158

Coenzyme Q10 and oxidative stress, the association with peripheral sensory neuropathy and cardiovascular disease in type 2 diabetes mellitus.

Forsberg E; Xu C; Grünler J; Frostegård J; Tekle M; Brismar K; Kärvestedt L
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):84

Bone mineral density and carotid atherosclerosis in systemic lupus erythematosus: a controlled cross-sectional study.

Ajeganova S; Gustafsson T; Jogestrand T; Frostegård J; Hafström I
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(3):e14

PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6.

Oparina NY; Delgado-Vega AM; Martinez-Bueno M; Magro-Checa C; Fernández C; Castro RO; Pons-Estel BA; D'Alfonso S; Sebastiani GD; Witte T; Lauwerys BR; Endreffy E; Kovács L; Escudero A; López-Pedrera C; Vasconcelos C; da Silva BM; Frostegård J; Truedsson L; Martin J; Raya E; Ortego-Centeno N; de Los Angeles Aguirre M; de Ramón Garrido E; Palma M-JC; Alarcon-Riquelme ME; Kozyrev SV
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(1):197-205

Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins.

Liu A; Ming JY; Fiskesund R; Ninio E; Karabina S-A; Bergmark C; Frostegård AG; Frostegård J
Article: ATHEROSCLEROSIS. 2014;236(2):394-399

Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men.

Gigante B; Leander K; Vikström M; Baldassarre D; Veglia F; Strawbridge RJ; McLeod O; Gertow K; Sennblad B; Shah S; Zabaneh D; Humphries SE; Kauhanen J; Rauramaa R; Smit AJ; Mannarino E; Giral P; Tremoli E; Hamsten A; Frostegård J; de Faire U; IMPROVE Study Group
Article: ATHEROSCLEROSIS. 2014;235(2):592-598

Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5.

Wan M; Hua X; Su J; Thiagarajan D; Frostegård AG; Haeggström JZ; Frostegård J
Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4551-4559

Naturally occurring human phosphorylcholine antibodies are predominantly products of affinity-matured B cells in the adult.

Fiskesund R; Steen J; Amara K; Murray F; Szwajda A; Liu A; Douagi I; Malmström V; Frostegård J
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(4):586-598

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.

Guthridge JM; Lu R; Sun H; Sun C; Wiley GB; Dominguez N; Macwana SR; Lessard CJ; Kim-Howard X; Cobb BL; Kaufman KM; Kelly JA; Langefeld CD; Adler AJ; Harley ITW; Merrill JT; Gilkeson GS; Kamen DL; Niewold TB; Brown EE; Edberg JC; Petri MA; Ramsey-Goldman R; Reveille JD; Vilá LM; Kimberly RP; Freedman BI; Stevens AM; Boackle SA; Criswell LA; Vyse TJ; Behrens TW; Jacob CO; Alarcón-Riquelme ME; Sivils KL; Choi J; Joo YB; Bang S-Y; Lee H-S; Bae S-C; Shen N; Qian X; Tsao BP; Scofield RH; Harley JB; Webb CF; Wakeland EK; James JA; Nath SK; Graham RR; Gaffney PM
Article: PLOS ONE. 2014;9(12):e111764

Antibodies against native and oxidized cardiolipin and phosphatidylserine and phosphorylcholine in atherosclerosis development.

Frostegård AG; Su J; Hua X; Vikström M; de Faire U; Frostegård J
Article: PLOS ONE. 2014;9(9):e106584

IgM-antibodies against phosphorylcholine in mothers and normal or low birth weight term newborn infants.

Frostegård AG; Sjöberg BG; Frostegård J; Norman M
Article: JOURNAL OF RHEUMATOLOGY. 2013;40(12):1958-1966

Disease factors in early rheumatoid arthritis are associated with differential risks for cardiovascular events and mortality depending on age at onset: a 10-year observational cohort study.

Ajeganova S; Andersson MLE; Frostegård J; Hafström I
Article: JOURNAL OF RHEUMATOLOGY. 2013;40(11):1856-1864

Low levels of antibodies against oxidized but not nonoxidized cardiolipin and phosphatidylserine are associated with atherosclerotic plaques in systemic lupus erythematosus.

Su J; Frostegård AG; Hua X; Gustafsson T; Jogestrand T; Hafström I; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2013;174(3):441-448

Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality.

Frostegård AG; Hua X; Su J; Carrero JJ; Heimbürger O; Bárány P; Stenvinkel P; Frostegård J
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;106:72-78

Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine.

Domeij H; Hua X; Su J; Bäcklund A; Yan Z; Frostegård AG; Haeggström JZ; Modéer T; Frostegård J
Article: HUMAN MOLECULAR GENETICS. 2013;22(19):4021-4029

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

Martin J-E; Assassi S; Diaz-Gallo L-M; Broen JC; Simeon CP; Castellvi I; Vicente-Rabaneda E; Fonollosa V; Ortego-Centeno N; González-Gay MA; Espinosa G; Carreira P; Spanish Scleroderma Group; SLEGEN consortium; U.S. Scleroderma GWAS group; BIOLUPUS; Camps M; Sabio JM; D'alfonso S; Vonk MC; Voskuyl AE; Schuerwegh AJ; Kreuter A; Witte T; Riemekasten G; Hunzelmann N; Airo P; Beretta L; Scorza R; Lunardi C; Van Laar J; Chee MM; Worthington J; Herrick A; Denton C; Fonseca C; Tan FK; Arnett F; Zhou X; Reveille JD; Gorlova O; Koeleman BPC; Radstake TRDJ; Vyse T; Mayes MD; Alarcón-Riquelme ME; Martin J
Article: LUPUS. 2013;22(11):1118-1127

Health-related quality of life, fatigue and mood in patients with SLE and high levels of pain compared to controls and patients with low levels of pain.

Waldheim E; Elkan A-C; Pettersson S; van Vollenhoven R; Bergman S; Frostegård J; Welin Henriksson E
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;167(2):464-469

IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes.

Caidahl K; Hartford M; Karlsson T; Herlitz J; Pettersson K; de Faire U; Frostegård J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(3):437-444

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.

Kaufman KM; Zhao J; Kelly JA; Hughes T; Adler A; Sanchez E; Ojwang JO; Langefeld CD; Ziegler JT; Williams AH; Comeau ME; Marion MC; Glenn SB; Cantor RM; Grossman JM; Hahn BH; Song YW; Yu C-Y; James JA; Guthridge JM; Brown EE; Alarcón GS; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri MA; Reveille JD; Vilá LM; Anaya J-M; Boackle SA; Stevens AM; Freedman BI; Criswell LA; Pons Estel BA; Argentine Collaborative Group; Lee J-H; Lee J-S; Chang D-M; Scofield RHA; Gilkeson GS; Merrill JT; Niewold TB; Vyse TJ; Bae S-C; Alarcón-Riquelme ME; BIOLUPUS network; Jacob CO; Moser Sivils K; Gaffney PM; Harley JB; Sawalha AH; Tsao BP
Article: LUPUS. 2013;22(2):136-143

Extent and characteristics of self-reported pain in patients with systemic lupus erythematosus.

Waldheim E; Elkan A-C; Bergman S; Frostegård J; van Vollenhoven R; Henriksson EW
Article: BMC CARDIOVASCULAR DISORDERS. 2013;13:1

Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study.

Su J; Hua X; Vikström M; Leander K; Gigante B; Hellenius M-L; de Faire U; Frostegård J
Article: PLOS GENETICS. 2013;9(10):e1003870

Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.

Sakurai D; Zhao J; Deng Y; Kelly JA; Brown EE; Harley JB; Bae S-C; Alarcόn-Riquelme ME; BIOLUPUS and GENLES networks; Edberg JC; Kimberly RP; Ramsey-Goldman R; Petri MA; Reveille JD; Vilá LM; Alarcón GS; Kaufman KM; Vyse TJ; Jacob CO; Gaffney PM; Sivils KM; James JA; Kamen DL; Gilkeson GS; Niewold TB; Merrill JT; Scofield RH; Criswell LA; Stevens AM; Boackle SA; Kim J-H; Choi J; Pons-Estel BA; Argentine Collaborative Group; Freedman BI; Anaya J-M; Martin J; Yu CY; Chang D-M; Song YW; Langefeld CD; Chen W; Grossman JM; Cantor RM; Hahn BH; Tsao BP
Article: PLOS GENETICS. 2013;9(2):e1003336

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.

Deng Y; Zhao J; Sakurai D; Kaufman KM; Edberg JC; Kimberly RP; Kamen DL; Gilkeson GS; Jacob CO; Scofield RH; Langefeld CD; Kelly JA; Ramsey-Goldman R; Petri MA; Reveille JD; Vilá LM; Alarcón GS; Vyse TJ; Pons-Estel BA; Argentine Collaborative Group; Freedman BI; Gaffney PM; Sivils KM; James JA; Gregersen PK; Anaya J-M; Niewold TB; Merrill JT; Criswell LA; Stevens AM; Boackle SA; Cantor RM; Chen W; Grossman JM; Hahn BH; Harley JB; Alarcόn-Riquelme ME; BIOLUPUS and GENLES networks; Brown EE; Tsao BP
Article: PLOS GENETICS. 2013;9(2):e1003222

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.

Molineros JE; Maiti AK; Sun C; Looger LL; Han S; Kim-Howard X; Glenn S; Adler A; Kelly JA; Niewold TB; Gilkeson GS; Brown EE; Alarcón GS; Edberg JC; Petri M; Ramsey-Goldman R; Reveille JD; Vilá LM; Freedman BI; Tsao BP; Criswell LA; Jacob CO; Moore JH; Vyse TJ; Langefeld CL; Guthridge JM; Gaffney PM; Moser KL; Scofield RH; Alarcón-Riquelme ME; BIOLUPUS Network; Williams SM; Merrill JT; James JA; Kaufman KM; Kimberly RP; Harley JB; Nath SK
Article: PLOS ONE. 2013;8(8):e69404

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.

Namjou B; Kim-Howard X; Sun C; Adler A; Chung SA; Kaufman KM; Kelly JA; Glenn SB; Guthridge JM; Scofield RH; Kimberly RP; Brown EE; Alarcón GS; Edberg JC; Kim J-H; Choi J; Ramsey-Goldman R; Petri MA; Reveille JD; Vilá LM; Boackle SA; Freedman BI; Tsao BP; Langefeld CD; Vyse TJ; Jacob CO; Pons-Estel B; Argentine Collaborative Group; Niewold TB; Moser Sivils KL; Merrill JT; Anaya J-M; Gilkeson GS; Gaffney PM; Bae S-C; Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks; Harley JB; Criswell LA; James JA; Nath SK
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(11):1809-1814

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.

Kim K; Brown EE; Choi C-B; Alarcón-Riquelme ME; BIOLUPUS; Kelly JA; Glenn SB; Ojwang JO; Adler A; Lee H-S; Boackle SA; Criswell LA; Alarcón GS; Edberg JC; Stevens AM; Jacob CO; Gilkeson GS; Kamen DL; Tsao BP; Anaya J-M; Guthridge JM; Nath SK; Richardson B; Sawalha AH; Kang YM; Shim SC; Suh C-H; Lee S-K; Kim C-S; Merrill JT; Petri M; Ramsey-Goldman R; Vilá LM; Niewold TB; Martin J; Pons-Estel BA; GENLES; Vyse TJ; Freedman BI; Moser KL; Gaffney PM; Williams A; Comeau M; Reveille JD; James JA; Scofield RH; Langefeld CD; Kaufman KM; Harley JB; Kang C; Kimberly RP; Bae S-C
Article: LUPUS. 2012;21(13):1405-1411

Diet and fatty acid pattern among patients with SLE: associations with disease activity, blood lipids and atherosclerosis.

Elkan A-C; Anania C; Gustafsson T; Jogestrand T; Hafström I; Frostegård J
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(11):3695-3705

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.

Adrianto I; Wang S; Wiley GB; Lessard CJ; Kelly JA; Adler AJ; Glenn SB; Williams AH; Ziegler JT; Comeau ME; Marion MC; Wakeland BE; Liang C; Kaufman KM; Guthridge JM; Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks; Alarcón GS; Anaya J-M; Bae S-C; Kim J-H; Joo YB; Boackle SA; Brown EE; Petri MA; Ramsey-Goldman R; Reveille JD; Vilá LM; Criswell LA; Edberg JC; Freedman BI; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martín J; Merrill JT; Niewold TB; Pons-Estel BA; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Harley JB; Wakeland EK; Moser KL; Montgomery CG; Gaffney PM
Article: GENES AND IMMUNITY. 2012;13(5):380-387

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.

Wang S; Adrianto I; Wiley GB; Lessard CJ; Kelly JA; Adler AJ; Glenn SB; Williams AH; Ziegler JT; Comeau ME; Marion MC; Wakeland BE; Liang C; Kaufman KM; Guthridge JM; Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks; Alarcón GS; Anaya J-M; Bae S-C; Kim J-H; Joo YB; Boackle SA; Brown EE; Petri MA; Ramsey-Goldman R; Reveille JD; Vilá LM; Criswell LA; Edberg JC; Freedman BI; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Pons-Estel BA; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Harley JB; Wakeland EK; Moser KL; Montgomery CG; Gaffney PM
Article: LUPUS. 2012;21(8):815-820

Microcirculation as determined by iontophoresis in SLE-patients and controls.

Anania C; Norman M; Heimburger M; Gustafsson T; Jogestrand T; Hafström I; Frostegård J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(7):1219-1226

Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein.

Delgado-Vega AM; Dozmorov MG; Quirós MB; Wu Y-Y; Martínez-García B; Kozyrev SV; Frostegård J; Truedsson L; de Ramón E; González-Escribano MF; Ortego-Centeno N; Pons-Estel BA; D'Alfonso S; Sebastiani GD; Witte T; Lauwerys BR; Endreffy E; Kovács L; Vasconcelos C; da Silva BM; Wren JD; Martin J; Castillejo-López C; Alarcón-Riquelme ME
Article: JOURNAL OF RHEUMATOLOGY. 2012;39(6):1146-1154

Carotid atherosclerosis, disease measures, oxidized low-density lipoproteins, and atheroprotective natural antibodies for cardiovascular disease in early rheumatoid arthritis -- an inception cohort study.

Ajeganova S; de Faire U; Jogestrand T; Frostegård J; Hafström I
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(6):1960-1969

Evaluation of TRAF6 in a large multiancestral lupus cohort.

Namjou B; Choi C-B; Harley ITW; Alarcón-Riquelme ME; BIOLUPUS Network; Kelly JA; Glenn SB; Ojwang JO; Adler A; Kim K; Gallant CJ; Boackle SA; Criswell LA; Kimberly RP; Brown EE; Edberg J; Alarcón GS; Stevens AM; Jacob CO; Gilkeson GS; Kamen DL; Tsao BP; Anaya J-M; Kim E-M; Park S-Y; Sung Y-K; Guthridge JM; Merrill JT; Petri M; Ramsey-Goldman R; Vilá LM; Niewold TB; Martin J; Pons-Estel BA; Genoma en Lupus Network; Vyse TJ; Freedman BI; Moser KL; Gaffney PM; Williams AH; Comeau ME; Reveille JD; Kang C; James JA; Scofield RH; Langefeld CD; Kaufman KM; Harley JB; Bae S-C
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(5):694-699

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

Hughes T; Adler A; Merrill JT; Kelly JA; Kaufman KM; Williams A; Langefeld CD; Gilkeson GS; Sanchez E; Martin J; Boackle SA; Stevens AM; Alarcón GS; Niewold TB; Brown EE; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri M; Reveille JD; Criswell LA; Vilá LM; Jacob CO; Gaffney PM; Moser KL; Vyse TJ; Alarcón-Riquelme ME; BIOLUPUS Network; James JA; Tsao BP; Scofield RH; Harley JB; Richardson BC; Sawalha AH
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;90(4):648-660

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.

Lessard CJ; Adrianto I; Ice JA; Wiley GB; Kelly JA; Glenn SB; Adler AJ; Li H; Rasmussen A; Williams AH; Ziegler J; Comeau ME; Marion M; Wakeland BE; Liang C; Ramos PS; Grundahl KM; Gallant CJ; Alarcón-Riquelme ME; Alarcón GS; Anaya J-M; Bae S-C; Boackle SA; Brown EE; Chang D-M; Cho S-K; Criswell LA; Edberg JC; Freedman BI; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Kim J-H; Martin J; Merrill JT; Niewold TB; Park S-Y; Petri MA; Pons-Estel BA; Ramsey-Goldman R; Reveille JD; Scofield RH; Song YW; Stevens AM; Tsao BP; Vila LM; Vyse TJ; Yu C-Y; Guthridge JM; Kaufman KM; Harley JB; Wakeland EK; Langefeld CD; Gaffney PM; Montgomery CG; Moser KL; BIOLUPUS Network; GENLES Network
Article: GENES AND IMMUNITY. 2012;13(3):268-274

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene.

Löfgren SE; Frostegård J; Truedsson L; Pons-Estel BA; D'Alfonso S; Witte T; Lauwerys BR; Endreffy E; Kovács L; Vasconcelos C; Martins da Silva B; Kozyrev SV; Alarcón-Riquelme ME
Article: GENES AND IMMUNITY. 2012;13(3):232-238

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis.

Lin CP; Adrianto I; Lessard CJ; Kelly JA; Kaufman KM; Guthridge JM; Freedman BI; Anaya J-M; Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks; Pons-Estel BA; Martin J; Glenn S; Adler A; Bae S-C; Park S-Y; Bang S-Y; Song Y-W; Boackle SA; Brown EE; Edberg JC; Alarcón GS; Petri MA; Criswell LA; Ramsey-Goldman R; Reveille JD; Vila LM; Gilkeson GS; Kamen DL; Ziegler J; Jacob CO; Rasmussen A; James JA; Kimberly RP; Merrill JT; Niewold TB; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Moser KL; Harley JB; Gaffney PM; Montgomery CG
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(2):485-492

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

Hughes T; Adler A; Kelly JA; Kaufman KM; Williams AH; Langefeld CD; Brown EE; Alarcón GS; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri M; Boackle SA; Stevens AM; Reveille JD; Sanchez E; Martín J; Niewold TB; Vilá LM; Scofield RH; Gilkeson GS; Gaffney PM; Criswell LA; Moser KL; Merrill JT; Jacob CO; Tsao BP; James JA; Vyse TJ; Alarcón-Riquelme ME; BIOLUPUS Network; Harley JB; Richardson BC; Sawalha AH
Article: RESULTS IN IMMUNOLOGY. 2012;2:13-18

IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with other auto-antibodies against modified LDL.

Fiskesund R; Su J; Bulatovic I; Vikström M; de Faire U; Frostegård J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(1):136-142

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.

Castillejo-López C; Delgado-Vega AM; Wojcik J; Kozyrev SV; Thavathiru E; Wu Y-Y; Sánchez E; Pöllmann D; López-Egido JR; Fineschi S; Domínguez N; Lu R; James JA; Merrill JT; Kelly JA; Kaufman KM; Moser KL; Gilkeson G; Frostegård J; Pons-Estel BA; D'Alfonso S; Witte T; Callejas JL; Harley JB; Gaffney PM; Martin J; Guthridge JM; Alarcón-Riquelme ME
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2011;29(6):942-950

Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis - a one year study.

Ajeganova S; Fiskesund R; de Faire U; Hafström I; Frostegård J
Article: RHEUMATOLOGY. 2011;50(10):1785-1793

Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset--a prospective cohort study.

Ajeganova S; Ehrnfelt C; Alizadeh R; Rohani M; Jogestrand T; Hafström I; Frostegård J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(10):1752-1757

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.

Sanchez E; Nadig A; Richardson BC; Freedman BI; Kaufman KM; Kelly JA; Niewold TB; Kamen DL; Gilkeson GS; Ziegler JT; Langefeld CD; Alarcón GS; Edberg JC; Ramsey-Goldman R; Petri M; Brown EE; Kimberly RP; Reveille JD; Vilá LM; Merrill JT; Anaya J-M; James JA; Pons-Estel BA; Martin J; Park S-Y; Bang S-Y; Bae S-C; Moser KL; Vyse TJ; Criswell LA; Gaffney PM; Tsao BP; Jacob CO; Harley JB; Alarcón-Riquelme ME; BIOLUPUS and GENLES; Sawalha AH
Article: ATHEROSCLEROSIS. 2011;218(1):117-122

Genetic and environmental regulation of inflammatory CVD biomarkers Lp-PLA2 and IgM anti-PC.

Rahman I; Atout R; Pedersen NL; de Faire U; Frostegård J; Ninio E; Bennet AM; Magnusson PKE
Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(9):2755-2763

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.

Tan W; Sunahori K; Zhao J; Deng Y; Kaufman KM; Kelly JA; Langefeld CD; Williams AH; Comeau ME; Ziegler JT; Marion MC; Bae S-C; Lee JH; Lee J-S; Chang D-M; Song YW; Yu C-Y; Kimberly RP; Edberg JC; Brown EE; Petri MA; Ramsey-Goldman R; Vilá LM; Reveille JD; Alarcón-Riquelme ME; Harley JB; Boackle SA; Stevens AM; Scofield RH; Merrill JT; Freedman BI; Anaya J-M; Criswell LA; Jacob CO; Vyse TJ; Niewold TB; Gaffney PM; Moser KL; Gilkeson GS; Kamen DL; James JA; Grossman JM; Hahn BH; Tsokos GC; Tsao BP; Alarcón GS; BIOLUPUS Network; GENLES Network
Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(6):1689-1697

Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.

Hughes T; Kim-Howard X; Kelly JA; Kaufman KM; Langefeld CD; Ziegler J; Sanchez E; Kimberly RP; Edberg JC; Ramsey-Goldman R; Petri M; Reveille JD; Martín J; Brown EE; Vilá LM; Alarcón GS; James JA; Gilkeson GS; Moser KL; Gaffney PM; Merrill JT; Vyse TJ; Alarcón-Riquelme ME; BIOLUPUS Network; Nath SK; Harley JB; Sawalha AH
Article: GENES AND IMMUNITY. 2011;12(4):270-279

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort.

Namjou B; Kothari PH; Kelly JA; Glenn SB; Ojwang JO; Adler A; Alarcón-Riquelme ME; Gallant CJ; Boackle SA; Criswell LA; Kimberly RP; Brown E; Edberg J; Stevens AM; Jacob CO; Tsao BP; Gilkeson GS; Kamen DL; Merrill JT; Petri M; Goldman RR; Vila LM; Anaya J-M; Niewold TB; Martin J; Pons-Estel BA; Sabio JM; Callejas JL; Vyse TJ; Bae S-C; Perrino FW; Freedman BI; Scofield RH; Moser KL; Gaffney PM; James JA; Langefeld CD; Kaufman KM; Harley JB; Atkinson JP
Article: PLOS GENETICS. 2011;7(5):e1002079

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

Zhao J; Wu H; Khosravi M; Cui H; Qian X; Kelly JA; Kaufman KM; Langefeld CD; Williams AH; Comeau ME; Ziegler JT; Marion MC; Adler A; Glenn SB; Alarcón-Riquelme ME; BIOLUPUS Network; GENLES Network; Pons-Estel BA; Harley JB; Bae S-C; Bang S-Y; Cho S-K; Jacob CO; Vyse TJ; Niewold TB; Gaffney PM; Moser KL; Kimberly RP; Edberg JC; Brown EE; Alarcon GS; Petri MA; Ramsey-Goldman R; Vilá LM; Reveille JD; James JA; Gilkeson GS; Kamen DL; Freedman BI; Anaya J-M; Merrill JT; Criswell LA; Scofield RH; Stevens AM; Guthridge JM; Chang D-M; Song YW; Park JA; Lee EY; Boackle SA; Grossman JM; Hahn BH; Goodship THJ; Cantor RM; Yu C-Y; Shen N; Tsao BP
Article: NATURE GENETICS. 2011;43(3):253-258

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.

Adrianto I; Wen F; Templeton A; Wiley G; King JB; Lessard CJ; Bates JS; Hu Y; Kelly JA; Kaufman KM; Guthridge JM; Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks; Anaya J-M; Bae S-C; Bang S-Y; Boackle SA; Brown EE; Petri MA; Gallant C; Ramsey-Goldman R; Reveille JD; Vila LM; Criswell LA; Edberg JC; Freedman BI; Gregersen PK; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Park S-Y; Pons-Estel BA; Scofield RH; Stevens AM; Tsao BP; Vyse TJ; Langefeld CD; Harley JB; Moser KL; Webb CF; Humphrey MB; Montgomery CG; Gaffney PM
Article: BMC MUSCULOSKELETAL DISORDERS. 2011;12:13

Low level of physical activity in women with rheumatoid arthritis is associated with cardiovascular risk factors but not with body fat mass--a cross sectional study.

Elkan A-C; Håkansson N; Frostegård J; Hafström I
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2011;88(1):83-91

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.

Lessard CJ; Adrianto I; Kelly JA; Kaufman KM; Grundahl KM; Adler A; Williams AH; Gallant CJ; Marta E. Alarcón-Riquelme on behalf of the BIOLUPU; Anaya J-M; Bae S-C; Boackle SA; Brown EE; Chang D-M; Criswell LA; Edberg JC; Freedman BI; Gregersen PK; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Park S-Y; Petri MA; Pons-Estel BA; Ramsey-Goldman R; Reveille JD; Song YW; Stevens AM; Tsao BP; Vila LM; Vyse TJ; Yu C-Y; Guthridge JM; Bruner GR; Langefeld CD; Montgomery C; Harley JB; Scofield RH; Gaffney PM; Moser KL
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(1):95-101

Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice.

Ewing MM; de Vries MR; Nordzell M; Pettersson K; de Boer HC; van Zonneveld AJ; Frostegård J; Jukema JW; Quax PHA
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(11):3404-3414

A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.

Löfgren SE; Delgado-Vega AM; Gallant CJ; Sánchez E; Frostegård J; Truedsson L; de Ramón Garrido E; Sabio JM; González-Escribano MF; Pons-Estel BA; D'Alfonso S; Witte T; Lauwerys BR; Endreffy E; Kovács L; Vasconcelos C; Martins da Silva B; Martín J; Alarcón-Riquelme ME; Kozyrev SV
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39(6):447-453

Anti-apoA-1 IgG and oxidized LDL are raised in rheumatoid arthritis (RA): potential associations with cardiovascular disease and RA disease activity.

Vuilleumier N; Bratt J; Alizadeh R; Jogestrand T; Hafström I; Frostegård J
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;21(2):577-584

Low levels of antibodies against phosphorylcholine in Alzheimer's disease.

Eriksson UK; Sjöberg BG; Bennet AM; de Faire U; Pedersen NL; Frostegård J
Article: STROKE. 2010;41(4):607-612

Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden.

Fiskesund R; Stegmayr B; Hallmans G; Vikström M; Weinehall L; de Faire U; Frostegård J
Article: JOURNAL OF AUTOIMMUNITY. 2010;34(2):73-79

Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism.

de Faire U; Su J; Hua X; Frostegård A; Halldin M; Hellenius M-L; Wikström M; Dahlbom I; Grönlund H; Frostegård J
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39(1):77-83

Effects of anti-cardiolipin antibodies and IVIg on annexin A5 binding to endothelial cells: implications for cardiovascular disease.

Frostegård AG; Su J; von Landenberg P; Frostegård J
Article: ARTHRITIS RESEARCH & THERAPY. 2010;12(6):R214

Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus.

Anania C; Gustafsson T; Hua X; Su J; Vikström M; de Faire U; Heimbürger M; Jogestrand T; Frostegård J
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(11):3454-3460

Low levels of IgM antibodies against phosphorylcholine-A increase mortality risk in patients undergoing haemodialysis.

Carrero JJ; Hua X; Stenvinkel P; Qureshi AR; Heimbürger O; Bárány P; Lindholm B; Frostegård J
Article: GENES AND IMMUNITY. 2009;10(5):397-403

Genetic associations of LYN with systemic lupus erythematosus.

Lu R; Vidal GS; Kelly JA; Delgado-Vega AM; Howard XK; Macwana SR; Dominguez N; Klein W; Burrell C; Harley IT; Kaufman KM; Bruner GR; Moser KL; Gaffney PM; Gilkeson GS; Wakeland EK; Li Q-Z; Langefeld CD; Marion MC; Divers J; Alarcón GS; Brown EE; Kimberly RP; Edberg JC; Ramsey-Goldman R; Reveille JD; McGwin G; Vilá LM; Petri MA; Bae S-C; Cho S-K; Bang S-Y; Kim I; Choi C-B; Martin J; Vyse TJ; Merrill JT; Harley JB; Alarcón-Riquelme ME; BIOLUPUS and GENLES Multicenter Collaborations; Nath SK; James JA; Guthridge JM
Article: JOURNAL OF CARDIOVASCULAR RISK. 2009;16(3):382-386

Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden.

Grönlund H; Hallmans G; Jansson JH; Boman K; Wikström M; de Faire U; Frostegård J
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2009;38(3):184-189

Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease.

Hua X; Su J; Svenungsson E; Hurt-Camejo E; Jensen-Urstad K; Angelin B; Båvenholm P; Frostegård J
Article: ATHEROSCLEROSIS. 2009;203(2):528-532

Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men.

Sjöberg BG; Su J; Dahlbom I; Grönlund H; Wikström M; Hedblad B; Berglund G; de Faire U; Frostegård J
Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(2):R37

Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study.

Elkan A-C; Håkansson N; Frostegård J; Cederholm T; Hafström I
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2008;37(5):352-359

Endothelial function and markers of endothelial activation in relation to cardiovascular disease in systemic lupus erythematosus.

Svenungsson E; Cederholm A; Jensen-Urstad K; Fei G-Z; de Faire U; Frostegård J
Article: RHEUMATOLOGY. 2008;47(8):1144-1150

Natural antibodies against phosphorylcholine as potential protective factors in SLE.

Su J; Hua X; Concha H; Svenungsson E; Cederholm A; Frostegård J
Article: CLINICAL SCIENCE. 2008;115(1):25-33

Anti-(apolipoprotein A-1) IgGs are associated with high levels of oxidized low-density lipoprotein in acute coronary syndrome.

Vuilleumier N; Charbonney E; Fontao L; Alvarez M; Turck N; Sanchez J-C; Burkhard PR; Mensi N; Righini M; Reber G; James R; Mach F; Chevrolet J-C; Dayer J-M; Frostegard J; Roux-Lombard P
Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(2):R34

Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study.

Elkan A-C; Sjöberg B; Kolsrud B; Ringertz B; Hafström I; Frostegård J
Article: JOURNAL OF RHEUMATOLOGY. 2007;34(9):1810-1816

Effects of low-dose prednisolone on endothelial function, atherosclerosis, and traditional risk factors for atherosclerosis in patients with rheumatoid arthritis--a randomized study.

Hafström I; Rohani M; Deneberg S; Wörnert M; Jogestrand T; Frostegård J
Article: DRUG NEWS AND PERSPECTIVES. 2007;20(5):321-326

Annexin A5 multitasking: a potentially novel antiatherothrombotic agent?

Cederholm A; Frostegård J
Article: NUTRITION & METABOLISM. 2007;4:7

Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea.

Frostegård J; Tao W; Georgiades A; Råstam L; Lindblad U; Lindeberg S
Article: NUTRITION & METABOLISM. 2006;3:39

A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.

Jönsson T; Ahrén B; Pacini G; Sundler F; Wierup N; Steen S; Sjöberg T; Ugander M; Frostegård J; Göransson L; Lindeberg S
Article: ATHEROSCLEROSIS. 2006;188(1):160-166

Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension.

Su J; Georgiades A; Wu R; Thulin T; de Faire U; Frostegård J
Article: ATHEROSCLEROSIS. 2006;187(2):408-414

Association of TNF-alpha serum levels and TNFA promoter polymorphisms with risk of myocardial infarction.

Bennet AM; van Maarle MC; Hallqvist J; Morgenstern R; Frostegård J; Wiman B; Prince JA; de Faire U
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2006;38(3):297-306

Systemic lupus-erythematosus: deoxyribonuclease 1 in necrotic chromatin disposal.

Napirei M; Gültekin A; Kloeckl T; Möröy T; Frostegård J; Mannherz HG
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2006;4(1):77-82

Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response.

van Rooijen M; Hansson LO; Frostegård J; Silveira A; Hamsten A; Bremme K
Article: LAKARTIDNINGEN. 2005;102(22):1752-1753

[Non-therapeutic ventilation , organ transplantation and medical ethics].

Frostegård J
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):192-200

Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations.

Frostegård J; Svenungsson E; Wu R; Gunnarsson I; Lundberg IE; Klareskog L; Hörkkö S; Witztum JL
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(1):198-203

Decreased binding of annexin v to endothelial cells: a potential mechanism in atherothrombosis of patients with systemic lupus erythematosus.

Cederholm A; Svenungsson E; Jensen-Urstad K; Trollmo C; Ulfgren A-K; Swedenborg J; Fei G-Z; Frostegård J
Article: ATHEROSCLEROSIS. 2004;177(2):409-414

The A-1087IL-10 allele is associated with cardiovascular disease in SLE.

Fei G-Z; Svenungsson E; Frostegård J; Padyukov L
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(9):2869-2876

Platelet-activating factor-acetylhydrolase and other novel risk and protective factors for cardiovascular disease in systemic lupus erythematosus.

Cederholm A; Svenungsson E; Stengel D; Fei G-Z; Pockley AG; Ninio E; Frostegård J
Article: EUROPEAN HEART JOURNAL. 2004;25(16):1447-1453

Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction.

Edfeldt K; Bennet AM; Eriksson P; Frostegård J; Wiman B; Hamsten A; Hansson GK; de Faire U; Yan Z-Q
Article: LAKARTIDNINGEN. 2004;101(25):2190-2193

[The new biology. Truth, social construction or something in between?].

Frostegård J
Article: LAKARTIDNINGEN. 2004;101(19):1678-1679

[Immunization--future cure against atherosclerosis?].

Frostegård J
Article: LAKARTIDNINGEN. 2004;101(3):229

[Organ donation and utilitarianism: medical ethics more important than medical efficiency].

Frostegård J
Article: ATHEROSCLEROSIS. 2003;171(2):359-367

Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction.

Bennet AM; Prince JA; Fei GZ; Lyrenäs L; Huang Y; Wiman B; Frostegård J; Faire UD
Article: EUROPEAN HEART JOURNAL. 2003;24(23):2099-2107

Risk factors for cardiovascular disease in patients with periodontitis.

Buhlin K; Gustafsson A; Pockley AG; Frostegård J; Klinge B
Article: CLINICAL SCIENCE. 2003;105(5):615-620

Circulating oxidized low-density lipoprotein is increased in hypertension.

Frostegård J; Wu R; Lemne C; Thulin T; Witztum JL; de Faire U
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;106(1):143-148

Induction of IL-4 by platelet-activating factor.

Huang YH; Schäfer-Elinder L; Owman H; Lorentzen JC; Rönnelid J; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;103(1):61-66

Effects of in vitro hyperthermia on proliferative responses and lymphocyte activity.

Huang YH; Haegerstrand A; Frostegård J
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):2533-2540

Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus.

Svenungsson E; Gunnarsson I; Fei G-Z; Lundberg IE; Klareskog L; Frostegård J
Article: HYPERTENSION. 2003;42(3):235-238

Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension.

Pockley AG; Georgiades A; Thulin T; de Faire U; Frostegård J
Article: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2003;189(2):568-573

Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion.

Frostegård J; Wramsby ML; Wu R; Bremme K
Article: ATHEROSCLEROSIS. 2003;169(1):77-85

Oxidised LDL modulates immune-activation by an IL-12 dependent mechanism.

Fei G-Z; Huang YH; Swedenborg J; Frostegård J
Article: LUPUS. 2003;12(6):454-461

TNF-alpha: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease.

Svenungsson E; Fei GZ; Jensen-Urstad K; de Faire U; Hamsten A; Frostegard J
Article: JOURNAL OF HYPERTENSION. 2002;20(9):1815-1820

Circulating heat shock protein and heat shock protein antibody levels in established hypertension.

Pockley AG; De Faire U; Kiessling R; Lemne C; Thulin T; Frostegård J
Article: LAKARTIDNINGEN. 2002;99(34):3306-3308

[A case report: Myocardial infarction in a 26-year-old man with SLE. Acute coronary syndrome can occur in patients with SLE independently of gender and age].

Lehtihet M; Frostegård J
Article: LUPUS. 2002;11(11):744-752

Cardiac valvular abnormalities are frequent in systemic lupus erythematosus patients with manifest arterial disease.

Jensen-Urstad K; Svenungsson E; de Faire U; Silveira A; Witztum JL; Hamsten A; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;116(2):326-331

Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism.

Huang YH; Schäfer-Elinder L; Wu R; Claesson HE; Frostegård J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(3):561-566

Antibodies to adult human endothelial cells cross-react with oxidized low-density lipoprotein and beta 2-glycoprotein I (beta 2-GPI) in systemic lupus erythematosus.

Wu R; Svenungsson E; Gunnarsson I; Haegerstrand-Gillis C; Andersson B; Lundberg I; Elinder LS; Frostegård J
Article: LAKARTIDNINGEN. 2001;98(42):4616-4619

[The debate on euthanasia with absurd conclusions].

Frostegård J
Article: CIRCULATION. 2001;104(16):1887-1893

Risk factors for cardiovascular disease in systemic lupus erythematosus.

Svenungsson E; Jensen-Urstad K; Heimbürger M; Silveira A; Hamsten A; de Faire U; Witztum JL; Frostegård J
Article: LAKARTIDNINGEN. 2001;98(26-27):3135

[Immunological changes in hypertension and atherosclerosis].

Frostegård J
Article: HYPERTENSION. 2001;37(1):154-159

Antibodies to Lysophosphatidylcholine Are Decreased in Borderline Hypertension.

Wu R; Lemne C; de Faire U; Frostegård J
Article: ATHEROSCLEROSIS. 2000;153(2):273-282

Induction of early atherosclerosis in CBA/J mice by combination of Trypanosoma cruzi infection and a high cholesterol diet.

Sunnemark D; Harris RA; Frostegård J; Orn A
Article: GENES AND IMMUNITY. 2000;1(6):380-385

Association analysis with microsatellite and SNP markers does not support the involvement of BCL-2 in systemic lupus erythematosus in Mexican and Swedish patients and their families.

Johansson C; Castillejo-López C; Johanneson B; Svenungsson E; Gunnarsson I; Frostegård J; Sturfelt G; Truedsson L; Löfström B; Alcocer-Varela J; Lundberg I; Gyllensten UB; Alarcón-Segovia D; Alarcón-Riquelme ME
Article: HYPERTENSION. 2000;36(2):303-307

Circulating heat shock protein 60 is associated with early cardiovascular disease.

Pockley AG; Wu R; Lemne C; Kiessling R; de Faire U; Frostegård J
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(4):389-397

Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome.

Wu R; Lemne C; De Faire U; Frostegârd J
Article: ATHEROSCLEROSIS. 1999;145(1):33-43

Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines.

Frostegård J; Ulfgren AK; Nyberg P; Hedin U; Swedenborg J; Andersson U; Hansson GK
Article: HYPERTENSION. 1999;33(1):53-59

Autoantibodies to OxLDL are decreased in individuals with borderline hypertension.

Wu R; de Faire U; Lemne C; Witztum JL; Frostegård J
Article: LUPUS. 1999;8(2):142-150

Antibodies against lysophosphatidylcholine and oxidized LDL in patients with SLE.

Wu R; Svenungsson E; Gunnarsson I; Andersson B; Lundberg I; Schäfer Elinder L; Frostegård J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;48(5):480-484

Cellular and cytokine characterization of vascular inflammation in CBA/J mice chronically infected with Trypanosoma cruzi.

Sunnemark D; Frostegård J; Orn A; Harris RA
Article: CIRCULATION. 1998;98(11):1092-1098

Antibodies to endothelial cells in borderline hypertension.

Frostegård J; Wu R; Gillis-Haegerstrand C; Lemne C; de Faire U
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1998;18(4):626-630

Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL.

Wu R; Huang YH; Elinder LS; Frostegård J
Article: JOURNAL OF INTERNAL MEDICINE. 1997;242(4):329-337

The influence of age on low density lipoprotein metabolism: effects of cholestyramine treatment in young and old healthy male subjects.

Ericsson S; Berglund L; Frostegård J; Einarsson K; Angelin B
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1997;17(10):2257-2263

Expression of phospholipase A2 isoforms in human normal and atherosclerotic arterial wall.

Elinder LS; Dumitrescu A; Larsson P; Hedin U; Frostegård J; Claesson HE
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1997;17(5):963-968

Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism.

Frostegård J; Huang YH; Rönnelid J; Schäfer-Elinder L
Article: HYPERTENSION. 1997;29(1 Pt 1):40-44

Association of serum antibodies to heat-shock protein 65 with borderline hypertension.

Frostegård J; Lemne C; Andersson B; van der Zee R; Kiessling R; de Faire U
Article: LAKARTIDNINGEN. 1996;93(17):1603-1604

[Historical perspective of euthanasia. From Hippokrates to Nazi physicians].

Frostegård J
Article: ATHEROSCLEROSIS. 1996;121(1):93-103

Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein.

Frostegård J; Kjellman B; Gidlund M; Andersson B; Jindal S; Kiessling R
Article: FREE RADICAL RESEARCH. 1995;23(6):581-592

The susceptibility of low density lipoprotein to chemical oxidation is closely related to proneness to biological modification.

Frostegård J; Regnström J; Tornvall P; Hamsten A; Nilsson J
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1995;15(10):1577-1583

Oxidized LDL induces enhanced antibody formation and MHC class II-dependent IFN-gamma production in lymphocytes from healthy individuals.

Huang YH; Rönnelid J; Frostegård J
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Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2022;18(5):525-532

Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation.

Frostegård J
Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2022;18(1):67-74

The role of PCSK9 in inflammation, immunity, and autoimmune diseases.

Frostegård J
Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2015;11(2):247-253

Prediction and management of cardiovascular outcomes in systemic lupus erythematosus.

Frostegård J
Review: FRONTIERS IN ENDOCRINOLOGY. 2013;4:162

Immune mechanisms in atherosclerosis, especially in diabetes type 2.

Frostegård J
Review: LAKARTIDNINGEN. 2013;110(43-44):1931-1934

[The immune system in atherosclerosis. Immunomodulatory or anti-inflammatory treatment that is effective against atherosclerosis and its complications are needed to ensure the hypothesis].

Frostegård J
Review: BMC MEDICINE. 2013;11:117

Immunity, atherosclerosis and cardiovascular disease.

Frostegård J
Editorial comment: JOURNAL OF RHEUMATOLOGY. 2012;39(12):2233-2234

Atherosclerosis and cardiovascular disease in rheumatoid arthritis.

Frostegård J
Review: CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY. 2012;42(2):154-163

Geographical differences in autoantibodies and anti-infectious agents antibodies among healthy adults.

Shapira Y; Poratkatz B-S; Gilburd B; Barzilai O; Ram M; Blank M; Lindeberg S; Frostegård J; Anaya J-M; Bizzaro N; Jara LJ; Damoiseaux J; Shoenfeld Y; Levin NA
Review: ARTHRITIS RESEARCH & THERAPY. 2011;13(3):225

Cardiovascular co-morbidity in patients with rheumatic diseases.

Frostegård J
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(5):892-893

Rheumatic diseases: insights into inflammation and atherosclerosis.

Frostegård J
Review: CLINICAL IMMUNOLOGY. 2010;134(1):47-54

Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease.

Frostegård J
Corrigendum: GENES AND IMMUNITY. 2010;11(1):98

Genetic associations of LYN with systemic lupus erythematosus (vol 10, pg 397, 2009)

Lu R; Vidal GS; Kelly JA; Delgado-Vega AM; Howard XK; Macwana SR; Dominguez N; Klein W; Burrell C; Harley IT; Kaufman KM; Bruner GR; Moser KL; Gaffney PM; Gilkeson GS; Wakeland EK; Li Q-Z; Langefeld CD; Marion MC; Divers J; Alarcon GS; Brown EE; Kimberly RP; Edberg JC; Ramsey-Goldman R; Reveille JD; McGwin GJ; Vila LM; Petri MA; Bae S-C; Cho S-K; Bang S-Y; Kim I; Choi CB; Martin J; Vyse TJ; Merrill JT; Harley JB; Alarcon-Riquelme ME; Nath SK; James JA; Guthridge JM
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1173:675-682

Antitreponemal antibodies leading to autoantibody production and protection from atherosclerosis in Kitavans from Papua New Guinea.

Agmon-Levin N; Bat-sheva PK; Barzilai O; Ram M; Lindeberg S; Frostegård J; Shoenfeld Y
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1173:292-300

Natural antibodies against phosphorylcholine in cardiovascular disease.

de Faire U; Frostegård J
Published conference paper: LUPUS. 2008;17(5):364-367

Systemic lupus erythematosus and cardiovascular disease.

Frostegård J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):62

ANNEXIN A5 INHIBITS LYSOPHOSPHATIDYLCHOLINE INDUCED MMP-9 PRODUCTION; IMPLICATIONS FOR SLE AND CARDIOVASCULAR DISEASE

Domeij H; Modeer T; Gilburd B; Svenungsson E; Shoenfeld Y; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):78

LOW LEVELS OF ANTIBODIES AGAINST PHOSPHORYLCHOLINE PREDICT DEVELOPMENT OF ATHEROSCLEROSIS

Frostegard J; Sjoberg B; Su J; Gronlund H; Dahlbom I; Hedblad B; Berglund G; de Faire U
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):78

IGM ANTIBODIES AGAINST PHOSPHOCHOLINE PROTECTION FACTORS FOR ATHEROSCLEROSIS IN PATIENTS WITH HYPERTENSION AND INHIBIT UPTAKE OF OXIDIZED LDL IN MACROPHAGES

Su J; Gronlund H; Cederholm A; Hua X; Georgiades A; Dahlbom I; de Faire U; Frostegard J
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1108:96-103

Annexin A5 as a novel player in prevention of atherothrombosis in SLE and in the general population.

Cederholm A; Frostegård J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):29

Decreased annexin A5 binding to endothelium is associated with cardiovascular disease in systemic lupus erythematosus and inhibited by IVIG

Cederholm A; Von Landenberg P; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):299

Dyslipidemia in SLE-related cardiovascular disease:: Paradoxical lipid pattern and antibodies against apo A1 and lipoprotein lipase

Hua X; Su J; Svenungsson E; Cederholm A; Frostegård J
Letter: JOURNAL OF INTERNAL MEDICINE. 2005;258(6):585-586

High iron stores and cardiovascular disease in systemic lupus erythematosus -: reply

Frostegård J
Editorial comment: HEART. 2005;91(9):1124-1126

Heat shock proteins in cardiovascular disease and the prognostic value of heat shock protein related measurements.

Pockley AG; Frostegård J
Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(9):1776-1785

Atherosclerosis in patients with autoimmune disorders.

Frostegård J
Review: JOURNAL OF INTERNAL MEDICINE. 2005;257(6):485-495

SLE, atherosclerosis and cardiovascular disease.

Frostegård J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):90

Anti-HDL antibodies and lipoprotein characteristics in SLE-related cardiovascular disease

Su J; Cederholm A; Hurt-Camejo E; Svenungsson E; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):65-66

Lipid-peroxidation is enhanced in sle patients and associated with arterial and renal disease manifestations

Frostegard J; Svenungsson E; Wu R; Gunnarsson I; Lundberg I; Klareskog L; Hörkkö S; Witztum J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S40

Anti-high-density lipoprotein antibodies and lipoprotein characteristics in systemic lupus erythematosus-related cardiovascular disease

Su J; Cederholm A; Hurt-Camejo E; Svenungsson E; Frostegard J
Published conference paper: IMMUNOBIOLOGY. 2005;210(10):761-768

Annexin A5 in cardiovascular disease and systemic lupus erythematosus.

Cederholm A; Frostegård J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S53

Endothelial function and activation in women with systemic lupus erythematosus

Svenungsson E; Cederholm A; Jensen-Urstad K; Fei G-Z; Frostegard J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S51-S52

Decreased binding of annexin V to endothelial cells:: a novel mechanism of atherothrombosis in patients with systemic lupus erythematosus

Cederholm A; Svenungsson E; Jensen-Urstad K; Trollmo C; Ulfgren A-K; Swedenborg J; Fei G-Z; Frostegard J
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S45

Non-traditional risk and protective factors for cardiovascular disease in systemic lupus erythematosus

Cederholm A; Svenungsson E; Stengel D; Fei G-Z; Pockley AG; Ninio E; Frostegard J
Letter: EUROPEAN HEART JOURNAL. 2004;25(15):1366

Cardiovascular disease, periodontitis and the monocyte relationship:: Reply

Buhlin K; Gustafsson A; Frostegård J; Klinge B; Pockley AG
Letter: HYPERTENSION. 2004;43(4):E18-E19

Is low-heat shock protein 70 a primary or a secondary event in the development of atherosclerosis?

Hooper PL; Hooper JJ
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):317

TNF-alpha, dyslipoproteinemia and LDL oxidation are risk factors for CVD in SLE

Svenungsson E; Fei GZ; Gunnarsson I; Lundberg IE; Wu R; Witztum JL; Frostegard J
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):315-316

Novel immunological risk factors for atherosclerosis

Frostegard J; Pockley AG; Georgiades A; Thulin T; Wu R; De Faire U
Review: AUTOIMMUNITY REVIEWS. 2002;1(4):233-237

Autoimmunity, oxidized LDL and cardiovascular disease.

Frostegård J
Review: LAKARTIDNINGEN. 1998;95(19):2203-2206

[Atherosclerosis not caused by overindulgence only. Infection may be a risk factor for cardiovascular disease].

Schäfer Elinder L; Frostegård J
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):283

Cytokine-stimulatory properties of phospholipids and oxidized LDL are mediated by the PAF receptor

Elinder LS; Huang YH; Frostegard J
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):284

Oxidised LDL induced T cell proliferation; LDL from patients with coronary artery disease inhibited the effect of oxidised LDL

Wu RH; Frostegard J; Giscombe R; Hamsten A; Holm G; Nilsson J; Lefvert AK
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