Johanna Nilsson

Publications
CV
Public outreach and news

Articles

Article: SCIENTIFIC REPORTS. 2019;9(1):8175
Closed and open state dependent block of potassium channels cause opposing effects on excitability - a computational approach
Agren R; Nilsson J; Arhem P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2018;21(12):1102-1108
The Beta-Arrestin-Biased Dopamine D₂ Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation
Agren R; Arhem P; Nilsson J; Sahlholm K
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2018;12:33
The Importance of the Dissociation Rate in Ion Channel Blocking
Zeberg H; Nilsson J; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;496(1):101-104
Point mutation of a conserved aspartate, D69, in the muscarinic M₂ receptor does not modify voltage-sensitive agonist potency
Agren R; Sahlholm K; Nilsson J; Arhem P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(3):467-476
The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D₂ receptor
Sahlholm K; Zeberg H; Nilsson J; Ogren SO; Fuxe K; Arhem P
Article: MOLECULAR PAIN. 2015;11:44
G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy
Lyu C; Mulder J; Barde S; Sahlholm K; Zeberg H; Nilsson J; Arhem P; Hokfelt T; Fried K; Shi T-JS
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(1):149-155
Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D₂ receptor
Sahlholm K; Marcellino D; Nilsson J; Ogren SO; Fuxe K; Arhem P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695
Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db^-/db^- mouse, a type 2 diabetes model
Shi T-JS; Zhang M-D; Zeberg H; Nilsson J; Grunler J; Liu S-X; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hokfelt TGM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(12):3081-3089
Voltage sensitivities and deactivation kinetics of histamine H₃ and H₄ receptors
Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;394(4):988-992
Cocaine produces D₂R-mediated conformational changes in the adenosine A_2AR-dopamine D₂R heteromer
Marcellino D; Navarro G; Sahlholm K; Nilsson J; Agnati LF; Canela EI; Lluis C; Arhem P; Franco R; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;377(4):1216-1221
Voltage-sensitivity at the human dopamine D_2S receptor is agonist-specific
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;95(11):5138-5152
Bupivacaine Blocks N-Type Inactivating K_v Channels in the Open State: No Allosteric Effect on Inactivation Kinetics
Nilsson J; Madeja M; Elinder F; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;374(3):496-501
Differential voltage-sensitivity of D₂-like dopamine receptors
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;591(1-3):52-58
Electrophysiology-based analysis of human histamine H₄ receptor pharmacology using GIRK channel coupling in Xenopus oocytes
Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: SYNAPSE-STRUCTURE FUNCTION CONNECTIVITY. 2008;62(6):476-480
Voltage-dependence of the human dopamine D₂ receptor
Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;94(8):3014-3022
A tyrosine substitution in the cavity wall of a K channel induces an inverted inactivation
Klement G; Nilsson J; Arhem P; Elinder F
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):1-7
On the opening of voltage-gated ion channels
Elinder F; Nilsson J; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;567(3):206-210
The human histamine H₃ receptor couples to GIRK channels in Xenopus oocytes
Sahlhollm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: DIABETOLOGIA. 2007;50(8):1670-1677
Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters:: indications for a long-chain acyl-CoA ester binding motif
Braenstroem R; Leibiger IB; Leibiger B; Klement G; Nilsson J; Arhem P; Aspinwall CA; Corkey BE; Larsson O; Berggren R-O
Article: BMC NEUROSCIENCE. 2005;6:65
A truncated Kv1.1 protein in the brain of the megencephaly mouse:: expression and interaction -: art. no. 65
Persson AS; Klement G; Almgren M; Sahlholm K; Nilsson J; Petersson S; Århem P; Schalling M; Lavebratt C
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3231-3240
Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly
Petersson S; Persson AS; Johansen JE; Ingvar M; Nilsson J; Klement G; Århem P; Schalling M; Lavebratt C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1652(1):35-51
Computational modelling of the open-state K_v1.5 ion channel block by bupivacaine
Luzhkov VB; Nilsson J; Århem P; Åqvist J
Article: MOLECULAR PHARMACOLOGY. 2003;63(6):1417-1429
Local anesthetic block of Kv channels:: Role of the S6 helix and the S5-S6 linker for bupivacaine action
Nilsson J; Madeja M; Århem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;360(1):21-29
Mechanisms of bupivacaine action on Na⁺ and K⁺ channels in myelinated axons of Xenopus laevis
Nilsson J; Elinder F; Århem P
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All other publications

Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S520
The fast-off hypothesis revisited: on-rates and reversibility of antipsychotic antagonism at the D2 receptor
Sahlholm K; Zeberg H; Marcellino D; Nilsson J; Ogren SO; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):126A
Local Anesthetics on Kv Channels - Closed State Binding of Bupivacaine?
Nilsson J; Zeberg H; Madeja M; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):26A
Novel Aspects of the Reversibility of the Antagonism at the Dopamine D2 Receptor by Antipsychotics
Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Ogren SO; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):134A
The Action of the Neuroprotective Compound Riluzole on Kv Channels
Nilsson J; Kempka M; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):517A
Dopamine D2 Receptor Antagonist Unbinding Rates Investigated using a Time-Resolved Ion Channel Activation Assay
Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):290A
Agonist-Specific Effects of TM V Serine Mutations on Dopamine D2S Receptor Voltage-Sensitivity
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):213A
Kv Channel Modulation: Closed State Block of Benzocaine But Not of Bupivacaine
Nilsson J; Madeja M; Sahlholm K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2009;96(3):369A
Differential Voltage-sensitivities Of Agonists At The Dopamine D_2S Receptor
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Doctoral thesis: 2004
Molecular mechanisms of local anaesthetic action on voltage-gated ion channels
Nilsson J
Published conference paper: NEUROPSYCHOPHARMACOLOGY. 2003;28:S40-S47
Mechanisms of anesthesia:: Towards integrating network, cellular, and molecular level modeling
Århem P; Klement G; Nilsson J

Employments

Affiliated to Teaching/Tutoring, Department of Clinical Neuroscience, Karolinska Institutet, 2025-2028

Degrees and Education

Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2004
University Medical Degree, Karolinska Institutet, 1997

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