Johan Holmberg

Publications
CV
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2022;13(1):5093
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Article: SCIENCE ADVANCES. 2022;8(34):eabo1543
PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons
Toskas K; Yaghmaeian-Salmani B; Skiteva O; Paslawski W; Gillberg L; Skara V; Antoniou I; Sodersten E; Svenningsson P; Chergui K; Ringner M; Perlmann T; Holmberg J
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: NATURE COMMUNICATIONS. 2021;12(1):5309
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
Article: EMBO JOURNAL. 2021;40(9):e106423
Activation of endogenous retroviruses during brain development causes an inflammatory response
Jonsson ME; Garza R; Sharma Y; Petri R; Sodersten E; Johansson JG; Johansson PA; Atacho DAM; Pircs K; Madsen S; Yudovich D; Ramakrishnan R; Holmberg J; Larsson J; Jern P; Jakobsson J
Article: NUCLEIC ACIDS RESEARCH (NAR). 2021;49(5):2509-2521
Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors
Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019;508(4):1233-1239
EPAS1/HIF2α correlates with features of low-risk neuroblastoma and with adrenal chromaffin cell differentiation during sympathoadrenal development
Westerlund I; Shi Y; Holmberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(2):136-142
Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth
Pinheiro T; Otrocka M; Seashore-Ludlow B; Rraklli V; Holmberg J; Forsberg-Nilsson K; Simon A; Kirkham M
Article: NATURE COMMUNICATIONS. 2018;9(1):1226
A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
Sodersten E; Toskas K; Rraklli V; Tiklova K; Bjorklund AK; Ringner M; Perlmann T; Holmberg J
Article: CELL DEATH AND DIFFERENTIATION. 2018;25(3):600-615
Sumoylation of Notch1 represses its target gene expression during cell stress
Antila CJM; Rraklli V; Blomster HA; Dahlstrom KM; Salminen TA; Holmberg J; Sistonen L; Sahlgren C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;494(3-4):477-483
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth
Pinheiro T; Otrocka M; Seashore-Ludlow B; Rraklli V; Holmberg J; Forsberg-Nilsson K; Simon A; Kirkham M
Article: CANCER RESEARCH. 2017;77(18):4985-4997
SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells
Kurtsdotter I; Topcic D; Karlen A; Singla B; Hagey DW; Bergsland M; Siesjo P; Nister M; Carlson JW; Lefebvre V; Persson O; Holmberg J; Muhr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146
Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression
Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Sodersten E; Kogner P; Nyman U; Schlisio S; Holmberg J
Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA
Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
Article: NATURE IMMUNOLOGY. 2016;17(11):1282-1290
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Shen X; Burguillos MA; Osman AM; Frijhoff J; Carrillo-Jimenez A; Kanatani S; Augsten M; Saidi D; Rodhe J; Kavanagh E; Rongvaux A; Rraklli V; Nyman U; Holmberg J; Ostman A; Flavell RA; Barragan A; Venero JL; Blomgren K; Joseph B
Article: STEM CELL RESEARCH. 2016;16(1):1-9
Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming
Rraklli V; Sodersten E; Nyman U; Hagey DW; Holmberg J
Article: CELL RESEARCH. 2014;24(4):433-450
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner
Sjoqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C
Article: NEURO-ONCOLOGY. 2014;16(2):241-249
NCoR controls glioblastoma tumor cell characteristics
Heldring N; Nyman U; Lonnerberg P; Onnestam S; Herland A; Holmberg J; Hermanson O
Article: DEVELOPMENTAL CELL. 2013;26(3):223-236
CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression
Egan CM; Nyman U; Skotte J; Streubel G; Turner S; O'Connell DJ; Rraklli V; Dolan MJ; Chadderton N; Hansen K; Farrar GJ; Helin K; Holmberg J; Bracken AP
Article: PLOS ONE. 2011;6(3):e18454
Activation of Neural and Pluripotent Stem Cell Signatures Correlates with Increased Malignancy in Human Glioma
Holmberg J; He X; Peredo I; Orrego A; Hesselager G; Ericsson C; Hovatta O; Oba-Shinjo SM; Nagahashi Marie SK; Nister M; Muhr J
Article: STEM CELLS. 2010;28(7):1196-1205
Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle
Genander M; Holmberg J; Frisen J
Article: DEVELOPMENT. 2008;135(10):1843-1851
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: CELL. 2006;125(6):1151-1163
EphB receptors coordinate migrationand proliferation in the intestinal stem cell niche
Holmberg J; Genander M; Halford MM; Anneren C; Sondell M; Chumley MJ; Silvany RE; Henkemeyer M; Frisen J
Article: DEVELOPMENT. 2006;133(7):1335-1345
Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5
Nomura T; Holmberg J; Frisen J; Osumi N
Article: GENES & DEVELOPMENT. 2005;19(4):462-471
Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis
Holmberg J; Armulik A; Senti KA; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J
Article: NATURE. 2000;408(6809):203-206
Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
Holmberg J; Clarke DL; Frisén J
Show more

All other publications

Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection (vol 13, 5093, 2022)
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Corrigendum: NATURE METABOLISM. 2022;4(10):1421
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):4639
A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons (vol 9, 1226, 2018)
Sodersten E; Toskas K; Rraklli V; Tiklova K; Bjorklund AK; Ringer M; Perlmanni T; Holmberg J
Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(51):E10859-E10860
High levels of EPAS1 are closely associated with key features of low-risk neuroblastoma
Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Sodersten E; Schlisio S; Holmberg J
Review: NATURE REVIEWS GENETICS. 2012;13(6):429-439
Maintaining differentiated cellular identity
Holmberg J; Perlmann T
Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;76(2):205-215
PACAP promotes neural stem cell proliferation in adult mouse brain
Mercer A; Rönnholm H; Holmberg J; Lundh H; Heidrich J; Zachrisson O; Ossoinak A; Frisén J; Patrone C
Thesis / dissertation: 2003
Ephrins off the beaten path
Holmberg, Johan
Review: TRENDS IN NEUROSCIENCES. 2002;25(5):239-243
Ephrins are not only unattractive
Holmberg J; Frisén J
Review: EMBO JOURNAL. 1999;18(19):5159-5165
Ephrins and their Eph receptors:: multitalented directors of embryonic development
Frisén J; Holmberg J; Barbacid M

Employments

Affiliated to Research, Department of Cell and Molecular Biology, Karolinska Institutet, 2021-2024

Degrees and Education

Docent, Karolinska Institutet, 2018
Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2003

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI