Johan Holmberg

Publications
CV
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2022;13(1):5093
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Article: SCIENCE ADVANCES. 2022;8(34):eabo1543
PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons
Toskas K; Yaghmaeian-Salmani B; Skiteva O; Paslawski W; Gillberg L; Skara V; Antoniou I; Sodersten E; Svenningsson P; Chergui K; Ringner M; Perlmann T; Holmberg J
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: NATURE COMMUNICATIONS. 2021;12(1):5309
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
Article: EMBO JOURNAL. 2021;40(9):e106423
Activation of endogenous retroviruses during brain development causes an inflammatory response
Jonsson ME; Garza R; Sharma Y; Petri R; Sodersten E; Johansson JG; Johansson PA; Atacho DAM; Pircs K; Madsen S; Yudovich D; Ramakrishnan R; Holmberg J; Larsson J; Jern P; Jakobsson J
Article: NUCLEIC ACIDS RESEARCH. 2021;49(5):2509-2521
Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors
Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019;508(4):1233-1239
EPAS1/HIF2α correlates with features of low-risk neuroblastoma and with adrenal chromaffin cell differentiation during sympathoadrenal development
Westerlund I; Shi Y; Holmberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(2):136-142
Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth
Pinheiro T; Otrocka M; Seashore-Ludlow B; Rraklli V; Holmberg J; Forsberg-Nilsson K; Simon A; Kirkham M
Article: NATURE COMMUNICATIONS. 2018;9(1):1226
A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
Sodersten E; Toskas K; Rraklli V; Tiklova K; Bjorklund AK; Ringner M; Perlmann T; Holmberg J
Article: CELL DEATH AND DIFFERENTIATION. 2018;25(3):600-615
Sumoylation of Notch1 represses its target gene expression during cell stress
Antila CJM; Rraklli V; Blomster HA; Dahlstrom KM; Salminen TA; Holmberg J; Sistonen L; Sahlgren C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;494(3-4):477-483
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth
Pinheiro T; Otrocka M; Seashore-Ludlow B; Rraklli V; Holmberg J; Forsberg-Nilsson K; Simon A; Kirkham M
Article: CANCER RESEARCH. 2017;77(18):4985-4997
SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells
Kurtsdotter I; Topcic D; Karlen A; Singla B; Hagey DW; Bergsland M; Siesjo P; Nister M; Carlson JW; Lefebvre V; Persson O; Holmberg J; Muhr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146
Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression
Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Sodersten E; Kogner P; Nyman U; Schlisio S; Holmberg J
Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA
Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
Article: NATURE IMMUNOLOGY. 2016;17(11):1282-1290
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Shen X; Burguillos MA; Osman AM; Frijhoff J; Carrillo-Jimenez A; Kanatani S; Augsten M; Saidi D; Rodhe J; Kavanagh E; Rongvaux A; Rraklli V; Nyman U; Holmberg J; Ostman A; Flavell RA; Barragan A; Venero JL; Blomgren K; Joseph B
Article: STEM CELL RESEARCH. 2016;16(1):1-9
Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming
Rraklli V; Sodersten E; Nyman U; Hagey DW; Holmberg J
Article: CELL RESEARCH. 2014;24(4):433-450
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner
Sjoqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C
Article: NEURO-ONCOLOGY. 2014;16(2):241-249
NCoR controls glioblastoma tumor cell characteristics
Heldring N; Nyman U; Lonnerberg P; Onnestam S; Herland A; Holmberg J; Hermanson O
Article: DEVELOPMENTAL CELL. 2013;26(3):223-236
CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression
Egan CM; Nyman U; Skotte J; Streubel G; Turner S; O'Connell DJ; Rraklli V; Dolan MJ; Chadderton N; Hansen K; Farrar GJ; Helin K; Holmberg J; Bracken AP
Article: PLOS ONE. 2011;6(3):e18454
Activation of Neural and Pluripotent Stem Cell Signatures Correlates with Increased Malignancy in Human Glioma
Holmberg J; He X; Peredo I; Orrego A; Hesselager G; Ericsson C; Hovatta O; Oba-Shinjo SM; Nagahashi Marie SK; Nister M; Muhr J
Article: STEM CELLS. 2010;28(7):1196-1205
Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle
Genander M; Holmberg J; Frisen J
Article: DEVELOPMENT. 2008;135(10):1843-1851
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: CELL. 2006;125(6):1151-1163
EphB receptors coordinate migrationand proliferation in the intestinal stem cell niche
Holmberg J; Genander M; Halford MM; Anneren C; Sondell M; Chumley MJ; Silvany RE; Henkemeyer M; Frisen J
Article: DEVELOPMENT. 2006;133(7):1335-1345
Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5
Nomura T; Holmberg J; Frisen J; Osumi N
Article: GENES & DEVELOPMENT. 2005;19(4):462-471
Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis
Holmberg J; Armulik A; Senti KA; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J
Article: NATURE. 2000;408(6809):203-206
Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
Holmberg J; Clarke DL; Frisén J
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All other publications

Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection (vol 13, 5093, 2022)
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Corrigendum: NATURE METABOLISM. 2022;4(10):1421
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):4639
A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons (vol 9, 1226, 2018)
Sodersten E; Toskas K; Rraklli V; Tiklova K; Bjorklund AK; Ringer M; Perlmanni T; Holmberg J
Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(51):E10859-E10860
High levels of EPAS1 are closely associated with key features of low-risk neuroblastoma
Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Sodersten E; Schlisio S; Holmberg J
Review: NATURE REVIEWS GENETICS. 2012;13(6):429-439
Maintaining differentiated cellular identity
Holmberg J; Perlmann T
Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;76(2):205-215
PACAP promotes neural stem cell proliferation in adult mouse brain
Mercer A; Rönnholm H; Holmberg J; Lundh H; Heidrich J; Zachrisson O; Ossoinak A; Frisén J; Patrone C
Thesis / dissertation: 2003
Ephrins off the beaten path
Holmberg, Johan
Review: TRENDS IN NEUROSCIENCES. 2002;25(5):239-243
Ephrins are not only unattractive
Holmberg J; Frisén J
Review: EMBO JOURNAL. 1999;18(19):5159-5165
Ephrins and their Eph receptors:: multitalented directors of embryonic development
Frisén J; Holmberg J; Barbacid M

Employments

Affiliated to Research, Department of Cell and Molecular Biology, Karolinska Institutet, 2025-2026

Degrees and Education

Docent, Karolinska Institutet, 2018
Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2003

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