Johan Ericson

About me
Publications
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About me

Professor of Developmental Biology.

Research

I'm focusing on stem cells and neural development. My reserach group is
presented here.

Articles

Article: NATURE COMMUNICATIONS. 2022;13(1):3046

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery

Alekseenko Z; Dias JM; Adler AF; Kozhevnikova M; van Lunteren JA; Nolbrant S; Jeggari A; Vasylovska S; Yoshitake T; Kehr J; Carlen M; Alexeyenko A; Parmar M; Ericson J
Article: SCIENCE ADVANCES. 2020;6(38):eaba8196

A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells

Dias JM; Alekseenko Z; Jeggari A; Boareto M; Vollmer J; Kozhevnikova M; Wang H; Matise MP; Alexeyenko A; Iber D; Ericson J
Article: EMBO REPORTS. 2018;19(11):e46635

Sequentially acting SOX proteins orchestrate astrocyte- and oligodendrocyte-specific gene expression

Klum S; Zaouter C; Alekseenko Z; Bjorklund AK; Hagey DW; Ericson J; Muhr J; Bergsland M
Article: NUCLEIC ACIDS RESEARCH. 2018;46(W1):W163-W170

EviNet: a web platform for network enrichment analysis with flexible definition of gene sets

Jeggari A; Alekseenko Z; Petrov L; Dias JM; Ericson J; Alexeyenko A
Article: DEVELOPMENTAL BIOLOGY. 2017;429(1):132-146

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model

Hoelzl MA; Heby-Henricson K; Gerling M; Dias JM; Kuiper RV; Trunkle C; Bergstrom A; Ericson J; Toftgard R; Teglund S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4387-E4396

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

Doucet-Beaupre H; Gilbert C; Profes MS; Chabrat A; Pacelli C; Giguere N; Rioux V; Charest J; Deng Q; Laguna A; Ericson J; Perlmann T; Ang S-L; Cicchetti F; Parent M; Trudeau L-E; Levesque M
Article: DEVELOPMENT. 2016;143(14):2616-2628

The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2

Gross S; Garofalo DC; Balderes DA; Mastracci TL; Dias JM; Perlmann T; Ericson J; Sussel L
Article: SCIENTIFIC REPORTS. 2016;6:26448

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors

Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
Article: NATURE NEUROSCIENCE. 2015;18(6):826-U404

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
Article: NEURON. 2015;85(3):497-504

A Conserved Regulatory Logic Controls Temporal Identity in Mouse Neural Progenitors

Mattar P; Ericson J; Blackshaw S; Cayouette M
Article: PLOS ONE. 2015;10(4):e0124408

Nkx2.2 and Nkx2.9 Are the Key Regulators to Determine Cell Fate of Branchial and Visceral Motor Neurons in Caudal Hindbrain

Jarrar W; Dias JM; Ericson J; Arnold H-H; Holz A
Article: NEURON. 2014;84(5):927-939

Tgfβ Signaling Regulates Temporal Neurogenesis and Potency of Neural Stem Cells in the CNS

Dias JM; Alekseenko Z; Applequist JM; Ericson J
Article: CELL REPORTS. 2014;8(4):1018-1025

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons

Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
Article: CELL REPORTS. 2014;8(3):665-670

CtBPs Sense Microenvironmental Oxygen Levels to Regulate Neural Stem Cell State

Dias JM; Ilkhanizadeh S; Karaca E; Duckworth JK; Lundin V; Rosenfeld MG; Ericson J; Hermanson O; Teixeira AI
Article: STEM CELLS. 2014;32(3):609-622

Transcription Factor-Induced Lineage Programming of Noradrenaline and Motor Neurons from Embryonic Stem Cells

Mong J; Panman L; Alekseenko Z; Kee N; Stanton LW; Ericson J; Perlmann T
Article: STEM CELLS AND DEVELOPMENT. 2014;23(1):5-15

Detailed Expression Analysis of Regulatory Genes in the Early Developing Human Neural Tube

Marklund U; Alekseenko Z; Andersson E; Falci S; Westgren M; Perlmann T; Graham A; Sundstrom E; Ericson J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(18):7330-7335

SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals

Oosterveen T; Kurdija S; Enstero M; Uhde CW; Bergsland M; Sandberg M; Sandberg R; Muhr J; Ericson J
Article: DEVELOPMENTAL CELL. 2012;23(5):1006-1019

Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling

Oosterveen T; Kurdija S; Alekseenko Z; Uhde CW; Bergsland M; Sandberg M; Andersson E; Dias JM; Muhr J; Ericson J
Article: DEVELOPMENT. 2012;139(14):2625-2634

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

Metzakopian E; Lin W; Salmon-Divon M; Dvinge H; Andersson E; Ericson J; Perlmann T; Whitsett JA; Bertone P; Ang S-L
Article: DEVELOPMENT. 2011;138(17):3711-3721

Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS

Wang H; Lei Q; Oosterveen T; Ericson J; Matise MP
Article: DEVELOPMENT. 2011;138(16):3399-3408

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Deng Q; Andersson E; Hedlund E; Alekseenko Z; Coppola E; Panman L; Millonig JH; Brunet J-F; Ericson J; Perlmann T
Article: CELL STEM CELL. 2011;8(6):663-675

Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells

Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T
Article: DEVELOPMENT. 2010;137(24):4249-4260

The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance

Holz A; Kollmus H; Ryge J; Niederkofler V; Dias J; Ericson J; Stoeckli ET; Kiehn O; Arnold H-H
Article: DEVELOPMENT. 2010;137(23):4051-4060

A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning

Lek M; Dias JM; Marklund U; Uhde CW; Kurdija S; Lei Q; Sussel L; Rubenstein JL; Matise MP; Arnold H-H; Jessell TM; Ericson J
Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942

Control of Notch-ligand endocytosis by ligand-receptor interaction

Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
Article: NATURE NEUROSCIENCE. 2010;13(9):1066-1074

Hindbrain interneurons and axon guidance signaling critical for breathing

Bouvier J; Thoby-Brisson M; Renier N; Dubreuil V; Ericson J; Champagnat J; Pierani A; Chedotal A; Fortin G
Article: DEVELOPMENT. 2010;137(3):437-445

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression

Marklund U; Hansson EM; Sundstrom E; de Angelis MH; Przemeck GKH; Lendahl U; Muhr J; Ericson J
Article: SCIENCE SIGNALING. 2009;2(95):ra70

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis

Ashique AM; Choe Y; Karlen M; May SR; Phamluong K; Solloway MJ; Ericson J; Peterson AS
Article: DEVELOPMENT. 2009;136(15):2545-2555

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Prakash N; Puelles E; Freude K; Truembach D; Omodei D; Di Salvio M; Sussel L; Ericson J; Sander M; Simeone A; Wurst W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(18):7613-7618

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

Friling S; Andersson E; Thompson LH; Jonssonc ME; Hebsgaard JB; Nanou E; Alekseenko Z; Marklund U; Kjellander S; Volakakis N; Hovatta O; El Manira A; Bjorklund A; Perlmann T; Ericson J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: JOURNAL OF NEUROSCIENCE. 2008;28(4):963-975

Retrograde signaling onto Ret during motor nerve terminal maturation

Baudet C; Pozas E; Adameyko I; Andersson E; Ericson J; Ernfors P
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(16):3108-3119

A global genomic transcriptional code associated with CNS-expressed genes

Bailey PJ; Klos JM; Andersson E; Karlen M; Kallstrom M; Ponjavic J; Muhr J; Lenhard B; Sandelin A; Ericson J
Article: DEVELOPMENTAL CELL. 2006;10(2):187-197

Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

Svärd J; Henricson KH; Persson-Lek M; Rozell B; Lauth M; Bergstrm Å; Ericson J; Toftgård R; Teglund S
Article: CELL. 2006;124(2):393-405

Identification of intrinsic determinants of midbrain dopamine neurons

Andersson E; Tryggvason U; Deng QL; Friling S; Alekseenko Z; Robert B; Perlmann T; Ericson J
Article: GENE EXPRESSION PATTERNS. 2006;6(2):162-170

Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development

Alanentalo T; Chatonnet F; Karlen M; Sulniute R; Ericson J; Andersson E; Ahlgren U
Article: DEVELOPMENTAL BIOLOGY. 2005;287(2):378-389

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

May SR; Ashique AM; Karlen M; Wang BL; Shen YG; Zarbalis K; Reiter J; Ericson J; Peterson AS
Article: NEURON. 2005;47(5):667-679

A Cxcl12-Cxcr4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons

Lieberam I; Agalliu D; Nagasawa T; Ericson J; Jessell TM
Article: DEVELOPMENT. 2005;132(13):3139-3149

NKX6 transcription factor activity is required for α- and β-cell development in the pancreas

Henseleit KD; Nellson SB; Kuhlbrodt K; Hennings JC; Ericson J; Sander M
Article: DEVELOPMENT. 2005;132(12):2697-2707

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2

Singh MK; Christoffels VM; Dias JM; Trowe MO; Petry M; Schuster-Gossler K; Bürger A; Ericson J; Kispert A
Article: NEURON. 2005;45(1):55-67

Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain

Vallstedt A; Klos JM; Ericson J
Article: BMC GENOMICS. 2004;5(1):99

Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes -: art. no. 99

Sandelin A; Bailey P; Bruce S; Engström PG; Klos JM; Wasserman WW; Ericson J; Lenhard B
Article: DEVELOPMENT. 2004;131(16):4071-4083

Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins

Samad OA; Geisen MJ; Caronia G; Variet I; Zappavigna V; Ericson J; Goridis C; Rijli FM
Article: NATURE NEUROSCIENCE. 2003;6(9):933-938

Lmx1b is essential for the development of serotonergic neurons

Ding YQ; Marklund U; Yuan WL; Yin J; Wegman L; Ericson J; Deneris E; Johnson RL; Chen ZF
Article: DEVELOPMENT. 2003;130(17):4149-4159

Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain

Pattyn A; Vallstedt A; Dias JM; Sander M; Ericson J
Article: GENES & DEVELOPMENT. 2003;17(6):729-737

Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors

Pattyn A; Vallstedt A; Dias JM; Samad OA; Krumlauf R; Rijli FM; Brunet JF; Ericson J
Article: GENES & DEVELOPMENT. 2002;16(22):2865-2878

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

Persson M; Stamataki D; Welscher PT; Andersson E; Böse J; Rüther U; Ericson J; Briscoe J
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2001;18(6):649-663

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem

Wallén Å; Castro DS; Zetterström RH; Karlén M; Olson L; Ericson J; Perlmann T
Article: NEURON. 2001;31(5):743-755

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification

Vallstedt A; Muhr J; Pattyn A; Pierani A; Mendelsohn M; Sander M; Jessell TM; Ericson J
Article: CELL. 2001;104(6):861-873

Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

Muhr J; Andersson E; Persson M; Jessell TM; Ericson J
Article: GENES & DEVELOPMENT. 2000;14(17):2134-2139

Ventral neural patterning by Nkx homeobox genes:: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

Sander M; Paydar S; Ericson J; Briscoe J; Berber E; German M; Jessell TM; Rubenstein JLR
Article: CELL. 2000;101(4):435-445

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

Briscoe J; Pierani A; Jessell TM; Ericson J
Article: FEBS LETTERS. 1999;461(3):287-294

Cloning and DNA-binding properties of the rat pancreatic β-cell-specific factor Nkx6.1

Jorgensen MC; Petersen HV; Ericson J; Madsen OD; Serup P
Article: DEVELOPMENT. 1998;125(6):1005-1015

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary.

Ericson J; Norlin S; Jessell TM; Edlund T
Article: CELL. 1995;81(5):747-756

Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube.

Ericson J; Muhr J; Placzek M; Lints T; Jessell TM; Edlund T
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All other publications

Letter: DEVELOPMENT. 2016;143(10):1638-1640

Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models

Uhde CW; Ericson J
Meeting abstract: MECHANISMS OF DEVELOPMENT. 2009;126:S245

Intrinsic transcriptional determinants promote efficient generation of neuronal subtypes from ES cells

Panman L; Andersson E; Hedlund E; Udhe C; Mong J; Alexsenko Z; Sandberg R; Ericson J; Perlmann T
Meeting abstract: DEVELOPMENTAL BIOLOGY. 2007;306(1):360

RFX4 transcription factor regulates IFT172 expression, cilia formation and dorsoventral patterning of the central nervous system

Ashique AM; Karlen M; Choe Y; Ericson J; Rubenstein JL; Peterson AS
Meeting abstract: DEVELOPMENTAL BIOLOGY. 2007;306(1):430

Temporal patterning determines visceral motoneuron subtypes generated from Nkx2.2⁺ progenitors in the hindbrain

Applequist JM; Karlen M; Jordi E; Perlmann T; Ericson J
Corrigendum: DEVELOPMENTAL CELL. 2006;10(3):409

Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway (vol 10, pg 187, 2006)

Svärd J; Heby-Henricson K; Persson-Lek M; Rozell B; Lauth M; Bergström A; Ericson J; Toftgård R; Teglund S
Review: CURRENT OPINION IN NEUROBIOLOGY. 2001;11(1):43-49

Specification of neuronal fates in the ventral neural tube

Briscoe J; Ericson J
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 1999;10(3):353-362

The specification of neuronal identity by graded sonic hedgehog signalling

Briscoe J; Ericson J

Employments

Professor, Department of Cell and Molecular Biology, Karolinska Institutet, 2006-

Degrees and Education

Docent, Karolinska Institutet, 2000

About me

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