Joar Guterstam

About me
Publications
Grants
CV
Public outreach and news

About me

MD, PhD, Docent. Specialist in psychiatry and addiction medicine.

Research

My PhD-thesis (2017) investigated the role of the brain opioid system in amphetamine addiction, using the imaging techniques PET and fMRI. Currently, my research is focused on pharmacotherapy for substance use disorders, and biomarkers in addiction medicine.

Teaching

I lecture frequently on topics related to psychiatry, addiction medicine and psychopharmacology. I am responsible for several courses for residents in addiction medicine, and the course in neurobiology for PhD students in the research school for clinical psychiatry.
I have also contributed to several textbooks and other educational materials.

Articles

Article: ALCOHOL AND ALCOHOLISM. 2024;59(6):agae070
Phosphatidylethanol as an outcome measure in treatment aimed at controlled drinking
Hammarberg A; Hammarberg SI; Cuellar SR; Guterstam J
Journal article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2024;343:111860
Neural correlates of impulsivity in amphetamine use disorder
Kaboodvand N; Shabanpour M; Guterstam J
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2024;243:116075
A multicomponent LC-MS/MS method for drugs of abuse testing using volumetric DBS and a clinical evaluation by comparison with urine
Guterstam J; Tavic C; Barosso M; Beck O
Journal article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2024;1240:124142
Validation and application of an automated multitarget LC-MS/MS method for drugs of abuse testing using exhaled breath as specimen
Sinapour H; Guterstam J; Grosse S; Astorga-Wells J; Stambeck P; Stambeck M; Winberg J; Hermansson S; Beck O
Article: PSYCHOLOGICAL MEDICINE. 2024;54(7):1391-1402
The risk and development of work disability among individuals with gambling disorder: a longitudinal case-cohort study in Sweden
Mansson V; Pettersson E; Mittendorfer-Rutz E; Guterstam J; Berman AH; Jayaram-Lindstrom N; Molero Y
Article: LAKARTIDNINGEN. 2024;121:23157
Nya svenska diagnoskoder för beroendetillstånd i remission.
Guterstam J; Heilig M
Article: EUROPEAN ADDICTION RESEARCH. 2024;30(1):1-13
The Effect of Methylphenidate on Cognition in Patients with Comorbid Attention Deficit/Hyperactivity Disorder and Amphetamine Use Disorder: An Exploratory Single-Blinded within-Subject Study
Brynte C; Konstenius M; Khemiri L; Backer A; Guterstam J; Levin FR; Jayaram-Lindstrom N; Franck J
Article: BMC PUBLIC HEALTH. 2023;23(1):1608
A study protocol for a European, mixed methods, prospective, cohort study of the effectiveness of naloxone administration by community members, in reversing opioid overdose: NalPORS
Metrebian N; Carter B; Eide D; Mcdonald R; Neale J; Parkin S; Dascal T; Mackie C; Day E; Guterstam J; Horsburgh K; Kaberg M; Kelleher M; Smith J; Thiesen H; Strang J
Article: LAKARTIDNINGEN. 2022;119
Spelberoende – en allvarlig biverkan av dopaminagonister.
Guterstam J
Article: EUROPEAN ADDICTION RESEARCH. 2022;28(3):210-219
The Hypothesis of Subliminal Cue Reactivity in Addiction Revisited: An fMRI Study
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Article: BMC PSYCHIATRY. 2021;21(1):458
Self-rated impulsivity in healthy individuals, substance use disorder and ADHD: psychometric properties of the Swedish Barratt impulsiveness scale
Khemiri L; Brynte C; Konstenius M; Guterstam J; Rosendahl I; Franck J; Jayaram-Lindstrom N
Article: LAKARTIDNINGEN. 2020;117:20165
Välkommet med ny standard för kiral analys av amfetamin.
Guterstam J
Article: MOLECULAR PAIN. 2020;16:1744806920927625
Naltrexone during pain conditioning: A double-blind placebo-controlled experimental trial
Ponten M; Fust J; Kosek E; Guterstam J; Jensen K
Article: PSYCHOPHARMACOLOGY. 2020;237(1):69-82
Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence
Khemiri L; Steensland P; Guterstam J; de Manzano O; Franck J; Jayaram-Lindstrom N
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:s177
Subliminal cue reactivity in amphetamine dependence
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Article: DRUG AND ALCOHOL DEPENDENCE. 2018;191:91-97
Cue reactivity and opioid blockade in amphetamine dependence: A randomized, controlled fMRI study
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Journal article: 2018
Subliminal cue reactivity in amphetamine dependence
Guterstam J
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:s1064-s1065
P.6.d.003 Cue reactivity and opioid blockade in amphetamine dependence: a randomised, controlled fMRI study
Guterstam J; Lindström NJ; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1104
Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study
Jayaram-Lindstrom N; Guterstam J; Haggkvist J; Ericson M; Malmlof T; Schilstrom B; Halldin C; Cervenka S; Saijo T; Nordstrom A-L; Franck J
Article: LAKARTIDNINGEN. 2016;113:DSU6
[Substitution therapy tested against amphetamine dependence].
Bloniecki Kallio V; Guterstam J; Franck J
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(12):2240-2251
The effects of the monoamine stabilizer (-)-OSU6162 on craving in alcohol dependent individuals: A human laboratory study
Khemiri L; Steensland P; Guterstam J; Beck O; Carlsson A; Franck J; Jayaram-Lindstrom N
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2015;39(11):2200-2208
Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and -Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level
Walther L; de Bejczy A; Lof E; Hansson T; Andersson A; Guterstam J; Hammarberg A; Asanovska G; Franck J; Soderpalm B; Isaksson A
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2015;39(11):2189-2199
Varenicline for Treatment of Alcohol Dependence: A Randomized, Placebo-Controlled Trial
de Bejczy A; Lof E; Walther L; Guterstam J; Hammarberg A; Asanovska G; Franck J; Isaksson A; Soderpalm B
Article: ADDICTION. 2014;109(3):440-449
Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial
Konstenius M; Jayaram-Lindstroem N; Guterstam J; Beck O; Philips B; Franck J
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(4):763-769
Effects of amphetamine on the human brain opioid system - a positron emission tomography study
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Frost JJ; Farde L; Halldin C; Franck J
Journal article: LAKARTIDNINGEN. 2013;110(3):101
[Time for intellectual honesty in the substance abuse debate].
Guterstam J
Journal article: EUROPEAN PSYCHIATRY. 2013;28:1
1128 – Methylphenidate for ADHD in adults with substance dependence: A 24-week randomized placebo-controlled trial
Konstenius M; Jayaram-Lindström N; Guterstam J; Philips B; Beck O; Franck J
Article: BMC PSYCHIATRY. 2012;12:221
Amphetamine-induced psychosis - a separate diagnostic entity or primary psychosis triggered in the vulnerable?
Bramness JG; Gundersen OH; Guterstam J; Rognli EB; Konstenius M; Loberg E-M; Medhus S; Tanum L; Franck J
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22:s55
P.3.004 Amphetamine-opioid interactions in the human brain reward system – a PET study using [11C]carfentanil
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Halldin C; Farde L; Frost J; Franck J
Article: PLOS ONE. 2012;7(6):e39882
Alcohol Dependence Associated with Increased Utilitarian Moral Judgment: A Case Control Study
Khemiri L; Guterstam J; Franck J; Jayaram-Lindstrom N
Journal article: LAKARTIDNINGEN. 2006;103(15-16):1225
[Exaggerated simplification of animal ethics].
Guterstam J; Sjöstrand M
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All other publications

Preprint: MEDRXIV. 2024
Genetic liability for anxiety associates with treatment response to the monoamine stabilizer OSU6162 in alcohol dependence
Hong M-G; Khemiri L; Guterstam J; Franck J; Jayaram-Lindström N; Melas PA
Editorial comment: EUROPEAN ADDICTION RESEARCH. 2024;30(3):138-139
Toward a European Standard of Training in Addiction Medicine and Psychology
Guterstam J
Review: LAKARTIDNINGEN. 2022;119:21105
[The dark side of ADHD - comorbidity with substance use disorder and criminality - an overview].
Johansson Capusan A; Guterstam J; Ginsberg Y; Borg Skoglund L
Thesis / dissertation: 2017
Imaging of the brain opioid system in amphetamine dependence
Guterstam, Joar
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S1054
Effect of the monoamine stabilizer (-)-OSU6162 on cognitive function in alcohol dependent patients
Khemiri L; Steensland P; Guterstam J; Carlsson A; Franck J; Jayaram-Lindstrom N
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S1065-S1066
Cue reactivity and opioid blockade in amphetamine dependence: a randomised, controlled fMRI study
Guterstam J; Lindstrom NJ; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Letter: LAKARTIDNINGEN. 2015;112:DEEX
["Dialogical floor" can become a trap door].
Guterstam J; Hammarberg A; Finn SW; Cervenka S; Lekander M; Petrovic P; Hedman E
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S691-S692
Neural correlates of cue-induced craving for amphetamine
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Ingvar M; Franck J
Corrigendum: ADDICTION. 2014;109(9):1571-1572
Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial (vol 109, pg 440, 2014)
Konstenius M; Jayaram-Lindstroem N; Guterstam J; Beck O; Philips B; Franck J
Conference publication: EUROPEAN PSYCHIATRY. 2014;28:e109
METHYLPHENIDATE FOR ADHD IN ADULTS WITH SUBSTANCE DEPENDENCE A 24-WEEK RANDOMIZED PLACEBO-CONTROLLED TRIAL
Konstenius M; Jayaram-Lindstrom N; Guterstam J; Philips B; Beck O; Franck J
Conference publication: BIOLOGICAL PSYCHIATRY. 2014;75(9):18S
The Effects of the Monoamine Stabilizer (-)-OSU6162 on Craving in Alcohol Dependent Patients
Khemiri L; Steensland P; Guterstam J; Carlsson A; Jayaram-Lindstrom N; Franck J
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2014;38:306A
EVALUATION OF THEMONOAMINE STABILIZER (-)-OSU6162 AS A POTENTIAL NOVEL TREATMENT OF ALCOHOL USE DISORDERS - FROM BENCH TOCLINIC
Jayaram-Lindstrom N; Khemiri L; Carlsson A; Guterstam J; Steensland P; Franck J
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2014;38:158A
THE MONOAMINE STABILIZER (-)-OSU6162 MODULATES CRAVING IN ALCOHOL DEPENDENT SUBJECTS
Khemiri L; Steensland P; Guterstam J; Carlsson A; Jayaram-Lindstrom N; Franck J
Conference publication: BIOLOGICAL PSYCHIATRY. 2014;75(9):379S
Effects of Naltrexone on Amphetamine-induced Changes in the Brain Dopamine System: Pre-clinical and Clinical Studies
Jayaram-Lindstrom N; Haggkvist J; Guterstam J; Malmlof T; Halldin C; Schilstrom B; Nordstrom A-L; Franck J
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:41
ADHD in drug addiction : A RCT on the feasibility of methylphenidate treatment in criminal amphetamine users
Franck J; Konstenius M; Jayaram-Lindstrom N; Philips B; Guterstam J
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36:64A
THE ETHANOL-nAChR INTERACTION AND ITS RELEVANCE FOR MODULATING ETHANOL CONSUMPTION IN RODENTS AND MAN
Soderpalm B; deBejczy A; Ericson M; Guterstam J; Hammarberg A; Franck J; Asanovska G; Lof E
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36:358A
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE EFFECT OF VARENICLINE IN THE TREATMENT OF ALCOHOL DEPENDENCE
Lof E; deBejczy A; Guterstam J; Hammarberg A; Franck J; Asanovska G; Soderpalm B
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22:S55
Amphetamine-opioid interactions in the human brain reward system - a PET study using [¹¹C]carfentanil
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Halldin C; Farde L; Frost J; Franck J

Grants

Placebo responsiveness and cognitive behavior therapy outcomes: Investigating expectations and neural variability in anxious individuals
Swedish Research Council
1 January 2024 - 31 December 2027
Prescription opioid misuse: improving prevention and treatment
Swedish Research Council for Health Working Life and Welfare
1 January 2021 - 31 December 2023
ADHD and co-occuring substance use disorder: a clinical trials programme of pharmacological treatments
Swedish Research Council
1 January 2013 - 31 December 2015
Development of a new psychopharmacological treatment for amphetamine dependence and ADHD: Clinical and experimental studies
Swedish Research Council
1 January 2010 - 31 December 2012

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2024-2026

Degrees and Education

Docent, Psychiatry, Karolinska Institutet, 2024
Docent, Karolinska Institutet, 2024
Degree Of Doctor Of Philosophy, Karolinska Institutet, 2017
University Medical Degree, Karolinska Institutet, 2006

About me

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Articles

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