Joar Guterstam

About me
Publications
Grants
CV
Public outreach and news

About me

MD, PhD, Specialist in psychiatry and addiction medicine

Research

My PhD-thesis (2017) investigated the role of the brain opioid system in amphetamine addiction, using the imaging techniques PET and fMRI. As a post-doc, I have continued to work with neuroimaging, both at Karolinska Institutet and at the Zentralinstitut für Seelische Gesundheit in Mannheim, Germany. I am also involved in clinical trials of pharmacotherapy for substance use disorders.

Articles

Journal article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2024;343:111860
Neural correlates of impulsivity in amphetamine use disorder
Kaboodvand N; Shabanpour M; Guterstam J
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2024;243:116075
A multicomponent LC-MS/MS method for drugs of abuse testing using volumetric DBS and a clinical evaluation by comparison with urine
Guterstam J; Tavic C; Barosso M; Beck O
Journal article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2024;1240:124142
Validation and application of an automated multitarget LC-MS/MS method for drugs of abuse testing using exhaled breath as specimen
Sinapour H; Guterstam J; Grosse S; Astorga-Wells J; Stambeck P; Stambeck M; Winberg J; Hermansson S; Beck O
Article: PSYCHOLOGICAL MEDICINE. 2024;54(7):1391-1402
The risk and development of work disability among individuals with gambling disorder: a longitudinal case-cohort study in Sweden
Mansson V; Pettersson E; Mittendorfer-Rutz E; Guterstam J; Berman AH; Jayaram-Lindstrom N; Molero Y
Article: LAKARTIDNINGEN. 2024;121:23157
Nya svenska diagnoskoder för beroendetillstånd i remission.
Guterstam J; Heilig M
Article: EUROPEAN ADDICTION RESEARCH. 2024;30(1):1-13
The Effect of Methylphenidate on Cognition in Patients with Comorbid Attention Deficit/Hyperactivity Disorder and Amphetamine Use Disorder: An Exploratory Single-Blinded within-Subject Study
Brynte C; Konstenius M; Khemiri L; Backer A; Guterstam J; Levin FR; Jayaram-Lindstrom N; Franck J
Article: BMC PUBLIC HEALTH. 2023;23(1):1608
A study protocol for a European, mixed methods, prospective, cohort study of the effectiveness of naloxone administration by community members, in reversing opioid overdose: NalPORS
Metrebian N; Carter B; Eide D; Mcdonald R; Neale J; Parkin S; Dascal T; Mackie C; Day E; Guterstam J; Horsburgh K; Kaberg M; Kelleher M; Smith J; Thiesen H; Strang J
Article: LAKARTIDNINGEN. 2022;119
Spelberoende – en allvarlig biverkan av dopaminagonister.
Guterstam J
Article: EUROPEAN ADDICTION RESEARCH. 2022;28(3):210-219
The Hypothesis of Subliminal Cue Reactivity in Addiction Revisited: An fMRI Study
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Article: BMC PSYCHIATRY. 2021;21(1):458
Self-rated impulsivity in healthy individuals, substance use disorder and ADHD: psychometric properties of the Swedish Barratt impulsiveness scale
Khemiri L; Brynte C; Konstenius M; Guterstam J; Rosendahl I; Franck J; Jayaram-Lindstrom N
Article: LAKARTIDNINGEN. 2020;117:20165
Välkommet med ny standard för kiral analys av amfetamin.
Guterstam J
Article: PSYCHOPHARMACOLOGY. 2020;237(1):69-82
Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence
Khemiri L; Steensland P; Guterstam J; de Manzano O; Franck J; Jayaram-Lindstrom N
Article: MOLECULAR PAIN. 2020;16:1744806920927625
Naltrexone during pain conditioning: A double-blind placebo-controlled experimental trial
Ponten M; Fust J; Kosek E; Guterstam J; Jensen K
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S177
Subliminal cue reactivity in amphetamine dependence
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Article: DRUG AND ALCOHOL DEPENDENCE. 2018;191:91-97
Cue reactivity and opioid blockade in amphetamine dependence: A randomized, controlled fMRI study
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Journal article: 2018
Subliminal cue reactivity in amphetamine dependence
Guterstam J
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:s1064-s1065
P.6.d.003 Cue reactivity and opioid blockade in amphetamine dependence: a randomised, controlled fMRI study
Guterstam J; Lindström NJ; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1104
Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study
Jayaram-Lindstrom N; Guterstam J; Haggkvist J; Ericson M; Malmlof T; Schilstrom B; Halldin C; Cervenka S; Saijo T; Nordstrom A-L; Franck J
Article: LAKARTIDNINGEN. 2016;113:DSU6
[Substitution therapy tested against amphetamine dependence].
Bloniecki Kallio V; Guterstam J; Franck J
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(12):2240-2251
The effects of the monoamine stabilizer (-)-OSU6162 on craving in alcohol dependent individuals: A human laboratory study
Khemiri L; Steensland P; Guterstam J; Beck O; Carlsson A; Franck J; Jayaram-Lindstrom N
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2015;39(11):2200-2208
Phosphatidylethanol is Superior to Carbohydrate-Deficient Transferrin and -Glutamyltransferase as an Alcohol Marker and is a Reliable Estimate of Alcohol Consumption Level
Walther L; de Bejczy A; Lof E; Hansson T; Andersson A; Guterstam J; Hammarberg A; Asanovska G; Franck J; Soderpalm B; Isaksson A
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2015;39(11):2189-2199
Varenicline for Treatment of Alcohol Dependence: A Randomized, Placebo-Controlled Trial
de Bejczy A; Lof E; Walther L; Guterstam J; Hammarberg A; Asanovska G; Franck J; Isaksson A; Soderpalm B
Article: ADDICTION. 2014;109(3):440-449
Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial
Konstenius M; Jayaram-Lindstroem N; Guterstam J; Beck O; Philips B; Franck J
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(4):763-769
Effects of amphetamine on the human brain opioid system - a positron emission tomography study
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Frost JJ; Farde L; Halldin C; Franck J
Journal article: LAKARTIDNINGEN. 2013;110(3):101
[Time for intellectual honesty in the substance abuse debate].
Guterstam J
Journal article: EUROPEAN PSYCHIATRY. 2013;28:1
1128 – Methylphenidate for ADHD in adults with substance dependence: A 24-week randomized placebo-controlled trial
Konstenius M; Jayaram-Lindström N; Guterstam J; Philips B; Beck O; Franck J
Article: BMC PSYCHIATRY. 2012;12:221
Amphetamine-induced psychosis - a separate diagnostic entity or primary psychosis triggered in the vulnerable?
Bramness JG; Gundersen OH; Guterstam J; Rognli EB; Konstenius M; Loberg E-M; Medhus S; Tanum L; Franck J
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22:s55
P.3.004 Amphetamine-opioid interactions in the human brain reward system – a PET study using [11C]carfentanil
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Halldin C; Farde L; Frost J; Franck J
Article: PLOS ONE. 2012;7(6):e39882
Alcohol Dependence Associated with Increased Utilitarian Moral Judgment: A Case Control Study
Khemiri L; Guterstam J; Franck J; Jayaram-Lindstrom N
Journal article: LAKARTIDNINGEN. 2006;103(15-16):1225
[Exaggerated simplification of animal ethics].
Guterstam J; Sjöstrand M
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All other publications

Preprint: MEDRXIV. 2024
Genetic liability for anxiety associates with treatment response to the monoamine stabilizer OSU6162 in alcohol dependence
Hong M-G; Khemiri L; Guterstam J; Franck J; Jayaram-Lindström N; Melas PA
Editorial comment: EUROPEAN ADDICTION RESEARCH. 2024;30(3):138-139
Toward a European Standard of Training in Addiction Medicine and Psychology
Guterstam J
Review: LAKARTIDNINGEN. 2022;119:21105
[The dark side of ADHD - comorbidity with substance use disorder and criminality - an overview].
Johansson Capusan A; Guterstam J; Ginsberg Y; Borg Skoglund L
Thesis / dissertation: 2017
Imaging of the brain opioid system in amphetamine dependence
Guterstam, Joar
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S1054
Effect of the monoamine stabilizer (-)-OSU6162 on cognitive function in alcohol dependent patients
Khemiri L; Steensland P; Guterstam J; Carlsson A; Franck J; Jayaram-Lindstrom N
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S1065-S1066
Cue reactivity and opioid blockade in amphetamine dependence: a randomised, controlled fMRI study
Guterstam J; Lindstrom NJ; Berrebi J; Petrovic P; Ingvar M; Fransson P; Franck J
Letter: LAKARTIDNINGEN. 2015;112:DEEX
["Dialogical floor" can become a trap door].
Guterstam J; Hammarberg A; Finn SW; Cervenka S; Lekander M; Petrovic P; Hedman E
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S691-S692
Neural correlates of cue-induced craving for amphetamine
Guterstam J; Jayaram-Lindstrom N; Berrebi J; Ingvar M; Franck J
Corrigendum: ADDICTION. 2014;109(9):1571-1572
Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial (vol 109, pg 440, 2014)
Konstenius M; Jayaram-Lindstroem N; Guterstam J; Beck O; Philips B; Franck J
Conference publication: EUROPEAN PSYCHIATRY. 2014;28:e109
METHYLPHENIDATE FOR ADHD IN ADULTS WITH SUBSTANCE DEPENDENCE A 24-WEEK RANDOMIZED PLACEBO-CONTROLLED TRIAL
Konstenius M; Jayaram-Lindstrom N; Guterstam J; Philips B; Beck O; Franck J
Conference publication: BIOLOGICAL PSYCHIATRY. 2014;75(9):18S
The Effects of the Monoamine Stabilizer (-)-OSU6162 on Craving in Alcohol Dependent Patients
Khemiri L; Steensland P; Guterstam J; Carlsson A; Jayaram-Lindstrom N; Franck J
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2014;38:306A
EVALUATION OF THEMONOAMINE STABILIZER (-)-OSU6162 AS A POTENTIAL NOVEL TREATMENT OF ALCOHOL USE DISORDERS - FROM BENCH TOCLINIC
Jayaram-Lindstrom N; Khemiri L; Carlsson A; Guterstam J; Steensland P; Franck J
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2014;38:158A
THE MONOAMINE STABILIZER (-)-OSU6162 MODULATES CRAVING IN ALCOHOL DEPENDENT SUBJECTS
Khemiri L; Steensland P; Guterstam J; Carlsson A; Jayaram-Lindstrom N; Franck J
Conference publication: BIOLOGICAL PSYCHIATRY. 2014;75(9):379S
Effects of Naltrexone on Amphetamine-induced Changes in the Brain Dopamine System: Pre-clinical and Clinical Studies
Jayaram-Lindstrom N; Haggkvist J; Guterstam J; Malmlof T; Halldin C; Schilstrom B; Nordstrom A-L; Franck J
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:41
ADHD in drug addiction : A RCT on the feasibility of methylphenidate treatment in criminal amphetamine users
Franck J; Konstenius M; Jayaram-Lindstrom N; Philips B; Guterstam J
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22:S55
Amphetamine-opioid interactions in the human brain reward system - a PET study using [¹¹C]carfentanil
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Halldin C; Farde L; Frost J; Franck J
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36:64A
THE ETHANOL-nAChR INTERACTION AND ITS RELEVANCE FOR MODULATING ETHANOL CONSUMPTION IN RODENTS AND MAN
Soderpalm B; deBejczy A; Ericson M; Guterstam J; Hammarberg A; Franck J; Asanovska G; Lof E
Conference publication: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36:358A
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE EFFECT OF VARENICLINE IN THE TREATMENT OF ALCOHOL DEPENDENCE
Lof E; deBejczy A; Guterstam J; Hammarberg A; Franck J; Asanovska G; Soderpalm B

Grants

Placebo responsiveness and cognitive behavior therapy outcomes: Investigating expectations and neural variability in anxious individuals
Swedish Research Council
1 January 2024 - 31 December 2027
Prescription opioid misuse: improving prevention and treatment
Swedish Research Council for Health Working Life and Welfare
1 January 2021 - 31 December 2023
ADHD and co-occuring substance use disorder: a clinical trials programme of pharmacological treatments
Swedish Research Council
1 January 2013 - 31 December 2015
Development of a new psychopharmacological treatment for amphetamine dependence and ADHD: Clinical and experimental studies
Swedish Research Council
1 January 2010 - 31 December 2012

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2024-2026

Degrees and Education

Degree Of Doctor Of Philosophy, Karolinska Institutet, 2017
University Medical Degree, Karolinska Institutet, 2006

About me

Research

Articles

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