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About me

I am a Postdoctoral Research Fellow funded by the Wellcome Trust in the UK. I joined MEB in March 2016 to work on the Child and Adolescent Twin Study in Sweden (CATSS) sample with Prof Paul Lichtenstein and others.

My background is in Psychology. After obtaining my BSc in Experimental Psychology from the University of Bristol, I worked as a Research Assistant at Cardiff University, collecting data and performing analyses as part of the Study of ADHD, Genes and Environment. I completed my PhD at Cardiff University in 2014. The title of my PhD thesis was “Examining the clinical and genetic overlap of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder traits”. After my PhD and before joining MEB, I spent a year working at the Stanley Center for Psychiatric Research at the Broad Institute in Cambridge, USA, with Dr Ben Neale. 

Education

2012-2014 - PhD - MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK; PhD supervisors: Dr Marian Hamshere, Prof Anita Thapar & Prof Michael O’Donovan
2004-2007 - BSc (Hons) Experimental Psychology - University of Bristol, UK

Research description

My main research interests concern investigating the genetic risks for neurodevelopmental disorders, including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Specifically, I am intrigued by the sexual dimorphism of the prevalence of these disorders and also the genetic overlap of these clinical disorders with variation in related quantitative traits in the general population. 
I am currently being funded by the Wellcome Trust (2015-2019) to investigate a series of inter-related genetic hypotheses for the increased prevalence of neurodevelopmental disorders in boys compared to girls. This project involves collaborations with Prof Paul Lichtenstein at MEB, Dr Ben Neale at the Broad Institute, USA, as well as Prof Anita Thapar at Cardiff University, UK. During this project, I am working on genetic data from the Psychiatric Genomics Consortium ADHD dataset and the Child and Adolescent Twin Study in Sweden.

Links

Publications

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder
23andme Research Team, Ipsych–broad Adhd Workgroup, Psychiatric Genomics Consortium: Adhd Subgroup, Martin J, Walters Rk, Demontis D, et al
Biological psychiatry 2018;83(12):1044-1053

Assessing the evidence for shared genetic risks across psychiatric disorders and traits
Martin J, Taylor Mj, Lichtenstein P
Psychological medicine 2018;48(11):1759-1774

Association of copy number variation across the genome with neuropsychiatric traits in the general population
Guyatt Al, Stergiakouli E, Martin J, Walters J, O'donovan M, Owen M, et al
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2018;177(5):489-502

Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population
Martin J, Taylor Mj, Rydell M, Riglin L, Eyre O, Lu Y, et al
Journal of child psychology and psychiatry, and allied disciplines 2018;59(8):908-916

Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population
Stergiakouli E, Martin J, Hamshere Ml, Heron J, St Pourcain B, Timpson Nj, et al
International journal of epidemiology 2017;46(2):421-428

Investigating the genetic underpinnings of early-life irritability
Riglin L, Eyre O, Cooper M, Collishaw S, Martin J, Langley K, et al
Translational psychiatry 2017;7(9):e1241-

Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development
Stergiakouli E, Davey Smith G, Martin J, Skuse Dh, Viechtbauer W, Ring Sm, et al
Molecular autism 2017;8():18-

Association of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study
Martin J, Tilling K, Hubbard L, Stergiakouli E, Thapar A, Davey Smith G, et al
American journal of epidemiology 2016;183(12):1149-58

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
Ipsych-ssi-broad Autism Group, Robinson Eb, St Pourcain B, Anttila V, Kosmicki Ja, Bulik-sullivan B, et al
Nature genetics 2016;48(5):552-5

Psychiatric gene discoveries shape evidence on ADHD's biology
Thapar A, Martin J, Mick E, Arias Vásquez A, Langley K, Scherer Sw, et al
Molecular psychiatry 2016;21(9):1202-7

Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014
Aas M, Blokland Ga, Chawner Sj, Choi Sw, Estrada J, Forsingdal A, et al
Psychiatric genetics 2016;26(1):1-47

Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder
Martin J, Hamshere Ml, Stergiakouli E, O'donovan Mc, Thapar A
Journal of child psychology and psychiatry, and allied disciplines 2015;56(6):648-56

Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD
Stergiakouli E, Martin J, Hamshere Ml, Langley K, Evans Dm, St Pourcain B, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2015;54(4):322-7

The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome
Niarchou M, Martin J, Thapar A, Owen Mj, Van Den Bree Mb
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015;168(8):730-8

The relative contribution of common and rare genetic variants to ADHD
Martin J, O'donovan Mc, Thapar A, Langley K, Williams N
Translational psychiatry 2015;5():e506-

Autistic traits in children with ADHD index clinical and cognitive problems
Cooper M, Martin J, Langley K, Hamshere M, Thapar A
European child & adolescent psychiatry 2014;23(1):23-34

Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants
Martin J, Cooper M, Hamshere Ml, Pocklington A, Scherer Sw, Kent L, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2014;53(7):761-70.e26

Factor structure of autistic traits in children with ADHD
Martin J, Hamshere Ml, O'donovan Mc, Rutter M, Thapar A
Journal of autism and developmental disorders 2014;44(1):204-15

Genetic risk for attention-deficit/hyperactivity disorder contributes to neurodevelopmental traits in the general population
Martin J, Hamshere Ml, Stergiakouli E, O'donovan Mc, Thapar A
Biological psychiatry 2014;76(8):664-71

High loading of polygenic risk for ADHD in children with comorbid aggression
Hamshere Ml, Langley K, Martin J, Agha Ss, Stergiakouli E, Anney Rj, et al
The American journal of psychiatry 2013;170(8):909-16

Intellectual disability in children with attention deficit hyperactivity disorder
Ahuja A, Martin J, Langley K, Thapar A
The Journal of pediatrics 2013;163(3):890-5.e1

Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
Hamshere Ml, Stergiakouli E, Langley K, Martin J, Holmans P, Kent L, et al
The British journal of psychiatry : the journal of mental science 2013;203(2):107-11

Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants
Langley K, Martin J, Agha Ss, Davies C, Stergiakouli E, Holmans P, et al
The British journal of psychiatry : the journal of mental science 2011;199(5):398-403

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