Joakim Dahlin
Principal Researcher | Docent
E-mail: joakim.dahlin@ki.se
Visiting address: Center for Molecular Medicine (CMM) L8, Visionsgatan 18, 17164 Stockholm
Postal address: K2 Medicin, Solna, K2 Imm o lung Nilsson G Dahlin J, 171 77 Stockholm
Articles
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(1):e13333Rosell A; Karlstrom C; Dahlin JS; Boey D; Klimkowska M; Ax K; Thalin C; Ungerstedt J
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;152(1):205-213Soderlund S; Boey D; van Midden W; Kjellander M; Ax K; Qian H; Dahlin JS; Ungerstedt J
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1151754Ronnberg E; Ravindran A; Mazzurana L; Gong Y; Safholm J; Lorent J; Dethlefsen O; Orre A-C; Al-Ameri M; Adner M; Dahlen S-E; Dahlin JS; Mjosberg J; Nilsson G
- Article: BLOOD ADVANCES. 2022;6(15):4439-4449Wu C; Boey D; Bril O; Grootens J; Vijayabaskar MS; Sorini C; Ekoff M; Wilson NK; Ungerstedt JS; Nilsson G; Dahlin JS
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:902881Gao Y; Alisjahbana A; Boey DZH; Mohammad I; Sleiers N; Dahlin JS; Dahlin S; Willinger T
- Article: FRONTIERS IN IMMUNOLOGY. 2022;12:804812Ronnberg E; Boey DZH; Ravindran A; Safholm J; Orre A-C; Al-Ameri M; Adner M; Dahlen S-E; Dahlin JS; Nilsson G
- Article: ALLERGY. 2021;76(6):1731-1742Single-cell molecular profiling provides a high-resolution map of basophil and mast cell developmentHamey FK; Lau WWY; Kucinski I; Wang X; Diamanti E; Wilson NK; Gottgens B; Dahlin JS
- Article: FRONTIERS IN IMMUNOLOGY. 2020;11:321Salomonsson M; Dahlin JS; Ungerstedt J; Hallgren J
- Article: ALLERGY. 2020;75(1):211-214Grootens J; Ungerstedt JS; Wu C; Levedahl KH; Nilsson G; Dahlin JS
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2019;49(6):874-882Salomonsson M; Malinovschi A; Kalm-Stephens P; Dahlin JS; Janson C; Alving K; Hallgren J
- Article: EBIOMEDICINE. 2019;43:150-158Grootens J; Ungerstedt JS; Ekoff M; Ronnberg E; Klimkowska M; Amini R-M; Arock M; Soderlund S; Mattsson M; Nilsson G; Dahlin JS
- Article: GENOME BIOLOGY. 2019;20(1):59Wolf FA; Hamey FK; Plass M; Solana J; Dahlin JS; Gottgens B; Rajewsky N; Simon L; Theis FJ
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2193Ravindran A; Ronnberg E; Dahlin JS; Mazzurana L; Safholm J; Orre A-C; Al-Ameri M; Peachell P; Adner M; Dahlen S-E; Mjosberg J; Nilsson G
- Article: BLOOD. 2018;131(21):e1-e11A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant miceDahlin JS; Hamey FK; Pijuan-Sala B; Shepherd M; Lau WWY; Nestorowa S; Weinreb C; Wolock S; Hannah R; Diamanti E; Kent DG; Gottgens B; Wilson NK
- Article: BLOOD. 2017;130(16):1785-1794Dahlin JS; Ekoff M; Grootens J; Lof L; Amini R-M; Hagberg H; Ungerstedt JS; Olsson-Stromberg U; Nilsson G
- Article: SCIENTIFIC REPORTS. 2017;7(1):623Lof L; Arngarden L; Olsson-Stromberg U; Siart B; Jansson M; Dahlin JS; Thorn I; Christiansson L; Hermansson M; Larsson A; Ahlstrand E; Walinder G; Soderberg O; Rosenquist R; Landegren U; Kamali-Moghaddam M
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:310Zarnegar B; Mendez-Enriquez E; Westin A; Soderberg C; Dahlin JS; Gronvik K-O; Hallgren J
- Article: SCIENTIFIC REPORTS. 2016;6:28290Ding Z; Dahlin JS; Xu H; Heyman B
- Article: BLOOD. 2016;127(4):383-391Dahlin JS; Malinovschi A; Ohrvik H; Sandelin M; Janson C; Alving K; Hallgren J
- Article: STEM CELLS AND DEVELOPMENT. 2015;24(14):1703-1711Dahlin JS; Ding Z; Hallgren J
- Article: JOURNAL OF IMMUNOLOGY. 2014;193(10):4783-4789Cui Y; Dahlin JS; Feinstein R; Bankova LG; Xing W; Shin K; Gurish MF; Hallgren J
- Article: ALLERGY. 2013;68(10):1333-1337Dahlin JS; Heyman B; Hallgren J
- Article: JOURNAL OF IMMUNOLOGY. 2012;189(8):3869-3877Dahlin JS; Feinstein R; Cui Y; Heyman B; Hallgren J
- Article: SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE. 2012;39(1):11-15Dahlin J; Kanui TI; Wambugu SN; Abelson KSP
- Article: PLOS ONE. 2011;6(7):e21760Henningsson F; Ding Z; Dahlin JS; Linkevicius M; Carlsson F; Gronvik K-O; Hallgren J; Heyman B
- Article: PLOS ONE. 2011;6(5):e20261Dahlin JS; Ivarsson MA; Heyman B; Hallgren J
- Article: SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE. 2009;36(2):205-213Dahlin J; Lam J; Hau J; Astuti P; Siswanto H; Abelson KSP
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All other publications
- Letter: BLOOD ADVANCES. 2024;8(15):3941-3945Mo J; Wermeling F; Nilsson G; Dahlin JS
- Editorial comment: BLOOD. 2024;143(11):945-947Dahlin JS; Nilsson G
- Conference publication: EXPERIMENTAL HEMATOLOGY. 2023;124:s41Calderbank E; Bastos H; Mantica G; Sham K; Wu C; Dahlin J; Laurenti E
- Conference publication: EXPERIMENTAL HEMATOLOGY. 2023;124:S41Calderbank E; Bastos H; Mantica G; Sham K; Wu C; Dahlin J; Laurenti E
- Editorial comment: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY. 2022;32(6):489-491Salomonsson M; Cardenas EI; Dahlin JS; Kalm-Stephens P; Janson C; Malinovschi A; Alving K; Hallgren J
- Conference publication: BLOOD. 2022;140:3014Wu C; Boey D; Mo J; Papavasileiou S; Ungerstedt J; Xu M; Nilsson G; Dahlin JS
- Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;150(4):785-787Boey D; Nilsson G; Dahlin JS
- Review: ALLERGY. 2022;77(1):83-99Dahlin JS; Maurer M; Metcalfe DD; Pejler G; Sagi-Eisenberg R; Nilsson G
- Preprint: BIORXIV. 2021Wu C; Boey D; Bril O; Grootens J; Vijayabaskar MS; Sorini C; Ekoff M; Wilson N; Ungerstedt J; Nilsson G; Dahlin J
- Preprint: AUTHOREA PREPRINTS. 2021Rönnberg E; Hao DBZ; Ravindran A; Säfholm J; Orre A-C; Al-Ameri M; Adner M; Dahlén S-E; Dahlin J; Nilsson G
- Preprint: BIORXIV. 2021Rönnberg E; Boey DZH; Ravindran A; Säfholm J; Orre A-C; Al-Ameri M; Adner M; Dahlén S-E; Dahlin J; Nilsson G
- Editorial comment: SCIENCE IMMUNOLOGY. 2021;6(56):eabf7901Dahlin JS
- Preprint: AUTHOREA. 2020Dahlin J; Maurer M; Metclafe D; Pejler G; Sagi-Eisenberg R; Nilsson G
- Preprint: BIORXIV. 2019Hamey FK; Lau WWY; Kucinski I; Wang X; Diamanti E; Wilson NK; Göttgens B; Dahlin JS
- Conference publication: ALLERGY. 2019;74:87Hockerlind RE; Dahlin J; Tebroke J; Lieverse J; Ravindran A; Safholm J; Nilsson G
- Review: BLOOD ADVANCES. 2018;2(17):2273-2281Grootens J; Ungerstedt JS; Nilsson G; Dahlin JS
- Preprint: BIORXIV. 2018Grootens J; Ungerstedt JS; Ekoff M; Rönnberg E; Klimkowska M; Amini R-M; Arock M; Söderlund S; Mattsson M; Nilsson G; Dahlin JS
- Conference publication: EXPERIMENTAL HEMATOLOGY. 2018;64:s70Hamey F; Dahlin J; Wolf FA; Pijuan-Sala B; Shepherd M; Lau W; Nestorowa S; Weinreb C; Wolock S; Hannah R; Diamanti E; Theis F; Kent D; Göttgens B; Wilson N
- Conference publication: EXPERIMENTAL HEMATOLOGY. 2018;64:S70Hamey F; Dahlin J; Wolf FA; Pijuan-Sala B; Shepherd M; Lau W; Nestorowa S; Weinreb C; Wolock S; Hannah R; Diamanti E; Theis F; Kent D; Gottgens B; Wilson N
- Preprint: BIORXIV. 2017Wolf FA; Hamey F; Plass M; Solana J; Dahlin JS; Göttgens B; Rajewsky N; Simon L; Theis FJ
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):300Avinash R; Hockerlind ER; Dahlin J; Bergman P; Orre A-C; Adner M; Safholm J; Dahlen S-E; Peachell P; Mjosberg J; Nilsson G
- Letter: LEUKEMIA. 2016;30(9):1953-1956Dahlin JS; Ungerstedt JS; Grootens J; Sander B; Guelen T; Haegglund H; Nilsson G
- Published conference paper: MOLECULAR IMMUNOLOGY. 2015;63(1):9-17Dahlin JS; Hallgren J
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Grants
- Swedish Research Council1 January 2023 - 31 December 2026Significant efforts have been made to map the differentiation of hematopoietic stem and progenitor cells into the various myelo-erythroid cell types. However, the basophil and mast cell differentiation trajectories in human hematopoiesis have yet to be charted in detail. Here, we will leverage single-cell multi-omics approaches with mutation analyses and cell fate assays to resolve a comprehensive roadmap of basophil and mast cell differentiation in health and hematologic disease. This is complemented with high-precision validation experiments, including genetic perturbations of primary cells, to gain mechanistic insights into normal and deregulated hematopoiesis.The research described in this proposal focuses on 1) health, 2) the hematologic neoplasm systemic mastocytosis, driven by the accumulation of aberrant mast cells, and 3) chronic myeloid leukemia, in which basophilia is associated with poor prognosis. My team of experimental and computational researchers combined with well-established clinical collaborations constitute a strong foundation to decipher basophil and mast cell differentiation in these conditions. We hope that the described research contributes to discoveries of novel diagnostic markers and the identification of factors that drive disease development – laying the groundwork for new and improved treatment strategies.
- Swedish Cancer Society1 January 2023Mutations in a person's genome can cause a number of different diseases. When mutations arise in blood stem cells and immature blood cells, blood cell development becomes misregulated and diseases such as systemic mastocytosis, myeloproliferative neoplasia, and other types of blood cancer can then occur. Through a combination of the latest techniques, so-called 'single-cell multi-omics', it is now possible to create a clear and almost complete picture of how blood cell development is incorrect in individual patients. The purpose of my research is to create maps of blood cell development for patients with systemic mastocytosis and myeloproliferative neoplasias, above all chronic myeloid leukemia, as well as healthy ones. By generating blood cell maps at diagnosis and during the course of treatment, one can examine the prognosis, see if the treatment has the desired effect and how much of the disease remains. The results of the study facilitate the diagnosis and prognostication of blood cancer, as the blood cell maps of new patients can be compared with previous cases of established blood cancer cases and healthy ones. The hope is that when enough patients are studied, the blood cell maps of newly diagnosed patients can be analyzed to tailor an optimal treatment. Since you will easily see how blood cell development is misregulated upon diagnosis, we hope in the future to be able to find new drugs that restore blood cell development to a normal state.
- Swedish Cancer Society1 January 2020Mutations in genes can cause a variety of diseases. When mutations occur in blood stem cells and immature blood cells, blood cell development is misregulated and diseases such as systemic mastocytosis, myeloproliferative neoplasms, and other types of blood cancer can then occur. Diagnosis of patients today requires evaluation of a line samples with a variety of techniques. Through a new technology - so-called "single-cell RNA sequencing" - one can now analyze all genes expressed by tens of thousands of individual immature blood cells. This allows you to quickly get a clear picture of if and how the blood cell development is incorrect in a patient. The purpose of my research is to create maps of blood cell development for patients with systemic mastocytosis and myeloproliferative neoplasms and healthy. By generating blood cell maps at diagnosis and during treatment Once you can see if the treatment has the desired effect and how much of the disease is left. The results of the study facilitate the diagnosis of blood cancer, as new patients' blood cell maps can be compared with previous cases of diagnosed blood cancer cases and healthy. When enough patients are studied, we will come hopefully be able to analyze new patients' blood cell maps to tailor an optimal treatment. Since you will easily see how blood cell development is misregulated at diagnosis, so we hope in the future to be able to find new drugs that restore blood cell development to normal.
- Swedish Research Council1 January 2019 - 31 December 2022
- Deciphering the transcriptional landscape of mast cell differentiation in systemic mastocytosis and myeloproliferative neoplasmsSwedish Cancer Society1 January 2019Mutations in genes can cause a variety of diseases. When mutations occur in blood stem cells and immature blood cells, blood cell development is misregulated and diseases such as systemic mastocytosis, myeloproliferative neoplasms, and other types of blood cancer can then occur. Diagnosis of patients today requires evaluation of a line samples with a variety of techniques. Through a new technology - so-called "single-cell RNA sequencing" - one can now analyze all genes expressed by tens of thousands of individual immature blood cells. This allows you to quickly get a clear picture of if and how the blood cell development is incorrect in a patient. The purpose of my research is to create maps of blood cell development for patients with systemic mastocytosis and myeloproliferative neoplasms and healthy. By generating blood cell maps at diagnosis and during treatment Once you can see if the treatment has the desired effect and how much of the disease is left. The results of the study facilitate the diagnosis of blood cancer, as new patients' blood cell maps can be compared with previous cases of diagnosed blood cancer cases and healthy. When enough patients are studied, we will come hopefully be able to analyze new patients' blood cell maps to tailor an optimal treatment. Since you will easily see how blood cell development is misregulated at diagnosis, so we hope in the future to be able to find new drugs that restore blood cell development to normal.
- Swedish Research Council1 January 2016 - 31 December 2018
Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2023-
Degrees and Education
- Docent, Karolinska Institutet, 2024