Jesper Säfholm
About me
I am currently employed as a Research Specialist in the research environment of the Unit of Integrative Metabolomics. My group consists of supervising two master students, one postdoc and two affilliated scientists. My lab is currently located at Centre for Molecular Medicine (CMM).
I initiated my PhD-studies within
- the field of airway pharmacology and physiology in 2008 and graduated 2013. This was followed by post graduate work 2014-2018 on mechanisms in asthmatic airway inflammation and I subsequently acquired an assistant professorship for continuation of translational airway pharmacology studies of lipid mediators, airway hyperresponsiveness and inflammation using /in vivo, ex vivo/ and /in vitro/ methods in both animal and human tissue. I am currently a supervisor of three PhD-students in the lab and have successfully supervised Master students during
their graduation projects. - Between 1999 and 2012 I worked at Astra Zeneca within the departements Safety
- Assessment, Neuroscience and Molecular Toxicology as a research technician.
*Awards*
* In 2020 I was given the IMM Junior Faculty Strategic Award by The
Institute of Environmental Medicine, IMM, Karolinska Institutet.
* In 2017 I was awarded the Veritas Pharma Inc. Dom Spina Prize by the
British Pharmacological Society.
*Commissions of trust*
* 2018-2019 I was the organiser of a bi-monthly seminar series within
physiology and pharmacology at Karolinska Instiutet.
* 2014-2017 I was board member of Centre for Allergy Research PhD and
Postdoc Association at Karolinska Instiutet.
* 2009-2013 I was member of the Educational Board at the Institute of
Environmental Medicine at Karolinska Instiutet.
* High School Education (Chemistry), Europaskolan, Strängnäs, 1998-2001
* Master of Science in Biology (MSc), Uppsala Universitet, Uppsala,
2003-2007
* Doctor of Philosophy (PhD), Institute of Environmental Medicine and
Experimental Asthma and Allergy Research, Karolinska Institutet, Stockholm
2008-2013
Research
Asthma is a major public health concern affecting between 5 and 10% of the
population. The exacerbations of asthma occur on a background of chronic
inflammation where inflammatory cells, such as eosinophils and mast cells,
and their respective mediators, including lipid mediators, orchestrate
different patterns of inflammation and bronchoconstriction. The purpose of my
research programme is to define the role of different lipid mediators for
airway function in relation to the pathobiology of asthma.
Teaching
I teach the sections anatomy, physiology, pharmacology, toxicology and pathophysiology of the pulmonary system as well as animal models in pulmonary diseases at two International Master's
- Programme (Master's Programme in Toxicology and Master's Programme in Translational Physiology and Pharmacology) at Karolinska Institutet.
- I also lecture in allergy, airway diseases and inflammation.
I also teaching visiting researchers, internship students, master students, doctoral students and post-doctoral students in scientific methodology, design of quantitative research, methods for systematic literature review, clinical immunology and allergy, diagnosis and management of asthma and other respiratory diseases, and prevention strategies of allergy and asthma.
Articles
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024
- Article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 2024;78(2):313-319
- Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1393802
- Article: ONCOIMMUNOLOGY. 2023;12(1):2233402
- Journal article: AUTHOREA. 2023
- Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2023;168:106761
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1151754
- Article: SCIENTIFIC REPORTS. 2022;12(1):18924
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2022;934:175257
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(9):2677-2687
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2021;907:174282
- Article: CELL RESEARCH. 2021;31(5):554-568
- Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2021;1866(5):158886
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:804812
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:761317
- Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2020;149:106428
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(3):808-817.e2
- Article: CELLS. 2019;8(11):1372
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(4):984-992
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2019;49(3):285-291
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1361
- Article: ANALYTICAL CHEMISTRY. 2018;90(17):10239-10248
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2193
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;136(5):1232-9.e1
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2014;740:302-311
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;718(1-3):277-282
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2013;168(4):794-806
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;303(11):L956-L966
- Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2010;333(1):273-280
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All other publications
- Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2023;53(10):1062-1066
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:pa595
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:pa4404
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:pa1303
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:pa4405
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:oa4209
- Preprint: AUTHOREA. 2023
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023;207:a2809
- Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;78:179
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2022;60:2392
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2022;60:2519
- Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(7):2270-2273
- Preprint: AUTHOREA PREPRINTS. 2021
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:2043
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:2897
- Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2020;177(11):2581-2582
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2019;54:pa4092
- Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(16):3021
- Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(16):3037-3038
- Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74:87
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2018;52:pa1044
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018;197
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):300
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:pa5054
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:oa1983
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:67-68
- Other: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;70(11):1353-1355
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2015;46:oa4465
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2015;46:pa3603
- Thesis / dissertation: 2013
- Conference publication: 2012;:a6477
- Review: PULMONARY PHARMACOLOGY AND THERAPEUTICS. 2011;24(4):361-366
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:a6381
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2009;179:a6323
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Grants
- Swedish Heart-Lung Foundation1 January 2021 - 31 December 2023
Employments
- Research Specialist, Institute of Environmental Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Degree Of Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2013