James Tribble
- Department of Clinical Neuroscience
- Division of Eye and Vision
- Glaucoma – Pete Williams' research group
About me
I received a BSc (Hons) in Medical Pharmacology (2011) and PhD in Visual Neuroscience and Molecular Biology (2016) from Cardiff University, Wales. This was followed by postdoctoral training at Cardiff University focusing on early dendrite and synapse refinement during glaucoma using human patient and glaucoma animal model tissues. I joined the Pete Williams Lab in 2018 to further my postdoctoral training where I focused on the early mechanisms of neurodegeneration in glaucoma, particularly on mitochondrial and neuronal metabolism. In November 2021, I was promoted to Assistant Professor within the Williams Glaucoma Group, and lead an independent research program while continuing to work with the Williams Group.
Current lab memebers:
- Anne Rombaut (PhD student)
- Navid Golpour (PhD student)
Research
My research investigates the interaction of metabolism, neurodegeneration, and neuroinflammation in neurodegnerative disease with a particular focus on the retina and glaucoma.
Through my career I have developed a broad skillset covering fundamental and translational research. These include mechanistic and therapeutic work in retinal cell culture and animal models of glaucoma and retinal dehgneration using molecular biology, gene therapy, and -omics (transcriptomics, metabolomics) techniques. Further experience includes confirmation of findings in post-mortem and biopsy human tissue, and existing human genetic datasets. Utilizing these strengths, my research seeks to streamline the process of taking findings from animals to patients by prioritizing mechanisms and treatments that have supporting evidence from human data. To this purpose, my lab is pursuing multiple mechanisms of degeneration in glaucoma, particularly targeting the modulation of metabolism and neuroinflammation with metabolite supplementation (e.g. with vitamins that have good clinical safety profiles) or FDA approved drugs that can be re-purposed to glaucoma.
Teaching
- 2024. Lecturer, (PhD course: The Vascular Brain 3193). Dept. of Clinical Neuroscience, Karolinska Institutet.
- 2023, 2024. Practical demonstrator (BSc’s level: The eyes anatomy, physiology and pathologies course 1OP072). Dept. of Clinical Neuroscience, Karolinska Institutet.
- 2023, 2024. Lecturer (BSc’s level: The eyes anatomy, physiology and pathologies course 1OP072). Dept. of Clinical Neuroscience, Karolinska Institutet.
- 2023, 2024. Lecturer (Master’s level: Ocular Pharmacology and Diagnostics 3OP011). Dept. of Clinical Neuroscience, Karolinska Institutet.
- 2022, 2024. Teacher/Mentor (PhD course: Basic immunology course 3187). Dept. of Clinical Neuroscience, Karolinska Institutet.
Articles
- Article: REDOX BIOLOGY. 2025;85:103732Jonk SM; Nicol A; Chrysostomou V; Lardner E; Yu S-C; Stalhammar G; Crowston JG; Tribble JR; Swoboda P; Williams PA
- Article: MOLECULAR BRAIN. 2025;18(1):54Mouhammad ZA; Rombaut A; Bermudez MYG; Vohra R; Tribble JR; Williams PA; Kolko M
- Article: CELL REPORTS MEDICINE. 2025;6(5):102127Tribble JR; Wong VHY; Stuart KV; Chidlow G; Nicol A; Rombaut A; Rabiolo A; Hoang A; Lee PY; Rutigliani C; Enz TJ; Canovai A; Lardner E; Stalhammar G; Nguyen CTO; Garway-Heath DF; Casson RJ; Khawaja AP; Bui BV; Williams PA
- Article: MOLECULAR BRAIN. 2024;17(1):84Rombaut A; Brautaset R; Williams PA; Tribble JR
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):8143Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
- Article: NATURE COMMUNICATIONS. 2024;15(1):6256Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):79Rombaut A; Jovancevic D; Wong RC-B; Nicol A; Brautaset R; Finkelstein DI; Nguyen CTO; Tribble JR; Williams PA
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):37Otmani A; Johannesson G; Brautaset R; Tribble JR; Williams PA
- Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)Tribble JR; Rutigliani C; Canovai A; Williams PA
- Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(14):34Gustavsson ST; Enz TJ; Tribble JR; Nilsson M; Lindqvist A; Linden C; Hagstrom A; Rutigliani C; Lardner E; Stalhammar G; Williams PA; Johannesson G
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):146Canovai A; Tribble JR; Joe M; Westerlund DY; Amato R; Trounce IA; Dal Monte M; Williams PA
- Article: GENE THERAPY. 2023;30(6):503-519Nieuwenhuis B; Laperrousaz E; Tribble JR; Verhaagen J; Fawcett JW; Martin KR; Williams PA; Osborne A
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18Tribble JR; Hagstrom A; Jusseaume K; Lardner E; Wong RC-B; Stalhammar G; Williams PA
- Article: JOURNAL OF BIOPHOTONICS. 2022;15(12):e202200169Enz TJ; Maloca PM; Tschopp M; Menke MN; Tribble JR; Williams PA; Inglin N; Steitz U; Scholl HPN; Papazoglou A
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):118Rutigliani C; Tribble JR; Hagstrom A; Lardner E; Johannesson G; Stalhammar G; Williams PA
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:903436Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
- Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2022;11(2):1-13Enz TJ; Bittner M; Tribble JR; Williams PA; Thiel MA; Schmid MK; Bachmann LM; Bochmann F
- Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(17):3938Enz TJ; Tribble JR; Williams PA
- Article: REDOX BIOLOGY. 2021;43:101988Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Joe M; Lardner E; Venkataraman AP; Dominguez-Vicent A; Kokkali E; Rho S; Johnnesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
- Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):22Tribble JR; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; Andre H; Morgan JE; Williams PA
- Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):21Tribble JR; Otmani A; Kokkali E; Lardner E; Morgan JE; Williams PA
- Article: NATURE COMMUNICATIONS. 2020;11(1):5614Petrova V; Pearson CS; Ching J; Tribble JR; Solano AG; Yang Y; Love FM; Watt RJ; Osborne A; Reid E; Williams PA; Martin KR; Geller HM; Eva R; Fawcett JW
- Article: MOLECULAR BRAIN. 2020;13(1):81Tribble J; Harder JM; Williams P; John SWM
- Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
- Article: MOLECULAR BRAIN. 2018;11(1):69Tribble JR; Williams PA; Caterson B; Sengpiel F; Morgan JE
- Article: EYE. 2017;31(2):199-205Morgan JE; Tribble J; Fergusson J; White N; Erchova I
- Article: MOLECULAR NEURODEGENERATION. 2016;11:26Williams PA; Tribble JR; Pepper KW; Cross SD; Morgan BP; Morgan JE; John SWM; Howell GR
- Article: EXPERIMENTAL EYE RESEARCH. 2015;141:9-14Morgan JE; Tribble JR
- Article: VISUAL NEUROSCIENCE. 2014;31(6):373-380Tribble JR; Cross SD; Samsel PA; Sengpiel F; Morgan JE
- Article: JOURNAL OF NEUROSCIENCE METHODS. 2014;225:65-70Binley KE; Ng WS; Tribble JR; Song B; Morgan JE
- Show more
All other publications
- Review: BRAIN RESEARCH BULLETIN. 2025;229:111437Jonk SM; Tribble JR; Swoboda P; Williams PA
- Review: BMJ OPEN OPHTHALMOLOGY. 2025;10(1):e002103Golpour N; Brautaset RL; Hui F; Nilsson M; Svensson JE; Williams PA; Tribble JR
- Review: FRONTIERS IN OPHTHALMOLOGY. 2023;3:1290465Rombaut A; Brautaset R; Williams PA; Tribble JR
- Review: MOLECULAR NEURODEGENERATION. 2023;18(1):64Soucy JR; Aguzzi EA; Cho J; Gilhooley MJ; Keuthan C; Luo Z; Monavarfeshani A; Saleem MA; Wang X-W; Wohlschlegel J; Baranov P; Di Polo A; Fortune B; Gokoffski KK; Goldberg JL; Guido W; Kolodkin AL; Mason CA; Ou Y; Reh TA; Ross AG; Samuels BC; Welsbie D; Zack DJ; Johnson TV
- Review: MOLECULAR ASPECTS OF MEDICINE. 2023;92:101193Tribble JR; Hui F; Quintero H; El Hajji S; Bell K; Di Polo A; Williams PA
- Review: CELLS. 2021;10(2):295Tribble JR; Hui F; Joe M; Bell K; Chrysostomou V; Crowston JG; Williams PA
Employments
- Assistant Senior Lecturer, Department of Clinical Neuroscience, Karolinska Institutet, 2025-
- Assistant Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2021-2025