Jaan-Olle Andressoo
 Principal Researcher
E-mail: jaan-olle.andressoo@ki.se
Visiting address: Neo, Blickagången 16, 14151 Huddinge
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Andressoo, 171 77 Stockholm
 Part of:
- Department of Neurobiology, Care Sciences and Society
- Jaan-Olle Andressoo's research group
About me
- CURRENT POSITIONS
 • Assistant Professor, Department of Neurobiology, Care Sciences and
 Society, Karolinska Institutet, Sweden
 • Associate Professor, Translational Neuroscience, Faculty of Medicine,
 University of Helsinki, Finland
 PUBLICATIONS
 https://www.ncbi.nlm.nih.gov/pubmed/?term=andressoo [1]
 • 2017-2022 Nominee of European Research Council (ERC) Consolidator Grant
 • 2017-2022 Nominee of Center of Innovative Medicine Young Investigator
 Grant at Karolinska Institutet, Stockholm
 • 2010-2015 Academy of Finland Research Fellow – the most prestigious
 start-up package for early and mid-stage scientists in Finland
 • 2005-2008 Academy of Finland post-doctoral Fellow – the most
 prestigious post-doctoral grant in Finland
 • 2009 Docent (Adj. Prof.) of Genetics, University of Helsinki (UH),
 Finland
 • 2004 PhD, Erasmus Medical Center, Department of Cell Biology and
 Genetics, Erasmus University, Rotterdam, The Netherlands, Prof Jan H.J.
 Hoeijmakers
 • 1991-1998 Undergraduate studies of Biology, University of Tartu, Estonia
 PREVIOUS POSITIONS
 • Sabbatical year 03.2017 – 12.2017 - Visiting Associate Professor in
 Neurobiology at the Department of Psychiatry, Columbia University, New
 York, USA. Host: Prof David Sulzer
 • 09.2016-08.2017 - Associate Professor, Cell and Tissue Engineering,
 University of Tampere, Finland
 • 2010 – 2017 Principal Investigator, Institute of Biotechnology,
 University of Helsinki, Finland
 • 2010-2015 Academy of Finland Research Fellow (PI) at the Institute of
 Biotechnology (BI), University of Helsinki (UH), Finland
 • 2008-2010 Senior Postdoctoral Associate (Mart Saarma’s group) at the
 BI, UH, Finland
 • 2005-2008 Academy of Finland Post-doctoral Research Fellow (Mart
 Saarma’s group), at the BI, UH, Finland
 • 2004-2005 Post-doctoral researcher at Prof Jan Hoeijmakers laboratory,
 Erasmus Medical Center, Department of Cell Biology and Genetics, Erasmus
 University, Rotterdam, The Netherlands
 • 1999-2004 PhD studies at Prof Jan Hoeijmakers laboratory, Erasmus
 Medical Center, Department of Cell Biology and Genetics, Erasmus University,
 Rotterdam, The Netherlands
 • 1993-1999 Junior scientist in Prof Toivo Maimets laboratory at the
 Institute of Molecular and Cellular Biology, University of Tartu, Estonia
 [1] https://www.ncbi.nlm.nih.gov/pubmed/?term=andressoo
Research
- Our laboratory’s goal is to develop novel therapeutic approaches by 
 fine-tuning the expression of a gene selectively in cells in which the gene
 is normally expressed. We have generated the first proof-of-concept data
 showing that such an approach is technically feasible, can provide new
 information on gene function and may allow development of new treatment
 modes.
 Specifically, we manipulate the 3’UTR of target genes which allows us to
 control endogenous gene expression in cells that naturally express the gene
 of interest.
 At Karolinska Institutet our laboratory’s primary goal is to develop
 treatment for currently incurable neurodegenerative diseases such as
 Alzheimer’s disease. Recently, our laboratory received funding from Center
 of Innovative Medicine (CIMED) with the focus on generating better mouse
 models and treatment modes for Alzheimer’s disease. More specifically, we
 aim to study how increase in endogenous beta-amyloid impacts Alzheimer’s
 disease etiology and investigate how upregulation of endogenous genes which
 control proteostasis, mitochondrial and neurotrophic functions impact AD
 etiology in mice. My laboratory at the University of Helsinki Faculty of
 Medicine, recently supported with ERC CoG and several other grants, focuses
 on similar objectives for Parkinson’s disease.
 Our laboratory uses genetic engineering in mouse models accompanied with
 analysis at the molecular, cellular, tissue, behavioral and recently -
 electrophysiological level. For enhancing power of our genetic experiments we
 are, as a new opening, currently implementing alternative model organisms
 such as zebrafish.
 As a serendipitous spin-off from our genetic experiments with neurotrophic
 factor GDNF signaling system we have also generated a new mouse model for
 long-segment Hirschsprung’s disease, which allows characterization and
 treatment discovery in postnatal mice. We have also generated a new mouse
 mouse model for Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)
 which we currently analyze in collaboration with Dr Satu Kuure’s group at
 the University of Helsinki.
Teaching
- 98h of lecturing experience since 2007 at the University of Helsinki, 
 Finland and at Tallinn University of Technology, Estonia.
Articles
- Journal article: NEUROSCIENCE. 2025;576:27-41Nagaeva E; Turconi G; Matlik K; Segerstrale M; Olfat S; Iivanainen V; Taira T; Andressoo J-O
- Journal article: NATURE COMMUNICATIONS. 2025;16(1):3219Choopanian P; Andressoo J-O; Mirzaie M
- Journal article: NATURE COMMUNICATIONS. 2025;16(1):2231Choopanian P; Andressoo J-O; Mirzaie M
- Article: ISCIENCE. 2024;27(12):111246Lemmetyinen TT; Viitala EW; Wartiovaara L; Paivinen P; Virtanen HT; Pentinmikko N; Katajisto P; Makela TP; Wang TC; Andressoo J-O; Ollila S
- Article: HELIYON. 2024;10(14):e34355Turconi G; Alam F; Sengupta T; Pirnes-Karhu S; Olfat S; Schmidt MS; Matlik K; Montano-Rodriguez A; Heiskanen V; Garton D; Piepponen PT; Brenner C; Holmberg CI; Nilsen H; Pirinen E; Andressoo J-O
- Article: CELLS. 2024;13(12):1059Montano-Rodriguez AR; Schorling T; Andressoo J-O
- Article: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2024;18(6):101405Virtanen HT; Choopanian P; Porokuokka LL; Forsgard R; Garton DR; Olfat S; Korpela R; Mirzaie M; Andressoo J-O
- Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S13)Olfat S; Andressoo J
- Article: BIOMOLECULES. 2023;13(9):1428Casserly L; Garton DR; Montano-Rodriguez A; Andressoo J-O
- Journal article: PARKINSONISM & RELATED DISORDERS. 2023;113:47Turconi G; Alam F; SenGupta T; Pirnes-Karhu S; Olfat S; Schmidt M; Matlik K; Montano-Rodriguez A; Heiskanen V; Piepponen P; Brenner C; Holmberg C; Nilsen H; Andressoo J-O; Pirinen E
- Article: BIOMOLECULES. 2023;13(5):761Garton DR; Turconi G; Iivanainen V; Andressoo J-O
- Article: HELIYON. 2023;9(3):e13844Matlik K; Olfat S; Cowlishaw MC; Moreno ED; Ollila S; Andressoo J-O
- Article: ENEURO. 2023;10(2):ENEURO.0097-ENEU22.2023Olfat S; Matlik K; Kopra JJ; Garton DR; Iivanainen VH; Bhattacharya D; Jakobsson J; Piepponen TP; Andressoo J-O
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(2):102897Lekk I; Cabrera-Cabrera F; Turconi G; Tuvikene J; Esvald E-E; Rahni A; Casserly L; Garton DR; Andressoo J-O; Timmusk T; Koppel I
- Article: MOLECULAR PSYCHIATRY. 2022;27(8):3247-3261Matlik K; Garton DR; Montano-Rodriguez AR; Olfat S; Eren F; Casserly L; Damdimopoulos A; Panhelainen A; Porokuokka LL; Kopra JJ; Turconi G; Schweizer N; Bereczki E; Piehl F; Engberg G; Cervenka S; Piepponen TP; Zhang F-P; Sipila P; Jakobsson J; Sellgren CM; Erhardt S; Andressoo J-O
- Journal article: ALCOHOL AND ALCOHOLISM. 2022;57(4):405-412Koskela M; Piepponen TP; Andressoo J-O; Voikar V; Airavaara M
- Article: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2022;14(1):27-34Virtanen H; Garton DR; Andressoo J-O
- Article: JOURNAL OF BIOMEDICAL SCIENCE. 2021;28(1):87Koskela M; Piepponen TP; Lindahl M; Harvey BK; Andressoo J-O; Voikar V; Airavaara M
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:714186Mitra S; Turconi G; Darreh-Shori T; Matlik K; Aquilino M; Eriksdotter M; Andressoo J-O
- Article: DEVELOPMENT. 2021;148(10):dev197475Li H; Kurtzeborn K; Kupari J; Gui Y; Siefker E; Lu B; Matlik K; Olfat S; Montano-Rodriguez AR; Huh S-H; Costantini F; Andressoo J-O; Kuure S
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2021;53(8):2469-2482Marshall P; Garton DR; Taira T; Voikar V; Vilenius C; Kulesskaya N; Rivera C; Andressoo J-O
- Article: SCIENTIFIC REPORTS. 2020;10(1):21023Terzioglu M; Saralahti A; Piippo H; Ramet M; Andressoo J-O
- Article: MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT. 2020;17:831-842Turconi G; Kopra J; Voikar V; Kulesskaya N; Vilenius C; Piepponen TP; Andressoo J-O
- Article: NEUROBIOLOGY OF DISEASE. 2020;134:104696Lindahl M; Chalazonitis A; Palm E; Pakarinen E; Danilova T; Pham TD; Setlik W; Rao M; Voikar V; Huotari J; Kopra J; Andressoo J-O; Piepponen PT; Airavaara M; Panhelainen A; Gershon MD; Saarma M
- Article: SCIENTIFIC REPORTS. 2019;9(1):14318Galli E; Rossi J; Neumann T; Andressoo J-O; Drinda S; Lindholm P
- Article: SCIENTIFIC REPORTS. 2019;9(1):5302Li H; Jakobson M; Ola R; Gui Y; Kumar A; Sipila P; Sariola H; Kuure S; Andressoo J-O
- Article: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2019;7(3):655-678Porokuokka LL; Virtanen HT; Linden J; Sidorova Y; Danilova T; Lindahl M; Saarma M; Andressoo J-O
- Article: BEHAVIOURAL BRAIN RESEARCH. 2018;352:116-124Koskela M; Piepponen TP; Andressoo J-O; Voikar V; Airavaara M
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2018;48(6):2354-2361Penttinen A-M; Parkkinen I; Blom S; Kopra J; Andressoo J-O; Pitkanen K; Voutilainen MH; Saarma M; Airavaara M
- Article: SCIENTIFIC REPORTS. 2018;8(1):11861Matlik K; Voikar V; Vilenius C; Kulesskaya N; Andressoo J-O
- Article: NEUROPHARMACOLOGY. 2018;128:221-230Kopra J; Villarta-Aguilera M; Savolainen M; Weingerl S; Myohanen TT; Rannanpaa S; Salvatore ME; Andressoo J-O; Piepponen TP
- Article: JOURNAL OF NEUROSCIENCE. 2017;37(6):1581-1590Kopra JJ; Panhelainen A; af Bjerken S; Porokuokka LL; Varendi K; Olfat S; Montonen H; Piepponen TP; Saarma M; Andressoo J-O
- Article: PLOS GENETICS. 2015;11(12):e1005710Kumar A; Kopra J; Varendi K; Porokuokka LL; Panhelainen A; Kuure S; Marshall P; Karalija N; Harma M-A; Vilenius C; Lillevaeli K; Tekko T; Mijatovic J; Pulkkinen N; Jakobson M; Jakobson M; Ola R; Palm E; Lindahl M; Stromberg I; Voikar V; Piepponen TP; Saarma M; Andressoo J-O
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2014;71(22):4443-4456Varendi K; Kumar A; Harma M-A; Andressoo J-O
- Article: SPRINGERPLUS. 2014;3:502Kumar A; Varendi K; Peranen J; Andressoo J-O
- Article: CELL REPORTS. 2014;7(2):366-375Lindahl M; Danilova T; Palm E; Lindholm P; Voikar V; Hakonen E; Ustinov J; Andressoo J-O; Harvey BK; Otonkoski T; Rossi J; Saarma M
- Article: PLOS ONE. 2014;9(4):e93911Varendi K; Airavaara M; Anttila J; Vose S; Planken A; Saarma M; Mitchell JR; Andressoo J-O
- Article: DNA REPAIR. 2012;11(11):874-883van de Ven M; Andressoo J-O; van der Horst GTJ; Hoeijmakers JHJ; Mitchell JR
- Article: EJNMMI RESEARCH. 2012;2(1):55Pitkonen M; Hippelainen E; Raki M; Andressoo J-O; Urtti A; Mannisto PT; Savolainen S; Saarma M; Bergstrom K
- Journal article: PARKINSONISM & RELATED DISORDERS. 2012;18:s208Kopra J; Andressoo J-O; Mijatovic J; Amberg C; Piepponen P; Saarma M
- Article: NEUROSCIENCE. 2011;192:550-563Piltonen M; Planken A; Leskela O; Myohanen TT; Hanninen A-L; Auvinen P; Alitalo K; Andressoo J-O; Saarma M; Mannisto PT
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2009;29(5):1276-1290Andressoo J-O; Weeda G; de Wit J; Mitchell JR; Beems RB; van Steeg H; van der Horst GTJ; Hoeijmakers JH
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;39(3):356-371Lindholm P; Peranen J; Andressoo J-O; Kalkkinen N; Kokaia Z; Lindvall O; Timmusk T; Saarma M
- Journal article: PLOS GENETICS. 2008;4(10):10.1371/annotation/315026van de Ven M; Andressoo J-O; Holcomb VB; von Lindern M; Jong WMC; Zeeuw CID; Suh Y; Hasty P; Hoeijmakers JHJ; van der Horst GTJ; Mitchell JR
- Article: NATURE. 2007;448(7149):73-77Lindholm P; Voutilainen MH; Lauren J; Peranen J; Leppanen V-M; Andressoo J-O; Lindahl M; Janhunen S; Kalkkinen N; Timmusk T; Tuominen RK; Saarma M
- Article: PLOS GENETICS. 2006;2(12):e192van de Ven M; Andressoo J-O; Holcomb VB; von Lindern M; Jong WMC; De Zeeuw CI; Suh Y; Hasty P; Hoeijmakers JHJ; van der Horst GTJ; Mitchell JR
- Journal article: PLOS GENETICS. 2006;2(12):2013-2025de Ven MV; Andressoo J-O; Holcomb VB; von Lindern M; Jong WMC; De Zeeuw CI; Suh Y; Hasty P; Hoeijmakers JHJ; van der Horst GTJ; Mitchell JR
- Article: PLOS BIOLOGY. 2006;4(10):1821-1830Andressoo J-O; Jans J; de Wit J; Coin F; Hoogstraten D; van de Ven M; Toussaint W; Huijmans J; Thio HB; van Leeuwen WJ; de Boer J; Egly J-M; Hoeijmakers JHJ; van der Horst GTJ; Mitchell JR
- Article: CANCER CELL. 2006;10(2):121-132Andressoo J-O; Mitchell JR; de Wit J; Hoogstraten D; Volker M; Toussaint W; Speksnijder E; Beems RB; van Steeg H; Jans J; de Zeeuw CI; Jaspers NGJ; Raams A; Lehmann AR; Vermeulen W; Hoeijmakers JHJ; van der Horst GTJ
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(18):8368-8378Theron T; Fousteri MI; Volker M; Harries LW; Botta E; Stefanini M; Fujimoto M; Andressoo JO; Mitchell J; Jaspers NGJ; McDaniel LD; Mullenders LH; Lehmann AR
- Journal article: PLOS GENETICS. 2005;preprint(2006):e192van de Ven M; Andressoo J-O; Holcomb VB; von Lindern M; Jong W; De Zeeuw CI; Suh Y; Hasty P; Hoeijmakers JHJ; van der Horst GTJ; Mitchell JR
- Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2005;570:45-81Andressoo JO; Hoeijmakers JHJ; de Waard H
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(18):7941-7948de Waard H; de Wit J; Andressoo JO; van Oostrom CTM; Riis B; Weimann A; Poulsen HE; van Steeg H; Hoeijmakers JHJ; van der Horst GTJ
- Article: DNA REPAIR. 2003;2(1):13-25de Waard H; de Wit J; Gorgels TGMF; van den Aardweg G; Andressoo JO; Vermeij M; van Steeg H; Hoeijmakers JHJ; van der Horst GTJ
- Article: SCIENCE. 2002;296(5571):1276-1279de Boer J; Andressoo JO; de Wit J; Huijmans J; Beems RB; van Steeg H; Weeda G; van der Horst GTJ; van Leeuwen W; Themmen APN; Meradji M; Hoeijmakers JHJ
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All other publications
- Preprint: BIORXIV. 2025Choopanian P; Andressoo J-O; Mirzaie M
- Preprint: BIORXIV. 2024Garton DR; Runneberger I; Casserly L; Schorling T; Montaño-Rodríguez AR; Iivananen V; Kopra JJ; Mätlik K; Fagerström-Billai F; Damdimopoulos A; Piepponen TP; Andressoo J-O
- Preprint: BIORXIV. 2024Nagaeva E; Turconi G; Mätlik K; Segerstråle M; Olfat S; Iivanainen V; Taira T; Andressoo J-O
- Preprint: PREPRINTS.ORG. 2024Montaño-Rodriguez AR; Schorling T; Andressoo J-O
- Letter: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2022;14(4):968-969Virtanen H; Garton D; Andressoo J-O
- Preprint: BIORXIV. 2021Turconi G; Alam F; SenGupta T; Pirnes-Karhu S; Olfat S; Schmidt MS; Mätlik K; Montaño-Rodriguez A; Heiskanen V; Piepponen PT; Brenner C; Holmberg CI; Nilsen H; Andressoo J-O; Pirinen E
- Preprint: BIORXIV. 2020Li H; Kupari J; Gui Y; Siefker E; Lu B; Mätlik K; Olfat S; Montaño-Rodríguez AR; Huh S-H; Costantini F; Andressoo J-O; Kuure S
- Preprint: BIORXIV. 2019Mätlik K; Olfat S; Garton DR; Montaño-Rodriguez A; Turconi G; Porokuokka LL; Panhelainen A; Schweizer N; Kopra J; Cowlishaw MC; Piepponen TP; Zhang F-P; Sipilä P; Jakobsson J; Andressoo J-O
- Conference publication: MOVEMENT DISORDERS. 2018;33:S180Turconi G; Olfat S; Matlik K; Andressoo J
- Meeting abstract: RADIOTHERAPY AND ONCOLOGY. 2018;127:S304Peng X; Varendi K; Maimets M; Andressoo JO; Coppes RP
- Published conference paper: RADIOTHERAPY AND ONCOLOGY. 2017;124(3):448-454Peng X; Varendi K; Maimets M; Andressoo J-O; Coppes RP
- Review: NEUROBIOLOGY OF DISEASE. 2017;97(Pt B):80-89Ibanez CF; Andressoo J-O
- Corrigendum: PLOS GENETICS. 2016;12(1):e1005808Kumar A; Kopra J; Varendi K; Porokuokka LL; Panhelainen A; Kuure S; Marshall P; Karalija N; Härma M-A; Vilenius C; Lilleväli K; Tekko T; Mijatovic J; Pulkkinen N; Jakobson M; Jakobson M; Ola R; Palm E; Lindahl M; Strömberg I; Võikar V; Piepponen TP; Saarma M; Andressoo J-O
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2015;72(9):1779-1794Varendi K; Matlik K; Andressoo J-O
- Letter: NATURE NEUROSCIENCE. 2015;18(3):319-322Kopra J; Vilenius C; Grealish S; Harma M-A; Varendi K; Lindholm J; Castren E; Voikar V; Bjorklund A; Piepponen TP; Saarma M; Andressoo J-O
- Published conference paper: JOURNAL OF NEUROSCIENCE METHODS. 2010;194(1):122-131Planken A; Porokuokka LL; Hanninen A-L; Tuominen RK; Andressoo J-O
- Conference publication: CELL TRANSPLANTATION. 2010;19(3):359-360Saarma M; Lindholm P; Andressoo J-O; Perlinen J; Lindahl M
- Review: CURRENT OPINION IN NEUROBIOLOGY. 2008;18(3):297-306Andressoo J-O; Saarma M
- Published conference paper: MECHANISMS OF AGEING AND DEVELOPMENT. 2007;128(1):58-63van de Ven M; Andressoo J-O; Holcomb VB; Hasty P; Suh Y; van Steeg H; Garinis GA; Hoeijmakers JHJ; Mitchell JR
- Review: CELL CYCLE. 2006;5(24):2886-2888Andressoo J-O; Hoeijmakers JHJ; Mitchell JR
- Meeting abstract: TOXICOLOGY. 2006;226(1):19-20Hoeijmakers JHJ; Garinis G; van der Pluijm I; Mitchell J; Andressoo J-O; Diderich K; Lalai A; de Waard H; Beems D; van Steeg H; Niedernhofer L; van der Horst B
- Review: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2005;577(1-2):179-194Andressoo JO; Hoeijmakers JHJ
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