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About me

Associate professor (Docent), Formal group leader together with Prof. Jan-Åke Gustafsson

Education

Associate professor, Docent, 2018 (Molecular Endocrinology, Track: Research, Karolinska Institutet)

Formal Group leader, 2018 (informal since 2014)

Senior researcher 2013 - (Estrogen signalling, Dept. Bioscinences and Nutrition, Karolinska Instiutet)

Assistant Professor 2013 - 2017 (Estrogen signalling, Dept. Bioscinences and Nutrition, Karolinska Instiutet) 

Post doc 2010-2013 (Breast cancer research, Friedrich Miescher Instsitute, Basel, Switzerland)

Post doc 2006-2010 (Estrogen signalling, Dept. Bisocinences and Nutrition, Karolinska Instiutet)

PhD in Medical Sciences 2002-2006 (Dept. Bioscinences and Nutrition, Karolinska Instiutet)

MSc, Biomolecular Chemistry, Södertörn University / Karolinska Institutet, 2001

Research description

My research focuses on the female sex hormone estrogen and its signalling in the brain, during development and in adulthood, as well as its implications for neurological disorders. A main topic is estrogen's neruoprotecive role in Alzheimers disease. I also study the impact of estrogen receptors in breast- and prostate cancers.

Teaching portfolio

2019- : Course leader: Biomedicine Master program thesis work and examination, Karolinska Institutet

21018- : Target Organ Toxicology, Nuclear receptor signalling & EDCs, Karolinska Institutet

2016- : Tutor in “Sex hormones and ESC differentiation”, Post-graduate course in Human Embryonic Stem Cells, 2212, Karolinska Institutet

2015-: Co-organizer and Responsible for the course Functional Genomics, Biomedicine Bachelor programme, Karolinska Institute, Stockholm, Sweden

2014-2017: Applied Science Communication (ACB2), Biomedicine Master programme, Karolinska Institute, Stockholm, Sweden

2013- : Applied Science Communication (ACB4), Biomedicine Master programme, Karolinska Institute, Stockholm, Sweden

2014- : Tutor in “Proteomic techniques and applications”, Biomedicine Bachelor programme, Karolinska Institute, Stockholm, Sweden

03/2012: Tutor in WiMo 2012 Wissenschaftsmonat für Medizinstudierende, theory, University of Basel, basel, Switzerland

09-10/2011: Tutor in Introduction to Biology, theory. University of Basel, Basel, Switzerland

2008-2009: Tutor in “Proteomic techniques and applications”, Molecular Nutrition undergraduate programme, Stockholm University, Stockholm, Sweden

2008-2009: Responsible for the Theoretical and practical teaching in proteomics for researchers. Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden

2007-2009: Molecular biology. Theory and practice. Co-responsible for the course. Biomedicine undergraduate programme, Karolinska Institute, Stockholm, Sweden

2002-2006: Teaching assistance at undergraduate courses in Molecular immunology, Molecular Biology, Cell Biology, and General Chemistry at Södertörns högskola and Karolinska Institute, Stockholm, Sweden.

Publications

Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro
Lupu D, Varshney Mk, Mucs D, Inzunza J, Norinder U, Loghin F, et al
Molecular pharmacology 2018;94(4):1220-1231

Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders
Varshney M, Nalvarte I
Brain sciences 2017;7(3):-

Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells
Varshney Mk, Inzunza J, Lupu D, Ganapathy V, Antonson P, Rüegg J, et al
Proceedings of the National Academy of Sciences of the United States of America 2017;114(48):E10428-E10437

Estrogen receptor β controls MMP-19 expression in mouse ovaries during ovulation
Nalvarte I, Töhönen V, Lindeberg M, Varshney M, Gustafsson JÅ, Inzunza J
Reproduction (Cambridge, England) 2016;151(3):253-9

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization
Frei A, Macdonald G, Lund I, Gustafsson JÅ, Hynes Ne, Nalvarte I
Oncotarget 2016;7(35):56170-56182

Developmental exposure to bisphenol A alters expression and DNA methylation of Fkbp5, an important regulator of the stress response
Kitraki E, Nalvarte I, Alavian-ghavanini A, Rüegg J
Molecular and cellular endocrinology 2015;417():191-9

Identification of proteins highly expressed in uterine fluid from mice with hydrometra
Antonson P, Nalvarte I, Varshney M, Xu L, Windahl Sh, Humire P, et al
Biochemical and biophysical research communications 2015;466(4):650-5

The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion
Nalvarte I, Damdimopoulos Ae, Rüegg J, Spyrou G
Bioscience reports 2015;35(6):-

Memo is a copper-dependent redox protein with an essential role in migration and metastasis
Macdonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, et al
Science signaling 2014;7(329):ra56-

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis (vol 7, er4, 2014)
Macdonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Doelemeyer A, et al
SCIENCE SIGNALING 2014;7(333)

Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells
Gattelli A, Nalvarte I, Boulay A, Roloff Tc, Schreiber M, Carragher N, et al
EMBO molecular medicine 2013;5(9):1335-50

Inhibition of the Ret receptor tyrosine kinase in combination with endocrine therapy impacts on migration and metastatic potential of estrogen receptor positive breast cancer models.
Hynes Ne, Gattelli A, Nalvarte I, Roloff T
CANCER RESEARCH 2012;

The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation
Tammimies K, Tapia-páez I, Rüegg J, Rosin G, Kere J, Gustafsson JÅ, et al
Molecular endocrinology (Baltimore, Md.) 2012;26(4):619-29

Proteomics analysis of the estrogen receptor alpha receptosome
Nalvarte I, Schwend T, Gustafsson Ja
Molecular & cellular proteomics : MCP 2010;9(7):1411-22

Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain
Sugiyama N, Andersson S, Lathe R, Fan X, Alonso-magdalena P, Schwend T, et al
MOLECULAR PSYCHIATRY 2009;14(2):223-32

Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells
Sroka J, Antosik A, Czyz J, Nalvarte I, Ollsson Jm, Spyrou G, et al
BIOLOGY OF THE CELL 2007;99(12):677-87

The selenoprotein thioredoxin reductase is involved in expression of several genes associated with differentiation, adhesion and migration
Nalvarte I, Spyrou G
TOXICOLOGY LETTERS 2006;:S299-S299

The role of thioredoxin reductase activity in selenium-induced cytotoxicity
Madeja Z, Sroka J, Nystrom C, Bjorkhem-bergman L, Nordman T, Damdimopoulos A, et al
BIOCHEMICAL PHARMACOLOGY 2005;69(12):1765-72

Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition
Nalvarte I, Damdimopoulos Ae, Spyrou G
FREE RADICAL BIOLOGY AND MEDICINE 2004;36(10):1270-8

Novel functions of the mammalian thioredoxin systems
Nalvarte I, Damdimopoulos A, Cunnea P, Psarra Am, Bjornstedt M, Olsson Jm, et al
FREE RADICAL BIOLOGY AND MEDICINE 2004;:S14-S14

Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells - Effect on cell growth and differentiation
Nalvarte I, Damdimopoulos Ae, Nystom C, Nordman T, Miranda-vizuete A, Olsson Jm, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(52):54510-7

The human selenoprotein mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition
Nalvarte I, Damdimopoulos Ae, Spyrou G
FREE RADICAL BIOLOGY AND MEDICINE 2004;:S73-S73

Novel functions of the mammalian thioredoxin systems
Nalvarte I, Damdimopoulos A, Cunnea P, Psarra Am, Bjornstedt M, Olsson Jm, et al
FREE RADICAL RESEARCH 2003;:44-44

Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
Nordman T, Xia L, Bjorkhem-bergman L, Damdimopoulos A, Nalvarte I, Arner Esj, et al
BIOFACTORS 2003;18(1-4):45-50

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone - A novel mechanism for defense against oxidative stress
Xia L, Nordman T, Olsson Jm, Damdimopoulos A, Bjorkhem-bergman L, Nalvarte I, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(4):2141-6

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Hälsovägen 7
Huddinge