Isabelle Magalhaes

Isabelle Magalhaes

Affiliated to Research | Docent
Visiting address: NEO Medicinaren 25, HERM plan 7, Hälsovägen 7C (lastkaj), 14157 Huddinge
Postal address: H7 Medicin, Huddinge, H7 Hematologi Uhlin, 171 77 Stockholm
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About me

  • Associate professor (Docent) in Immunology, Karolinska Institutet.
    Since March 2024, Team leader, Karolinska Institutet, Dept. of Medicine Huddinge, Center for Hematology and Regenerative Medicine (HERM).

    February 2023-February 2024, Team leader, Karolinska Institutet, Dept. of Clinical Science, Intervention and Technology.
    April 2019 - January 2023, Senior researcher, deputy group leader, Karolinska 

  • Institutet, Dept. of Oncology Pathology.

    April 2015 - March 2019, Assistant professor, Karolinska Institutet, Dept. of  

  • Oncology Pathology.
    September 2013 - March 2015, Postdoctoral fellow, U1016 INSERM, Institut  
  • Cochin, Dept. of Endocrinology, Metabolism and Diabetes (Paris, France).
    September 2010 - August 2013, Researcher, Karolinska University Hospital 
  • Huddinge &
  • Karolinska Institutet, Dept. of Laboratory Medicine.

    June 2009 - August 2010, Postdoctoral fellow, Karolinska Institutet, Dept. of Microbiology, Tumor and Cell Biology.
    2005-2009, PhD in Immunobiology, Karolinska Institutet, Dept. of 

  • Microbiology, Tumor and Cellular Biology.

    Thesis title: “/CD8alpha/alpha+ T-cells and Immune Memory/”.

    https://openarchive.ki.se/xmlui/bitstream/handle/10616/39450/thesis.pdf?sequence=1&

  • isAllowed=y
    2002, Master in Immunology (Diplôme d’études approfondies), Paris VII 
  • University &
  • Institut Pasteur (Paris, France).
    2000, Bachelor in Cellular Biology and Physiology, Rennes II University (Rennes, France).

Research

  • My goal is to contribute to the improvement of chimeric antigen receptor 

  • (CAR) T cell therapy for the treatment of cancer. Our group is working on the  
  • development of mesothelin (MSLN) CAR T cell therapy for the treatment of 
  • ovarian cancer. A preclinical model of orthotopic ovarian cancer in mice has 
  • been established in our group, which allows to test /in vivo/ the antitumor 
  • efficacy of MSLN CAR T cells.


    Recent publications:
    Schoutrop E, Poiret T, El-Serafi I, Zhao Y, He R, Moter A, Henriksson J,  

  • Hassan M, Magalhaes I*, Mattsson J*. Tuned activation of MSLN-CAR T cells
    induces superior antitumor responses in ovarian cancer models. [1]J 
  • Immunother Cancer. 2023 Feb
  • 11(2). doi: 10.1136/jitc-2022-005691.


    Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand 

  • H, Magalhaes I. Molecular, cellular and systemic aspects of epithelial
    ovarian cancer and its tumor microenvironment. [2]Semin Cancer Biol. 2022 
  • Nov
  • 86(Pt 3):207-223. doi: 10.1016/j.semcancer.2022.03.027.


    Schoutrop E, Renken S, Micallef Nilsson I, Hahn P, Poiret T, Kiessling R,  

  • Wickström SL, Mattsson J, Magalhaes I. Trogocytosis and fratricide killing
    impede MSLN-directed CAR T cell functionality. 
  • [3]Oncoimmunology. 2022
  • 11(1):2093426. doi: 10.1080/2162402X.2022.2093426.


    Renken S, Nakajima T, Magalhaes I, Mattsson J, Lundqvist A, Arnér ESJ,  

  • Kiessling R, Wickström SL. Targeting of Nrf2 improves antitumoral responses
    by human NK cells, TIL and CAR T cells during oxidative stress. [4]J 
  • Immunother Cancer. 2022 Jun
  • 10(6). doi: 10.1136/jitc-2021-004458.


    Schoutrop E, El-Serafi I, Poiret T, Zhao Y, Gultekin O, He R, Moyano-Galceran 

  • L, Carlson JW, Lehti K, Hassan M, Magalhaes I*, Mattsson 
  • J*. Mesothelin-Specific CAR T Cells Target Ovarian Cancer. [5]Cancer 
  • Res. 2021 Jun 1
  • 81(11):3022-3035. doi: 10.1158/0008-5472.CAN-20-2701.


    Magalhaes I, Fernebro J, Abd Own S, Glaessgen D, Corvigno S, Remberger M,  

  • Mattsson J, Dahlstrand H. Mesothelin Expression in Patients with High-Grade 
  • Serous Ovarian Cancer Does Not Predict Clinical Outcome But Correlates with 
  • CD11c+ Expression in Tumor. [6]Adv Ther. 2020 Dec
  • 37(12):5023-5031. doi: 
  • 10.1007/s12325-020-01520-w.


    [1] https://www.ncbi.nlm.nih.gov/pubmed/36746513/
    [2] https://www.ncbi.nlm.nih.gov/pubmed/35395389/
    [3] https://www.ncbi.nlm.nih.gov/pubmed/35898704/
    [4] https://www.ncbi.nlm.nih.gov/pubmed/35738800/
    [5] https://www.ncbi.nlm.nih.gov/pubmed/33795251/
    [6] https://www.ncbi.nlm.nih.gov/pubmed/33052561/

Teaching

Articles

All other publications

Employments

  • Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026

Degrees and Education

  • Docent, Karolinska Institutet, 2021
  • Degree Of Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2009

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