Ida Karlsson

Ida Karlsson

Assistant Professor
Visiting address: ,
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB II Hägg, 171 77 Stockholm
Part of:

About me

  • I am an assistant professor and research group leader, interested in combining genetic and longitudinal designs to understand complex aging-related traits. My primary research aim is to understand how obesity influences late-life health, by studying how differences among adiposity-related traits and why they have different associations with age-related diseases such as dementia, cardiovascular disease, and type-2 diabetes. I am also involved in several projects aiming to understand how different factors across the life course affect dementia risk, including genetic factors, life style, and environmental exposures.

Research

  • Adiposity and the risk of age-related disease
    The project aims to leverage the heterogeneity of adiposity-related traits, to understand better how adiposity influences the risk of cardiovascular disease, type 2 diabetes, and dementia. My hypothesis is that specific adiposity-related traits have different effects on the risk of the age-related diseases, and that these differences are explained by differences in e.g. metabolic factors or accelerated aging. I study adiposity in general (e.g. BMI and body fat distribution), and specific adiposity-related traits: a) metabolically unhealthy vs healthy adiposity

  • b) environmentally vs genetically driven adiposity, and c) adiposity measured in midlife vs late-life. These adiposity-related traits are associated with substantially increased, vs only slightly increased or even decreased risk of age-related disease (compared to having normal weight), and by studying what differs between them, I aim to advance our understanding of both the heterogeneity of overweight and of how adiposity in general affects late-life health.
    In addition to myself, two PhD students are conducting their thesis work within this project:
    - Peggy Ler, doctoral thesis title: How do body mass index and metabolic health in mid and late-life impact biological aging and mortality?
    - Elsa Ojalehto, doctoral thesis title: /How does adiposity influence the risk of cardiovascular disease and type 2 diabetes? Exploring confounding and mediating factors
    Two medical students are conducting the course "Degree project in medicine" within the project:
    - Axel ryding, thesis title: Metabolic health in genetically and environmentally influenced obesity
    - Martin Nakash, thesis title: Metabolically healthy obesity and the risk of dementia and cognitive decline

    The Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium
    I am part of the IGEMS consortium, which integrates data across twin studies of adult development and aging to address issues of gene-environment interplay in Alzheimer’s Disease and related dementias (ADRD). Within IGEMS, I lead studies of cardiometabolic risk factors of ADRD and am the lead of the Statistical Methods work group and the Genotyping and Polygenic Scores work group.

    The Lifecourse Geographic Exposome in Swedish Twins (LifeGEIST) consortium
    I am co-lead of the LifeGEIST consortium, together with colleagues in Sweden, the UK, and the US. Our aims are to study life course geographic circumstances in relation to dementia and other outcomes related to late-life health. Our aims are to examine 1) how genetic and environmental factors contribute to how people choose where to live, and 2) how life course geographic circumstances affect the risk of dementia and other late-life outcomes.
    Within the scope of this project, I co-supervise one PhD student at the University of Edinburgh, and have supervised two master students from
    Stockholm University:
    - Otto-Emil Jutila, PhD thesis title: Air pollution and Dementia: Exploring genetic and epigenetic moderators and mechanisms
    - Anita Paul, master thesis title: Understanding the relationship between birth weight and frailty, and differences in urban vs. rural living
    - Elsa Ojalehto (as co-supervisor, now PhD student), master thesis title: Influences of genetic predisposition to higher education on social and
    geographical mobility

Teaching

  • Course director:
    - "An introduction to genetic and molecular epidemiology", Karolinska Institutet, from 2021 (PhD course, 1.5 credits)
    - "Statistical Methods", School of Health and Welfare, Jönköping University, 2020 (PhD course, 7.5 credits)

    Lecturer
    Karolinska Institutet, from 2021:
    - Lectures on genetic epidemiology, cognition, and dementia (bachelor and master level)
    - Leader of seminars, group work, laboratory assignments in epidemiology and biostatistics
    School of Health and Welfare, Jönköping University, 2018-2020:
    - Lectures on statistical methods (doctoral level)
    - Lectures on cognition and dementia (bachelor and master level)

    Supervision:
    - Peggy Ler, PhD student at Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
    - Elsa Ojalehto, PhD student at Karolinska Institutet, Department of Medical Epidemiology and Biostatistics
    - Otto-Emil Jutila (as co-supervisor), PhD student at the University of Edinburgh, Precision Medicine Doctoral Training Program
    - Emilija Romic (as co-supervisor), PhD student at Umeå University
    - Axel ryding, medical degree student at Karolinska Institutet, HT 2023
    - Martin Nakash, medical degree student at Karolinska Institutet, VT 2024
    Former students:
    - Anita Paul, master student from Stockholm University, Public health department, VT 2022
    - Elsa Ojalehto (as co-supervisor, now PhD student), master student from Stockholm University, Public health department, VT 2022

Articles

All other publications

  • Review: JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. 2024;11(2):422-427
    Ji Q; Lian W; Meng Y; Liu W; Zhuang M; Zheng N; Karlsson IK; Zhan Y
  • Review: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;:glad251
    Mak JKL; Karlsson IK; Tang B; Wang Y; Pedersen NL; Hägg S; Jylhävä J; Reynolds CA
  • Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):716
    de Rojas I; Moreno-Grau S; Tesi N; Grenier-Boley B; Andrade V; Jansen IE; Pedersen NL; Stringa N; Zettergren A; Hernández I; Montrreal L; Antúnez C; Antonell A; Tankard RM; Bis JC; Sims R; Bellenguez C; Quintela I; González-Perez A; Calero M; Franco-Macías E; Macías J; Blesa R; Cervera-Carles L; Menéndez-González M; Frank-García A; Royo JL; Moreno F; Huerto Vilas R; Baquero M; Diez-Fairen M; Lage C; García-Madrona S; García-González P; Alarcón-Martín E; Valero S; Sotolongo-Grau O; Ullgren A; Naj AC; Lemstra AW; Benaque A; Pérez-Cordón A; Benussi A; Rábano A; Padovani A; Squassina A; de Mendonça A; Arias Pastor A; Kok AAL; Meggy A; Pastor AB; Espinosa A; Corma-Gómez A; Martín Montes A; Sanabria Á; DeStefano AL; Schneider A; Haapasalo A; Kinhult Ståhlbom A; Tybjærg-Hansen A; Hartmann AM; Spottke A; Corbatón-Anchuelo A; Rongve A; Borroni B; Arosio B; Nacmias B; Nordestgaard BG; Kunkle BW; Charbonnier C; Abdelnour C; Masullo C; Martínez Rodríguez C; Muñoz-Fernandez C; Dufouil C; Graff C; Ferreira CB; Chillotti C; Reynolds CA; Fenoglio C; Van Broeckhoven C; Clark C; Pisanu C; Satizabal CL; Holmes C; Buiza-Rueda D; Aarsland D; Rujescu D; Alcolea D; Galimberti D; Wallon D; Seripa D; Grünblatt E; Dardiotis E; Düzel E; Scarpini E; Conti E; Rubino E; Gelpi E; Rodriguez-Rodriguez E; Duron E; Boerwinkle E; Ferri E; Tagliavini F; Küçükali F; Pasquier F; Sanchez-Garcia F; Mangialasche F; Jessen F; Nicolas G; Selbæk G; Ortega G; Chêne G; Hadjigeorgiou G; Rossi G; Spalletta G; Giaccone G; Grande G; Binetti G; Papenberg G; Hampel H; Bailly H; Zetterberg H; Soininen H; Karlsson IK; Alvarez I; Appollonio I; Giegling I; Skoog I; Saltvedt I; Rainero I; Rosas Allende I; Hort J; Diehl-Schmid J; Van Dongen J; Vidal J-S; Lehtisalo J; Wiltfang J; Thomassen JQ; Kornhuber J; Haines JL; Vogelgsang J; Pineda JA; Fortea J; Popp J; Deckert J; Buerger K; Morgan K; Fließbach K; Sleegers K; Molina-Porcel L; Kilander L; Weinhold L; Farrer LA; Wang L-S; Kleineidam L; Farotti L; Parnetti L; Tremolizzo L; Hausner L; Benussi L; Froelich L; Ikram MA; Deniz-Naranjo MC; Tsolaki M; Rosende-Roca M; Löwenmark M; Hulsman M; Spallazzi M; Pericak-Vance MA; Esiri M; Bernal Sánchez-Arjona M; Dalmasso MC; Martínez-Larrad MT; Arcaro M; Nöthen MM; Fernández-Fuertes M; Dichgans M; Ingelsson M; Herrmann MJ; Scherer M; Vyhnalek M; Kosmidis MH; Yannakoulia M; Schmid M; Ewers M; Heneka MT; Wagner M; Scamosci M; Kivipelto M; Hiltunen M; Zulaica M; Alegret M; Fornage M; Roberto N; van Schoor NM; Seidu NM; Banaj N; Armstrong NJ; Scarmeas N; Scherbaum N; Goldhardt O; Hanon O; Peters O; Skrobot OA; Quenez O; Lerch O; Bossù P; Caffarra P; Dionigi Rossi P; Sakka P; Mecocci P; Hoffmann P; Holmans PA; Fischer P; Riederer P; Yang Q; Marshall R; Kalaria RN; Mayeux R; Vandenberghe R; Cecchetti R; Ghidoni R; Frikke-Schmidt R; Sorbi S; Hägg S; Engelborghs S; Helisalmi S; Botne Sando S; Kern S; Archetti S; Boschi S; Fostinelli S; Gil S; Mendoza S; Mead S; Ciccone S; Djurovic S; Heilmann-Heimbach S; Riedel-Heller S; Kuulasmaa T; Del Ser T; Lebouvier T; Polak T; Ngandu T; Grimmer T; Bessi V; Escott-Price V; Giedraitis V; Deramecourt V; Maier W; Jian X; Pijnenburg YAL; EADB contributors; GR@ACE study group; DEGESCO consortium; IGAP (ADGC, CHARGE, EADI, GERAD); PGC-ALZ consortia; Kehoe PG; Garcia-Ribas G; Sánchez-Juan P; Pastor P; Pérez-Tur J; Piñol-Ripoll G; Lopez de Munain A; García-Alberca JM; Bullido MJ; Álvarez V; Lleó A; Real LM; Mir P; Medina M; Scheltens P; Holstege H; Marquié M; Sáez ME; Carracedo Á; Amouyel P; Schellenberg GD; Williams J; Seshadri S; van Duijn CM; Mather KA; Sánchez-Valle R; Serrano-Ríos M; Orellana A; Tárraga L; Blennow K; Huisman M; Andreassen OA; Posthuma D; Clarimón J; Boada M; van der Flier WM; Ramirez A; Lambert J-C; van der Lee SJ; Ruiz A
  • Corrigendum: NATURE GENETICS. 2022;54(7):1062
    Wightman DP; Jansen IE; Savage JE; Shadrin AA; Bahrami S; Holland D; Rongve A; Børte S; Winsvold BS; Drange OK; Martinsen AE; Skogholt AH; Willer C; Bråthen G; Bosnes I; Nielsen JB; Fritsche LG; Thomas LF; Pedersen LM; Gabrielsen ME; Johnsen MB; Meisingset TW; Zhou W; Proitsi P; Hodges A; Dobson R; Velayudhan L; Heilbron K; Auton A; 23andMe Research Team; Sealock JM; Davis LK; Pedersen NL; Reynolds CA; Karlsson IK; Magnusson S; Stefansson H; Thordardottir S; Jonsson PV; Snaedal J; Zettergren A; Skoog I; Kern S; Waern M; Zetterberg H; Blennow K; Stordal E; Hveem K; Zwart J-A; Athanasiu L; Selnes P; Saltvedt I; Sando SB; Ulstein I; Djurovic S; Fladby T; Aarsland D; Selbæk G; Ripke S; Stefansson K; Andreassen OA; Posthuma D
  • Preprint: MEDRXIV. 2022
    Hou J; Hess JL; Armstrong N; Bis JC; Grenier-Boley B; Karlsson IK; Leonenko G; Numbers K; O’Brien EK; Shadrin A; Thalamuthu A; Yang Q; Andreassen OA; Brodaty H; Gatz M; Kochan NA; Lambert J-C; Laws SM; Masters CL; Mather KA; Pedersen NL; Posthuma D; Sachdev PS; Williams J; Initiative TADN; Fan CC; Faraone SV; Fennema-Notestine C; Lin S-J; Escott-Price V; Holmans P; Seshadri S; Tsuang MT; Kremen WS; Glatt SJ
  • Corrigendum: NATURE GENETICS. 2021;53(12):1722
    Wightman DP; Jansen IE; Savage JE; Shadrin AA; Bahrami S; Holland D; Rongve A; Børte S; Winsvold BS; Drange OK; Martinsen AE; Skogholt AH; Willer C; Bråthen G; Bosnes I; Nielsen JB; Fritsche LG; Thomas LF; Pedersen LM; Gabrielsen ME; Johnsen MB; Meisingset TW; Zhou W; Proitsi P; Hodges A; Dobson R; Velayudhan L; Heilbron K; Auton A; 23andMe Research Team; Sealock JM; Davis LK; Pedersen NL; Reynolds CA; Karlsson IK; Magnusson S; Stefansson H; Thordardottir S; Jonsson PV; Snaedal J; Zettergren A; Skoog I; Kern S; Waern M; Zetterberg H; Blennow K; Stordal E; Hveem K; Zwart J-A; Athanasiu L; Selnes P; Saltvedt I; Sando SB; Ulstein I; Djurovic S; Fladby T; Aarsland D; Selbæk G; Ripke S; Stefansson K; Andreassen OA; Posthuma D
  • Editorial comment: FRONTIERS IN GENETICS. 2021;12:771109
    Karlsson IK; Arpawong TE; Zhan Y; Lehto K
  • Letter: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. 2020;28(4):499-500
    Kodesh A; Sandin S; Reichenberg A; Rotstein A; Pedersen NL; Ericsson M; Karlsson IK; Davidson M; Levine SZ
  • Corrigendum: NATURE GENETICS. 2020;52(3):354
    Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Hägg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Brækhus A; Bråthen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbæk G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
  • Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):2068
    Davies G; Lam M; Harris SE; Trampush JW; Luciano M; Hill WD; Hagenaars SP; Ritchie SJ; Marioni RE; Fawns-Ritchie C; Liewald DCM; Okely JA; Ahola-Olli AV; Barnes CLK; Bertram L; Bis JC; Burdick KE; Christoforou A; DeRosse P; Djurovic S; Espeseth T; Giakoumaki S; Giddaluru S; Gustavson DE; Hayward C; Hofer E; Ikram MA; Karlsson R; Knowles E; Lahti J; Leber M; Li S; Mather KA; Melle I; Morris D; Oldmeadow C; Palviainen T; Payton A; Pazoki R; Petrovic K; Reynolds CA; Sargurupremraj M; Scholz M; Smith JA; Smith AV; Terzikhan N; Thalamuthu A; Trompet S; van der Lee SJ; Ware EB; Windham BG; Wright MJ; Yang J; Yu J; Ames D; Amin N; Amouyel P; Andreassen OA; Armstrong NJ; Assareh AA; Attia JR; Attix D; Avramopoulos D; Bennett DA; Böhmer AC; Boyle PA; Brodaty H; Campbell H; Cannon TD; Cirulli ET; Congdon E; Conley ED; Corley J; Cox SR; Dale AM; Dehghan A; Dick D; Dickinson D; Eriksson JG; Evangelou E; Faul JD; Ford I; Freimer NA; Gao H; Giegling I; Gillespie NA; Gordon SD; Gottesman RF; Griswold ME; Gudnason V; Harris TB; Hartmann AM; Hatzimanolis A; Heiss G; Holliday EG; Joshi PK; Kähönen M; Kardia SLR; Karlsson I; Kleineidam L; Knopman DS; Kochan NA; Konte B; Kwok JB; Le Hellard S; Lee T; Lehtimäki T; Li S-C; Lill CM; Liu T; Koini M; London E; Longstreth WT; Lopez OL; Loukola A; Luck T; Lundervold AJ; Lundquist A; Lyytikäinen L-P; Martin NG; Montgomery GW; Murray AD; Need AC; Noordam R; Nyberg L; Ollier W; Papenberg G; Pattie A; Polasek O; Poldrack RA; Psaty BM; Reppermund S; Riedel-Heller SG; Rose RJ; Rotter JI; Roussos P; Rovio SP; Saba Y; Sabb FW; Sachdev PS; Satizabal CL; Schmid M; Scott RJ; Scult MA; Simino J; Slagboom PE; Smyrnis N; Soumaré A; Stefanis NC; Stott DJ; Straub RE; Sundet K; Taylor AM; Taylor KD; Tzoulaki I; Tzourio C; Uitterlinden A; Vitart V; Voineskos AN; Kaprio J; Wagner M; Wagner H; Weinhold L; Wen KH; Widen E; Yang Q; Zhao W; Adams HHH; Arking DE; Bilder RM; Bitsios P; Boerwinkle E; Chiba-Falek O; Corvin A; De Jager PL; Debette S; Donohoe G; Elliott P; Fitzpatrick AL; Gill M; Glahn DC; Hägg S; Hansell NK; Hariri AR; Ikram MK; Jukema JW; Vuoksimaa E; Keller MC; Kremen WS; Launer L; Lindenberger U; Palotie A; Pedersen NL; Pendleton N; Porteous DJ; Räikkönen K; Raitakari OT; Ramirez A; Reinvang I; Rudan I; Dan Rujescu; Schmidt R; Schmidt H; Schofield PW; Schofield PR; Starr JM; Steen VM; Trollor JN; Turner ST; Van Duijn CM; Villringer A; Weinberger DR; Weir DR; Wilson JF; Malhotra A; McIntosh AM; Gale CR; Seshadri S; Mosley TH; Bressler J; Lencz T; Deary IJ
  • Thesis / dissertation: 2017
    Karlsson, Ida K

Employments

  • Assistant Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2022-2028
  • Postdoctoral Researcher, School of Health and Welfare, Institute of Gerontology, Jönköping University, 2017-2020

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2017
  • Master Of Medical Science, Karolinska Institutet, 2010

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