Harriet Wallberg
Professor, Senior
E-mail: harriet.wallberg@ki.se
Telephone: +46852486480
Visiting address: Solnavägen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Integrativ Fysiologi, 171 77 Stockholm
About me
- I am a Professor of Physiology and was the President (Vice-Chancellor) of Karolinska Institutet during the years 2004-2012. I served as the Secretary General of the Scientific Council for Medicine at the Swedish Research Council (2001-2003), and as University Chancellor and Head of the Swedish Higher Education Authority (2014-2016).
Since 2004, I am a member of the Tokyo-based international Science and Technology in Society Forum (STS). I have also served as a member of the International Scientific Advisory Council to the Government of Singapore, a member of the Research Advisory Council to the Danish Government, a member of the Swedish Government's Science Policy Council, and a member of the Swedish Globalization Council. From 2002 to 2005, I was Vice President of the European Association for the Study of Diabetes, a major European diabetes organization.
I have been awarded with honorary doctorates from several international universities, as well as the Order of the Rising Sun from the Japanese Government. In 2008, I was honored with H. M. the King’s Medal for my distinguished achievements in medical education and research. I am a member of the Nobel Assembly at Karolinska Institutet, which selects Nobel laureates in Physiology or Medicine.
My book - Koll på diabetes typ 2
Together with Professor Kerstin Brismar, I have written a book for people with type 2 diabetes called "Koll på diabetes typ 2". Professor Brismar and I have many years of experience in research, education, and counseling on type 2 diabetes. In this book, we outline what happens in the body when you suffer from the disease, how different medications work and what you yourself can do to feel better - today and in the future. The idea is that the book should be an inspiration to live a good life even with type 2 diabetes.
"Koll på diabetes typ 2" is a practical handbook written in Swedish for people who want to take control of their diabetes. It is also a source of knowledge and understanding for anyone who meets and cares for people with type 2 diabetes as a relative or in the health care sector.
Research
- I made a unique discovery in the early 1980's as a visiting scientist at Washington University School of Medicine in St. Louis, USA. At that time, everyone was convinced that insulin was required to transport glucose into muscle cells. Together with Professor John O. Holloszy, I was able to provide evidence that contracting skeletal muscle stimulates glucose transport in muscle cells by an insulin-independent mechanism. This was contrary to the prevailing paradigm at that time. Thus, we were able to show that muscle contraction works in the same way as insulin in terms of stimulating glucose uptake, but that the signaling mechanisms differed. This finding explains why exercise is an important part of the treatment for type 2 diabetes.
A major problem in people with type 2 diabetes is that the body becomes insulin resistant, ie that muscles, fat and liver do not respond to insulin properly. My research team has studied the molecular mechanisms behind insulin resistance. We have been able to show that the signalling pathways that activate the glucose transport molecules are partly inhibited in diabetes. The causes behind this insulin resistance might differ between people, but high levels of fat, stress hormones and inflammatory molecules clearly have a deleterious effect on insulin sensitivity.
An exciting part of my research has been devoted to physical exercise, ie how exercise affects glucose metabolism in diabetes. We provided evidence that people with type 1 diabetes can perform exercise without deteriorating blood glucose control. In people with type 2 diabetes, we have been able to show that both Nordic walking and high intensity exercise training improves blood glucose control. A novel discovery is that the time during the day when exercising is performed can play an important role to achieve the positive effects of physical exercise on blood glucose control. This was an unexpected, but important finding, which is currently being explored in my laboratory with studies on the underlying causes and whether it applies to all types of exercise.
Articles
- Article: DIABETOLOGIA. 2025;68(9):2023-2035Keller MJ; Brady AJ; Smith JAB; Savikj M; MacGregor K; Jollet M; Oberg SB; Nylen C; Bjornholm M; Rickenlund A; Carlsson M; Caidahl K; Krook A; Pillon NJ; Zierath JR; Wallberg-Henriksson H
- Article: CELL REPORTS MEDICINE. 2024;5(1):101348Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2022;135:155268Savikj M; Stocks B; Sato S; Caidahl K; Krook A; Deshmukh AS; Zierath JR; Wallberg-Henriksson H
- Article: SCIENCE ADVANCES. 2022;8(36):eabo3192Pillon NJ; Smith JAB; Alm PS; Chibalin AV; Alhusen J; Arner E; Carninci P; Fritz T; Otten J; Olsson T; de ten Ryen SVD; Deldicque L; Caidahl K; Wallberg-Henriksson H; Krook A; Zierath JR
- Article: DIABETOLOGIA. 2019;62(2):233-237Savikj M; Gabriel BM; Alm PS; Smith J; Caidahl K; Bjoernholm M; Fritz T; Krook A; Zierath JR; Wallberg-Henriksson H
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2018;315(5):E995-E1004Nylen C; Aoi W; Abdelmoez AM; Lassiter DG; Lundell LS; Wallberg-Henriksson H; Naslund E; Pillon OJ; Krook A
- Article: DIABETOLOGIA. 2018;61(2):424-432Lassiter DG; Nylen C; Sjogren RJO; Chibalin AV; Wallberg-Henriksson H; Naslund E; Krook A; Zierath JR
- Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
- Article: DIABETES CARE. 2015;38(6):1154-1160Osler ME; Fritz T; Caidahl K; Krook A; Zierath JR; Wallberg-Henriksson H
- Article: DIABETOLOGIA. 2010;53(6):1142-1150Deshmukh AS; Long YC; Barbosa TDC; Karlsson HKR; Glund S; Zavadoski WJ; Gibbs EM; Koistinen HA; Wallberg-Henriksson H; Zierath JR
- Article: DIABETES. 2009;58(4):847-854Karlsson HKR; Chibalin AV; Koistinen HA; Yang J; Koumanov F; Wallberg-Henriksson H; Zierath JR; Holman GD
- Article: CELL. 2008;132(3):375-386Chibalin AV; Leng Y; Vieira E; Krook A; Bjoernholm M; Long YC; Kotova O; Zhong Z; Sakane F; Steiler T; Nylen C; Wang J; Laakso M; Topham MK; Gilbert M; Wallberg-Henriksson H; Zierath JR
- Article: DIABETES. 2006;55(5):1283-1288Karlsson HKR; Ahlsen M; Zierath JR; Wallberg-Henriksson H; Koistinen HA
- Article: DIABETOLOGIA. 2005;48(11):2354-2364Long YC; Barnes BR; Mahlapuu M; Steiler TL; Martinsson S; Leng Y; Wallberg-Henriksson H; Andersson L; Zierath JR
- Article: DIABETES. 2005;54(9):2685-2693Bach D; Naon D; Pich S; Soriano FX; Vega N; Rieusset J; Laville M; Guillet C; Boirie Y; Wallberg-Henriksson H; Manco M; Calvani M; Castagneto M; Palacín M; Mingrone G; Zierath JR; Vidal H; Zorzano A
- Article: DIABETES. 2005;54(6):1692-1697Karlsson HKR; Zierath JR; Kane S; Krook A; Lienhard GE; Wallberg-Henriksson H
- Article: GENDER MEDICINE. 2005;2(2):62-64Wallberg-Henriksson H
- Article: DIABETES. 2005;54(4):1157-1163Krämer DK; Al-Khalili L; Perrini S; Skogsberg J; Wretenberg P; Kannisto K; Wallberg-Henriksson H; Ehrenborg E; Zierath JR; Krook A
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217Krook A; Wallberg-Henriksson H; Zierath JR
- Article: OBESITY. 2004;12(1):25-31Koistinen HA; Forsgren M; Wallberg-Henriksson H; Zierath JR
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(19):17190-17197Bach D; Pich S; Soriano FX; Vega N; Baumgartner B; Oriola J; Daugaard JR; Lloberas J; Camps M; Zierath JR; Rabasa-Lhoret R; Wallberg-Henriksson H; Laville M; Palacín M; Vidal H; Rivera F; Brand M; Zorzano A
- Article: DIABETES. 2003;52(5):1066-1072Koistinen HA; Galuska D; Chibalin AV; Yang J; Zierath JR; Holman GD; Wallberg-Henriksson H
- Article: PANCREAS. 2003;26(2):173-177Isaksson B; Strömmer L; Friess H; Büchler MW; Herrington MK; Wang F; Zierath JR; Wallberg-Henriksson H; Larsson J; Pennert J
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2003;23(1):21-30Krook A; Holm I; Pettersson S; Wallberg-Henriksson H
- Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31Tsuchida H; Björnholm M; Fernström M; Galuska D; Johansson P; Wallberg-Henriksson H; Zierath JR; Lake S; Krook A
- Article: DIABETOLOGIA. 2002;45(1):56-65Song XM; Fiedler M; Galuska D; Ryder JW; Fernström M; Chibalin AV; Wallberg-Henriksson H; Zierath JR
- Article: DIABETOLOGIA. 2001;44(12):2180-2186Fiedler M; Zierath JR; Selén G; Wallberg-Henriksson H; Liang Y; Sakariassen KS
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259Kawano Y; Ryder JW; Rincon J; Zierath JR; Krook A; Wallberg-Henriksson H
- Article: ENDOCRINOLOGY. 2001;142(8):3474-3482Chibalin AV; Kovalenko MV; Ryder JW; Féraille E; Wallberg-Henriksson H; Zierath JR
- Article: EXPERIMENTAL PHYSIOLOGY. 2001;86(2):205-209Jiao Y; Shashkin P; Hjeltnes N; Wallberg-Henriksson H; Katz A
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34Yu M; Blomstrand E; Chibalin AV; Wallberg-Henriksson H; Zierath JR; Krook A
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721Krook A; Widegren U; Jiang XJ; Henriksson J; Wallberg-Henriksson H; Alessi D; Zierath JR
- Article: DIABETES. 2000;49(4):647-654Ryder JW; Yang J; Galuska D; Rincón J; Björnholm M; Krook A; Lund S; Pedersen O; Wallberg-Henriksson H; Zierath JR; Holman GD
- Article: DIABETES. 2000;49(2):284-292Krook A; Björnholm M; Galuska D; Jiang XJ; Fahlman R; Myers MGJ; Wallberg-Henriksson H; Zierath JR
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462Ryder JW; Fahlman R; Wallberg-Henriksson H; Alessi DR; Krook A; Zierath JR
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43Chibalin AV; Yu M; Ryder JW; Song XM; Galuska D; Krook A; Wallberg-Henriksson H; Zierath JR
- Article: FASEB JOURNAL. 1999;13(15):2246-2256Ryder JW; Kawano Y; Galuska D; Fahlman R; Wallberg-Henriksson H; Charron MJ; Zierath JR
- Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1999;439(1-2):130-133Rincón J; Galuska D; Ryder JW; Kawano Y; Wallberg-Henriksson H; Gorrod JW; Zierath JR
- Article: DIABETOLOGIA. 1999;42(9):1071-1079Changes in glucose transport and protein kinase Cβ2 in rat skeletal muscle induced by hyperglycaemiaKawano Y; Rincon J; Soler A; Ryder JW; Nolte LA; Zierath JR; Wallberg-Henriksson H
- Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142Rincón J; Krook A; Galuska D; Wallberg-Henriksson H; Zierath JR
- Article: DIABETES. 1999;48(3):664-670Song XM; Kawano Y; Krook A; Ryder JW; Efendic S; Roth RA; Wallberg-Henriksson H; Zierath JR
- Article: FASEB JOURNAL. 1998;12(15):1701-1712Hjeltnes N; Galuska D; Björnholm M; Aksnes AK; Lannem A; Zierath JR; Wallberg-Henriksson H
- Article: SPINAL CORD. 1998;36(10):691-698Hjeltnes N; Wallberg-Henriksson H
- Article: FASEB JOURNAL. 1998;12(13):1379-1389Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscleWidegren U; Jiang XJ; Krook A; Chibalin AV; Björnholm M; Tally M; Roth RA; Henriksson J; Wallberg-Henriksson H; Zierath JR
- Article: DIABETES. 1998;47(9):1528-1531Krook A; Digby J; O'Rahilly S; Zierath JR; Wallberg-Henriksson H
- Article: DIABETES. 1998;47(8):1281-1286Krook A; Roth RA; Jiang XJ; Zierath JR; Wallberg-Henriksson H
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;275(2):E351-E358Strommer L; Permert J; Arnelo U; Koehler C; Isaksson B; Larsson J; Lundkvist I; Bjornholm M; Kawano Y; Wallberg-Henriksson H; Zierath JR
- Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160Zierath JR; Krook A; Wallberg-Henriksson H
- Article: DIABETES. 1997;46(12):2110-2114Krook A; Kawano Y; Song XM; Efendic S; Roth RA; WallbergHenriksson H; Zierath JR
- Article: DIABETES. 1997;46(12):1965-1969Lund S; Holman GD; Zierath JR; Rincon J; Nolte LA; Clark AE; Schmitz O; Pedersen O; WallbergHenriksson H
- Article: DIABETOLOGIA. 1997;40(10):1172-1177Shepherd PR; Nave BT; Rincon J; Haigh RJ; Foulstone E; Proud C; Zierath JR; Siddle K; WallbergHenriksson H
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(3):R1072-R1079Hjeltnes N; Aksnes AK; Birkeland KI; Johansen J; Lannem A; WallbergHenriksson H
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(30):19000-19007Shepherd PR; Nave BT; Rincon J; Nolte LA; Bevan AP; Siddle K; Zierath JR; WallbergHenriksson H
- Article: DIABETOLOGIA. 1996;39(10):1180-1189Zierath JR; He L; Guma A; Wahlstrom EO; Klip A; WallbergHenriksson H
- Article: JOURNAL OF INTERNAL MEDICINE. 1996;240(3):115-124Wahren J; Johansson BL; WallbergHenriksson H; Linde B; FernqvistForbes E; Zierath JR
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1996;271(3):E593-E600Aksnes AK; Hjeltnes N; Wahlstrom EO; Katz A; Zierath JR; WallbergHenriksson H
- Article: ENDOCRINOLOGY. 1996;137(6):2397-2405Moller DE; Chang PY; Yaspelkis BB; Flier JS; Wallberg-Henriksson H; Ivy JL
- Article: DIABETES. 1996;45(5):615-621Rincon J; Holmang A; Wahlstrom EO; Lonnroth P; Bjorntorp P; Zierath JR; WallbergHenriksson H
- Article: DIABETOLOGIA. 1996;39(3):306-313Zierath JR; Handberg A; Tally M; WallbergHenriksson H
- Article: BIOCHEMICAL JOURNAL. 1995;311(Pt 2):517-521ZIERATH JR; NOLTE LA; WAHLSTROM E; GALUSKA D; SHEPHERD PR; KAHN BB; WALLBERGHENRIKSSON H
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;268(4):E613-E622GUMA A; ZIERATH JR; WALLBERGHENRIKSSON H; KLIP A
- Article: CLINICAL SCIENCE. 1995;88(3):301-306NOLTE LA; ABDELHALIM SM; MARTIN IK; GUENIFI A; ZIERATH JR; OSTENSON CG; WALLBERGHENRIKSSON H
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All other publications
- Review: CELL METABOLISM. 2015;22(1):25-30Zierath JR; Wallberg-Henriksson H
- Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2015;11(4):198-200Wallberg-Henriksson H; Zierath JR
- Other: REPRODUCTIVE BIOMEDICINE ONLINE. 2011;23:1-98Ahuja K; Bennett F; Cohen J; Edwards R; Pritchard H; Silver A; Sirlin J; Slee J; Abse D; Ashwood-Smith MJ; Bavister B; Bedford JM; Beier HM; Bronson R; Cattanach B; Daniel JC; Dawes EA; Ferguson-Smith M; Gardner R; Griffin D; Hunter RHF; Johnson M; Jones H; Lunenfeld B; Mittwoch U; Moor R; Rankin B; Schally AV; Sharpe DJ; Simpson D; Yanagimachi RY; Ahuja K; Alexandre H; Bhargava PM; Cohen J; Dexter A; Diedrich K; Emperaire J-C; Findlay A; Fishel S; Fox NL; Goddard H; Gomel V; Gore-Langton RE; Gosden R; Iritani A; Koskimies AI; MacDonald G; Menezo Y; Mettler L; Monk M; Mori T; Mortimer D; Papaioannou VE; Racowsky C; Surani A; Trounson A; Van Blerkom J; Vincent P; Walters E; Webster J; Williams P; Aboulghar M; Barri PN; Benagiano G; Blackwell C; Bolton VN; Brinsden PR; Bustillo M; Coulam C; Chaouat G; Crosignani P; Gardner D; Gianaroli L; Hamberger L; Hartshorne G; Hollands P; Howles C; Illmensee K; Jauniaux E; Kini D; Lee S; Lees M; Leese H; Mathews T; Moate E; Nygren K; Ockleford C; Palermo GD; Pandiyan N; Rizk B; Rosenwaks Z; Sallam H; Sathananthan AH; Saunders DM; Simpson JL; Sunde A; Tan SL; Ulloa-Aguirre A; Gosden LV; Veiga A; Albertini DF; Alikani M; Balaban B; Thornhill A; Beard HK; Ben-Shlomo I; Bennett F; Borini A; Carrell D; De Jonge C; Eichenlaub-Ritter U; Fleming S; Geber S; Gerris J; Golombok S; Leather DS; Nagy ZP; Nielsen HI; Oehninger S; Olivennes F; Patrizio P; Paulson RJ; Polak de Fried E; Pool TBR; Risquez F; Sauer MV; Sciarra JJ; Basuray R; Boiso I; Bose CK; Cryan B; Falconer A; Hansis C; Kahraman S; Ko MSH; Korsak V; Loeffler F; Ludwig M; Magli MC; Robertson JA; Roche LA; Thornhill A; Wallberg-Henriksson H; Woo G
- Editorial comment: CELL. 2009;137(1):22-24Wallberg-Henriksson H; Zierath JR
- Corrigendum: PHYSIOLOGY & BEHAVIOR. 2008;93(4-5):1086Wallberg-Henriksson H
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2002;967:120-134Zierath JR; Wallberg-Henriksson H
- Review: MOLECULAR MEMBRANE BIOLOGY. 2001;18(3):205-211Wallberg-Henriksson H; Zierath JR
- Review: DIABETOLOGIA. 2000;43(7):821-835Zierath JR; Krook A; Wallberg-Henriksson H
- Review: SPORTS MEDICINE. 1998;25(1):25-35Wallberg-Henriksson H; Rincon J; Zierath JR
- Other: DIABETES. 1995;44(11):1345-1348NOLTE LA; RINCON J; WAHLSTROM EO; CRAIG BW; ZIERATH JR; WALLBERGHENRIKSSON H
Employments
- Professor, Senior, Department of Physiology and Pharmacology, Karolinska Institutet, 2025-2026
- Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 1998-2025