Harald Lund

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About me

I did my PhD at Karolinska Institutet with Bob Harris on microglial biology
(2018). After a postdoc with Tony Yaksh at UC San Diego (2018-2019), I
returned to Karolinska Institutet and joined Camilla Svensson's research
group as postdoc (2020). I am currently studying macrophages in the
peripheral nervous system.

Articles

Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675

CD163+ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier.

Lund H; Hunt MA; Kurtović Z; Sandor K; Kägy PB; Fereydouni N; Julien A; Göritz C; Vazquez-Liebanas E; Andaloussi Mäe M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
Article: EMBO REPORTS. 2022;23(7):e54499

Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.

Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Min J-H; Benito-Cuesta I; Lund H; Amor S; Wang J; Zhang X-M; Kutter C; Guerreiro-Cacais AO; Högberg B; Harris RA
Article: JOURNAL OF NEUROSCIENCE METHODS. 2022;371:109497

DRGquant: A new modular AI-based pipeline for 3D analysis of the DRG.

Hunt MA; Lund H; Delay L; Dos Santos GG; Pham A; Kurtovic Z; Telang A; Lee A; Parvathaneni A; Kussick E; Corr M; Yaksh TL
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20

An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion.

Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603

Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion.

Han J; Fan Y; Zhou K; Zhu K; Blomgren K; Lund H; Zhang X-M; Harris RA
Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077

Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation.

Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824

Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis.

Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
Article: GLIA. 2020;68(7):1466-1478

Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice.

Zhu K; Pieber M; Han J; Blomgren K; Zhang X-M; Harris RA; Lund H
Article: NATURE COMMUNICATIONS. 2018;9(1):4845

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells.

Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Överby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: NATURE IMMUNOLOGY. 2018;19(5):1-7

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling.

Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: NEUROBIOLOGY OF AGING. 2017;60:173-182

Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells.

Sackmann V; Ansell A; Sackmann C; Lund H; Harris RA; Hallbeck M; Nilsberth C
Article: BMC BIOINFORMATICS. 2017;18(1):486

Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies.

Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
Article: GLIA. 2016;64(11):1925-1937

TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells.

Parsa R; Lund H; Tosevski I; Zhang X-M; Malipiero U; Beckervordersandforth J; Merkler D; Prinz M; Gyllenberg A; James T; Warnecke A; Hillert J; Alfredsson L; Kockum I; Olsson T; Fontana A; Suter T; Harris RA
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.

Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Ortlieb Guerreiro-Cacais A; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
Article: GLIA. 2014;62(5):804-817

Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice.

Zhang X-M; Lund H; Mia S; Parsa R; Harris RA
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2014;2:22

MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.

Lund H; Gustafsson E; Svensson A; Nilsson M; Berg M; Sunnemark D; von Euler G
Article: NEUROMOLECULAR MEDICINE. 2013;15(3):458-469

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.

Gu GJ; Lund H; Wu D; Blokzijl A; Classon C; von Euler G; Landegren U; Sunnemark D; Kamali-Moghaddam M
Article: BRAIN PATHOLOGY. 2013;23(4):378-389

Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.

Lund H; Cowburn RF; Gustafsson E; Strömberg K; Svensson A; Dahllund L; Malinowsky D; Sunnemark D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;33(3):699-713

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.

Gu GJ; Wu D; Lund H; Sunnemark D; Kvist AJ; Milner R; Eckersley S; Nilsson LNG; Agerman K; Landegren U; Kamali-Moghaddam M
Article: PHYTOTHERAPY RESEARCH. 2011;25(6):851-857

Dietary quinic acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine.

Pero RW; Lund H
Article: PHYTOTHERAPY RESEARCH. 2009;23(3):335-346

Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide.

Pero RW; Lund H; Leanderson T
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All other publications

Preprint: BIORXIV. 2023

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
KI thesis / dissertation: 2018

Regulation of microglia and monocyte function by the cytokine TGF-beta

Lund, Harald
Review: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:234

Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies.

Lund H; Pieber M; Harris RA

Employments

Assistant Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-2030
Postdoctoral Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2022-2024

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2018

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