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About me

I am currently associate professor of epidemiology and research group leader at this department and a physician at the Department of Hematology at Karolinska University Hospital. My research focuses on short- and long-term health effects of blood donations and transfusions, trauma, and cancer epidemiology. I defended my PhD thesis at Karolinska Institutet in 2007 and subsequently did a post doctoral fellowship at the department of epidemiology at Harvard School of Public Health. I hold several research grants from the Swedish Research Council, the Swedish Heart Lung Foundation and the US National Institutes of Health.

I am the Swedish PI of the Scandinavian Donations and Transfusions (SCANDAT) database, which holds data on blood donations and transfusions in Sweden and Denmark between 1968 and 2012.

In addition to my research and clinical work, I am is a frequent teacher both in post graduate courses in epidemiologic methods as well as in the undergraduate medical program at Karolinska Institutet. I have also taught courses in SAS programming and have developed several freely available SAS macros.


  • MD, Karolinska Institutet, 2010.
  • PhD, epidemiology, Karolinska Institutet, 2010.
  • BSc, medicine, Karolinska Institutet, 2004.

Research description

The main focus of my research is etiological epidemiology with an emphasis on topics somewhere in the intersection between cancer epidemiology and transfusion medicine. In addition, I also participate in more clinically related transfusion medicine projects, and then especially studies of the acute health effects of blood transfusions. As a separate research interest, I've also participated in a series of studies on the heritability of breast cancer as well as of the dynamics of breast density and its implications.

Current supervision of PhD students

Academic honours, awards and prizes

My PhD thesis entitled "Blood donors long term health: implications for transfusion safety" was awarded Dmitris N Chorafas' prize in 2008.



ABO blood type and risk of porcine bioprosthetic aortic valve degeneration: SWEDEHEART observational cohort study
Persson M, Edgren G, Dalén M, Glaser N, Olsson Ml, Franco-cereceda A, et al
BMJ open 2019;9(5):e029109-

A longer duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion: a cohort study
Rydén J, Clements M, Hellström-lindberg E, Höglund P, Edgren G
Transfusion 2019;():-

Epidemiology of donors and recipients: lessons from the SCANDAT database
Edgren G, Hjalgrim H
Transfusion medicine (Oxford, England) 2019;29 Suppl 1():6-12

Frequent blood donation and offspring birth weight-a next-generation association?
Rigas As, Pedersen Ob, Sørensen E, Thørner Lw, Larsen Mh, Katz Lm, et al
Transfusion 2019;59(3):995-1001

HLA-selected platelets for platelet refractory patients with HLA antibodies: a single-center experience
Karlström C, Linjama T, Edgren G, Lauronen J, Wikman A, Höglund P
Transfusion 2019;59(3):945-952

Male sex and the pattern of recurrent myeloid mutations are strong independent predictors of blood transfusion intensity in patients with myelodysplastic syndromes
Rydén J, Edgren G, Karimi M, Walldin G, Tobiasson M, Wikman A, et al
Leukemia 2019;33(2):522-527

Trends in survival of young adult patients with acute lymphoblastic leukemia in Sweden and USA
Björkholm M, Edgren G, Dickman Pw
Blood 2019;():-

Blood use in hematologic malignancies: a nationwide overview in Sweden between 2000 and 2010
Zhao J, Rydén J, Wikman A, Norda R, Stanworth Sj, Hjalgrim H, et al
Transfusion 2018;58(2):390-401

Does prophylactic calcium in apheresis cause more harm than good? - Centre heterogeneity within the World Apheresis Association Register prevents firm conclusions
Toss F, Edgren G, Berlin G, Stegmayr B, Witt V
Vox sanguinis 2018;113(7):632-638

Epidemiology of chronic red-cell transfusion recipients in Sweden and Denmark-a 10 year follow-up study
Didriksen M, Rostgaard K, Grønbaek K, Pedersen Ob, Titlestad K, Erikstrup C, et al
Vox sanguinis 2018;113(8):770-778

Is Blood Transfusion Linked to Celiac Disease? A Nationwide Cohort Study
Ludvigsson Jf, Lebwohl B, Green Phr, Murray Ja, Hjalgrim H, Edgren G
American journal of epidemiology 2018;187(1):120-124

Searching for unknown transfusion-transmitted hepatitis viruses: a binational cohort study of 1.5 million transfused patients
Nhlbi Recipient Epidemiology And Donor Evaluation Study-iii (reds-iii), Edgren G, Hjalgrim H, Rostgaard K, Dahl V, Titlestad K, et al
Journal of internal medicine 2018;284(1):92-103

Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study
Kreuger Al, Rostgaard K, Middelburg Ra, Kerkhoffs Jh, Edgren G, Erikstrup C, et al
Transfusion 2018;58(1):16-24

Transmission of rheumatoid arthritis through blood transfusion: a retrospective cohort study
Just Sa, Rostgaard K, Titlestad K, Edgren G, Erikstrup C, Ullum H, et al
Annals of the rheumatic diseases 2018;77(10):1536-1537

Association of Donor Age and Sex With Survival of Patients Receiving Transfusions
Edgren G, Ullum H, Rostgaard K, Erikstrup C, Sartipy U, Holzmann Mj, et al
JAMA internal medicine 2017;177(6):854-860

Blood Transfusions From Previously Pregnant Women and Mortality: Interpreting the Evidence
Cable Rg, Edgren G
JAMA 2017;318(15):1445-1447

Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study
Ng Jh, Iyer Ng, Tan Mh, Edgren G
Head & neck 2017;39(2):297-304

Deferral for low hemoglobin is not associated with increased risk of infection in Danish blood donors
Kotzé Sr, Pedersen Ob, Petersen Ms, Sørensen E, Manh Dinh K, Agergård Kaspersen K, et al
Transfusion 2017;57(3):571-577

Demographic and epidemiologic characterization of transfusion recipients from four US regions: evidence from the REDS-III recipient database
National Heart Lung And Blood Institute Recipient Epidemiology And Donor Evaluation Study-iii (reds-iii), Karafin Ms, Bruhn R, Westlake M, Sullivan Mt, Bialkowski W, et al
Transfusion 2017;57(12):2903-2913

Haemoglobin decline before coeliac disease diagnosis: a nationwide transfusion cohort study of 1.1 million blood donors
Ludvigsson Jf, Sjölander A, Murray Ja, Hjalgrim H, Edgren G
Gut 2017;66(11):2036-2037

Is there a standard-of-care for transfusion support of patients with haematological malignancies?
Zhao J, Edgren G, Stanworth Sj
Current opinion in hematology 2017;24(6):515-520

Length of Storage of Red Blood Cells and Patient Survival After Blood Transfusion: A Binational Cohort Study
Halmin M, Rostgaard K, Lee Bk, Wikman A, Norda R, Nielsen Kr, et al
Annals of internal medicine 2017;166(4):248-256

No association between frequent apheresis donation and risk of fractures: a retrospective cohort analysis from Sweden
National Heart Lung And Blood Institute (nhlbi) Recipient Epidemiology And Donor Evaluation Study-iii (reds-iii), Grau K, Vasan Sk, Rostgaard K, Bialkowski W, Norda R, et al
Transfusion 2017;57(2):390-396

Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a Swedish cohort study
Mörner Me, Edgren G, Martling A, Gunnarsson U, Egenvall M
International journal of colorectal disease 2017;32(2):223-232

Sex differences in cancer risk and survival: A Swedish cohort study
Radkiewicz C, Johansson Alv, Dickman Pw, Lambe M, Edgren G
European journal of cancer (Oxford, England : 1990) 2017;84():130-140

Socio-demographic characteristics of Danish blood donors
Burgdorf Ks, Simonsen J, Sundby A, Rostgaard K, Pedersen Ob, Sørensen E, et al
PloS one 2017;12(2):e0169112-

Weekday and Survival After Cardiac Surgery-A Swedish Nationwide Cohort Study in 106 473 Patients
Dalén M, Edgren G, Ivert T, Holzmann Mj, Sartipy U
Journal of the American Heart Association 2017;6(5):-

ABO blood group and risk of cancer: A register-based cohort study of 1.6 million blood donors
Vasan Sk, Hwang J, Rostgaard K, Nyrén O, Ullum H, Pedersen Obv, et al
Cancer epidemiology 2016;44():40-43

ABO Blood Group and Risk of Thromboembolic and Arterial Disease: A Study of 1.5 Million Blood Donors
Vasan Sk, Rostgaard K, Majeed A, Ullum H, Titlestad Ke, Pedersen Ob, et al
Circulation 2016;133(15):1449-57

A case management intervention targeted to reduce healthcare consumption for frequent Emergency Department visitors: results from an adaptive randomized trial
Edgren G, Anderson J, Dolk A, Torgerson J, Nyberg S, Skau T, et al

["Active health management" can provide support for vulnerable patients. New model for the prevention of unplanned healthcare]
Edgren G, Anderson J, Dolk A, Torgerson J, Nyberg S, Skau T, et al
Lakartidningen 2016;113():-

Blood donation and risk of polycythemia vera
Edgren G, Nyrén O, Hultcrantz M, Nielsen Kr, Pedersen Ob, Björkholm M, et al
Transfusion 2016;56(6 Pt 2):1622-7

Cardiovascular Events Associated With Use of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: A Population-Based Cohort Study
Swedish Cml Group And The Swedish Cml Register Group, Dahlén T, Edgren G, Lambe M, Höglund M, Björkholm M, et al
Annals of internal medicine 2016;165(3):161-6

Citrate anticoagulation: Are blood donors donating bone?
Bialkowski W, Bruhn R, Edgren G, Papanek P
Journal of clinical apheresis 2016;31(5):459-63

Epidemiology of Massive Transfusion: A Binational Study From Sweden and Denmark
Halmin M, Chiesa F, Vasan Sk, Wikman A, Norda R, Rostgaard K, et al
Critical care medicine 2016;44(3):468-77

Haemostasis monitored in stored red blood cells, plasma and platelet concentrates in the proportion of 4 :  4 :  1 diluted with crystalloids and colloids
Ågren A, Edgren G, Ambrosio D, Gryfelt G, Östlund A, Wikman A
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2016;27(3):334-9

Lack of association between blood donor age and survival of transfused patients
Vasan Sk, Chiesa F, Rostgaard K, Magnusson Pk, Halmin M, Nielsen Kr, et al
Blood 2016;127(5):658-61

Replik angående könsomatchade transfusioner: - Vår slutsats om könsmatchning av blodenheter står fast
Edgren G
Lakartidningen 2016;113():-

[Reply to Carl-Gustaf Elinder: Active health management - neither new nor unknown intervention]
Edgren G, Andersson J, Dolk A, Torgerson J, Nyberg S, Skau T, et al
Lakartidningen 2016;113():-

Risk of basal cell carcinoma in Swedish organ transplant recipients: a population-based study
Krynitz B, Olsson H, Lundh Rozell B, Lindelöf B, Edgren G, Smedby Ke
The British journal of dermatology 2016;174(1):95-103

Sex-Discordant Blood Transfusions and Survival After Cardiac Surgery: A Nationwide Cohort Study
Holzmann Mj, Sartipy U, Olsson Ml, Dickman P, Edgren G
Circulation 2016;134(21):1692-1694

The impact of in situ breast cancer and family history on risk of subsequent breast cancer events and mortality - a population-based study from Sweden
Sackey H, Hui M, Czene K, Verkooijen H, Edgren G, Frisell J, et al
Breast cancer research : BCR 2016;18(1):105-

Transmission of Neurodegenerative Disorders Through Blood Transfusion: A Cohort Study
Edgren G, Hjalgrim H, Rostgaard K, Lambert P, Wikman A, Norda R, et al
Annals of internal medicine 2016;165(5):316-24

ABO Blood Group and Dementia Risk--A Scandinavian Record-Linkage Study
Vasan Sk, Rostgaard K, Ullum H, Melbye M, Hjalgrim H, Edgren G
PloS one 2015;10(6):e0129115-

Blood donation and blood donor mortality after adjustment for a healthy donor effect
Ullum H, Rostgaard K, Kamper-jørgensen M, Reilly M, Melbye M, Nyrén O, et al
Transfusion 2015;55(10):2479-85

No evidence of transmission of chronic lymphocytic leukemia through blood transfusion
Hjalgrim H, Rostgaard K, Vasan Sk, Ullum H, Erikstrup C, Pedersen Ob, et al
Blood 2015;126(17):2059-61

Red Blood Cell Concentrate Storage and Survival After Cardiac Surgery
Sartipy U, Holzmann Mj, Hjalgrim H, Edgren G
JAMA 2015;314(15):1641-3

The heritability of blood donation: a population-based nationwide twin study
Pedersen Ob, Axel S, Rostgaard K, Erikstrup C, Edgren G, Nielsen Kr, et al
Transfusion 2015;55(9):2169-74

The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility
Edgren G, Rostgaard K, Vasan Sk, Wikman A, Norda R, Pedersen Ob, et al
Transfusion 2015;55(7):1600-6

In response
Agren A, Wikman A, Ostlund A, Edgren G
Anesthesia and analgesia 2014;119(6):1453-

In vitro combinations of red blood cell, plasma and platelet components evaluated by thromboelastography
Agren A, Edgren G, Kardell M, Ostlund A, Wikman At
Blood transfusion = Trasfusione del sangue 2014;12(4):491-6

Pregnancy during breast cancer: does a mother's parity status modify an offspring's mortality risk?
Simonella L, Verkooijen Hm, Edgren G, Liu J, Hui M, Salim A, et al
Breast cancer research and treatment 2014;146(2):393-9

Splenectomy and the risk of sepsis: a population-based cohort study
Edgren G, Almqvist R, Hartman M, Utter Gh
Annals of surgery 2014;260(6):1081-7

TEG® functional fibrinogen analysis may overestimate fibrinogen levels
Agren A, Wikman At, Ostlund A, Edgren G
Anesthesia and analgesia 2014;118(5):933-5

The authors reply
Halmin Ma, Edgren G
Critical care medicine 2014;42(3):e245-6

A global assessment of the oesophageal adenocarcinoma epidemic
Edgren G, Adami Ho, Weiderpass E, Nyrén O
Gut 2013;62(10):1406-14

A global assessment of the oesophageal adenocarcinoma epidemic (vol 62, pg 1406, 2013)
Edgren G, Adami Ho, Weiderpass E
GUT 2013;62(12):1820-1820

A telephone-based case-management intervention reduces healthcare utilization for frequent emergency department visitors
Reinius P, Johansson M, Fjellner A, Werr J, Ohlén G, Edgren G
European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2013;20(5):327-34

Effect of plasma-to-RBC ratios in trauma patients: a cohort study with time-dependent data*
Halmin M, Boström F, Brattström O, Lundahl J, Wikman A, Östlund A, et al
Critical care medicine 2013;41(8):1905-14

Mammographic density reduction is a prognostic marker of response to adjuvant tamoxifen therapy in postmenopausal patients with breast cancer
Li J, Humphreys K, Eriksson L, Edgren G, Czene K, Hall P
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(18):2249-56

Overall and cause-specific mortality in transplant recipients with a pretransplantation cancer history
Brattström C, Granath F, Edgren G, Smedby Ke, Wilczek He
Transplantation 2013;96(3):297-305

Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008--a Swedish population-based study
Krynitz B, Edgren G, Lindelöf B, Baecklund E, Brattström C, Wilczek H, et al
International journal of cancer 2013;132(6):1429-38

Screening, case finding or primary cancer prevention in the developing world?
Edgren G, Lagiou P, Trichopoulos D, Adami Ho
European journal of epidemiology 2013;28(4):287-90

Thromboelastography (TEG®) compared to conventional coagulation tests in surgical patients--a laboratory evaluation
Ågren A, Wikman At, Holmström M, Östlund A, Edgren G
Scandinavian journal of clinical and laboratory investigation 2013;73(3):214-20

Enigmatic sex disparities in cancer incidence
Edgren G, Liang Lm, Adami Ho, Chang Et

Epidemiology of adult ankle fractures in Sweden between 1987 and 2004 A population-based study of 91,410 Swedish inpatients
Thur Ck, Edgren G, Jansson Ka, Wretenberg P
ACTA ORTHOPAEDICA 2012;83(3):276-81

Temporal Trends in Cause of Death Among Swedish and US Men with Prostate Cancer
Epstein Mm, Edgren G, Rider Jr, Mucci La, Adami Ho

The impact of plasma preparations and their storage time on short-term posttransfusion mortality: A population-based study using the Scandinavian Donation and Transfusion database
Norda R, Andersson Tml, Edgren G, Nyren O, Reilly M

[The risk of acute readmission can be predicted. Former care consumption patterns and certain diagnoses are strongly predictive]
Stäck P, Forsberg B, Högberg M, Werr J, Edgren G
Lakartidningen 2012;109(48):2211-5

[TRALI is an overlooked transfusion reaction. Can be life-threatening, increased knowledge among Swedish physicians is needed]
Halmin M, Wikman At, Edgren G
Lakartidningen 2012;109(1-2):34-7

Response to "Alternate analysis strategies for retrospective assessment of outcomes with a male donor-only plasma policy" by Welsby, Stafford-Smith, and Phillips-Bute
Reilly M, Nyren O, Andersson Tml, Edgren G, Norda R, Shanwell A, et al
TRANSFUSION 2011;51(2):445-446

Time Trends in Risk and Risk Determinants of Non-Hodgkin Lymphoma in Solid Organ Transplant Recipients
Fernberg P, Edgren G, Adami J, Ingvar A, Bellocco R, Tufveson G, et al

Diagnostic work-up of contralateral breast cancers has not improved over calendar period
Sandberg Mec, Hartman M, Edgren G, Eloranta S, Ploner A, Hall P, et al

Duration of red blood cell concentrate storage and survival of transfused patients. (vol 50, pg 1185, 2010)
Edgren G, Kamper-jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullman H, et al
TRANSFUSION 2010;50(8):1857-1857

Duration of red blood cell storage and survival of transfused patients (CME)
Edgren G, Kamper-jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullum H, et al
TRANSFUSION 2010;50(6):1185-95

Epidemiological considerations for the use of databases in transfusion research: a Scandinavian perspective
Edgren G, Hjalgrim H

Expensive blood safety initiatives may offer less benefit than we think
Kamper-jorgensen M, Hjalgrim H, Edgren G, Titlestad K, Ullum H, Shanwell A, et al
TRANSFUSION 2010;50(1):240-2

Ullum H, Kamper-jorgensen M, Edgren G, Rostgaard K, Melbye M, Nyren O, et al
VOX SANGUINIS 2010;:184-185

Pattern of declining hemoglobin concentration before cancer diagnosis
Edgren G, Bagnardi V, Bellocco R, Hjalgrim H, Rostgaard K, Melbye M, et al

Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study
Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, et al

Should plasma from female donors be avoided? A population-based cohort study of plasma recipients in Sweden from 1990 through 2002
Tynell E, Andersson Tm, Norda R, Edgren G, Nyren O, Shanwell A, et al
TRANSFUSION 2010;50(6):1249-56

Custer S, Kamper-jorgensen M, Rostgaard K, Edgren G
VOX SANGUINIS 2010;:228-228

Blood transfusion exposure in Denmark and Sweden
Kamper-jorgensen M, Edgren G, Rostgaard K, Biggar Rj, Nyren O, Reilly M, et al
TRANSFUSION 2009;49(5):888-94

Post-transfusion mortality among recipients of ABO-compatible but non-identical plasma
Shanwell A, Andersson Tml, Rostgaard K, Edgren G, Hjalgrim H, Norda R, et al
VOX SANGUINIS 2009;96(4):316-23

Socioeconomic Differences in Patient Survival Are Increasing for Acute Myeloid Leukemia and Multiple Myeloma in Sweden
Kristinsson Sy, Derolf Ar, Edgren G, Dickman Pw, Bjorkholm M

Blood transfusion exposure in Denmark and Sweden
Kamper-jorgensen M, Rostgaard K, Biggar R, Edgren G, Nyren O, Reilly M, et al
TRANSFUSION 2008;48(2):202A-202A

Breast cancer onset in twins and women with bilateral disease
Hartman M, Hall P, Edgren G, Reilly M, Lindstrom L, Lichtenstein P, et al

Cancer as a ferrotoxic disease: Are we getting hard stainless evidence?
Edgren G, Nyren O, Melbye M

Donation frequency, iron loss, and risk of cancer among blood donors
Edgren G, Reilly M, Hjalgrim H, Tran Tn, Rostgaard K, Adami J, et al

Survival after blood transfusion
Kamper-jargensen M, Ahlgren M, Rostgaard K, Edgren G, Nyren O, Reilly M, et al
TRANSFUSION 2008;48(2):206A-206A

Survival after blood transfusion
Kamper-jorgensen M, Ahlgren M, Rostgaard K, Melbye M, Edgren G, Nyren O, et al
TRANSFUSION 2008;48(12):2577-84

Cancer incidence in blood transfusion recipients
Hjalgrim H, Edgren G, Rostgaard K, Reilly M, Tran Tn, Titlestad Ke, et al

Improving health profile of blood donors as a consequence of transfusion safety efforts
Edgren G, Tran Tn, Hjalgrim H, Rostgaard K, Shanwell A, Titlestad K, et al
TRANSFUSION 2007;47(11):2017-24

Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study
Edgren G, Sparen P
LANCET ONCOLOGY 2007;8(4):311-6

Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study
Edgren G, Hjalgrim H, Reilly M, Tran Tn, Rostgaard K, Shanwell A, et al
LANCET 2007;369(9574):1724-30

Risk of cancer from blood donated by people with cancer - Reply
Nyren O, Edgren G, Hjalgrim H, Reilly M, Melbye M
LANCET 2007;370(9587):563-564

A population-based binational register for monitoring long-term outcome and possible disease concordance among blood donors and recipients
Edgren G, Hjalgrim H, Tran Tn, Rostgaard K, Shanwell A, Titlestad K, et al
VOX SANGUINIS 2006;91(4):316-23

Survival after blood transfusion - A study of more than one mill on transfusion recipients
Titlestad K, Ahlgren M, Hjalgrim H, Rostgaard Petersen K, Shanwell A, Edgren G, et al
VOX SANGUINIS 2006;:27-27

[Health care services during summer--a dilemma?]
Nordenvall C, Edgren G, Gillispie A, Larsson M, Adami J, Johansson A, et al
Lakartidningen 2004;101(4):290-2

[Medical students' requirements: Make the medical education more scientific!]
Edgren G
Lakartidningen 2002;99(41):4078-9

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