Gunnar Nordvall

Publications
Public outreach and news

Articles

Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2025;392(4):103400
y-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice
Nordvall G; Yan P; Agholme L; Lundkvist J; Sandin J; Biverstal H; Winblad B; Zetterberg H; Klintenberg R; Ferm M; Cirrito JR; Lee J-M
Article: ACS CHEMICAL NEUROSCIENCE. 2024;15(22):4210-4219
Identification and In Vitro and In Vivo Characterization of KAC-50.1 as a Potential α-Synuclein PET Radioligand
Guarino DS; Azpiazu PM; Sunnemark D; Elmore CS; Bergare J; Artelsmair M; Nordvall G; Moren AF; Jia Z; Cortes-Gonzalez M; Mach R; Wilcox KC; Finnema S; Schou M; Varrone A
Article: PSYCHOPHARMACOLOGY. 2023;240(8):1789-1804
Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling - a potential therapeutic concept?
Madjid N; Lidell V; Nordvall G; Lindskog M; Ogren S-O; Forsell P; Sandin J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(13):11159
Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer's Disease
Fernandez CP; Juric S; Backlund M; Dahlstrom M; Madjid N; Lidell V; Rasti A; Sandin J; Nordvall G; Forsell P
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2022;26(3):880-892
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing
Weber TA; Lundkvist J; Wanngren J; Kvartsberg H; Jin S; Larssen P; Wu D; Oliveira DV; Minta K; Brinkmalm G; Zetterberg H; Blennow K; Nordvall G; Winblad B; Portelius E; Karlstrom H
Article: CELLS. 2021;10(8):1871
Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction
Dahlstrom M; Madjid N; Nordvall G; Halldin MM; Vazquez-Juarez E; Lindskog M; Sandin J; Winblad B; Eriksdotter M; Forsell P
Article: BMC BIOLOGY. 2021;19(1):57
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling
Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2019;50(9):3487-3501
Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons
Dahlstrom M; Nordvall G; Sundstrom E; Akesson E; Tegerstedt G; Eriksdotter M; Forsell P
Article: NEUROSCIENCE. 2015;298:112-119
Small constrained SP1-7 analogs bind to a unique site and promote anti-allodynic effects following systemic injection in mice.
Jonsson A; Fransson R; Haramaki Y; Skogh A; Brolin E; Watanabe H; Nordvall G; Hallberg M; Sandström A; Nyberg F
Article: ACS MEDICINAL CHEMISTRY LETTERS. 2014;5(12):1272-1277
Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.
Fransson R; Nordvall G; Bylund J; Carlsson-Jonsson A; Kratz JM; Svensson R; Artursson P; Hallberg M; Sandström A
Article: FRONTIERS IN PHARMACOLOGY. 2014;5:102
The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries
Lundkvist J; Halldin MM; Sandin J; Nordvall G; Forsell P; Svensson S; Jansson L; Johansson G; Winblad B; Ekstrand J
Article: ACS MEDICINAL CHEMISTRY LETTERS. 2014;5(4):440-445
Creation of Novel Cores for β-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy.
Viklund J; Kolmodin K; Nordvall G; Swahn B-M; Svensson M; Gravenfors Y; Rahm F
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(8):3177-3190
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).
Karlström S; Nordvall G; Sohn D; Hettman A; Turek D; Åhlin K; Kers A; Claesson M; Slivo C; Lo-Alfredsson Y; Petersson C; Bessidskaia G; Svensson PH; Rein T; Jerning E; Malmberg Å; Ahlgen C; Ray C; Vares L; Ivanov V; Johansson R
Article: EXPERIMENTAL CELL RESEARCH. 2005;302(1):108-114
A basic peptide within the juxtamembrane region is required for EGF receptor dimerization
Aifa S; Aydin J; Nordvall G; Lundström I; Svensson SPS; Hermanson O
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2004;47(16):3927-3930
Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists.
Holmberg P; Sohn D; Leideborg R; Caldirola P; Zlatoidsky P; Hanson S; Mohell N; Rosqvist S; Nordvall G; Johansson AM; Johansson R
Article: JOURNAL OF NEUROIMMUNOLOGY. 2003;142(1-2):75-85
Effector stage CC chemokine receptor-1 selective antagonism reduces multiple sclerosis-like rat disease
Eltayeb S; Sunnemark D; Berg AL; Nordvall G; Malmberg Å; Lassmann H; Wallström E; Olsson T; Ericsson-Dahlstrand A
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2000;43(15):2837-2850
Synthesis of novel 5-substituted 3-amino-3,4-dihydro-2H-1-benzopyran derivatives and their interactions with the 5-HT1A receptor.
Hammarberg E; Nordvall G; Leideborg R; Nylöf M; Hanson S; Johansson L; Thorberg SO; Tolf BR; Jerning E; Svantesson GT; Mohell N; Ahlgren C; Westlind-Danielsson A; Csöregh I; Johansson R
Article: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION. 1998;18(4-6):225-241
Mutagenesis of the human 5-HT1B receptor: differences from the closely related 5-HT1A receptor and the role of residue F331 in signal transduction.
Grånäs C; Nordvall G; Larhammar D
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;349(2-3):367-375
Site-directed mutagenesis of the human 5-HT1B receptor.
Grånäs C; Nordvall G; Larhammar D
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;346(2-3):299-307
Interactions of ligands with active and inactive conformations of the dopamine D2 receptor.
Malmberg A; Mohell N; Backlund Höök B; Johansson AM; Hacksell U; Nordvall G
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1997;40(23):3804-3819
Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.
Johansson G; Sundquist S; Nordvall G; Nilsson BM; Brisander M; Nilvebrant L; Hacksell U
Article: FEBS JOURNAL. 1997;249(2):601-606
Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1
Berthold M; Kahl U; Jureus A; Kask K; Nordvall G; Langel U; Bartfai T
Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 1997;37(4):812-818
Molecular design using the minireceptor concept.
Jansen JM; Koehler KF; Hedberg MH; Johansson AM; Hacksell U; Nordvall G; Snyder JP
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1996;39(18):3503-3513
11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.
Hedberg MH; Linnanen T; Jansen JM; Nordvall G; Hjorth S; Unelius L; Johansson AM
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1996;39(18):3491-3502
10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.
Hedberg MH; Jansen JM; Nordvall G; Hjorth S; Unelius L; Johansson AM
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1996;39(17):3269-3277
3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.
Nordvall G; Sundquist S; Johansson G; Glas G; Nilvebrant L; Hacksell U
Article: EMBO JOURNAL. 1996;15(2):236-244
Delineation of the peptide binding site of the human galanin receptor.
Kask K; Berthold M; Kahl U; Nordvall G; Bartfai T
Article: CHIRALITY. 1996;8(8):531-544
Synthesis and pharmacology of the enantiomers of UH301: opposing interactions with 5-HT1A receptors.
Hillver SE; Björk L; Höök BB; Cortizo L; Nordvall G; Johansson AM; Ertan A; Csöregh I; Johansson L; Lewander T; Hacksell U
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1995;38(4):647-658
(R)-11-hydroxy- and (R)-11-hydroxy-10-methylaporphine: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.
Hedberg MH; Johansson AM; Nordvall G; Yliniemelä A; Li HB; Martin AR; Hjorth S; Unelius L; Sundell S; Hacksell U
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1995;38(3):473-487
3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships.
Nilsson BM; Sundquist S; Johansson G; Nordvall G; Glas G; Nilvebrant L; Hacksell U
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1995;38(1):150-160
Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
Liu Y; Yu H; Mohell N; Nordvall G; Lewander T; Hacksell U
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Review: PHARMACEUTICALS. 2024;17(8):997
Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer's Disease
Forsell P; Fernandez CP; Nilsson B; Sandin J; Nordvall G; Segerdahl M
Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2023;16:1279740
Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease
Nordvall G; Lundkvist J; Sandin J
Review: DRUG DISCOVERY TODAY. 2022;27(10):103318
Neurotrophin-targeted therapeutics: A gateway to cognition and more?
Nordvall G; Forsell P; Sandin J
Review: DESIGN OF COVALENT-BASED INHIBITORS. 2014;49:59-73
Stimulating Neurotrophin Receptors in the Treatment of Neurodegenerative Disorders
Nordvall G; Forsell P
Letter: JOURNAL OF MEDICINAL CHEMISTRY. 2001;44(9):1337-1340
Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.
Linnanen T; Brisander M; Unelius L; Rosqvist S; Nordvall G; Hacksell U; Johansson AM
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1998;863:78-85
Mutagenesis study on human galanin receptor GalR1 reveals domains involved in ligand binding
Kask K; Berthold M; Kahl U; Juréus A; Nordvall G; Langel U; Bartfai T
Review: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 1996;109:141-145
3-Heteroarylquinuclidin-2-ene derivatives as muscarinic antagonists: synthesis, structure-activity relationships and molecular modelling.
Nordvall G; Nilsson BM; Sundquist S; Johansson G; Glas G; Nilvebrant L; Hacksell U
Published conference paper: LIFE SCIENCES. 1995;56(11-12):831-836
Quinuclidin-2-ene-based muscarinic antagonists.
Hacksell U; Nilsson BM; Nordvall G; Johansson G; Sundquist S; Nilvebrant L

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