Gilberto Fisone
Professor
| Head of department
E-mail: gilberto.fisone@ki.se
Telephone: +46852487375
Visiting address: , Solna
Postal address: C4 Neurovetenskap, C4 Forskning Fisone, 171 77 Stockholm
About me
Education
1990 – Ph.D. Stockholm University.
1991-1994 – Postdoctoral Fellow, The Rockefeller University, New York.
1994-1995 – Assistant Professor, The Rockefeller University, New York.
1996-2000 – Assistant Professor, Department of Neuroscience, Karolinska Institutet.
2000-2006 – Associate Professor, Department of Neuroscience, Karolinska Institutet.
From 2006 – Professor of Neuroscience, Department of Neuroscience, Karolinska Institutet.From 20018 – Chair, Department of Neuroscience, Karolinska Institutet
Research
- We study signal transduction mechanisms involved in neurodegenerative and neuropsychiatric disorders, such as Parkinson’s disease, schizophrenia and drug addiction. We have been particularly interested in the study of dopamine transmission, which is profoundly affected in all these conditions.
Our final goal is to identify molecular changes, which may represent novel targets for therapeutic interventions. Methodology is based on a combination of molecular biological, biochemical and behavioral techniques. Disease modelling coupled to cell-targeted expression of fluorescent proteins is used to investigate abnormal signaling and gene expression at the level of discrete groups of neurons. In parallel, specific signaling components are studied at the biochemical and behavioral level using pharmacological tools, or by manipulating their expression both systemically and in a cell-specific manner. Using these strategies we have characterized key molecular events involved in the effects of various classes of psychoactive drugs. We have also identified abnormalities in signal transduction affecting distinct neuronal populations and underlying the severe motor complications, or dyskinesia, caused by prolonged administration of L-DOPA to parkinsonian patients. More recently, we have started to investigate the mechanisms at the basis of non-motor symptoms of PD, which include cognitive impairment and neuropsychiatric conditions, such as depression and anxiety.
We are also studying the effects of typical and atypical antipsychotic drugs on signal transduction processes in various brain regions.
Articles
-
Journal article: MOLECULAR PSYCHIATRY. 2024;:1-10
-
Article: HELIYON. 2024;10(16):e35948
-
Journal article: ELIFE. 2024;12
-
Article: INTERNATIONAL REVIEW OF NEUROBIOLOGY. 2024;p. 119-186
-
Article: PROGRESS IN NEUROBIOLOGY. 2023;231:102536
-
Article: NATURE COMMUNICATIONS. 2022;13(1):5944
-
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(19):11637
-
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2108768119
-
Article: BIOMEDICINES. 2021;9(6):598
-
Article: MOVEMENT DISORDERS. 2021;36(5):1137-1146
-
Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2021;41(1):191-198
-
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29(5):616-628
-
Article: FRONTIERS IN NEUROSCIENCE. 2019;13:683
-
Article: NATURE NEUROSCIENCE. 2018;21(6):834-842
-
Article: NEUROBIOLOGY OF DISEASE. 2018;110:37-46
-
Article: NATURE. 2018;553(7689):455-460
-
Article: FRONTIERS IN NEUROLOGY. 2018;9:208
-
Article: NATURE NEUROSCIENCE. 2018;21(1):139-149
-
Article: NATURE COMMUNICATIONS. 2017;8(1):293
-
Article: NEURON. 2017;94(4):855-865.e5
-
Article: NATURE BIOTECHNOLOGY. 2017;35(5):444-452
-
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1088
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2017;45(1):73-91
-
Article: NEUROBIOLOGY OF DISEASE. 2016;96:201-215
-
Article: NEUROPHARMACOLOGY. 2016;107:89-99
-
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(6):pyv134
-
Article: BIOLOGICAL PSYCHIATRY. 2016;79(5):362-371
-
Article: EXPERIMENTAL NEUROLOGY. 2014;261:733-743
-
Article: PLOS GENETICS. 2014;10(9):e1004574
-
Article: BIOLOGICAL PSYCHIATRY. 2014;75(9):701-710
-
Article: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2014;8:290
-
Article: NEUROPHARMACOLOGY. 2014;76:127-136
-
Article: NEUROBIOLOGY OF DISEASE. 2013;58:116-122
-
Article: JOURNAL OF NEUROSCIENCE. 2013;33(36):14331-14341
-
Article: NEUROPHARMACOLOGY. 2013;72:197-203
-
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(3):240-252
-
Article: NEUROPHARMACOLOGY. 2013;66:179-186
-
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(2):146-159
-
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(33):27806-27812
-
Article: EXPERIMENTAL NEUROLOGY. 2011;232(2):240-250
-
Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(12):2561-2570
-
Article: PLOS ONE. 2011;6(5):e19415
-
Article: JOURNAL OF PARKINSONS DISEASE. 2011;1(4):339-346
-
Article: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2011;5:71
-
Article: PLOS ONE. 2010;5(8):e12322
-
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14845-14850
-
Article: CELL CYCLE. 2010;9(14):2713-2718
-
Article: NEUROBIOLOGY OF DISEASE. 2010;38(3):434-445
-
Article: SCIENCE SIGNALING. 2009;2(80):ra36
-
Article: NEUROPSYCHOPHARMACOLOGY. 2009;34(7):1710-1720
-
Article: FASEB JOURNAL. 2009;23(2):613-622
-
Article: JOURNAL OF NEUROCHEMISTRY. 2009;108(3):621-633
-
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;39(4):586-591
-
Article: NEUROSCIENCE. 2008;156(3):515-526
-
Article: JOURNAL OF NEUROSCIENCE. 2008;28(41):10404-10414
-
Article: NEUROPHARMACOLOGY. 2008;55(2):230-237
-
Article: NEUROPHARMACOLOGY. 2008;54(7):1051-1061
-
Article: NEUROPHARMACOLOGY. 2008;54(5):815-823
-
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;37(2):335-345
-
Article: NEUROPHARMACOLOGY. 2008;54(1):31-35
-
Journal article: NEUROPSYCHOPHARMACOLOGY. 2007;32(11):2440
-
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):8-14
-
Article: NEUROPSYCHOPHARMACOLOGY. 2007;32(9):1995-2003
-
Article: JOURNAL OF NEUROSCIENCE. 2007;27(26):6995-7005
-
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2006;31(2):293-302
-
Article: JOURNAL OF NEUROCHEMISTRY. 2006;96(2):482-488
-
Article: JOURNAL OF NEUROSCIENCE. 2005;25(37):8432-8438
-
Article: EXPERIMENTAL NEUROLOGY. 2005;194(1):66-75
-
Article: ANNALS OF NEUROLOGY. 2005;57(1):17-26
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2004;20(4):1108-1112
-
Article: NEUROPHARMACOLOGY. 2004;47:14-23
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(5):1265-1278
-
Article: JOURNAL OF NEUROCHEMISTRY. 2003;86(2):451-459
-
Article: NATURE NEUROSCIENCE. 2003;6(5):501-506
-
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(7):4305-4309
-
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2002;91(6):382-386
-
Article: NATURE. 2002;418(6899):774-778
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2002;15(4):769-773
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2001;13(4):773-780
-
Article: JOURNAL OF NEUROCHEMISTRY. 2000;75(1):248-257
-
Article: JOURNAL OF NEUROCHEMISTRY. 2000;74(6):2470-2477
-
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(4):1856-1860
-
Article: JOURNAL OF NEUROCHEMISTRY. 1999;73(4):1492-1501
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(7):2589-2592
-
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(6):2182-2186
-
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;275(6):F863-F869
-
Article: NEUROSCIENCE. 1998;84(1):223-228
-
Article: MOLECULAR MEDICINE. 1998;4(4):258-265
-
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(3):c893-c901
-
Journal article: JOURNAL OF NEUROCHEMISTRY. 1994;63(5):1766-1771
-
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1993;90(23):11277-11281
-
Journal article: BRAIN RESEARCH. 1993;612(1-2):258-262
-
Journal article: BRAIN RESEARCH. 1992;589(1):33-38
-
Journal article: TRENDS IN PHARMACOLOGICAL SCIENCES. 1992;13(8):312-317
-
Journal article: BRAIN RESEARCH. 1991;568(1-2):279-284
-
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1991;203(1):111-114
-
Journal article: JOURNAL OF NEUROCHEMISTRY. 1991;56(3):739-747
-
Journal article: JOURNAL OF NEUROSCIENCE. 1990;10(11):3695-3700
-
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1990;182(1):137-141
-
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1989;86(23):9588-9591
-
Journal article: FEBS JOURNAL. 1989;181(1):269-276
-
Journal article: BRAIN RESEARCH. 1988;461(1):194-198
-
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1988;148(3):479-480
-
Journal article: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 1988;28:285-310
-
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1987;84(20):7339-7343
-
Journal article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1986;334(1):86-91
-
Journal article: PHYSIOLOGY & BEHAVIOR. 1986;38(3):321-326
-
Journal article: BIOCHEMICAL PHARMACOLOGY. 1983;32(19):2993-2996
- Show more
All other publications
-
Preprint: BIORXIV. 2024;BIORXIV
-
Review: FRONTIERS IN PHARMACOLOGY. 2019;10:1414
-
Review: JOURNAL OF NEURAL TRANSMISSION. 2018;125(8):1171-1186
-
Review: PROGRESS IN NEUROBIOLOGY. 2015;132:96-168
-
Book chapter: DOPAMINE RECEPTOR TECHNOLOGIES: NEUROMETHODS. 2015;p. 79-100
-
Editorial comment: CURRENT PROTEIN & PEPTIDE SCIENCE. 2014;15(7):647
-
Review: LEARNING & MEMORY. 2013;20(10):592-600
-
Review: NEUROPHARMACOLOGY. 2013;66:53-64
-
Editorial comment: PARKINSONS DISEASE. 2012;2012:639080-2
-
Editorial comment: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2012;6:72
-
Review: FRONTIERS IN NEUROANATOMY. 2011;5:38
-
Review: INTERNATIONAL REVIEW OF NEUROBIOLOGY. 2011;98:95-122
-
Editorial comment: EXPERIMENTAL NEUROLOGY. 2010;226(1):11-14
-
Review: TRENDS IN NEUROSCIENCES. 2009;32(10):538-547
-
Review: FEBS JOURNAL. 2008;275(7):1392-1399
-
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S5-S6
-
Published conference paper: PROGRESS IN NEUROBIOLOGY. 2007;83(5):277-292
-
Published conference paper: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2007;31(1):79-88
-
Published conference paper: PARKINSONISM & RELATED DISORDERS. 2005;11:S25-S29
-
Published conference paper: PARKINSONISM & RELATED DISORDERS. 2004;10(5):281-286
-
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(7-8):857-872
-
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2004;44:269-296
-
Corrigendum: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(6):1717
-
Review: PROGRESS IN NEUROBIOLOGY. 1999;59(4):355-396
-
Letter: NEUROSCIENCE. 1999;88(4):1005-1008
-
Published conference paper: BRAIN RESEARCH REVIEWS. 1998;26(2-3):274-284
-
Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(6):2427-2430
-
Book chapter: NEUROPEPTIDE TECHNOLOGY - GENE EXPRESSION AND NEUROPEPTIDE RECEPTORS: METHODS IN NEUROSCIENCES. 1991;p. 225-234
-
Book chapter: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 1990;p. 279-287
-
Book chapter: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 1989;p. 85-91
- Show more
Employments
- Professor, Department of Neuroscience, Karolinska Institutet, 2006-
Leadership and responsibility assignments
- Head of department, Department of Neuroscience, Karolinska Institutet, 2021-