Ghada Nouairia

Ghada Nouairia

Postdoctoral Researcher
Visiting address: Karolinska Universitetssjukhuset Huddinge, C177, 14186 Huddinge
Postal address: H7 Medicin, Huddinge, H7 Gastroenterologi och Reumatologi Bergquist, 171 77 Stockholm
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About me

  • Computational oncologist and bioinformatician with focus on clinical research in oncology and hepato-biliary disorders. 


  • With a background in engineering, a PhD in molecular genetics since 2018 (Carthage University, Tunisia) and a master degree equivalent in Bioinformatics and genomics (Institut Pasteur), I have innovative, interdisciplinary solutions to medical and translational research questions. Specifically, I apply computational methods, including machine learning, deep learning and neural networks in disease modelling and biomarker discovery for different types of cancers (cholangiocarcinoma and gallladder cancer) and liver disorders such as primary sclerosing cholangitis, using multiomics data analysis (namely epigenomics, proteomics, metabolomics, auto-antibodies and expression data).

     

  • Previously, I explored computational and molecular evolution in Stockholm University where I studied the evolution and the diversity of a key protein family (riboluncleotide reductases: RNRs) in the tree of life. I also studied genomics and population genetics in animal species.


    I am also part of the Center for Bioinformatics and Biostatistics (CBB) where I offer mentoring and consulting in bioinformatics and computational methods for PhD students and researchers. I am as well involved in many teaching activities at CBB including educational seminars and workshops.
    In Karolinska Institutet, I am a member of the bioinformaticians network and the WISE network.


    More importantly, I am an eager reader of science, psychology, history, politics (and much more) and am hungry for such discussions!

Research

  • Primary sclerosing cholangitis (PSC) is a chronic liver disease with the dramatic outcomes of premature death, liver transplantation or malignancy development (cholangiocarcinoma CCA, colorectal cancer CRC or Gallbladder cancer GBC). Unfortunately, Scandinavia is the most touched area in the world. The underlying pathophysiologic mechanisms of PSC and other Biliary Tract Cancers (BTC) are poorly understood and the ability to diagnose them early and to predict their progression is crucial.
    We aim to contribute to the understanding of these -often- related disorders and to develop clinical tools for diagnosis, prognosis and monitoring of these diseases, by combining long clinical experience and the promising multiomics technologies.

Teaching

  • As a mentor in Bioinformatics affiliated to the Center for Bioinformatics and Biostatistics (CBB), I mentored several PhD students and master students in different bioinformatics projects including analyzing omics data and using machine learning techniques. I gave educational talks to clinicians, PhD students and researchers in the medical field. I also teaches in educational events and workshops in Bioinformatics tools together with my colleagues in CBB.

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