Ghada Nouairia

Ghada Nouairia

Postdoctoral Researcher
Visiting address: Karolinska Universitetssjukhuset Huddinge, C177, 14186 Huddinge
Postal address: H7 Medicin, Huddinge, H7 Gastroenterologi och Reumatologi Bergquist, 171 77 Stockholm
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About me

  • Computational biologist and biostatistician with focus on clinical research in oncology and liver disorders.
    I have a PhD in molecular genetics since 2018 (Carthage University, Tunisia) and master degree equivalent in Bioinformatics and genomics (Institut Pasteur, Tunisia). Driven by curiosity, I moved to explore computational and molecular evolution in Stockholm University where I studied the evolution and the diversity a large family of proteins (riboluncleotide reductases: RNRs) in the tree of life. Now, I redirected my knowledge and skills to the applications of computational methods in the exciting field of clinical research with focus on multiomics data analysis of different types of cancers (biliary tract cancers), liver disorders such as primary sclerosing cholangitis and other related diseases.
    I am also part of the Center for Bioinformatics and Biostatistics (CBB) where I offer mentoring and consulting in bioinformatics and computational methods for PhD students and researchers. I am as well involved in many teaching activities at CBB including educational seminars and workshops.
    In Karolinska Institutet, I am a member of the bioinformaticians network and the WISE network.
    More importantly, I am an eager reader of science, psychology, history, politics (and much more) and am hungry for such discussions!

Research

  • Primary sclerosing cholangitis (PSC) is a chronic liver disease with the dramatic outcomes of premature death, liver transplantation or malignancy development (cholangiocarcinoma CCA, colorectal cancer CRC or Gallbladder cancer GBC). Unfortunately, Scandinavia is the most touched area in the world. The underlying pathophysiologic mechanisms of PSC and other Biliary Tract Cancers (BTC) are poorly understood and the ability to diagnose them early and to predict their progression is crucial.
    We aim to contribute to the understanding of these -often- related disorders and to develop clinical tools for diagnosis, prognosis and monitoring of these diseases, by combining long clinical experience and the promising multiomics technologies.

Teaching

  • As a mentor in Bioinformatics affiliated to the Center for Bioinformatics and Biostatistics (CBB), I mentored several PhD students and master students in different bioinformatics projects including analyzing omics data and using machine learning techniques. I gave educational talks to clinicians, PhD students and researchers in the medical field. I also teaches in educational events and workshops in Bioinformatics tools together with my colleagues in CBB.

Articles

Grants

  • Genome-scale DNA methylation in biliary tract cancers and primary sclerosing cholangitis
    Mag-Tarmfonden
    1 March 2023

Employments

  • Postdoctoral Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2022-2025
  • Researcher, Department of Biosciences and Nutrition, Karolinska Institutet, 2012-2022
  • Postdoctoral Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2018-2019

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