Fredrik Sand Aronsson
Phd Student
E-mail: fredrik.sand@ki.se
Visiting address: Blickagången 9 A, Enheten för logopedi F67, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Logopedi, 141 52 Huddinge
Research
- Alzheimer’s disease (AD) is a neurodegenerative disease in which damage to
the central nervous system accumulates over a long period of time and leads
to impairments in several cognitive domains, for example episodic memory.
Language impairments, including writing disorders, are also common. The
complexity of spoken and written language is reduced and a correlation
between low syntactic complexity and cognitive decline has been observed in
retrospective studies. A prospective, longitudinal study is needed to
evaluate syntactic complexity as a clinical marker of AD and to investigate
the relationships between syntactic complexity, neuroradiological changes and
neurocognitive functions.
The overall aim of the project is to evaluate the connection between
syntactic complexity measured by computer-based, automated analysis methods
and cognitive decline in AD. Participants with 'mild cognitive impairment'
and 'subjective cognitive impairment' are of primary interest in this study
as possible prodromes of AD - they have subjective and/or objective cognitive
symptoms but do not fulfill the diagnostic criteria for dementia. A
longitudinal follow-up is planned after approximately four years to evaluate
syntactic complexity as a predictor of cognitive decline in AD.
Neuroradiological correlates in two stratified groups (high vs low syntactic
complexity) will be investigated and the validity of the syntactic complexity
measurements will be evaluated based on the possible correlation with
measures of cognitive function.
Articles
- Article: APHASIOLOGY. 2021;35(7):900-913
All other publications
- Thesis / dissertation: 2003