Fredrik Sand Aronsson

Phd Student
Visiting address: Blickagången 9 A, Enheten för logopedi F67, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Logopedi, 171 77 Stockholm


  • Alzheimer’s disease (AD) is a neurodegenerative disease in which damage to
    the central nervous system accumulates over a long period of time and leads
    to impairments in several cognitive domains, for example episodic memory.
    Language impairments, including writing disorders, are also common. The
    complexity of spoken and written language is reduced and a correlation
    between low syntactic complexity and cognitive decline has been observed in
    retrospective studies. A prospective, longitudinal study is needed to
    evaluate syntactic complexity as a clinical marker of AD and to investigate
    the relationships between syntactic complexity, neuroradiological changes and
    neurocognitive functions.
    The overall aim of the project is to evaluate the connection between
    syntactic complexity measured by computer-based, automated analysis methods
    and cognitive decline in AD. Participants with 'mild cognitive impairment'
    and 'subjective cognitive impairment' are of primary interest in this study
    as possible prodromes of AD
  • they have subjective and/or objective cognitive
    symptoms but do not fulfill the diagnostic criteria for dementia. A
    longitudinal follow-up is planned after approximately four years to evaluate
    syntactic complexity as a predictor of cognitive decline in AD.
    Neuroradiological correlates in two stratified groups (high vs low syntactic
    complexity) will be investigated and the validity of the syntactic complexity
    measurements will be evaluated based on the possible correlation with
    measures of cognitive function.


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