Faiez Al Nimer

About me
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About me

Neurologist, Clinical Researcher interested in immunopathogenesis of multiple
sclerosis with focus on HLA, EBV infection and B cell depleting therapies.

Articles

Article: BRAIN. 2024;147(10):3573-3582
Genetics of immune response to Epstein-Barr virus: prospects for multiple sclerosis pathogenesis
Huang J; Tengvall K; Lima IB; Hedstroem AK; Butt J; Brenner N; Gyllenberg A; Stridh P; Khademi M; Ernberg I; Al Nimer F; Manouchehrinia A; Hillert J; Alfredsson L; Andersen O; Sundstroem P; Waterboer T; Olsson T; Kockum I
Article: ANNALS OF NEUROLOGY. 2024;95(6):1112-1126
HLA Associations of Intrathecal IgG Production against Specific Viruses in Multiple Sclerosis
Neidhart S; Vlad B; Hilty M; Hogelin KA; Ziegler M; Berenjeno-Correa E; Reichen I; Stridh P; Jelcic I; Khademi M; Kockum I; Sospedra M; Al Nimer F; Martin R; Jelcic I
Article: CLINICAL IMMUNOLOGY. 2024;258:109870
B cell activating factor levels are linked to distinct B cell markers in multiple sclerosis and following B cell depletion and repopulation
Hogelin KA; Isac B; Khademi M; Al Nimer F
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200056
Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis
Starvaggi Cucuzza C; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29(11):3317-3328
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients
Hogelin KA; Ruffin N; Pin E; Hober S; Nilsson P; Cucuzza CS; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: LANCET NEUROLOGY. 2022;21(8):693-703
Safety and efficacy of rituximab versus dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome in Sweden: a rater-blinded, phase 3, randomised controlled trial
Svenningsson A; Frisell T; Burman J; Salzer J; Fink K; Hallberg S; Hambraeus J; Axelsson M; Al Nimer F; Sundstrom P; Gunnarsson M; Johansson R; Mellergard J; Rosenstein I; Ayad A; Sjoblom I; Risedal A; de Flon P; Gilland E; Lindeberg J; Shawket F; Piehl F; Lycke J
Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2022;9(7):962-976
Copy number variations across the blood-brain barrier in multiple sclerosis
Bedri SK; Evertsson B; Khademi M; Al Nimer F; Olsson T; Hillert J; Glaser A
Article: SCIENCE ADVANCES. 2022;8(17):eabn1823
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Bronge M; Hogelin KA; Thomas OG; Ruhrmann S; Carvalho-Queiroz C; Nilsson OB; Kaiser A; Zeitelhofer M; Holmgren E; Linnerbauer M; Adzemovic MZ; Hellstrom C; Jelcic I; Liu H; Nilsson P; Hillert J; Brundin L; Fink K; Kockum I; Tengvall K; Martin R; Tegel H; Graslund T; Al Nimer F; Guerreiro-Cacais AO; Khademi M; Gafvelin G; Olsson T; Gronlund H
Article: ISCIENCE. 2021;24(9):103078
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
Hogelin KA; Ruffin N; Pin E; Manberg A; Hober S; Gafvelin G; Gronlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: JOURNAL OF IMMUNOLOGY. 2021;207(1):90-100
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain Injury
Needham EJ; Stoevesandt O; Thelin EP; Zetterberg H; Zanier ER; Al Nimer F; Ashton NJ; Outtrim JG; Newcombe VFJ; Mousa HS; Simren J; Blennow K; Yang Z; Hutchinson PJ; Piehl F; Helmy AE; Taussig MJ; Wang KKW; Jones JL; Menon DK; Coles AJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(17):e2011574118
Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
Zheleznyakova GY; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Han Y; James T; Khademi M; Al Nimer F; Scicluna P; Huang J; Kockum I; Faridani OR; Olsson T; Piehl F; Jagodic M
Article: CRITICAL CARE. 2021;25(1):103
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study
Lindblad C; Pin E; Just D; Al Nimer F; Nilsson P; Bellander B-M; Svensson M; Piehl F; Thelin EP
Article: CLINICA CHIMICA ACTA. 2021;512:74-83
Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain injury
Minta K; Brinkmalm G; Thelin EP; Al Nimer F; Piehl F; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: SCIENTIFIC REPORTS. 2020;10(1):18075
Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury
Minta K; Brinkmalm G; Al Nimer F; Thelin EP; Piehl F; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2020;6(4):2055217320964505
A comparative study of tolerability and effects on immunoglobulin levels and CD19 cell counts with ocrelizumab vs low dose of rituximab in multiple sclerosis
Evertsson B; Hoyt T; Christensen A; AL Nimer F; Foley J; Piehl F
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2020;7(4):e775
Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS
Duell F; Evertsson B; Al Nimer F; Sandin A; Olsson D; Olsson T; Khademi M; Hietala MA; Piehl F; Hansson M
Article: NEUROTHERAPEUTICS. 2020;17(3):1142-1152
Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate
Carlstrom KE; Chinthakindi PK; Espinosa B; Al Nimer F; Arner ESJ; Arvidsson PI; Piehl F; Johansson K
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2020;37:101468
Interrupting rituximab treatment in relapsing-remitting multiple sclerosis; no evidence of rebound disease activity
Juto A; Fink K; Al Nimer F; Piehl F
Article: JOURNAL OF NEUROTRAUMA. 2019;36(20):2850-2862
A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury
Thelin E; Al Nimer F; Frostell A; Zetterberg H; Blennow K; Nystrom H; Svensson M; Bellander B-M; Piehl F; Nelson DW
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2019;57(10):1565-1573
Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury
Minta K; Cullen NC; Al Nimer F; Thelin EP; Piehl F; Clarin M; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: NATURE MEDICINE. 2019;25(8):1290-1300
GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis
Galli E; Hartmann FJ; Schreiner B; Ingelfinger F; Arvaniti E; Diebold M; Mrdjen D; van der Meer F; Krieg C; Al Nimer F; Sanderson N; Stadelmann C; Khademi M; Piehl F; Claassen M; Derfuss T; Olsson T; Becher B
Article: NATURE COMMUNICATIONS. 2019;10(1):3081
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
Carlstrom KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: BMJ CASE REPORTS. 2019;12(2):e226832
Morvan's syndrome treated successfully with rituximab and lacosamide
Sveinsson O; Al Nimer F; Piehl F
Article: CELL. 2018;175(1):85-100.e23
Memory B Cells Activate Brain-Homing, Autoreactive CD4⁺ T Cells in Multiple Sclerosis
Jelcic I; Al Nimer F; Wang J; Lentsch V; Planas R; Jelcic I; Madjovski A; Ruhrmann S; Faigle W; Frauenknecht K; Pinilla C; Santos R; Hammer C; Ortiz Y; Opitz L; Gronlund H; Rogler G; Boyman O; Reynolds R; Lutterotti A; Khademi M; Olsson T; Piehl F; Sospedra M; Martin R
Article: ENEURO. 2018;5(2):ENEURO.0335-ENEU17.2018
Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures
Gunther M; Al Nimer F; Piehl F; Risling M; Mathiesen T
Article: PSYCHONEUROENDOCRINOLOGY. 2018;89:53-58
Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers
Brenner P; Granqvist M; Konigsson J; Al Nimer F; Piehl F; Jokinen J
Journal article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2018;5(1):&na
Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis.
Al Nimer F; Jelcic I; Kempf C; Pieper T; Budka H; Sospedra M; Martin R
Article: CLINICAL IMMUNOLOGY. 2016;166:89-95
Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function
Lindblom RPF; Aeinehband S; Strom M; Al Nimer F; Sandholm K; Khademi M; Nilsson B; Piehl F; Ekdahl KN
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2016;3(1):&na
Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination
Al Nimer F; Elliott C; Bergman J; Khademi M; Dring AM; Aeinehband S; Bergenheim T; Christensen JR; Sellebjerg F; Svenningsson A; Linington C; Olsson T; Piehl F
Article: JOURNAL OF NEUROINFLAMMATION. 2015;12:192
Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response
Lindblom RPF; Berg A; Strom M; Aeinehband S; Dominguez CA; Al Nimer F; Abdelmagid N; Heinig M; Zelano J; Harnesk K; Hubner N; Nilsson B; Ekdahl KN; Diez M; Cullheim S; Piehl F
Article: PLOS ONE. 2015;10(7):e0132177
Comparative Assessment of the Prognostic Value of Biomarkers in Traumatic Brain Injury Reveals an Independent Role for Serum Levels of Neurofilament Light
Al Nimer F; Thelin E; Nystrom H; Dring AM; Svenningsson A; Piehl F; Nelson DW; Bellander B-M
Article: PLOS ONE. 2015;10(4):e0122048
Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis
Aeinehband S; Lindblom RPF; Al Nimer F; Vijayaraghavan S; Sandholm K; Khademi M; Olsson T; Nilsson B; Ekdahl KN; Darreh-Shori T; Piehl F
Article: MOLECULAR PAIN. 2014;10:78
Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury
Dominguez CA; Carlstrom KE; Zhang X-M; Al Nimer F; Lindblom RPF; Guerreiro-Cacais AO; Piehl F
Journal article: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):124
High Glutathione-S-transferase 4 alpha expression promotes nerve cell survival in neurodegenerative disorders
Carlstrom K
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1138-1153
Unbiased Expression Mapping Identifies a Link between the Complement and Cholinergic Systems in the Rat Central Nervous System
Lindblom RPF; Stroem M; Heinig M; Al Nimer F; Aeinehband S; Berg A; Dominguez CA; Vijayaraghavan S; Zhang X-M; Harnesk K; Zelano J; Huebner N; Cullheim S; Darreh-Shori T; Diez M; Piehl F
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:60
Genetic variability in the rat Aplec C-type lectin gene cluster regulates lymphocyte trafficking and motor neuron survival after traumatic nerve root injury
Lindblom RPF; Aeinehband S; Parsa R; Strom M; Al Nimer F; Zhang X-M; Dominguez CA; Flytzani S; Diez M; Piehl F
Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(7):784-794
Naturally Occurring Variation in the Glutathione-S-Transferase 4 Gene Determines Neurodegeneration After Traumatic Brain Injury
Al Nimer F; Strom M; Lindblom R; Aeinehband S; Bellander B-M; Nyengaard JR; Lidman O; Piehl F
Article: PLOS ONE. 2013;8(5):e63172
Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: A Reflection by Cerebrospinal Fluid Biomarkers
Khademi M; Dring AM; Gilthorpe JD; Wuolikainen A; Al Nimer F; Harris RA; Andersson M; Brundin L; Piehl F; Olsson T; Svenningsson A
Article: BRAIN BEHAVIOR AND IMMUNITY. 2013;27(1):109-122
Strain influences on inflammatory pathway activation, cell infiltration and complement cascade after traumatic brain injury in the rat
Al Nimer F; Lindblom R; Strom M; Guerreiro-Cacais AO; Parsa R; Aeinehband S; Mathiesen T; Lidman O; Piehl F
Article: ACTA NEUROCHIRURGICA. 2012;154(4):689-697
iNOS-mediated secondary inflammatory response differs between rat strains following experimental brain contusion
Guenther M; Al Nimer F; Gahm C; Piehl F; Mathiesen T
Article: NEUROMOLECULAR MEDICINE. 2012;14(1):15-29
Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons
Strom M; Al Nimer F; Lindblom R; Nyengaard JR; Piehl F
Article: BRAIN BEHAVIOR AND IMMUNITY. 2011;25(5):981-990
Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury
Al Nimer F; Beyeen AD; Lindblom R; Strom M; Aeinehband S; Lidman O; Piehl F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;212(1-2):82-92
Identification of gene regions regulating inflammatory microglial response in the rat CNS after nerve injury
Diez M; Abdelmagid N; Harnesk K; Strom M; Lidman O; Swanberg M; Lindblom R; Al-Nimer F; Jagodic M; Olsson T; Piehl F
Article: EXPERIMENTAL NEUROLOGY. 2006;199(2):339-347
Sustained survival of xenografted human neural stem/progenitor cells in experimental brain trauma despite discontinuation of immunosuppression
Wennersten A; Holmin S; Al Nimer F; Meijer X; Wahlberg LU; Mathiesen T
Article: ACTA NEUROCHIRURGICA. 2006;148(2):199-205
Autoreactive antibodies against neurons and basal lamina found in serum following experimental brain contusion in rats
Rudehill S; Muhallab S; Wennersten A; von Gertten C; Al Nimer F; Sandberg-Nordqvist AC; Holmin S; Mathiesen T
Article: NEUROREPORT. 2004;15(12):1871-1875
MHC expression after human neural stem cell transplantation to brain contused rats
Al Nimer F; Wennersten A; Holmin S; Meijer X; Wahlberg L; Mathiesen T
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Thesis / dissertation: 2012
Genetics in experimental traumatic brain injury
Al Nimer, Faiez

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2024

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2012

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