Faiez Al Nimer

About me
Publications
CV
Public outreach and news

About me

Neurologist, Clinical Researcher interested in immunopathogenesis of multiple
sclerosis with focus on HLA, EBV infection and B cell depleting therapies.

Articles

Article: BRAIN. 2024;147(10):3573-3582
Genetics of immune response to Epstein-Barr virus: prospects for multiple sclerosis pathogenesis
Huang J; Tengvall K; Lima IB; Hedstroem AK; Butt J; Brenner N; Gyllenberg A; Stridh P; Khademi M; Ernberg I; Al Nimer F; Manouchehrinia A; Hillert J; Alfredsson L; Andersen O; Sundstroem P; Waterboer T; Olsson T; Kockum I
Article: ANNALS OF NEUROLOGY. 2024;95(6):1112-1126
HLA Associations of Intrathecal IgG Production against Specific Viruses in Multiple Sclerosis
Neidhart S; Vlad B; Hilty M; Hogelin KA; Ziegler M; Berenjeno-Correa E; Reichen I; Stridh P; Jelcic I; Khademi M; Kockum I; Sospedra M; Al Nimer F; Martin R; Jelcic I
Article: CLINICAL IMMUNOLOGY. 2024;258:109870
B cell activating factor levels are linked to distinct B cell markers in multiple sclerosis and following B cell depletion and repopulation
Hogelin KA; Isac B; Khademi M; Al Nimer F
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200056
Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis
Starvaggi Cucuzza C; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29(11):3317-3328
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients
Hogelin KA; Ruffin N; Pin E; Hober S; Nilsson P; Cucuzza CS; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: LANCET NEUROLOGY. 2022;21(8):693-703
Safety and efficacy of rituximab versus dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome in Sweden: a rater-blinded, phase 3, randomised controlled trial
Svenningsson A; Frisell T; Burman J; Salzer J; Fink K; Hallberg S; Hambraeus J; Axelsson M; Al Nimer F; Sundstrom P; Gunnarsson M; Johansson R; Mellergard J; Rosenstein I; Ayad A; Sjoblom I; Risedal A; de Flon P; Gilland E; Lindeberg J; Shawket F; Piehl F; Lycke J
Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2022;9(7):962-976
Copy number variations across the blood-brain barrier in multiple sclerosis
Bedri SK; Evertsson B; Khademi M; Al Nimer F; Olsson T; Hillert J; Glaser A
Article: SCIENCE ADVANCES. 2022;8(17):eabn1823
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Bronge M; Hogelin KA; Thomas OG; Ruhrmann S; Carvalho-Queiroz C; Nilsson OB; Kaiser A; Zeitelhofer M; Holmgren E; Linnerbauer M; Adzemovic MZ; Hellstrom C; Jelcic I; Liu H; Nilsson P; Hillert J; Brundin L; Fink K; Kockum I; Tengvall K; Martin R; Tegel H; Graslund T; Al Nimer F; Guerreiro-Cacais AO; Khademi M; Gafvelin G; Olsson T; Gronlund H
Article: ISCIENCE. 2021;24(9):103078
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
Hogelin KA; Ruffin N; Pin E; Manberg A; Hober S; Gafvelin G; Gronlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: JOURNAL OF IMMUNOLOGY. 2021;207(1):90-100
Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain Injury
Needham EJ; Stoevesandt O; Thelin EP; Zetterberg H; Zanier ER; Al Nimer F; Ashton NJ; Outtrim JG; Newcombe VFJ; Mousa HS; Simren J; Blennow K; Yang Z; Hutchinson PJ; Piehl F; Helmy AE; Taussig MJ; Wang KKW; Jones JL; Menon DK; Coles AJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(17):e2011574118
Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
Zheleznyakova GY; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Han Y; James T; Khademi M; Al Nimer F; Scicluna P; Huang J; Kockum I; Faridani OR; Olsson T; Piehl F; Jagodic M
Article: CRITICAL CARE. 2021;25(1):103
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study
Lindblad C; Pin E; Just D; Al Nimer F; Nilsson P; Bellander B-M; Svensson M; Piehl F; Thelin EP
Article: CLINICA CHIMICA ACTA. 2021;512:74-83
Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain injury
Minta K; Brinkmalm G; Thelin EP; Al Nimer F; Piehl F; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: SCIENTIFIC REPORTS. 2020;10(1):18075
Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury
Minta K; Brinkmalm G; Al Nimer F; Thelin EP; Piehl F; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: MULTIPLE SCLEROSIS JOURNAL - EXPERIMENTAL, TRANSLATIONAL AND CLINICAL. 2020;6(4):2055217320964505
A comparative study of tolerability and effects on immunoglobulin levels and CD19 cell counts with ocrelizumab vs low dose of rituximab in multiple sclerosis
Evertsson B; Hoyt T; Christensen A; AL Nimer F; Foley J; Piehl F
Article: NEUROTHERAPEUTICS. 2020;17(3):1142-1152
Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate
Carlstrom KE; Chinthakindi PK; Espinosa B; Al Nimer F; Arner ESJ; Arvidsson PI; Piehl F; Johansson K
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2020;7(4):e775
Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS
Duell F; Evertsson B; Al Nimer F; Sandin A; Olsson D; Olsson T; Khademi M; Hietala MA; Piehl F; Hansson M
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2020;37:101468
Interrupting rituximab treatment in relapsing-remitting multiple sclerosis; no evidence of rebound disease activity
Juto A; Fink K; Al Nimer F; Piehl F
Article: JOURNAL OF NEUROTRAUMA. 2019;36(20):2850-2862
A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury
Thelin E; Al Nimer F; Frostell A; Zetterberg H; Blennow K; Nystrom H; Svensson M; Bellander B-M; Piehl F; Nelson DW
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2019;57(10):1565-1573
Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury
Minta K; Cullen NC; Al Nimer F; Thelin EP; Piehl F; Clarin M; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: NATURE MEDICINE. 2019;25(8):1290-1300
GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis
Galli E; Hartmann FJ; Schreiner B; Ingelfinger F; Arvaniti E; Diebold M; Mrdjen D; van der Meer F; Krieg C; Al Nimer F; Sanderson N; Stadelmann C; Khademi M; Piehl F; Claassen M; Derfuss T; Olsson T; Becher B
Article: NATURE COMMUNICATIONS. 2019;10(1):3081
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
Carlstrom KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: BMJ CASE REPORTS. 2019;12(2):e226832
Morvan's syndrome treated successfully with rituximab and lacosamide
Sveinsson O; Al Nimer F; Piehl F
Article: CELL. 2018;175(1):85-100.e23
Memory B Cells Activate Brain-Homing, Autoreactive CD4⁺ T Cells in Multiple Sclerosis
Jelcic I; Al Nimer F; Wang J; Lentsch V; Planas R; Jelcic I; Madjovski A; Ruhrmann S; Faigle W; Frauenknecht K; Pinilla C; Santos R; Hammer C; Ortiz Y; Opitz L; Gronlund H; Rogler G; Boyman O; Reynolds R; Lutterotti A; Khademi M; Olsson T; Piehl F; Sospedra M; Martin R
Article: ENEURO. 2018;5(2):ENEURO.0335-ENEU17.2018
Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures
Gunther M; Al Nimer F; Piehl F; Risling M; Mathiesen T
Article: PSYCHONEUROENDOCRINOLOGY. 2018;89:53-58
Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers
Brenner P; Granqvist M; Konigsson J; Al Nimer F; Piehl F; Jokinen J
Journal article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2018;5(1):&na
Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis.
Al Nimer F; Jelcic I; Kempf C; Pieper T; Budka H; Sospedra M; Martin R
Article: CLINICAL IMMUNOLOGY. 2016;166:89-95
Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function
Lindblom RPF; Aeinehband S; Strom M; Al Nimer F; Sandholm K; Khademi M; Nilsson B; Piehl F; Ekdahl KN
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2016;3(1):e191
Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination
Al Nimer F; Elliott C; Bergman J; Khademi M; Dring AM; Aeinehband S; Bergenheim T; Christensen JR; Sellebjerg F; Svenningsson A; Linington C; Olsson T; Piehl F
Article: JOURNAL OF NEUROINFLAMMATION. 2015;12:192
Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response
Lindblom RPF; Berg A; Strom M; Aeinehband S; Dominguez CA; Al Nimer F; Abdelmagid N; Heinig M; Zelano J; Harnesk K; Hubner N; Nilsson B; Ekdahl KN; Diez M; Cullheim S; Piehl F
Article: PLOS ONE. 2015;10(4):e0122048
Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis
Aeinehband S; Lindblom RPF; Al Nimer F; Vijayaraghavan S; Sandholm K; Khademi M; Olsson T; Nilsson B; Ekdahl KN; Darreh-Shori T; Piehl F
Article: PLOS ONE. 2015;10(7):e0132177
Comparative Assessment of the Prognostic Value of Biomarkers in Traumatic Brain Injury Reveals an Independent Role for Serum Levels of Neurofilament Light
Al Nimer F; Thelin E; Nystrom H; Dring AM; Svenningsson A; Piehl F; Nelson DW; Bellander B-M
Article: MOLECULAR PAIN. 2014;10:78
Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury
Dominguez CA; Carlstrom KE; Zhang X-M; Al Nimer F; Lindblom RPF; Guerreiro-Cacais AO; Piehl F
Journal article: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):124
High Glutathione-S-transferase 4 alpha expression promotes nerve cell survival in neurodegenerative disorders
Carlstrom K
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1138-1153
Unbiased Expression Mapping Identifies a Link between the Complement and Cholinergic Systems in the Rat Central Nervous System
Lindblom RPF; Stroem M; Heinig M; Al Nimer F; Aeinehband S; Berg A; Dominguez CA; Vijayaraghavan S; Zhang X-M; Harnesk K; Zelano J; Huebner N; Cullheim S; Darreh-Shori T; Diez M; Piehl F
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:60
Genetic variability in the rat Aplec C-type lectin gene cluster regulates lymphocyte trafficking and motor neuron survival after traumatic nerve root injury
Lindblom RPF; Aeinehband S; Parsa R; Strom M; Al Nimer F; Zhang X-M; Dominguez CA; Flytzani S; Diez M; Piehl F
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2013;18(7):784-794
Naturally Occurring Variation in the Glutathione-S-Transferase 4 Gene Determines Neurodegeneration After Traumatic Brain Injury
Al Nimer F; Strom M; Lindblom R; Aeinehband S; Bellander B-M; Nyengaard JR; Lidman O; Piehl F
Article: PLOS ONE. 2013;8(5):e63172
Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: A Reflection by Cerebrospinal Fluid Biomarkers
Khademi M; Dring AM; Gilthorpe JD; Wuolikainen A; Al Nimer F; Harris RA; Andersson M; Brundin L; Piehl F; Olsson T; Svenningsson A
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2013;27(1):109-122
Strain influences on inflammatory pathway activation, cell infiltration and complement cascade after traumatic brain injury in the rat
Al Nimer F; Lindblom R; Strom M; Guerreiro-Cacais AO; Parsa R; Aeinehband S; Mathiesen T; Lidman O; Piehl F
Article: ACTA NEUROCHIRURGICA. 2012;154(4):689-697
iNOS-mediated secondary inflammatory response differs between rat strains following experimental brain contusion
Guenther M; Al Nimer F; Gahm C; Piehl F; Mathiesen T
Article: NEUROMOLECULAR MEDICINE. 2012;14(1):15-29
Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons
Strom M; Al Nimer F; Lindblom R; Nyengaard JR; Piehl F
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2011;25(5):981-990
Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury
Al Nimer F; Beyeen AD; Lindblom R; Strom M; Aeinehband S; Lidman O; Piehl F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;212(1-2):82-92
Identification of gene regions regulating inflammatory microglial response in the rat CNS after nerve injury
Diez M; Abdelmagid N; Harnesk K; Strom M; Lidman O; Swanberg M; Lindblom R; Al-Nimer F; Jagodic M; Olsson T; Piehl F
Article: EXPERIMENTAL NEUROLOGY. 2006;199(2):339-347
Sustained survival of xenografted human neural stem/progenitor cells in experimental brain trauma despite discontinuation of immunosuppression
Wennersten A; Holmin S; Al Nimer F; Meijer X; Wahlberg LU; Mathiesen T
Article: ACTA NEUROCHIRURGICA. 2006;148(2):199-205
Autoreactive antibodies against neurons and basal lamina found in serum following experimental brain contusion in rats
Rudehill S; Muhallab S; Wennersten A; von Gertten C; Al Nimer F; Sandberg-Nordqvist AC; Holmin S; Mathiesen T
Article: NEUROREPORT. 2004;15(12):1871-1875
MHC expression after human neural stem cell transplantation to brain contused rats
Al Nimer F; Wennersten A; Holmin S; Meijer X; Wahlberg L; Mathiesen T
Show more

All other publications

Thesis / dissertation: 2012
Genetics in experimental traumatic brain injury
Al Nimer, Faiez

Employments

Affiliated to Research, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2012

About me

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI