Ewa Ellis

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Articles

Article: JOURNAL OF LIPID RESEARCH. 2024;65(2):100498
APOE genotype dictates lipidomic signatures in primary human hepatocytes
Almeida FC; Patra K; Giannisis A; Niesnerova A; Nandakumar R; Ellis E; Oliveira TG; Nielsen HM
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S13)
APOE genotype‐specific lipidomic signatures in primary human hepatocytes
Patra K; Almeida F; Giannisis A; Niesnerova A; Nandakumar R; Ellis E; Oliveira TG; Nielsen HM
Article: DRUG METABOLISM AND DISPOSITION. 2023;51(12):1551-1560
The African Liver Tissue Biorepository Consortium: Capacitating Population-Appropriate Drug Metabolism, Pharmacokinetics, and Pharmacogenetics Research in Drug Discovery and Development
Masimirembwa C; Ramsay M; Botha J; Ellis E; Etheredge H; Hurrell T; Kanji CR; Kapungu NN; Maher H; Mthembu B; Naidoo J; Scholefield J; Rambarran S; van der Schyff F; Smyth N; Strobele B; Thelingwani RS; Loveland J; Fabian J
Journal article: TRANSPLANTATION. 2023;107(10):81
30 years of human hepatocyte isolation and cryogenic preservation
Gramignoli R; Berti A; Ellis E; Strom SC
Article: NATURE METABOLISM. 2023;5(7):1188-1203
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
Article: CELLS. 2023;12(12):1663
Increased Prevalence of Alpha-1-Antitrypsin Deficiency in Patients with Biliary Tract Cancer and Its Associated Clinicopathological Features
Cornillet M; Zemack H; Jansson H; Sparrelid E; Ellis E; Bjorkstrom NK
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s433
Liver innervation is dysregulated in a mouse model of Alagille syndrome
Verboven E; Van Hul NKM; Hankeova S; Adori C; Ellis E; Fischler B; Andersson E
Article: MOLECULAR PSYCHIATRY. 2022;27(8):3533-3543
Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
Giannisis A; Patra K; Edlund AK; Nieto LA; Benedicto-Gras J; Moussaud S; de la Rosa A; Twohig D; Bengtsson T; Fu Y; Bu G; Bial G; Foquet L; Hammarstedt C; Strom S; Kannisto K; Raber J; Ellis E; Nielsen HM
Journal article: JOURNAL OF HEPATOLOGY. 2022;77:S665-S666
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke V; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Article: HEPATOLOGY. 2022;75(5):1154-1168
Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma
Zimmer CL; Filipovic I; Cornillet M; O'Rourke CJ; Berglin L; Jansson H; Sun D; Strauss O; Hertwig L; Johansson H; Seth E; Sparrelid E; Dias J; Glaumann H; Melum E; Ellis EC; Sandberg JK; Andersen JB; Bergquist A; Bjorkstrom NK
Article: CELL TRANSPLANTATION. 2022;31:9636897211069900
Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death
Bluhme E; Henckel E; Gramignoli R; Kjellin T; Hammarstedt C; Nowak G; Karadagi A; Johansson H; Jynge O; Soderstrom M; Fischler B; Strom S; Ellis E; Hallberg B; Jorns C
Article: NATURE COMMUNICATIONS. 2021;12(1):7046
Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
Hildebrandt F; Andersson A; Saarenpaa S; Larsson L; Van Hul N; Kanatani S; Masek J; Ellis E; Barragan A; Mollbrink A; Andersson ER; Lundeberg J; Ankarklev J
Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Article: SCIENCE ADVANCES. 2021;7(30):eabg5733
Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging
Adori C; Daraio T; Kuiper R; Barde S; Horvathova L; Yoshitake T; Ihnatko R; Valladolid-Acebes I; Vercruysse P; Wellendorf AM; Gramignoli R; Bozoky B; Kehr J; Theodorsson E; Cancelas JA; Mravec B; Jorns C; Ellis E; Mulder J; Uhlen M; Bark C; Hokfelt T
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Zimmer CL; von Seth E; Buggert M; Strauss O; Hertwig L; Nguyen S; Wong AYW; Zotter C; Berglin L; Michaelsson J; Hansson MR; Arnelo U; Sparrelid E; Ellis ECS; Soderholm JD; Keita AV; Holm K; Ozenci V; Hov JR; Mold JE; Cornillet M; Ponzetta A; Bergquist A; Bjorkstrom NK
Article: MOLECULAR THERAPY. 2021;29(5):1903-1917
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
Zabulica M; Srinivasan RC; Akcakaya P; Allegri G; Bestas B; Firth M; Hammarstedt C; Jakobsson T; Jakobsson T; Ellis E; Jorns C; Makris G; Scherer T; Rimann N; van Zuydam NR; Gramignoli R; Forslow A; Engberg S; Maresca M; Rooyackers O; Thony B; Haberle J; Rosen B; Strom SC
Article: ELIFE. 2021;10:e60916
DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Dawit F; Jaros J; Bryja V; Lendahl U; Ellis E; Nemeth A; Fischler B; Hannezo E; Kaiser J; Andersson ER
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1217
Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells
Zabulica M; Jakobsson T; Ravaioli F; Vosough M; Gramignoli R; Ellis E; Rooyackers O; Strom SC
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S3)
Effects of a liver APOEε4‐genotype on synaptic integrity, gliosis and insulin signaling in the brain
Giannisis A; Patra K; Edlund AK; De La Rosa A; Nieto LA; Gras JB; Moussaud S; Bengtsson T; Fu Y; Bu G; Bial G; Foquet L; Hammarstedt C; Strom S; Kannisto K; Ellis E; Nielsen HM
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s43
AS058 Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Article: HEPATOLOGY. 2020;72(2):656-670
Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans
Minniti ME; Pedrelli M; Vedin L-L; Delbes A-S; Denis RGP; Oorni K; Sala C; Pirazzini C; Thiagarajan D; Nurmi HJ; Grompe M; Mills K; Garagnani P; Ellis ECS; Strom SC; Luquet SH; Wilson EM; Bial J; Steffensen KR; Parini P
Article: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):534-545
Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome
Johansson H; Svensson JF; Almstrom M; Van Hui N; Rudling M; Angelin B; Nowak G; Fischler B; Ellis E
Article: SCIENTIFIC REPORTS. 2020;10(1):7052
Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency
Karadagi A; Cavedon AG; Zemack H; Nowak G; Eybye ME; Zhu X; Guadagnin E; White RA; Rice LM; Frassetto AL; Strom S; Jorns C; Martini PGV; Ellis E
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2020;198:105558
Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine
Santinha D; Klopot A; Marques I; Ellis E; Jorns C; Johansson H; Melo T; Antonson P; Jakobsson T; Felix V; Gustafsson J-A; Domingues MR; Mode A; Helguero LA
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2020;10(2):106-113
Blood Group Antigen Expression in Isolated Human Liver Cells in Preparation for Implementing Clinical ABO-Incompatible Hepatocyte Transplantation
Tokodai K; Kumagai-Braesch M; Karadagi A; Johansson H; Agren N; Jorns C; Ericzon B-G; Ellis E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M
Article: NUTRIENTS. 2020;12(2):E277-277
Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver
Gensous N; Ravaioli F; Pirazzini C; Gramignoli R; Ellis E; Storci G; Capri M; Strom S; Laconi E; Franceschi C; Garagnani P; Marongiu F; Bacalini MG
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;499:110604
Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity
Gnocchi D; Ellis ECS; Johansson H; Eriksson M; Bruscalupi G; Steffensen KR; Parini P
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:554922
Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes
Johansson H; Sondergaard JN; Jorns C; Kutter C; Ellis ECS
Article: GASTROENTEROLOGY. 2019;157(4):1067-1080.e9
Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
Cornillet M; Jansson H; Schaffer M; Hertwig L; Berglin L; Zimmer CL; Johansson H; Ellis E; Isaksson B; Gonzalez-Galarza FF; Middleton D; Malmberg K-J; Sparrelid E; Bjorkstrom NK
Article: STEM CELLS AND DEVELOPMENT. 2019;28(14):907-919
Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes
Zabulica M; Srinivasan RC; Vosough M; Hammarstedt C; Wu T; Gramignoli R; Ellis E; Kannisto K; de l'Hortet AC; Takeishi K; Soto-Gutierrez A; Strom SC
Article: NATURE METABOLISM. 2019;1(4):445-459
Liver macrophages regulate systemic metabolism through non-inflammatory factors
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Article: ARCHIVES OF TOXICOLOGY. 2019;93(2):385-399
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
Copple IM; den Hollander W; Callegaro G; Mutter FE; Maggs JL; Schofield AL; Rainbow L; Fang Y; Sutherland JJ; Ellis EC; Ingelman-Sundberg M; Fenwick SW; Goldring CE; van de Water B; Stevens JL; Park BK
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(1):1-8
Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
Bacalini MG; Franceschi C; Gentilini D; Ravaioli F; Zhou X; Remondini D; Pirazzini C; Giuliani C; Marasco E; Gensous N; Di Blasio AM; Ellis E; Gramignoli R; Castellani G; Capri M; Strom S; Nardini C; Cescon M; Grazi GL; Garagnani P
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2018;8(2):162-168
Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood
Johansson H; Mork L-M; Li M; Sandblom AL; Bjorkhem I; Hoijer J; Ericzon B-G; Jorns C; Gilg S; Sparrelid E; Isaksson B; Nowak G; Ellis E
Article: GASTROENTEROLOGY. 2018;154(4):1080-1095
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson ER; Chivukula IV; Hankeova S; Sjoqvist M; Tsoi YL; Ramskold D; Masek J; Elmansuri A; Hoogendoorn A; Vazquez E; Storvall H; Netusilova J; Huch M; Fischler B; Ellis E; Contreras A; Nemeth A; Chien KC; Clevers H; Sandberg R; Bryja V; Lendahl U
Article: EUROPEAN SURGICAL RESEARCH. 2018;59(1-2):72-82
Serial Assessment of Growth Factors Associated with Liver Regeneration in Patients Operated with Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy
Sparrelid E; Johansson H; Gilg S; Nowak G; Ellis E; Isaksson B
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294
Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M; Berglin L; Kekalainen E; Carlsson A; Svedin E; Michaelsson J; Nagasawa M; Erjefalt JS; Mori M; Flodstrom-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Bjorkstrom NK; Mjosberg J
Article: PLOS ONE. 2017;12(5):e0177279
Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression
Karadagi A; Johansson H; Zemack H; Salipalli S; Mork L-M; Kannisto K; Jorns C; Gramignoli R; Strom S; Stokkeland K; Ericzon B-G; Jonigk D; Janciauskiene S; Nowak G; Ellis ECS
Article: HEPATOLOGY. 2016;64(5):1743-1756
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Lauschke VM; Vorrink SU; Moro SML; Rezayee F; Nordling A; Hendriks DFG; Bell CC; Sison-Young R; Park BK; Goldring CE; Ellis E; Johansson I; Mkrtchian S; Andersson TB; Ingelman-Sundberg M
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2016;6(2):87-93
Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes
Mork L-M; Strom SC; Mode A; Ellis ECS
Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2016;310(11):G952-G961
Changes in gluconeogenesis and intracellular lipid accumulation characterize uremic human hepatocytes ex vivo
Li M; Ellis E; Johansson H; Nowak G; Isaksson B; Gnocchi D; Parini P; Axelsson J
Article: SCIENTIFIC REPORTS. 2016;6:25187
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell CC; Hendriks DFG; Moro SML; Ellis E; Walsh J; Renblom A; Puigvert LF; Dankers ACA; Jacobs F; Snoeys J; Sison-Young RL; Jenkins RE; Nordling A; Mkrtchian S; Park BK; Kitteringham NR; Goldring CEP; Lauschke VM; Ingelman-Sundberg M
Journal article: GASTROENTEROLOGY. 2016;150(4):s1036
FGF19 and Bile Acids in Portal and Systemic Serum
Johansson H; Mork L-M; Li M; Zemack H; Sandblom AL; Hoijer J; Jorns C; Gilg S; Sparrelid E; Ericzon B-G; Isaksson B; Nowak G; Ellis E
Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2016;16(3):1021-1030
De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning
Jorns C; Nowak G; Nemeth A; Zemack H; Mork L-M; Johansson H; Gramignoli R; Watanabe M; Karadagi A; Alheim M; Hauzenberger D; van Dijk R; Bosma PJ; Ebbesen F; Szakos A; Fischler B; Strom S; Ellis E; Ericzon B-G
Article: PLOS ONE. 2016;11(9):e0161383
Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins
Watanabe M; Zemack H; Johansson H; Hagbard L; Jorns C; Li M; Ellis E
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471
Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a⁺ NK Cells
Marquardt N; Beziat V; Nystrom S; Hengst J; Ivarsson MA; Kekalainen E; Johansson H; Mjosberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaelsson J; Bjorkstrom NK
Article: CELL. 2015;160(1-2):299-312
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Huch M; Gehart H; van Boxtel R; Hamer K; Blokzijl F; Verstegen MMA; Ellis E; van Wenum M; Fuchs SA; de Ligt J; van de Wetering M; Sasaki N; Boers SJ; Kemperman H; de Jonge J; Ijzermans JNM; Nieuwenhuis EES; Hoekstra R; Strom S; Vries RRG; van der Laan LJW; Cuppen E; Clevers H
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1250:323-331
Assay of Bile Acid Conjugation and Excretion in Human Hepatocytes.
Johansson H; Ellis ECS
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2015;78:202-212
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Olayanju A; Copple IM; Bryan HK; Edge GT; Sison RL; Wong MW; Lai Z-Q; Lin Z-X; Dunn K; Sanderson CM; Alghanem AF; Cross MJ; Ellis EC; Ingelman-Sundberg M; Malik HZ; Kitteringham NR; Goldring CE; Park BK
Article: TOXICOLOGICAL SCIENCES. 2014;141(2):538-546
Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures
Liu J; Lu H; Lu Y-F; Lei X; Cui JY; Ellis E; Strom SC; Klaassen CD
Article: CELL TRANSPLANTATION. 2014;23(9):1153-1162
Hepatocyte Transplantation Ameliorates the Metabolic Abnormality in a Mouse Model of Acute Intermittent Porphyria
Yin Z; Wahlin S; Ellis ECS; Harper P; Ericzon B-G; Nowak G
Article: CELL TRANSPLANTATION. 2014;23(12):1545-1556
Rapid and Sensitive Assessment of Human Hepatocyte Functions
Gramignoli R; Tahan V; Dorko K; Venkataramanan R; Fox IJ; Ellis ECS; Vosough M; Strom SC
Article: PLOS ONE. 2014;9(8):e105375
In Situ Characterization of Intrahepatic Non-Parenchymal Cells in PSC Reveals Phenotypic Patterns Associated with Disease Severity
Berglin L; Bergquist A; Johansson H; Glaumann H; Jorns C; Lunemann S; Wedemeyer H; Ellis EC; Bjorkstrom NK
Article: CELL TRANSPLANTATION. 2014;23(8):1009-1018
Strategies for Short-Term Storage of Hepatocytes for Repeated Clinical Infusions
Jorns C; Gramignoli R; Saliem M; Zemack H; Mork L-M; Isaksson B; Nowak G; Ericzon B-G; Strom S; Ellis E
Article: CELL TRANSPLANTATION. 2014;23(9):1143-1151
Hypothermic Storage of Human Hepatocytes for Transplantation
Gramignoli R; Dorko K; Tahan V; Skvorak KJ; Ellis E; Jorns C; Ericzon B-G; Fox IJ; Strom SC
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2013;28:iv212-iv219
Impaired postprandial fibroblast growth factor (FGF)-19 response in patients with stage 5 chronic kidney diseases is ameliorated following antioxidative therapy
Li M; Qureshi AR; Ellis E; Axelsson J
Article: STEM CELL RESEARCH. 2013;11(1):563-573
New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants
Gramignoli R; Tahan V; Dorko K; Skvorak KJ; Hansel MC; Zhao W; Venkataramanan R; Ellis ECS; Jorns C; Ericzon B-G; Rosenborg S; Kuiper R; Soltys KA; Mazariegos GV; Fox IJ; Wilson EM; Grompe M; Strom SC
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(2):296-304
Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
Sharma S; Ellis ECS; Gramignoli R; Dorko K; Tahan V; Hansel M; Mattison DR; Caritis SN; Hines RN; Venkataramanan R; Strom SC
Article: PLOS ONE. 2013;8(11):e78550
Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism
Ellis ECS; Nauglers S; Parini P; Mork L-M; Jorns C; Zemack H; Sandblom AL; Bjorkhem I; Ericzon B-G; Wilson EM; Strom SC; Grompe M
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2012;2(4):315-322
Comparison of Culture Media for Bile Acid Transport Studies in Primary Human Hepatocytes
Moerk L-M; Isaksson B; Boran N; Ericzon B-G; Strom S; Fischler B; Ellis E
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2012;343(1):145-156
Evaluation of Organic Anion-Transporting Polypeptide 1B1 and CYP3A4 Activities in Primary Human Hepatocytes and HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor System
Ulvestad M; Darnell M; Molden E; Ellis E; Asberg A; Andersson TB
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2012;343(1):134-144
In Vitro Evaluation of Major In Vivo Drug Metabolic Pathways Using Primary Human Hepatocytes and HepaRG Cells in Suspension and a Dynamic Three-Dimensional Bioreactor System
Darnell M; Ulvestad M; Ellis E; Weidolf L; Andersson TB
Article: WORLD JOURNAL OF HEPATOLOGY. 2012;4(5):176-183
Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution
Saliem M; Holm F; Tengzelius RB; Jorns C; Nilsson L-M; Ericzon B-G; Ellis E; Hovatta O
Article: CELL TRANSPLANTATION. 2012;21(6):1245-1260
Development and Application of Purified Tissue Dissociation Enzyme Mixtures for Human Hepatocyte Isolation
Gramignoli R; Green ML; Tahan V; Dorko K; Skvorak KJ; Marongiu F; Zao W; Venkataramanan R; Ellis ECS; Geller D; Breite AG; Dwulet FE; McCarthy RC; Strom SC
Article: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2011;8(2):471-478
Liver X receptor agonist downregulates growth hormone signaling in the liver
Zadjali F; Santana-Farre R; Mirecki-Garrido M; Ellis E; Norstedt G; Fernandez-Perez L; Flores-Morales A
Article: HEPATOLOGY. 2011;53(5):1719-1729
Hepatic Differentiation of Amniotic Epithelial Cells
Marongiu F; Gramignoli R; Dorko K; Miki T; Ranade AR; Serra MP; Doratiotto S; Sini M; Sharma S; Mitamura K; Sellaro TL; Tahan V; Skvorak KJ; Ellis ECS; Badylak SF; Davila JC; Hines R; Laconi E; Strom SC
Article: HEPATOLOGY. 2011;53(3):996-1006
Overexpression of Cholesterol 7α-Hydroxylase Promotes Hepatic Bile Acid Synthesis and Secretion and Maintains Cholesterol Homeostasis
Li T; Matozel M; Boehme S; Kong B; Nilsson L-M; Guo G; Ellis E; Chiang JYL
Article: MOLECULAR ENDOCRINOLOGY. 2010;24(6):1151-1164
A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human Hepatocytes
Han S; Li T; Ellis E; Strom S; Chiang JYL
Article: DRUG METABOLISM AND DISPOSITION. 2010;38(5):723-727
Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
Sharma S; Ellis ECS; Dorko K; Zhang S; Mattison DR; Caritis SN; Venkataramanan R; Strom SC
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2010;Chapter 1:Unit-1E.5
Isolation of amniotic mesenchymal stem cells.
Marongiu F; Gramignoli R; Sun Q; Tahan V; Miki T; Dorko K; Ellis E; Strom SC
Article: GENES & DEVELOPMENT. 2010;24(4):381-395
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRβ in the hepatic acute phase response
Venteclef N; Jakobsson T; Ehrlund A; Damdimopoulos A; Mikkonen L; Ellis E; Nilsson L-M; Parini P; Janne OA; Gustafsson J-A; Steffensen KR; Treuter E
Article: PEDIATRIC RESEARCH. 2010;67(2):183-187
ATPase Class I Type 8B Member 1 and Protein Kinase C ζ Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes
Chen F; Ellis E; Strom SC; Shneider BL
Article: METHODS IN MOLECULAR BIOLOGY. 2010;640:417-430
The use of human hepatocytes to investigate bile acid synthesis.
Ellis ECS; Nilsson L-M
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2010;Chapter 1:Unit-1E.3
Isolation of amniotic epithelial stem cells.
Miki T; Marongiu F; Dorko K; Ellis ECS; Strom SC
Article: MOLECULAR PHARMACOLOGY. 2010;77(1):79-86
The Human ADFP Gene Is a Direct Liver-X-Receptor (LXR) Target Gene and Differentially Regulated by Synthetic LXR Ligands
Kotokorpi P; Venteclef N; Ellis E; Gustafsson J-A; Mode A
Article: MOLECULAR THERAPY. 2009;17(7):1266-1273
Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease
Skvorak KJ; Paul HS; Dorko K; Marongiu F; Ellis E; Chace D; Ferguson C; Gibson KM; Homanics GE; Strom SC
Article: GENES & DEVELOPMENT. 2009;23(8):986-996
Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation
Miao J; Xiao Z; Kanamaluru D; Min G; Yau PM; Veenstra TD; Ellis E; Strom S; Suino-Powell K; Xu HE; Kemper JK
Article: DRUG METABOLISM AND DISPOSITION. 2009;37(4):900-908
Human Pregnane X Receptor Activation and CYP3A4/CYP2B6 Induction by 2,3-Oxidosqualene: Lanosterol Cyclase Inhibition
Duniec-Dmuchowski Z; Fang H-L; Strom SC; Ellis E; Runge-Morris M; Kocarek TA
Article: GASTROENTEROLOGY. 2009;136(3):990-999
Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes
Basma H; Soto-Gutierrez A; Yannam GR; Liu L; Ito R; Yamamoto T; Ellis E; Carson SD; Sato S; Chen Y; Muirhead D; Navarro-Alvarez N; Wong RJ; Roy-Chowdhury J; Platt JL; Mercer DF; Miller JD; Strom SC; Kobayashi N; Fox IJ
Article: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2009;26(4):295-302
Long Term Cultures of Primary Human Hepatocytes as an Alternative to Drug Testing in Animals
Ullrich A; Soltz DB; Ellis EC; Strom SC; Michalopoulos GK; Hengstler JG; Runge D
Article: MOLECULAR PHARMACOLOGY. 2008;73(3):891-899
Identification of oxysterol 7α-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor α ( RORα) (NR1F1) target gene and a functional cross-talk between RORα and liver X receptor (NR1H3)
Wada T; Kang HS; Angers M; Gong H; Bhatia S; Khadem S; Ren S; Ellis E; Strom SC; Jetten AM; Xie W
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;364(4):743-747
Ethanol stimulates bile acid formation in primary human hepatocytes
Nilsson L-M; Sjoevall J; Strom S; Bodin K; Nowak G; Einarsson C; Ellis E
Article: HEPATOLOGY. 2007;46(6):1993-2002
Hepatocyte growth factor signaling pathway inhibits cholesterol 7α-hydroxylase and bile acid synthesis in human hepatocytes
Song K-H; Ellis E; Strom S; Chiang JYL
Article: BIOCHEMICAL PHARMACOLOGY. 2007;74(10):1535-1540
Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
Duniec-Dmuchowski Z; Ellis E; Strom SC; Kocarek TA
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2007;Chapter 1:Unit-1E.3
Isolation of amniotic epithelial stem cells.
Miki T; Marongiu F; Ellis E; C Strom S
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2007;323(2):586-598
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin:: Roles of hepatocyte nuclear factor 4α and pregnane X receptor
Fang H-L; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2007;20(10):1503-1512
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
Kostrubsky SE; Strom SC; Ellis E; Nelson SD; Mutlib AE
Article: MOLECULAR PHARMACOLOGY. 2007;72(4):947-955
Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2diphenylethyl)amino]propyloxy] phenylacetic acid hydrochloride (GW3965)
Kotokorpi P; Ellis E; Parini P; Nilsson L-M; Strom S; Steffensen KR; Gustafsson J-A; Mode A
Article: NATURE BIOTECHNOLOGY. 2007;25(8):903-910
Robust expansion of human hepatocytes in Fah^-/-/Rag2^-/-/Il2rg^-/- mice
Azuma H; Paulk N; Ranade A; Dorrell C; Al-Dhalimy M; Ellis E; Strom S; Kay MA; Finegold M; Grompe M
Article: CELL TRANSPLANTATION. 2007;16(8):859-865
Isolation of mouse hepatocytes for transplantation: A comparison between antegrade and retrograde liver perfusion
Yin Z; Ellis ECS; Nowak G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(39):28745-28754
Insulin regulation of cholesterol 7 α-hydroxylase expression in human hepatocytes -: Roles of forkhead box O1 and sterol regulatory element-binding protein 1c
Li T; Kong X; Owsley E; Ellis E; Strom S; Chiang JYL
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2006;12(29):4640-4645
Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes
Siljevik Ellis EC
Article: JOURNAL OF HEPATOLOGY. 2006;44(1):243-245
Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin
Ellis E; Wagner M; Lammert F; Nemeth A; Gumhold J; Strassburg CP; Kylander C; Katsika D; Trauner M; Einarsson C; Marschall HU
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;330(2):395-399
Feedback regulation of bile acid synthesis in human liver:: Importance of HNF-4α for regulation of CYP7A1
Abrahamsson A; Gustafsson U; Ellis E; Nilsson LM; Sahlin S; Björkhem I; Einarsson C
Article: MOLECULAR THERAPY. 2004;10(2):337-343
Adenoviral-mediated expression of porphobilinogen deaminase in liver restores the metabolic defect in a mouse model of acute intermittent porphyria
Johansson A; Nowak G; Möller C; Blomberg P; Harper P
Article: HEPATOLOGY. 2003;38(4):930-938
Feedback regulation of bile acid synthesis in primary human hepatocytes:: Evidence that CDCA is the strongest inhibitor
Ellis E; Axelson M; Abrahamsson A; Eggertsen G; Thörne A; Nowak G; Ericzon BG; Björkhem I; Einarsson C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1593(2-3):283-289
Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages
Hansson M; Ellis E; Hunt MC; Schmitz G; Babiker A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(35):31534-31540
Metabolism of 4β-hydroxycholesterol in Humans
Bodin K; Andersson U; Rystedt E; Ellis E; Norlin M; Pikuleva I; Eggertsen G; Björkhem I; Diczfalusy U
Article: LIVER TRANSPLANTATION. 2002;8(5):424-432
Metabolic changes in the liver graft monitored continuously with microdialysis during liver transplantation in a pig model
Nowak G; Ungerstedt J; Wernerman J; Ungerstedt U; Ericzon BG
Article: JOURNAL OF ENDOCRINOLOGY. 2002;172(3):457-465
GH is a regulator of IGF2 promoter-specific transcription in human liver
von Horn H; Ekström C; Ellis E; Olivecrona H; Einarsson C; Tally M; Ekström TJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(40):37004-37010
From brain to bile -: Evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
Björkhem I; Andersson U; Ellis E; Alvelius G; Ellegård L; Diczfalusy U; Sjövall J; Einarsson C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1530(2-3):155-161
Primary cultures of human hepatocytes but not HepG2 hepatoblastoma cells are suitable for the study of glycosidic conjugation of bile acids
Ellis E; Roeb E; Marschall HU
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2000;6(4):522-525
Bile acid formation in primary human hepatocytes
Einarsson C; Ellis E; Abrahamsson A; Ericzon BG; Björkhem I; Axelson M
Journal article: ATHEROSCLEROSIS. 2000;151(1):290
Primary human hepatocytes are more suitable than HepG2 cells for the study of catabolism of cholesterol to bile acids
Ellis E; Marschall H-U; Axelson M; Björkhem I; Einarsson C
Article: HEPATOLOGY. 2000;31(6):1305-1312
Bile acid synthesis in cultured human hepatocytes:: Support for an alternative biosynthetic pathway to cholic acid
Axelson M; Ellis E; Mörk B; Garmark K; Abrahamsson A; Björkhem I; Ericzon BG; Einarsson C
Article: HEPATOLOGY. 1998;27(2):615-620
Bile acid synthesis in primary cultures of rat and human hepatocytes
Ellis E; Goodwin B; Abrahamsson A; Liddle C; Mode A; Rudling M; Bjorkhem I; Einarsson C
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Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2023-2025

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Docent, Karolinska Institutet, 2021
Doctor Of Philosophy, Karolinska Institutet, 2003
Licentiate Degree, Department of Medicine, Huddinge, Karolinska Institutet, 2000

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