Ernest Arenas

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Articles

Journal article: STEM CELL RESEARCH. 2024;81:103523
Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types
Asgrimsdottir ES; Arenas E
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(1):683
Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations
Kojima R; Paslawski W; Lyu G; Arenas E; Zhang X; Svenningsson P
Article: SCIENCE. 2023;382(6667):eadf1226
Comprehensive cell atlas of the first-trimester developing human brain
Braun E; Danan-Gotthold M; Borm LE; Lee KW; Vinsland E; Lonnerberg P; Hu L; Li X; He X; Andrusivova Z; Lundeberg J; Barker RA; Arenas E; Sundstrom E; Linnarsson S
Article: SCIENCE. 2023;382(6667):eadd7046
Transcriptomic diversity of cell types across the adult human brain
Siletti K; Hodge R; Albiach AM; Lee KW; Ding S-L; Hu L; Lonnerberg P; Bakken T; Casper T; Clark M; Dee N; Gloe J; Hirschstein D; Shapovalova NV; Keene CD; Nyhus J; Tung H; Yanny AM; Arenas E; Lein ES; Linnarsson S
Journal article: IBRO NEUROSCIENCE REPORTS. 2023;15:s40
WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR
Siletti K; Hodge R; Albiach AM; Lee KW; Ding S-L; Hu L; Lönnerberg P; Bakken T; Casper T; Clark M; Dee N; Gloe J; Keene CD; Nyhus J; Tung H; Yanny AM; Arenas E; Lein E; Linnarsson S
Article: STAR PROTOCOLS. 2023;4(3):102355
A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons
Nishimura K; Asgrimsdottir ES; Yang S; Arenas E
Article: STEM CELL REPORTS. 2023;18(1):337-353
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation
Nishimura K; Yang S; Lee KW; Asgrimsdottir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Salto C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
Article: CELL REPORTS: METHODS. 2022;2(12):100367
In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution
Conforti P; Bocchi VD; Campus I; Scaramuzza L; Galimberti M; Lischetti T; Talpo F; Pedrazzoli M; Murgia A; Ferrari I; Cordiglieri C; Fasciani A; Arenas E; Felsenfeld D; Biella G; Besusso D; Cattaneo E
Article: CELL STEM CELL. 2022;29(12):1685-1702.e22
A reference human induced pluripotent stem cell line for collaborative studies
Pantazis CB; Yang A; Lara E; McDonough JA; Blauwendraat C; Peng L; Oguro H; Kanaujiya J; Zou J; Sebesta D; Pratt G; Cross E; Blockwick J; Buxton P; Kinner-Bibeau L; Medura C; Tompkins C; Hughes S; Santiana M; Faghri F; Nalls MA; Vitale D; Ballard S; Qi YA; Ramos DM; Anderson KM; Stadler J; Narayan P; Papademetriou J; Reilly L; Nelson MP; Aggarwal S; Rosen LU; Kirwan P; Pisupati V; Coon SL; Scholz SW; Priebe T; Ottl M; Dong J; Meijer M; Janssen LJM; Lourenco VS; van der Kant R; Crusius D; Paquet D; Raulin A-C; Bu G; Held A; Wainger BJ; Gabriele RMC; Casey JM; Wray S; Abu-Bonsrah D; Parish CL; Beccari MS; Cleveland DW; Li E; Rose IVL; Kampmann M; Aristoy CC; Verstreken P; Heinrich L; Chen MY; Schule B; Dou D; Holzbaur ELF; Zanellati MC; Basundra R; Deshmukh M; Cohen S; Khanna R; Raman M; Nevin ZS; Matia M; Van Lent J; Timmerman V; Conklin BR; Chase KJ; Zhang K; Funes S; Bosco DA; Erlebach L; Welzer M; Kronenberg-Versteeg D; Lyu G; Arenas E; Coccia E; Sarrafha L; Ahfeldt T; Marioni JC; Skarnes WC; Cookson MR; Ward ME; Merkle FT
Article: DEVELOPMENT. 2021;148(10):dev192054
MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus
Kaiser K; Jang A; Kompanikova P; Lun MP; Prochazka J; Machon O; Dani N; Prochazkova M; Laurent B; Gyllborg D; van Amerongen R; Fame RM; Gupta S; Wu F; Barker RA; Bukova I; Sedlacek R; Kozmik Z; Arenas E; Lehtinen MK; Bryja V
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:755406
Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH plus Neurons From Human Pluripotent Cells
Ahmed M; Owens MJS; Toledo EM; Arenas E; Bradley M; ffrench-Constant C
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:685594
The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson's Disease and Their Association With Disease State and Clinical Features
Griffiths WJ; Abdel-Khalik J; Moore SF; Wijeyekoon RS; Crick PJ; Yutuc E; Farrell K; Breen DP; Williams-Gray CH; Theofilopoulos S; Arenas E; Trupp M; Barker RA; Wang Y
Article: NATURE. 2020;587(7834):377-386
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky N; Almouzni G; Gorski SA; Aerts S; Amit I; Bertero MG; Bock C; Bredenoord AL; Cavalli G; Chiocca S; Clevers H; De Strooper B; Eggert A; Ellenberg J; Fernandez XM; Figlerowicz M; Gasser SM; Hubner N; Kjems J; Knoblich JA; Krabbe G; Lichter P; Linnarsson S; Marine J-C; Marioni JC; Marti-Renom MA; Netea MG; Nickel D; Nollmann M; Novak HR; Parkinson H; Piccolo S; Pinheiro I; Pombo A; Popp C; Reik W; Roman-Roman S; Rosenstiel P; Schultze JL; Stegle O; Tanay A; Testa G; Thanos D; Theis FJ; Torres-Padilla M-E; Valencia A; Vallot C; van Oudenaarden A; Vidal M; Voet T
Article: CELL REPORTS. 2020;31(5):107601
Srebf1 Controls Midbrain Dopaminergic Neurogenesis
Toledo EM; Yang S; Gyllborg D; van Wijk KE; Sinha I; Varas-Godoy M; Grigsby CL; Lonnerberg P; Islam S; Steffensen KR; Linnarsson S; Arenas E
Article: NATURE GENETICS. 2020;52(5):482-493
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Bryois J; Skene NG; Hansen TF; Kogelman LJA; Watson HJ; Liu Z; Brueggeman L; Breen G; Bulik CM; Arenas E; Hjerling-Leffler J; Sullivan PF
Article: FRONTIERS IN NEUROSCIENCE. 2020;14:570409
Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival
Rodriguez-Losada N; Wendelbob R; Ocana MC; Casares AD; Guzman de Villoria R; Aguirre Gomez JA; Arraez MA; Gonzalez-Alegre P; Medina MA; Arenas E; Narvaez JA
Article: DEVELOPMENT. 2019;146(16):dev172668
Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development
Ahmed M; Marziali LN; Arenas E; Feltri ML; Ffrench-Constant C
Article: BIOMOLECULES. 2019;9(4):E149-149
Mining for Oxysterols in Cyp7b1^-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5
Meljon A; Crick PJ; Yutuc E; Yau JL; Seckl JR; Theofilopoulos S; Arenas E; Wang Y; Griffiths WJ
Article: NATURE COMMUNICATIONS. 2019;10(1):1498
WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
Kaiser K; Gyllborg D; Prochazka J; Salasova A; Kompanikova P; Molina FL; Laguna-Goya R; Radaszkiewicz T; Harnos J; Prochazkova M; Potesil D; Barker RA; Casado AG; Zdrahal Z; Sedlacek R; Arenas E; Villaescusa JC; Bryja V
Article: NEUROSCIENCE. 2019;402:78-89
The T-type Ca²⁺ Channel Ca_v3.2 Regulates Differentiation of Neural Progenitor Cells during Cortical Development via Caspase-3
Rebellato P; Kaczynska A; Kanatani S; Al Rayyes I; Zhang S; Villaescusa C; Falk A; Arenas E; Hermanson O; Louhivuori L; Uhlen P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(11):4169-4176
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
Theofilopoulos S; de Oliveira WAA; Yang S; Yutuc E; Saeed A; Abdel-Khalik J; Ullgren A; Cedazo-Minguez A; Bjorkhem I; Wang Y; Griffiths WJ; Arenas E
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2019;1864(2):191-211
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma
Griffiths WJ; Crick PJ; Meljon A; Theofilopoulos S; Abdel-Khalik J; Yutuc E; Parker JE; Kelly DE; Kelly SL; Arenas E; Wang Y
Article: CANCER MEDICINE. 2018;7(12):6193-6204
Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63
Tanaka N; Katayama S; Reddy A; Nishimura K; Niwa N; Hongo H; Ogihara K; Kosaka T; Mizuno R; Kikuchi E; Mikami S; Miyakawa A; Arenas E; Kere J; Oya M; Uhlen P
Article: STEM CELL REPORTS. 2018;11(3):651-664
The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation
Gyllborg D; Ahmed M; Toledo EM; Theofilopoulos S; Yang S; Ffrench-Constant C; Arenas E
Article: CELL. 2018;174(4):999-1014.e22
Molecular Architecture of the Mouse Nervous System
Zeisel A; Hochgerner H; Lonnerberg P; Johnsson A; Memic F; van der Zwan J; Haring M; Braun E; Borm LE; La Manno G; Codeluppi S; Furlan A; Lee K; Skene N; Harris KD; Hjerling-Leffler J; Arenas E; Ernfors P; Marklund U; Linnarsson S
Article: NATURE COMMUNICATIONS. 2018;9(1):2595
Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
Okawa S; Salto C; Ravichandran S; Yang S; Toledo EM; Arenas E; del Sol A
Article: COMMUNICATIONS BIOLOGY. 2018;1:75
A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration
Yang S; Toledo EM; Rosmaninho P; Peng C; Uhlen P; Castro DS; Arenas E
Article: CELLULAR SIGNALLING. 2017;38:85-96
The tyrosine Y250^2.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled
Strakova K; Matricon P; Yokota C; Arthofer E; Bernatik O; Rodriguez D; Arenas E; Carlsson J; Bryja V; Schulte G
Article: SCIENCE SIGNALING. 2017;10(493):eaal4165
Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP
Zhang D; Yang S; Toledo EM; Gyllborg D; Salto C; Villaescusa JC; Arenas E
Article: BIOINFORMATICS. 2017;33(16):2547-2554
Mapping genes for calcium signaling and their associated human genetic disorders
Hortenhuber M; Toledo EM; Smedler E; Arenas E; Malmersjo S; Louhivuori L; Uhlen P
Article: MOLECULAR NEURODEGENERATION. 2017;12(1):54
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway
Salasova A; Yokota C; Potesil D; Zdrahal Z; Bryja V; Arenas E
Article: NATURE BIOTECHNOLOGY. 2017;35(5):444-452
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model
Cervo PRDV; Romanov RA; Spigolon G; Masini D; Martin-Montanez E; Toledo EM; La Manno G; Feyder M; Pifl C; Ng Y-H; Sanchez SP; Linnarsson S; Wernig M; Harkany T; Fisone G; Arenas E
Article: ELIFE. 2017;6:e25902
Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
Kaucka M; Zikmund T; Tesarova M; Gyllborg D; Hellander A; Jaros J; Kaiser J; Petersen J; Szarowska B; Newton PT; Dyachuk V; li L; Qian H; Johansson A-S; Mishina Y; Currie JD; Tanaka EM; Erickson A; Dudley A; Brismar H; Southam P; Coen E; Chen M; Weinstein LS; Hampl A; Arenas E; Chagin AS; Fried K; Adameyko I
Article: CELL. 2016;167(2):566-580.e19
Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells
La Manno G; Gyllborg D; Codeluppi S; Nishimura K; Salto C; Zeisel A; Borm LE; Stott SRW; Toledo EM; Villaescusa JC; Lonnerberg P; Ryge J; Barker RA; Arenas E; Linnarsson S
Article: EMBO JOURNAL. 2016;35(18):1963-1978
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease
Villaescusa JC; Li B; Toledo EM; Cervo PRDV; Yang S; Stott SRW; Kaiser K; Islam S; Gyllborg D; Laguna-Goya R; Landreh M; Lonnerberg P; Falk A; Bergman T; Barker RA; Linnarsson S; Selleri L; Arenas E
Article: SCIENCE ADVANCES. 2016;2(8):e1600060
Analysis of neural crest-derived clones reveals novel aspects of facial development
Kaucka M; Ivashkin E; Gyllborg D; Zikmund T; Tesarova M; Kaiser J; Xie M; Petersen J; Pachnis V; Nicolis SK; Yu T; Sharpe P; Arenas E; Brismar H; Blom H; Clevers H; Suter U; Chagin AS; Fried K; Hellander A; Adameyko I
Article: SCIENCE. 2016;352(6291):1326-1329
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques S; Zeisel A; Codeluppi S; van Bruggen D; Falcao AM; Xiao L; Li H; Haring M; Hochgerner H; Romanov RA; Gyllborg D; Munoz-Manchado AB; La Manno G; Lonnerberg P; Floriddia EM; Rezayee F; Ernfors P; Arenas E; Hjerling-Leffler J; Harkany T; Richardson WD; Linnarsson S; Castelo-Branco G
Article: SCIENTIFIC REPORTS. 2016;6:26448
Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
Article: STEM CELL REPORTS. 2016;6(4):607-617
Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Mansson-Broberg A; Rodin S; Bulatovic I; Ibarra C; Lofling M; Genead R; Wardell E; Felldin U; Granath C; Alici E; Le Blanc K; Smith CIE; Salasova A; Westgren M; Sundstrom E; Uhlen P; Arenas E; Sylven C; Tryggvason K; Corbascio M; Simonson OE; Osterholm C; Grinnemo K-H
Article: JOURNAL OF NEUROSCIENCE. 2015;35(39):13385-13401
Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse
Fukusumi Y; Meier F; Goetz S; Matheus F; Irmler M; Beckervordersandforth R; Faus-Kessler T; Minina E; Rauser B; Zhang J; Arenas E; Andersson E; Niehrs C; Beckers J; Simeone A; Wurst W; Prakash N
Article: DEVELOPMENT. 2015;142(11):1918-1936
How to make a midbrain dopaminergic neuron
Arenas E; Denham M; Villaescusa JC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(11):4829-4842
Cholestenoic acids regulate motor neuron survival via liver X receptors
Theofilopoulos S; Griffiths WJ; Crick PJ; Yang S; Meljon A; Ogundare M; Kitambi SS; Lockhart A; Tuschl K; Clayton PT; Morris AA; Martinez A; Reddy MA; Martinuzzi A; Bassi MT; Honda A; Mizuochi T; Kimura A; Nittono H; De Michele G; Carbone R; Criscuolo C; Yau JL; Seckl JR; Schuele R; Schoels L; Sailer AW; Kuhle J; Fraidakis MJ; Gustafsson J-A; Steffensen KR; Bjorkhem I; Ernfors P; Sjovall J; Arenas E; Wang Y
Journal article: CELL. 2014;157(2):313-328
Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (Retracted article. See vol. 170, pg. 407, 2017)
Kitambi SS; Toledo EM; Usoskin D; Wee S; Harisankar A; Svensson R; Sigmundsson K; Kalderen C; Niklasson M; Kundu S; Aranda S; Westermark B; Uhrbom L; Andang M; Damberg P; Nelander S; Arenas E; Artursson P; Walfridsson J; Nilsson KF; Hammarstrom LGJ; Ernfors P
Article: JOURNAL OF NEUROTRAUMA. 2014;31(6):565-581
Wnts Are Expressed in the Spinal Cord of Adult Mice and Are Differentially Induced after Injury
Gonzalez-Fernandez C; Maria Fernandez-Martos C; Shields SD; Arenas E; Javier Rodriguez F
Journal article: JOURNAL OF CELL SCIENCE. 2013;126(22):e1
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons
Yang S; Edman LC; Sánchez-Alcañiz JA; Fritz N; Bonilla S; Hecht J; Uhlén P; Pleasure SJ; Carlos Villaescusa J; Marín O; Arenas E
Article: DEVELOPMENT. 2013;140(22):4554-4564
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons
Yang S; Edman LC; Antonio Sanchez-Alcaniz J; Fritz N; Bonilla S; Hecht J; Uhlen P; Pleasure SJ; Villaescusa JC; Marin O; Arenas E
Article: JOURNAL OF NEUROTRAUMA. 2013;30(10):806-817
The Ryk Receptor Is Expressed in Glial and Fibronectin-Expressing Cells after Spinal Cord Injury
Gonzalez P; Maria Fernandez-Martos C; Arenas E; Javier Rodriguez F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532
Neural progenitors organize in small-world networks to promote cell proliferation
Malmersjo S; Rebellato P; Smedler E; Planert H; Kanatani S; Liste I; Nanou E; Sunner H; Abdelhady S; Zhang S; Andang M; El Manira A; Silberberg G; Arenas E; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(7):E602-E610
Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
Andersson ER; Salto C; Villaescusa JC; Cajanek L; Yang S; Bryjova L; Nagy II; Vainio SJ; Ramirez C; Bryja V; Arenas E
Article: NATURE CHEMICAL BIOLOGY. 2013;9(2):126-133
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Theofilopoulos S; Wang Y; Kitambi SS; Sacchetti P; Sousa KM; Bodin K; Kirk J; Salto C; Gustafsson M; Toledo EM; Karu K; Gustafsson J-A; Steffensen KR; Ernfors P; Sjovall J; Griffiths WJ; Arenas E
Article: MOLECULAR AND CELLULAR BIOLOGY. 2013;33(1):59-70
Tiam1 Regulates the Wnt/Dvl/Rac1 Signaling Pathway and the Differentiation of Midbrain Dopaminergic Neurons
Cajanek L; Ganji RS; Henriques-Oliveira C; Theofilopoulos S; Konik P; Bryja V; Arenas E
Article: PLOS ONE. 2013;8(12):e82095
Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell Pluripotency
Pereira SL; Graos M; Rodrigues AS; Anjo SI; Carvalho RA; Oliveira PJ; Arenas E; Ramalho-Santos J
Article: NEUROBIOLOGY OF DISEASE. 2013;49:118-127
Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens
Ribeiro D; Goya RL; Ravindran G; Vuono R; Parish CL; Foldi C; Piroth T; Yang S; Parmar M; Nikkhah G; Hjerling-Leffler J; Lindvall O; Barker RA; Arenas E
Article: JOURNAL OF LIPID RESEARCH. 2012;53(11):2469-2483
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
Meljon A; Theofilopoulos S; Shackleton CHL; Watson GL; Javitt NB; Knoelker H-J; Saini R; Arenas E; Wang Y; Griffiths WJ
Article: BRITISH JOURNAL OF CANCER. 2012;107(7):1144-1152
WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma
Rogers HA; Sousa S; Salto C; Arenas E; Coyle B; Grundy RG
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2012;90(7):1367-1381
Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
Schwartz CM; Tavakoli T; Jamias C; Park S-S; Maudsley S; Martin B; Phillips TM; Yao PJ; Itoh K; Ma W; Rao MS; Arenas E; Mattson MP
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:111
Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation
Halleskog C; Dijksterhuis JP; Kilander MBC; Becerril-Ortega J; Villaescusa JC; Lindgren E; Arenas E; Schulte G
Article: STEM CELLS. 2012;30(5):865-875
SFRP1 and SFRP2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells
Kele J; Andersson ER; Villaescusa JC; Cajanek L; Parish CL; Bonilla S; Toledo EM; Bryja V; Rubin JS; Shimono A; Arenas E
Article: PLOS ONE. 2012;7(12):e50793
Spatio-Temporal Expression Pattern of Frizzled Receptors after Contusive Spinal Cord Injury in Adult Rats
Gonzalez P; Maria Fernandez-Martos C; Gonzalez-Fernandez C; Arenas E; Javier Rodriguez F
Article: PLOS ONE. 2011;6(3):e18373
Wnt5a Regulates Midbrain Dopaminergic Axon Growth and Guidance
Blakely BD; Bye CR; Fernando CV; Horne MK; Macheda ML; Stacker SA; Arenas E; Parish CL
Article: PLOS ONE. 2011;6(3):e17560
Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model
Tonnesen J; Parish CL; Sorensen AT; Andersson A; Lundberg C; Deisseroth K; Arenas E; Lindvall O; Kokaia M
Article: PLOS ONE. 2011;6(2):e15786
Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis
Ribeiro D; Ellwanger K; Glagow D; Theofilopoulos S; Corsini NS; Martin-Villalba A; Niehrs C; Arenas E
Article: PLOS ONE. 2011;6(11):e27000
Differential Expression of Wnts after Spinal Cord Contusion Injury in Adult Rats
Maria Fernandez-Martos C; Gonzalez-Fernandez C; Gonzalez P; Maqueda A; Arenas E; Javier Rodriguez F
Article: STEM CELLS AND DEVELOPMENT. 2010;19(9):1355-1364
Ca²⁺ and cAMP Signaling in Human Embryonic Stem Cell-Derived Dopamine Neurons
Malmersjo S; Liste I; Dyachok O; Tengholm A; Arenas E; Uhlen P
Article: STEM CELLS. 2010;28(8):1326-1337
A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease
Lonardo E; Parish CL; Ponticelli S; Marasco D; Ribeiro D; Ruvo M; De Falco S; Arenas E; Minchiotti G
Article: JOURNAL OF NEUROSCIENCE. 2010;30(27):9280-9291
Interactions of Wnt/β-Catenin Signaling and Sonic Hedgehog Regulate the Neurogenesis of Ventral Midbrain Dopamine Neurons
Tang M; Villaescusa JC; Luo SX; Guitarte C; Lei S; Miyamoto Y; Taketo MM; Arenas E; Huang EJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):152-156
Towards stem cell replacement therapies for Parkinson's disease
Arenas E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(11):5184-5189
Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host
Jaderstad J; Jaderstad LM; Li J; Chintawar S; Salto C; Pandolfo M; Ourednik V; Teng YD; Sidman RL; Arenas E; Snyder EY; Herlenius E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(10):7246-7253
Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain
Sousa KM; Villaescusa JC; Cajanek L; Ondr JK; Castelo-Branco G; Hofstra W; Bryja V; Palmberg C; Bergman T; Wainwright B; Lang RA; Arenas E
Journal article: DEVELOPMENT. 2010;137(4):e406
Vang-like protein 2 and Rac1 interact to regulate adherens junctions
Lindqvist M; Horn Z; Bryja V; Schulte G; Papachristou P; Ajima R; Dyberg C; Arenas E; Yamaguchi TP; Lagercrantz H; Ringstedt T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(7):4666-4679
Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?
Ogundare M; Theofilopoulos S; Lockhart A; Hall LJ; Arenas E; Sjovall J; Brenton AG; Wang Y; Griffiths WJ
Journal article: EXPERIMENTAL CELL RESEARCH. 2010;316(4):676-677
The β-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons (vol 314, pg 2123, 2008)
Edman LC; Mira H; Arenas E
Article: JOURNAL OF CELL SCIENCE. 2010;123(3):472-483
Vang-like protein 2 and Rac1 interact to regulate adherens junctions
Lindqvist M; Horn Z; Bryja V; Schulte G; Papachristou P; Ajima R; Dyberg C; Arenas E; Yamaguchi TP; Lagercrantz H; Ringstedt T
Article: DEVELOPMENTAL DYNAMICS. 2010;239(1):211-221
Delayed Dopaminergic Neuron Differentiation in Lrp6 Mutant Mice
Castelo-Branco G; Andersson ER; Minina E; Sousa KM; Ribeiro D; Kokubu C; Imai K; Prakash N; Wurst W; Arenas E
Article: DEVELOPMENTAL DYNAMICS. 2010;239(1):237-245
Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
Andersson E; Bryjova L; Biris K; Yamaguchi TP; Arenas E; Bryja V
Article: STEM CELLS. 2009;27(12):2917-2927
Wnt/β-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells
Cajanek L; Ribeiro D; Liste I; Parish CL; Bryja V; Arenas E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;388(3):473-478
Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling
Rawal N; Corti O; Sacchetti P; Ardilla-Osorio H; Sehat B; Brice A; Arenas E
Article: CELL STEM CELL. 2009;5(4):409-419
Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells
Sacchetti P; Sousa KM; Hall AC; Liste I; Steffensen KR; Theofilopoulos S; Parish CL; Hazenberg C; Ahrlund-Richter L; Hovatta O; Gustafsson J-A; Arenas E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;386(4):628-633
Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs
Kunke D; Bryja V; Mygland L; Arenas E; Krauss S
Article: MOLECULAR BIOSYSTEMS. 2009;5(5):529-541
Targeted lipidomic analysis of oxysterols in the embryonic central nervous system
Wang Y; Sousa KM; Bodin K; Theofilopoulos S; Sacchetti P; Hornshaw M; Woffendin G; Karu K; Sjovall J; Arenas E; Griffiths WJ
Article: CIRCULATION RESEARCH. 2009;104(3):372-379
Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/β-Catenin and Protein Kinase Cα
Yang D-H; Yoon J-Y; Lee S-H; Bryja V; Andersson ER; Arenas E; Kwon Y-G; Choi K-Y
Article: MOLECULAR BIOLOGY OF THE CELL. 2009;20(3):924-936
The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
Bryja V; Andersson ER; Schambony A; Esner M; Bryjova L; Biris KK; Hall AC; Kraft B; Cajanek L; Yamaguchi TP; Buckingham M; Arenas E
Article: LANGMUIR. 2008;24(24):14133-14138
Control of Neural Stem Cell Adhesion and Density by an Electronic Polymer Surface Switch
Salto C; Saindon E; Bolin M; Kanciurzewska A; Fahlman M; Jager EWH; Tengvall P; Arenas E; Berggren M
Article: BMC CELL BIOLOGY. 2008;9:66
Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21^Cip/WAF1 pathway
Jung G-A; Yoon J-Y; Moon B-S; Yang D-H; Kim H-Y; Lee S-H; Bryja V; Arenas E; Choi K-Y
Article: EMBO REPORTS. 2008;9(12):1244-1250
β-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways
Bryja V; Schambony A; Cajanek L; Dominguez I; Arenas E; Schulte G
Article: STEM CELLS. 2008;26(7):1891-1900
α-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres
Edman LC; Mira H; Erices A; Malmersjo S; Andersson E; Uhlen P; Arenas E
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(10):2123-2130
The β-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons
Edman LC; Mira H; Arenas E
Article: GLIA. 2008;56(8):809-820
Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors
Bonilla S; Hall AC; Pinto L; Attardo A; Goetz M; Huttner WB; Arenas E
Article: NATURE. 2008;451(7177):460-464
Histone H2AX-dependent GABA_A receptor regulation of stem cell proliferation
Andang M; Hjerling-Leffler J; Moliner A; Lundgren TK; Castelo-Branco G; Nanou E; Pozas E; Bryja V; Halliez S; Nishimaru H; Wilbertz J; Arenas E; Koltzenburg M; Charnay P; El Manira A; Ibanez CF; Ernfors P
Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(1):149-160
Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
Parish CL; Castelo-Branco G; Rawal N; Tonnesen J; Sorensen AT; Salto C; Kokaia M; Lindvall O; Arenas E
Article: PLOS ONE. 2008;3(10):e3517
Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9-A10 Dopaminergic Cells In Vivo
Andersson ER; Prakash N; Cajanek L; Minina E; Bryja V; Bryjova L; Yamaguchi TP; Hall AC; Wurst W; Arenas E
Article: BIOINTERPHASES. 2007;2(4):165-172
Peptide-presenting two-dimensional protein matrix on supported lipid bilayers:: An efficient platform for cell adhesion
Berat R; Remy-Zolghadry M; Gounou C; Manigand C; Tan S; Salto C; Arenas E; Bordenave L; Brisson AR
Article: DEVELOPMENT. 2007;134(15):2881-2887
Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model
Parish CL; Beljajeva A; Arenas E; Simon A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(16):6690-6695
β-arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo
Bryja V; Gradl D; Schambony A; Arenas E; Schulte G
Article: CELLULAR SIGNALLING. 2007;19(3):610-616
Wnt-3a utilizes a novel low dose and rapidly pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate β-catenin
Bryja V; Schulte G; Arenas E
Article: JOURNAL OF CELL SCIENCE. 2007;120(4):586-595
Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
Bryja V; Schulte G; Rawal N; Grahn A; Arenas E
Article: CELL DEATH AND DIFFERENTIATION. 2007;14(2):381-383
Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats
Rawal N; Parish C; Castelo-Branco G; Arenas E
Article: STEM CELLS. 2007;25(2):511-519
Microarray analyses support a role for Nurr1 in resistance to oxidative stress and neuronal differentiation in neural stem cells
Sousa KM; Mira H; Hall AC; Jansson-Sjostrand L; Kusakabe M; Arenas E
Article: NEURODEGENERATIVE DISEASES. 2007;4(4):339-347
Stem-cell-based strategies for the treatment of Parkinson's disease
Parish CL; Arenas E
Article: GENE THERAPY. 2007;14(2):118-128
Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model:: optical neuroimage tracking of brain-grafted cells
Pineda JR; Rubio N; Akerud P; Urban N; Badimon L; Arenas E; Alberch J; Blanco J; Canals JM
Article: JOURNAL OF NEUROCHEMISTRY. 2006;99(1):343-352
BMPs, FGF8 and Wnts regulate the differentiation of locus coeruleus noradrenergic neuronal precursors
Holm PC; Rodriguez FJ; Kele J; Castelo-Branco G; Kitajewski J; Arenas E
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1626-1636
Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain
Rawal N; Castelo-Branco G; Sousa KM; Sousa KM; Kele J; Kobayashi K; Okano H; Arenas E
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2006;23(8):2119-2134
Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury
Bakshi A; Shimizu S; Keck CA; Cho S; LeBold DG; Morales D; Arenas E; Snyder EY; Watson DJ; McIntosh TK
Article: STEM CELLS. 2006;24(4):844-849
An efficient method for the derivation of mouse embryonic stem cells
Bryja V; Bonilla S; Cajanek L; Parish CL; Schwartz CM; Luo Y; Rao MS; Arenas E
Article: DEVELOPMENT. 2006;133(3):495-505
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
Kele J; Simplicio N; Ferri ALM; Mira H; Guillemot F; Arenas E; Ang SL
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2006;31(2):251-262
Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion
Castelo-Branco GA; Sousa KM; Bryja V; Pinto L; Wagner J; Arenas E
Article: NATURE PROTOCOLS. 2006;1(4):2082-2087
Derivation of mouse embryonic stem cells
Bryja V; Bonilla S; Arenas E
Article: NEURODEGENERATIVE DISEASES. 2006;3(1-2):5-11
Function of Wnts in dopaminergic neuron development
Castelo-Branco G; Arenas E
Article: DEVELOPMENT. 2006;133(1):89-98
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
Prakash N; Brodski C; Naserke T; Puelles E; Gogoi R; Hall A; Panhuysen M; Echevarria D; Sussel L; Weisenhorn DMV; Martinez S; Arenas E; Simeone A; Wurst W
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2005;30(3):437-451
Increased Wnt levels in the neural tube impair the function of adherens junctions during neurulation
Shariatmadari M; Peyronnet J; Papachristou P; Horn Z; Sousa KM; Arenas E; Ringstedt T
Article: STEM CELLS AND DEVELOPMENT. 2005;14(5):517-534
NTera2: A model system to study dopaminergic differentiation of human embryonic stem cells
Schwartz CM; Spivak CE; Baker SC; McDaniel TK; Loring JF; Nguyen C; Chrest FJ; Wersto R; Arenas E; Zeng XM; Freed WJ; Rao MS
Article: JOURNAL OF NEUROCHEMISTRY. 2005;93(5):1132-1140
The antimicrobial peptide rCRAMP is present in the central nervous system of the rat
Bergman P; Termén S; Johansson L; Nyström L; Arenas E; Jonsson AB; Hökfelt T; Gudmundsson GH; Agerberth B
Article: STEM CELLS. 2005;23(4):471-476
Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease
Parish CL; Parisi S; Persico MG; Arenas E; Minchiotti G
Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(6):1550-1553
Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
Schulte G; Bryja V; Rawal N; Castelo-Branco G; Sousa KM; Arenas E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;325(2):574-579
Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity
Brunkhorst A; Neuman T; Hall A; Arenas E; Bartfai T; Hermanson O; Metsis M
Article: JOURNAL OF CELL SCIENCE. 2004;117(24):5731-5737
GSK-3β inhibition/β-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons
Castelo-Branco G; Rawal N; Arenas E
Article: NEUROBIOLOGY OF DISEASE. 2004;17(2):163-170
Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons
Grothe C; Timmer M; Scholz T; Winkler C; Nikkhah G; Claus P; Itoh N; Arenas E
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2004;26(3):418-428
Disruption of EphA/ephrin-A signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine
Sieber BA; Kumin A; Canals JM; Danielsson A; Paratcha G; Arenas E; Alberch J; Ögren SO; Ibáñez CF
Article: GENES & DEVELOPMENT. 2003;17(24):3036-3047
Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
Wallén-Mackenzie Å; de Urquiza AM; Petersson S; Rodriguez FJ; Friling S; Wagner J; Ordentlich P; Lengqvist J; Heyman RA; Arenas E; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(22):12747-12752
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
Castelo-Branco GA; Wagner J; Rodriguez FJ; Kele J; Sousa K; Rawal N; Pasolli HA; Fuchs E; Kitajewski J; Arenas E
Article: DEVELOPMENT. 2003;130(15):3535-3545
Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons
Holm PC; Rodríguez FJ; Kresse A; Canals JM; Silos-Santiago I; Arenas E
Article: GLIA. 2003;43(1):47-51
Region-specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons
Hall AC; Mira H; Wagner J; Arenas E
Article: NEUROSCIENCE. 2003;119(2):443-451
Responses of rat trigeminal neurones to dental pulp cells or fibroblasts overexpressing neurotrophic factors in vitro
Lillesaar C; Arenas E; Hildebrand C; Fried K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(51):49101-49104
The p75 neurotrophin receptor interacts with multiple MAGE proteins
Tcherpakov M; Bronfman FC; Conticello SG; Vaskovsky A; Levy Z; Niinobe M; Yoshikawa K; Arenas E; Fainzilber M
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2002;21(2):205-222
Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease
Åkerud P; Holm PC; Castelo-Branco G; Sousa K; Rodriguez FJ; Arenas E
Article: JOURNAL OF NEUROCHEMISTRY. 2002;81(6):1318-1327
Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons
Holm PC; Åkerud P; Wagner J; Arenas E
Article: DEVELOPMENTAL NEUROBIOLOGY. 2002;50(4):323-332
Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's disease
Marco S; Pérez-Navarro E; Tolosa E; Arenas E; Alberch J
Article: DEVELOPMENTAL NEUROBIOLOGY. 2002;50(4):291-304
BMP-2 and cAMP elevation confer locus coeruleus neurons responsiveness to multiple neurotrophic factors
Reiriz J; Holm PC; Alberch J; Arenas E
Article: JOURNAL OF NEUROSCIENCE. 2001;21(20):8108-8118
Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
Åkerud P; Canals JM; Snyder EY; Arenas E
Article: JOURNAL OF NEUROCHEMISTRY. 2001;78(6):1287-1296
Neuroprotection of striatal neurons against kainate excitotoxicity by neurotrophins and GDNF family members
Gratacòs E; Pérez-Navarro E; Tolosa E; Arenas E; Alberch J
Article: JOURNAL OF NEUROCHEMISTRY. 2001;78(6):1201-1207
Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation
Naveilhan P; Canals JM; Arenas E; Ernfors P
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2001;13(12):2241-2246
Neuropeptide Y alters sedation through a hypothalamic Y₁-mediated mechanism
Naveilhan P; Canals JM; Valjakka A; Vartiainen J; Arenas E; Ernfors P
Article: ACTA NEUROPATHOLOGICA. 2001;101(3):229-238
Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
Ferrer I; Krupinski J; Goutan E; Martí E; Ambrosio S; Arenas E
Article: JOURNAL OF NEUROSCIENCE. 2001;21(1):117-124
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area
Canals JM; Checa N; Marco S; Åkerud P; Michels A; Pérez-Navarro E; Tolosa E; Arenas E; Alberch J
Article: JOURNAL OF NEUROCHEMISTRY. 2000;75(5):2190-2199
Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease
Pérez-Navarro E; Canudas AM; Åkerud P; Alberch J; Arenas E
Article: BRAIN CELL BIOLOGY. 2000;29(9):653-663
Fibroblast-like cells from rat plantar skin and neurotrophin-transfected 3T3 fibroblasts influence neurite growth from rat sensory neurons in vitro
Jerregård H; Åkerud P; Arenas E; Hildebrand C
Article: DEVELOPMENT. 2000;127(7):1489-1498
Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbAα orphan receptor
Chomez P; Neveu I; Mansén A; Kiesler E; Larsson L; Vennström B; Arenas E
Article: NEUROSCIENCE. 2000;98(1):89-96
Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease
Pérez-Navarro E; Åkerud P; Marco S; Canals JM; Tolosa E; Arenas E; Alberch J
Article: CELL TRANSPLANTATION. 2000;9(1):45-53
Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor
Espejo M; Cutillas B; Arenas E; Ambrosio S
Article: NATURE MEDICINE. 1999;5(10):1188-1193
Normal feeding behavior, body weight and leptin response require the neuropeptide YY2 receptor
Naveilhan P; Hassani H; Canals JM; Ekstrand AJ; Larefalk Å; Chhajlani V; Arenas E; Gedda K; Svensson L; Thoren P; Ernfors P
Article: NATURE BIOTECHNOLOGY. 1999;17(7):653-659
Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
Wagner J; Åkerud P; Castro DS; Holm PC; Canals JM; Snyder EY; Perlmann T; Arenas E
Article: JOURNAL OF NEUROCHEMISTRY. 1999;73(1):70-78
Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons
Åkerud P; Alberch J; Eketjäll S; Wagner J; Arenas E
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(1):241-249
Intrastriatal grafting of a GDNF-producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivo
Pérez-Navarro E; Arenas E; Marco S; Alberch J
Article: NEUROSCIENCE. 1999;91(4):1257-1264
Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo
Pérez-Navarro E; Alberch J; Neveu I; Arenas E
Article: NEUROSCIENCE LETTERS. 1998;257(2):85-88
Brain-derived neurotrophic factor does not prevent ionizing radiation-induced apoptosis in the developing rat brain
Ferrer I; Goutan E; Martí E; Arenas E
Article: NEUROSCIENCE. 1998;87(1):289-302
Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system
Naveilhan P; Neveu I; Arenas E; Ernfors P
Article: NEUROBIOLOGY OF DISEASE. 1998;5(5):357-364
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease
Canals JM; Marco S; Checa N; Michels A; Pérez-Navarro E; Arenas E; Alberch J
Article: NEURON. 1998;21(2):305-315
BDNF regulates Reelin expression and Cajal-Retzius cell development in the cerebral cortex
Ringstedt T; Linnarsson S; Wagner J; Lendahl U; Kokaia Z; Arenas E; Ernfors P; Ibáñez CF
Article: BRAIN PATHOLOGY. 1998;8(2):253-261
BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia
Ferrer I; Ballabriga J; Martí E; Pérez E; Alberch J; Arenas E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(8):4718-4724
Adenosine A₁ receptor-mediated modulation of dopamine D₁ receptors in stably cotransfected fibroblast cells
Ferré S; Torvinen M; Antoniou K; Irenius E; Civelli O; Arenas E; Fredholm BB; Fuxe K
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1996;316(2-3):325-331
Adenosine A(2A) receptors modulate the binding characteristics of dopamine D-2 receptors in stably cotransfected fibroblast cells
Dasgupta S; Ferre S; Kull B; Hedlund PB; Finnman UB; Ahlberg S; Arenas E; Fredholm BB; Fuxe K
Article: NEUROSCIENCE. 1996;75(2):345-352
Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage
PerezNavarro E; Arenas E; Reiriz J; Calvo N; Alberch J
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1996;8(8):1707-1717
Effects of BDNF and NT-4/5 on striatonigral neuropeptides or nigral GABA neurons in vivo
Arenas E; Akerud P; Wong V; Boylan C; Persson H; Lindsay RM; Altar CA
Article: MOLECULAR PSYCHIATRY. 1996;1(3):179-182
GDNF, a multispecific neurotrophic factor with potential therapeutic applications in neurodegenerative disorders
Arenas E
Article: NATURE. 1996;381(6585):785-789
Functional receptor for GDNF encoded by the c-ret proto-oncogene
Trupp M; Arenas E; Fainzilber M; Nilsson AS; Sieber BA; Grigoriou M; Kilkenny C; SalazarGrueso E; Pachnis V; Arumae U; Sariola H; Saarma M; Ibanez CF
Article: JOURNAL OF CELL BIOLOGY. 1996;133(3):631-646
Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo
Neveu I; Arenas E
Article: BRAIN RESEARCH. 1996;36(2):292-299
Regulation of dopamine D-2 receptor affinity by cholecystokinin octapeptide in fibroblast cells cotransfected with human CCKB and D(2)L receptor cDNAs
Dasgupta S; Li XM; Jansson A; Finnman UB; Matsui T; Rinken A; Arenas E; Agnati LF; Fuxe K
Article: NEURON. 1995;15(6):1465-1473
GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
Arenas E; Trupp M; Akerud P; Ibanez CF
Article: JOURNAL OF CELL BIOLOGY. 1995;130(1):137-148
PERIPHERAL EXPRESSION AND BIOLOGICAL-ACTIVITIES OF GDNF, A NEW NEUROTROPHIC FACTOR FOR AVIAN AND MAMMALIAN PERIPHERAL NEURONS
TRUPP M; RYDEN M; JORNVALL H; FUNAKOSHI H; TIMMUSK T; ARENAS E; IBANEZ CF
Article: SCIENCE. 1995;268(5216):1495-1499
MUSCLE-DERIVED NEUROTROPHIN-4 AS AN ACTIVITY-DEPENDENT TROPHIC SIGNAL FOR ADULT MOTOR-NEURONS
FUNAKOSHI H; BELLUARDO N; ARENAS E; YAMAMOTO Y; CASABONA A; PERSSON H; IBANEZ CF
Article: JOURNAL OF CELL BIOLOGY. 1995;128(1-2):185-199
IDENTIFICATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR PROMOTER REGIONS MEDIATING TISSUE-SPECIFIC, AXOTOMY-INDUCED, AND NEURONAL ACTIVITY-INDUCED EXPRESSION IN TRANSGENIC MICE
TIMMUSK T; LENDAHL U; FUNAKOSHI H; ARENAS E; PERSSON H; METSIS M
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1994;6(5):706-711
NERVE GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR PROTECT CHOLINERGIC NEURONS AGAINST QUINOLINIC ACID EXCITOTOXICITY IN RAT NEOSTRIATUM
PEREZNAVARRO E; ALBERCH J; ARENAS E; CALVO N; MARSAL J
Journal article: NATURE. 1994;367(6461):368-371
NEUROTROPHIN-3 PREVENTS THE DEATH OF ADULT CENTRAL NORADRENERGIC NEURONS IN-VIVO
ARENAS E; PERSSON H
Journal article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 1993;348(5):445-449
CONTROL OF TACHYKININ-EVOKED ACETYLCHOLINE-RELEASE FROM RAT STRIATAL SLICES BY DOPAMINERGIC-NEURONS
ALBERCH J; ARENAS E; PEREZNAVARRO E; MARSAL J
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1993;90(19):8802-8806
DIFFERENTIAL USAGE OF MULTIPLE BRAIN-DERIVED NEUROTROPHIC FACTOR PROMOTERS IN THE RAT-BRAIN FOLLOWING NEURONAL ACTIVATION
METSIS M; TIMMUSK T; ARENAS E; PERSSON H
Journal article: DEVELOPMENT. 1993;117(4):1345-1353
NEUROTROPHIN-4 IS A TARGET-DERIVED NEUROTROPHIC FACTOR FOR NEURONS OF THE TRIGEMINAL GANGLION
IBANEZ CF; ERNFORS P; TIMMUSK T; IP NY; ARENAS E; YANCOPOULOS GD; PERSSON H
Journal article: BRAIN RESEARCH. 1993;603(2):317-320
SELECTIVE RESISTANCE OF TACHYKININ-RESPONSIVE CHOLINERGIC NEURONS IN THE QUINOLINIC ACID LESIONED NEOSTRIATUM
ARENAS E; PEREZNAVARRO E; ALBERCH J; MARSAL J
Journal article: NEUROSCIENCE LETTERS. 1993;149(1):47-50
NERVE GROWTH-FACTOR AND ITS RECEPTOR ARE DIFFERENTIALLY MODIFIED BY CHRONIC NALTREXONE TREATMENT DURING RAT-BRAIN DEVELOPMENT
PEREZNAVARRO E; ALBERCH J; ARENAS E; MARSAL J
Journal article: JOURNAL OF NEUROCHEMISTRY. 1991;57(5):1483-1487
INVOLVEMENT OF NERVE GROWTH-FACTOR AND ITS RECEPTOR IN THE REGULATION OF THE CHOLINERGIC FUNCTION IN AGED RATS
ALBERCH J; PEREZNAVARRO E; ARENAS E; MARSAL J
Journal article: BRAIN RESEARCH. 1991;556(2):349-352
NEOSTRIATAL DOPAMINERGIC TERMINALS PREVENT THE GABAERGIC INVOLVEMENT IN THE MU-OPIOID AND DELTA-OPIOID INHIBITION OF KCL-EVOKED ENDOGENOUS ACETYLCHOLINE-RELEASE
ARENAS E; ALBERCH J; PEREZNAVARRO E; SOLSONA C; MARSAL J
Journal article: JOURNAL OF NEUROSCIENCE. 1991;11(8):2332-2338
NEUROKININ RECEPTORS DIFFERENTIALLY MEDIATE ENDOGENOUS ACETYLCHOLINE-RELEASE EVOKED BY TACHYKININS IN THE NEOSTRIATUM
ARENAS E; ALBERCH J; PEREZNAVARRO E; SOLSONA C; MARSAL J
Journal article: NEUROSCIENCE. 1991;42(3):707-714
DOPAMINERGIC SYSTEM MEDIATES ONLY DELTA-OPIATE INHIBITION OF ENDOGENOUS ACETYLCHOLINE-RELEASE EVOKED BY GLUTAMATE FROM RAT STRIATAL SLICES
ARENAS E; ALBERCH J; MARSAL J
Journal article: NEUROSCIENCE LETTERS. 1990;120(2):201-204
GABA-A AND GABA-B ANTAGONISTS PREVENT THE OPIOID INHIBITION OF ENDOGENOUS ACETYLCHOLINE-RELEASE EVOKED BY GLUTAMATE FROM RAT NEOSTRIATAL SLICES
ARENAS E; MARSAL J; ALBERCH J
Journal article: BRAIN RESEARCH. 1990;523(1):51-56
EFFECT OF OPIOIDS ON ACETYLCHOLINE-RELEASE EVOKED BY K+ OR GLUTAMIC-ACID FROM RAT NEOSTRIATAL SLICES
ARENAS E; ALBERCH J; ARROYOS RS; MARSAL J
Journal article: NEUROCHEMISTRY INTERNATIONAL. 1990;17(1):107-116
EXCITATORY AMINO-ACIDS RELEASE ENDOGENOUS ACETYLCHOLINE FROM RAT STRIATAL SLICES - REGULATION BY GAMMA-AMINOBUTYRIC-ACID
ALBERCH J; ARENAS E; ARROYOS RS; MARSAL J
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Preprint: ZAPPYLAB, INC.. 2024
Nuclei counting after Trypan Blue staining v1
Abaurre C; Wai Lee K; Arenas E
Preprint: BIORXIV. 2024
Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells
Ásgrímsdóttir ES; Bassini LF; di Val Cervo PR; Gyllborg D; Pastor CP; Lee K; Grigsby C; Islam S; Lönneberg P; Villaescusa C; Saltó C; Linnarsson S; La Manno G; Toledo EM; Arenas E
Review: MOLECULAR NEURODEGENERATION. 2023;18(1):11
Translational molecular imaging and drug development in Parkinson's disease
Haider A; Elghazawy NH; Dawood A; Gebhard C; Wichmann T; Sippl W; Hoener M; Arenas E; Liang SH
Preprint: BIORXIV. 2022
Comprehensive cell atlas of the first-trimester developing human brain
Braun E; Danan-Gotthold M; Borm L; Vinsland E; Lee KW; Lönnerberg P; Hu L; Li X; He X; Andrusivová Ž; Lundeberg J; Arenas E; Barker R; Sundström E; Linnarsson S
Preprint: BIORXIV. 2022
Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation
Nishimura K; Yang S; Lee KW; Ásgrímsdóttir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Saltó C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
Editorial comment: NATURE NEUROSCIENCE. 2022;25(5):536-538
Parkinson's disease in the single-cell era
Arenas E
Corrigendum: DEVELOPMENT. 2022;149(3):dev200517
MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus (vol 148, dev192054, 2021)
Kaiser K; Jang A; Kompanikova P; Lun MP; Prochazka J; Machon O; Dani N; Prochazkova M; Laurent B; Gyllborg D; van Amerongen R; Fame RM; Gupta S; Wu F; Barker RA; Bukova I; Sedlacek R; Kozmik Z; Arenas E; Lehtinen MK; Bryja V
Editorial comment: NATURE. 2020;582(7813):489-490
Method to combat Parkinson's disease by astrocyte-to-neuron conversion
Arenas E
Preprint: BIORXIV. 2020
MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus
Kaiser K; Jang A; Lun MP; Procházka J; Machon O; Procházková M; Laurent B; Gyllborg D; van Amerongen R; Kompaníková P; Wu F; Barker RA; Uramová I; Sedláček R; Kozmík Z; Arenas E; Lehtinen MK; Bryja V
Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:463
Midbrain Dopaminergic Neuron Development at the Single Cell Level:In vivoand in Stem Cells
Asgrimsdottir ES; Arenas E
Preprint: BIORXIV. 2018
Molecular architecture of the mouse nervous system
Zeisel A; Hochgerner H; Lönnerberg P; Johnsson A; Memic F; van der Zwan J; Häring M; Braun E; Borm L; La Manno G; Codeluppi S; Furlan A; Skene N; Harris K; Hjerling Leffler J; Arenas E; Ernfors P; Marklund U; Linnarsson S
Review: BRITISH JOURNAL OF PHARMACOLOGY. 2017;174(24):4716-4724
Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease
Toledo EM; Gyllborg D; Arenas E
Other: CELL. 2017;170(2):407
Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (Retraction of Vol 157, Pg 313, 2014)
Kitambi SS; Toledo EM; Usoskin D; Wee S; Harisankar A; Svensson R; Sigmundsson K; Kalderen C; Niklasson M; Kundu S; Aranda S; Westermark B; Uhrbom L; Andang M; Damberg P; Nelander S; Arenas E; Artursson P; Walfridsson J; Nilsson KF; Hammarstrom LGJ; Ernfors P
Preprint: BIORXIV. 2017
Molecular analysis of the midbrain dopaminergic niche during neurogenesis
Toledo EM; La Manno G; di Val Cervo PR; Gyllborg D; Islam S; Villaescusa C; Linnarsson S; Arenas E
Review: F1000 PRIME REPORTS. 2015;7:37
Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration.
Theofilopoulos S; Arenas E
Meeting abstract: SPRINGERPLUS. 2015;4(Suppl 1):L49
WNT signaling in midbrain dopaminergic neuron development and cell replacement therapies for Parkinson's disease
Arenas E; Salto C; Villaescusa C
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(1):42-53
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinsons disease
Arenas E
Editorial comment: JOURNAL OF CELLULAR BIOCHEMISTRY. 2010;111(5):1077-1079
WNT Unrelated Activities in Commercially Available Preparations of Recombinant WNT3a
Cajanek L; Adlerz L; Bryja V; Arenas E
Editorial comment: EXPERIMENTAL NEUROLOGY. 2010;222(2):173-178
Transplantable midbrain dopamine neurons: A moving target
Villaescusa JC; Arenas E
Review: NATURE REVIEWS NEUROSCIENCE. 2010;11(2):77-86
Emerging roles of Wnts in the adult nervous system
Inestrosa NC; Arenas E
Editorial comment: CELL STEM CELL. 2008;2(2):110-112
Foxa2: The rise and fall of dopamine neurons
Arenas E
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2005;1049:51-66
Engineering a dopaminergic phenotype in stem/precursor cells - Role of Nurr1, glia-derived signals, and Wnts
Arenas E
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(46):16390
Differential regulation of midbrain dopaminergic neuron development by Wnt-5, Wnt-3a, and Wnt-5a (vol 100, pg 12747, 2003)
Castelo-Branco G; Wagner J; Rodriguez FJ; Kele J; Sousa K; Rawal N; Pasolli HA; Fuchs E; Kitajewski J; Arenas E
Meeting abstract: PEDIATRIC RESEARCH. 2004;56(3):502
Overexpression of WNT7A in transgenic mouse neural stem cells increase VANGL2 expression and impair neurulation by disturbing actin microfilament formation
Shariatmadari M; Peyronnet J; Papachristou P; Schultz G; Sousa K; Arenas E; Ringstedt T
Published conference paper: BRAIN RESEARCH BULLETIN. 2002;57(6):795-808
Stem cells in the treatment of Parkinson's disease
Arenas E
Book chapter: DEVELOPMENT. 1999;p. 447-461
Neurotrophins in Development of the Nervous System
Arenas E; Ernfors P
Book chapter: CHEMICAL FACTORS IN NEURAL GROWTH, DEGENERATION AND REPAIR. 1996;p. 219-249
Chapter 9 Neurotrophin-3 and neurotrophin-4/5
Rocamora N; Arenas E
Book chapter: ADENOSINE AND ADENINE NUCLEOTIDES: FROM MOLECULAR BIOLOGY TO INTEGRATIVE PHYSIOLOGY. 1995;p. 499-507
Evidence for the Existence of Antagonistic Intramembrane Adenosine A2a/dopamine D2 Receptor Interactions in the Basal Ganglia: Analysis from the Network to the Molecular Level
Fuxe K; Ferré S; Dasgupta S; O’Connor WT; Snaprud P; Arenas E; Persson H; Ungerstedt U; Fredholm B
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Grants

A PRECISION CELL REPLACEMENT STRATEGY FOR PARKINSON’S DISEASE
European Research Council
1 March 2021 - 28 February 2026
Transcription factors in Parkinson´s disease
Swedish Research Council
1 January 2021 - 31 December 2024
From brain development to glioblastoma: the importance of Wnt signaling and stem cells
Swedish Cancer Society
1 January 2018
Midbrain dopaminergic neurons: From genes to development and Parkinson´s disease
Swedish Research Council
1 January 2017 - 31 December 2020
From brain development to glioblastoma: the importance of Wnt signaling and stem cells
Swedish Cancer Society
1 January 2017
From brain development to glioblastoma: the importance of Wnt signaling and stem cells
Swedish Cancer Society
1 January 2016
Wnt signaling in dopamine neuron development and Parkinson´s disease cell therapy
Swedish Research Council
1 January 2012 - 31 December 2016
Drug discovery and regeneration for Parkinson's disease
Swedish Foundation for Strategic Research
1 January 2012 - 31 December 2017
FUNCTION OF LAMININS IN THE GENERATION OF DOPAMINE NEURONS AND IN REGENERATIVE MEDICINE FOR PARKINSON´S DISEASE.
Swedish Research Council
1 January 2011 - 31 December 2013
European WNT meeting 2010 "WNT Signaling in Physiology and Disease"
Swedish Research Council
1 July 2010 - 31 December 2010
Function of Wnts in dopamine neuron development in vivo and in stem cells: Cell replacement strategies for Parkinson’s disease
Swedish Research Council
1 January 2009 - 31 December 2011
Development of a human embryonic and mesenchymal stem cell therapy for Parkinsons disease
Swedish Research Council
1 January 2009 - 31 December 2011
Development of stem cell therapies for Parkinson's disease
International Human Frontier Science Program Organization
1 May 2003 - 30 April 2006
Dopaminergic neuron development and neural stem cell therapy for Parkinson's disease
International Human Frontier Science Program Organization
1 May 2001 - 30 April 2004

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