Emanuela Santini

Publications
CV
Public outreach and news

Articles

Journal article: CELL REPORTS. 2024;43(12):114997
Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders.
Carbonell-Roig J; Aaltonen A; Wilson K; Molinari M; Cartocci V; McGuirt A; Mosharov E; Kehr J; Lieberman OJ; Sulzer D; Borgkvist A; Santini E
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6427-6450
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
Longo F; Mancini M; Ibraheem PL; Aryal S; Mesini C; Patel JC; Penhos E; Rahman N; Mamcarz M; Santini E; Rice ME; Klann E
Article: MOVEMENT DISORDERS. 2021;36(5):1137-1146
Involvement of Autophagy in Levodopa-Induced Dyskinesia
Feyder M; Plewnia C; Lieberman OJ; Spigolon G; Piccin A; Urbina L; Dehay B; Li Q; Nilsson P; Altun M; Santini E; Sulzer D; Bezard E; Borgkvist A; Fisone G
Article: ELIFE. 2020;9:e50843
Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy
Lieberman OJ; Frier MD; McGuirt AF; Griffey CJ; Rafikian E; Yang M; Yamamoto A; Borgkvist A; Santini E; Sulzer D
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2020;14:70
mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders
Lieberman OJ; Cartocci V; Pigulevskiy I; Molinari M; Carbonell J; Broseta MB; Post MR; Sulzer D; Borgkvist A; Santini E
Article: ELIFE. 2019;8:e51607
Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala
Ostroff LE; Santini E; Sears R; Deane Z; Kanadia RN; LeDoux JE; Lhakhang T; Tsirigos A; Heguy A; Klann E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(7):2707-2712
Inositol polyphosphate multikinase mediates extinction of fear memory.
Park J; Longo F; Park SJ; Lee S; Bae M; Tyagi R; Han J-H; Kim S; Santini E; Klann E; Snyder SH
Article: NEURON. 2018;99(3):540-554.e4
Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.
Lieberman OJ; McGuirt AF; Mosharov EV; Pigulevskiy I; Hobson BD; Choi S; Frier MD; Santini E; Borgkvist A; Sulzer D
Article: MOLECULAR PSYCHIATRY. 2018;23(6):1394-1401
Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory.
Huynh TN; Santini E; Mojica E; Fink AE; Hall BS; Fetcho RN; Grosenick L; Deisseroth K; LeDoux JE; Liston C; Klann E
Article: SCIENCE SIGNALING. 2017;10(504):eaan0665
Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.
Santini E; Huynh TN; Longo F; Koo SY; Mojica E; D'Andrea L; Bagni C; Klann E
Article: CEREBRAL CORTEX. 2017;27(2):1670-1685
Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.
Oaks AW; Zamarbide M; Tambunan DE; Santini E; Di Costanzo S; Pond HL; Johnson MW; Lin J; Gonzalez DM; Boehler JF; Wu GK; Klann E; Walsh CA; Manzini MC
Article: JOURNAL OF NEUROSCIENCE. 2016;36(45):11402-11410
Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy.
Chahrour M; O'Roak BJ; Santini E; Samaco RC; Kleiman RJ; Manzini MC
Article: BIOLOGICAL PSYCHIATRY. 2016;79(5):362-371
A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ΔFosB Expression
Feyder M; Sodersten E; Santini E; Vialou V; LaPlant Q; Watts EL; Spigolon G; Hansen K; Caboche J; Nestler EJ; Fisone G
Article: JOURNAL OF NEUROSCIENCE. 2015;35(49):16213-16220
Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice.
Santini E; Turner KL; Ramaraj AB; Murphy MP; Klann E; Kaphzan H
Article: NEUROBIOLOGY OF DISEASE. 2015;83:67-74
eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors.
Huynh TN; Shah M; Koo SY; Faraud KS; Santini E; Klann E
Article: JOURNAL OF NEUROSCIENCE. 2014;34(27):9034-9039
Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.
Huynh TN; Santini E; Klann E
Article: CELL REPORTS. 2013;4(3):405-412
Genetic reduction of the α1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome.
Kaphzan H; Buffington SA; Ramaraj AB; Lingrel JB; Rasband MN; Santini E; Klann E
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(3):240-252
Operant behavior to obtain palatable food modifies ERK activity in the brain reward circuit
Guegan T; Cutando L; Gangarossa G; Santini E; Fisone G; Martinez A; Valjent E; Maldonado R; Martin M
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(2):146-159
Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit
Guegan T; Cutando L; Ayuso E; Santini E; Fisone G; Bosch F; Martinez A; Valjent E; Maldonado R; Martin M
Article: NATURE. 2013;493(7432):411-415
Exaggerated translation causes synaptic and behavioural aberrations associated with autism.
Santini E; Huynh TN; MacAskill AF; Carter AG; Pierre P; Ruggero D; Kaphzan H; Klann E
Article: JOURNAL OF NEUROPHYSIOLOGY. 2013;109(1):68-76
Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation.
Hoeffer CA; Santini E; Ma T; Arnold EC; Whelan AM; Wong H; Pierre P; Pelletier J; Klann E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(33):27806-27812
Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism
Santini E; Feyder M; Gangarossa G; Bateup HS; Greengard P; Fisone G
Article: NEUROBIOLOGY OF DISEASE. 2012;45(3):1101-1110
Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.
Chévere-Torres I; Kaphzan H; Bhattacharya A; Kang A; Maki JM; Gambello MJ; Arbiser JL; Santini E; Klann E
Article: NEUROBIOLOGY OF DISEASE. 2012;45(1):156-164
Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin.
Chévere-Torres I; Maki JM; Santini E; Klann E
Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(12):2561-2570
Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32
Valjent E; Bertran-Gonzalez J; Bowling H; Lopez S; Santini E; Matamales M; Bonito-Oliva A; Herve D; Hoeffers C; Klann E; Girault J-A; Fisone G
Article: PLOS ONE. 2010;5(8):e12322
Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia
Santini E; Sgambato-Faure V; Li Q; Savasta M; Dovero S; Fisone G; Bezard E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14845-14850
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors
Bateup HS; Santini E; Shen W; Birnbaum S; Valjent E; Surmeier DJ; Fisone G; Nestler EJ; Greengard P
Article: CELL CYCLE. 2010;9(14):2713-2718
mTORC1 signaling in Parkinson disease and L-DOPA-induced dyskinesia A sensitized matter
Santini E; Valjent E; Fisone G
Article: NEUROBIOLOGY OF DISEASE. 2010;38(3):434-445
Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia
Napolitano F; Pasqualetti M; Usiello A; Santini E; Pacini G; Sciamanna G; Errico F; Tassone A; Di Dato V; Martella G; Cuomo D; Fisone G; Bernardi G; Mandolesi G; Mercuri NB; Standaert DG; Pisani A
Article: SCIENCE SIGNALING. 2009;2(80):ra36
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Santini E; Heiman M; Greengard P; Valjent E; Fisone G
Article: JOURNAL OF NEUROCHEMISTRY. 2009;108(3):621-633
l-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice
Santini E; Alcacer C; Cacciatore S; Heiman M; Herve D; Greengard P; Girault J-A; Valjent E; Fisone G
Article: NEUROPHARMACOLOGY. 2008;55(2):230-237
Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice
Borgkvist A; Valjent E; Santini E; Herve D; Girault J-A; Fisone G
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;37(2):335-345
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons
Errico F; Santini E; Migliarini S; Borgkvist A; Centonze D; Nasti V; Carta M; De Chiara V; Prosperetti C; Spano D; Herve D; Pasqualetti M; Di Lauro R; Fisone G; Usiello A
Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):8-14
Signaling in the basal ganglia:: Postsynaptic and presynaptic mechanisms
Fisone G; Hakansson K; Borgkvist A; Santini E
Article: JOURNAL OF NEUROSCIENCE. 2007;27(26):6995-7005
Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia
Santini E; Valjent E; Usiello A; Carta M; Borgkvist A; Girault J-A; Herve D; Greengard P; Fisone G
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All other publications

Editorial comment: NEURON. 2016;90(1):1-3
Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome.
Santini E; Klann E
Review: SWISS MEDICAL WEEKLY. 2016;146:w14314
Unlocking the molecular mechanisms of antipsychotics - a new frontier for discovery.
Bowling H; Santini E
Review: SCIENCE SIGNALING. 2014;7(349):re10
Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders.
Santini E; Klann E
Review: PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE. 2014;122:131-167
Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory.
Santini E; Huynh TN; Klann E
Review: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2011;5:76
Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs.
Santini E; Klann E
Thesis / dissertation: 2009
Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling
Santini, Emanuela
Review: THE FEBS JOURNAL. 2008;275(7):1392-1399
Parkinson's disease: Levodopa-induced dyskinesia and signal transduction
Santini E; Valjent E; Fisone G

Employments

Principal Researcher, Department of Neuroscience, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2009

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