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Elena Rodriguez-Vieitez

Senior researcher

Visiting address : Karolinska Institutet, Institutionen För Neurobiologi, Vårdvetenskap Och Samhälle (Nvs), Sektionen För Klinisk Geriatrik, Neo, Blickagången 16, Plan 7 141 52 Huddinge, Sweden
Postal address : Department of Neurobiology, Care Sciences and Society (NVS), H1, Division of Clinical geriatrics, Sektionen För Klinisk Geriatrik, Plan 7 141 83 Huddinge, Sweden
Delivery address : Sektionen För Klinisk Geriatrik, Neo/Lastkajen, Hälsovägen 7c 141 57 Huddinge, Sweden

About me

I am a researcher at the Division of Translational Alzheimer Neurobiology. My goal is to apply brain imaging techniques to the analysis of positron emission tomography (PET) data in Alzheimer patients as well as in a small animal transgenic model.

Education

PhD Nuclear Engineering, University of California, Berkeley, USA (2007)

 

 

Research description

My research is focused on the analysis of multi-tracer positron emission tomography (PET) imaging and its potential as an early diagnostic tool in Alzheimer's disease. Our group has a special interest in the early role of neuroinflammation and tau deposition in Alzheimer's disease. I am particularly involved in the analysis of PET data to understand the time courses and relationships between astrocytosis, cerebral blood flow, glucose metabolism, amyloid and tau deposition. A deeper understanding of the role of astrocytes in health and disease may open the path to novel therapeutic targets in Alzheimer's disease.  

Academic honours, awards and prizes

2013 Young Investigator Award, Human Amyloid Imaging Conference, Miami (USA), January 2013

2013-2014 Wenner-Gren Foundation Postdoctoral Fellowship

2012-2015 Research grants from Alzheimerfonden; Stiftelsen för ålderssjukdomar, Karolinska Institutet; KI Fonder; Gun och Bertil Stohnes Stiftelsen; Ahlén Stiftelsen; Stiftelsen för gamla tjänarinnor; Demensfonden; Loo och Hans Ostermans Stiftelsen

Links

Publications

Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
Rodriguez-vieitez E, Nordberg A
Methods in molecular biology (Clifton, N.J.) 2018;1750():231-251

Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease
Leuzy A, Rodriguez-vieitez E, Saint-aubert L, Chiotis K, Almkvist O, Savitcheva I, et al
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018;14(5):652-663

Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study
Thordardottir S, Rodriguez-vieitez E, Almkvist O, Ferreira D, Saint-aubert L, Kinhult-ståhlbom A, et al
Alzheimer's research & therapy 2018;10(1):45-

Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding
Lemoine L, Leuzy A, Chiotis K, Rodriguez-vieitez E, Nordberg A
Alzheimer's & dementia (Amsterdam, Netherlands) 2018;10():232-236

Comparability of [18F]THK5317 and [11C]PIB blood flow proxy images with [18F]FDG positron emission tomography in Alzheimer's disease
Rodriguez-vieitez E, Leuzy A, Chiotis K, Saint-aubert L, Wall A, Nordberg A
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017;37(2):740-749

Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer's disease dementia
Chiotis K, Saint-aubert L, Rodriguez-vieitez E, Leuzy A, Almkvist O, Savitcheva I, et al
Molecular psychiatry 2017;():-

Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease
Almkvist O, Rodriguez-vieitez E, Thordardottir S, Amberla K, Axelman K, Basun H, et al
Journal of the International Neuropsychological Society : JINS 2017;23(3):195-203

Tau PET imaging: present and future directions
Saint-aubert L, Lemoine L, Chiotis K, Leuzy A, Rodriguez-vieitez E, Nordberg A
Molecular neurodegeneration 2017;12(1):19-

Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease
Rodriguez-vieitez E, Carter Sf, Chiotis K, Saint-aubert L, Leuzy A, Schöll M, et al
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016;57(7):1071-7

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease
Rodriguez-vieitez E, Saint-aubert L, Carter Sf, Almkvist O, Farid K, Schöll M, et al
Brain : a journal of neurology 2016;139(Pt 3):922-36

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
Rodriguez-vieitez E, Ni R, Gulyás B, Tóth M, Häggkvist J, Halldin C, et al
European journal of nuclear medicine and molecular imaging 2015;42(7):1119-32

Case Report of Complex Amyotrophic Lateral Sclerosis with Cognitive Impairment and Cortical Amyloid Deposition
Farid K, Carter Sf, Rodriguez-vieitez E, Almkvist O, Andersen P, Wall A, et al
Journal of Alzheimer's disease : JAD 2015;47(3):661-7

Competing particle-hole excitations in Na-30: Constraining state-of-the-art effective interactions
Petri M, Fallon R, Macchiavelli Ao, Heil S, Rodriguez-vieitez E, Bazin D, et al
PHYSICS LETTERS B 2015;:173-177

Early astrocytosis in autosomal dominant Alzheimer's disease measured in vivo by multi-tracer positron emission tomography
Schöll M, Carter Sf, Westman E, Rodriguez-vieitez E, Almkvist O, Thordardottir S, et al
Scientific reports 2015;5():16404-

Statistical gamma rays in the analysis of surrogate nuclear reactions
Scielzo Nd, Escher Je, Allmond Jm, Basunia Ms, Beausang Cw, Bernstein La, et al
PHYSICAL REVIEW C 2012;85(5):-

Channel selection of neutron-rich nuclei following fusion-evaporation reactions of light systems
Gibelin J, Wiedeking M, Phair L, Fallon P, Basunia S, Bernstein La, et al
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2011;648(1):109-113

Benchmarking a surrogate reaction for neutron capture
Hatarik R, Bernstein La, Cizewski Ja, Bleuel Dl, Burke Jt, Escher Je, et al
PHYSICAL REVIEW C 2010;81(1):-

Two-proton knockout from Mg-32: Intruder amplitudes in Ne-30 and implications for the binding of F-29,F-31
Fallon P, Rodriguez-vieitez E, Macchiavelli Ao, Gade A, Tostevin Ja, Adrich P, et al
PHYSICAL REVIEW C 2010;81(4):-

Surrogate ratio method in the actinide region using the (alpha, alpha ' f) reaction
Lesher Sr, Burke Jt, Bernstein La, Ai H, Beausang Cw, Bleuel Dl, et al
PHYSICAL REVIEW C 2009;79(4):-

The (He-3, tf) as a surrogate reaction to determine (n, f) cross sections in the 10-20 MeV energy range
Basunia Ms, Clark Rm, Goldblum Bl, Bernstein La, Phair L, Burke Jt, et al
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 2009;267(11):1899-1903

Intruder excitations in P-35
Wiedeking M, Rodriguez-vieitez E, Fallon P, Carpenter Mp, Clark Rm, Cline D, et al
PHYSICAL REVIEW C 2008;78(3):-

Lifetime measurement of the first excited 2(+) state in C-16
Wiedeking M, Fallon P, Macchiavelli Ao, Gibelin J, Basunia Ms, Clark Rm, et al
PHYSICAL REVIEW LETTERS 2008;100(15):152501-

Nuclear structure of N-18 and the neighboring N=11 isotones
Wiedeking M, Fallon P, Macchiavelli Ao, Bernstein La, Gibelin J, Phair L, et al
PHYSICAL REVIEW C 2008;77(5):-

Absolute and relative surrogate measurements of the U-236(n,f) cross section as a probe of angular momentum effects
Lyles Bf, Bernstein La, Burke Jt, Dietrich Fs, Escher J, Thompson I, et al
PHYSICAL REVIEW C 2007;76(1):-

Absolute and relative surrogate measurements of the U-236(n,f) cross section as a probe of angular momentum effects (vol 76, pg 014606, 2007)
Lyles Bf, Bernstein La, Burke Jt, Dietrich Fs, Escher J, Thompson I, et al
PHYSICAL REVIEW C 2007;76(1):-

Deducing the U-237(n,f) cross section using the surrogate ratio method
Burke Jt, Bernstein La, Escher J, Ahle L, Church Ja, Dietrich Fs, et al
PHYSICAL REVIEW C 2006;73(5):-

Order-to-chaos transition in rotational nuclei
Lee Iy, Stephens Fs, Deleplanque Ma, Macchiavelli Ao, Ward D, Fallon P, et al
PHYSICA SCRIPTA 2006;:142-146

Shell structure at N=28 near the dripline: Spectroscopy of Si-42, P-43, and S-44
Fridmann J, Wiedenhover I, Gade A, Baby Lt, Bazin D, Brown Ba, et al
PHYSICAL REVIEW C 2006;74(3):-

Effects of neutron damage on the performance of large volume segmented germanium detectors
Descovich M, Lee Iy, Luke Pn, Clark Rm, Cromaz M, Deleplanque Ma, et al
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2005;545(1-2):199-209

GRETINA status and recent progress: The effect of neutron damage on energy and position resolution of the GRETINA detector
Descovich M, Lee Iy, Cromaz M, Clark Rm, Deleplanque Ma, Diamond Rm, et al
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 2005;241(1-4):931-934

'Magic' nucleus Si-42
Fridmann J, Wiedenhover I, Gade A, Baby Lt, Bazin D, Brown Ba, et al
NATURE 2005;435(7044):922-4

Order-to-chaos transition in rotational nuclei
Stephens Fs, Deleplanque Ma, Lee Iy, Macchiavelli Ao, Ward D, Fallon P, et al
PHYSICAL REVIEW LETTERS 2005;94(4):042501-

Population of nuclei via Li-7-induced binary reactions
Clark Rm, Phair Lw, Descovich M, Cromaz M, Deleplanque Ma, Fallon P, et al
PHYSICAL REVIEW C 2005;72(5):-

Searching for E(5) behavior in nuclei
Clark Rm, Cromaz M, Deleplanque Ma, Descovich M, Diamond Rm, Fallon P, et al
PHYSICAL REVIEW C 2004;69(6):-

Searching for X(5) behavior in nuclei
Clark Rm, Cromaz M, Deleplanque Ma, Descovich M, Diamond Rm, Fallon P, et al
PHYSICAL REVIEW C 2003;68(3):-

Kinetics of accelerated solid-state fermentation of organic-rich municipal solid waste
Vieitez Er, Mosquera J, Ghosh S
WATER SCIENCE AND TECHNOLOGY 2000;41(3):231-8

Biogasification of solid wastes by two-phase anaerobic fermentation
Vieitez Er, Ghosh S
BIOMASS & BIOENERGY 1999;16(5):299-309

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Presentations

Recent oral presentations:

“Divergent patterns of astrocytosis and fibrilar amyloid plaques as measured by PET in autosomal-dominant and sporadic Alzheimer’s disease”, Alzheimer's Association International Conference (AAIC 2015), July 18-23, 2015, Washington DC, USA

"Comparison of measurements of cerebral blood flow by early frames of 11C-deuterium-L-deprenyl (11C-DED) and 11C-PIB PET tracers at different stages of Alzheimer's disease", Alzheimer Imaging Consortium (AIC), Alzheimer's Association International Conference (AAIC 2014), July 12-17, 2014, Copenhagen, Denmark

"Astrocytosis precedes amyloid deposition in Alzheimer Tg2576 APPswe transgenic mice: A multi-tracer microPET imaging study", Alzheimer's Association International Conference (AAI C2013), July 13-18, 2013, Boston, USA