Duarte Ferreira
About me
In 2013, I received my PhD from the Faculty of Pharmacy, University of Lisbon where I did my PhD studies in Professor Rodrigues’ laboratory (iMed.UL, Faculty of Pharmacy, University of Lisbon), under her supervision and Dr Castro’s, to investigate the changes in the apoptosis and microRNAs among morbid obese patients with Non-Alcoholic Fatty Liver Diseases.
In 2013, thanks to Wenner-Gren Foundation, I moved to Stockholm, Sweden to pursue my postdoc under Professor Ruas mentorship at Karolinska Institutet. My postdoc studies explore different regulators of skeletal muscle mass and function as well as adipose tissue.
In 2018, I became Assistant professor, where I divide my time between teaching (70%) and research (30%).
In 2023, I joined Dr. Lanner lab at Karolinska Institutet, where I will focus on novel pharmacological interventions to improve mitochondrial function and enhance the antioxidant defence in dysfunctional skeletal muscle.
Research
I am studying how chronic inflammation reprograms whole-body metabolism by disrupting mitochondria and by altering liver and adipose fuel handling. I am interested in mapping the causal chain inflammation → mitochondrial stress → impaired insulin signalling across skeletal muscle, liver, and visceral fat, using arthritis and diet models (CFA/CAIA ± HFD), patient samples/biobanks, and advanced phenotyping (in vivo glucose uptake, ex vivo contractility, respirometry, targeted transcriptomics).
Keywords: inflammation, insulin resistance, skeletal muscle, liver, adipose tissue, mitochondria, RA, T2D, CAIA/CFA, HFD.
Teaching
I have accumulated over 1, 000 hours of teaching experience across various educational environments, including laboratories, seminars, and lectures. My teaching is primarily focused towards medical, dental, and biomedical students, with an emphasis on subjects around physiology and pharmacology. Moreover, I have supervised numerous students in their research theses at the bachelor's, master's, and doctoral levels. These teaching experiences have been extremely rewarding and fulfilling; I really enjoy helping students develop their understanding towards topics that I am passionate about.
Responsible teacher for the “Advanced Physiology, smaller course” (HL2017) and “Advanced Physiology” (HL2018) course for the master program in collaboration with KTH until autumn 2021.
Moment responsible teacher for the course DFM1 (until spring semester 2021) and DSM1.1 (until spring semester 2022) in the 5.5-year medical program.
Examiner and responsible teacher for the “Pharmacology with Toxicology” course (1BI045) for the Biomedicine bachelor program until spring 2023.
Responsible teacher for the course “Basic Science 5”, 30 HP (2LA004), in the 6-year medical program
Responsible teacher for the course “GCP and Clinical Pharmaceutical trials”, 3.5HP (4FF011) in the Master’s program in Translational Physiology and PharmacologyResponsible teacher for the course “Information literacy: searching, writing and presenting science”, 4.0HP (4FF013) in the Master’s program in Translational Physiology and Pharmacology
Examiner for the course “Laboratory animal science, behavior and metabolism”, 7.5HP (4FF009) in the Master’s program in Translational Physiology and Pharmacology
Examiner for the course “Applied physiology and pharmacology - research project 1”, 7.5HP (4FF005) in the Master’s program in Translational Physiology and Pharmacology
Examiner for the course “Applied physiology and pharmacology - research project 2”, 7.5HP (4FF006) in the Master’s program in Translational Physiology and Pharmacology
Examiner for the course “Degree project in translational physiology and pharmacology”, 30HP (4FF007) in the Master’s program in Translational Physiology and Pharmacology
Examiner and responsible teacher for the course to PhD students regarding “Mechanisms of Gene Regulation in Metabolism” (#3157).
Semester responsible and basic scientific competence responsible for the first semester of the 6-year medical program.
Director of Studies in Pharmacology
Director of Studies in the Master’s program in Translational Physiology and Pharmacology
Articles
- Article: FASEB JOURNAL. 2021;35(12):e22010Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
- Article: NATURE COMMUNICATIONS. 2021;12(1):5948Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
- Article: METABOLITES. 2021;11(8):508Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
- Article: BMC BIOLOGY. 2021;19(1):57Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
- Article: REDOX BIOLOGY. 2020;28:101387Peleli M; Ferreira DMS; Tarnawski L; Haworth SM; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlstrom M
- Article: SKELETAL MUSCLE. 2019;9(1):26Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
- Article: NATURE COMMUNICATIONS. 2019;10(1):2767Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
- Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):519-533Dadvar S; Ferreira DMS; Cervenka I; Ruas JL
- Article: MOLECULAR METABOLISM. 2018;9:28-42Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
- Article: CELL METABOLISM. 2018;27(2):378-392.e5Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
- Article: MOLECULAR METABOLISM. 2018;7:12-22Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
- Article: CELL. 2014;159(1):33-45Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2014;34(6):1100-1120Ferreira DMS; Afonso MB; Rodrigues PM; Simao AL; Pereira DM; Borralho PM; Rodrigues CMP; Castro RE
- Article: JOURNAL OF HEPATOLOGY. 2013;58(1):119-125Castro RE; Ferreira DMS; Afonso MB; Borralho PM; Machado MV; Cortez-Pinto H; Rodrigues CMP
- Article: PLOS ONE. 2012;7(2):e31738Machado MV; Ferreira DMS; Castro RE; Silvestre AR; Evangelista T; Coutinho J; Carepa F; Costa A; Rodrigues CMP; Cortez-Pinto H
- Article: PLOS ONE. 2011;6(8):e23787Borralho PM; Simoes AES; Gomes SE; Lima RT; Carvalho T; Ferreira DMS; Vasconcelos MH; Castro RE; Rodrigues CMP
- Article: DIABETOLOGIA. 2011;54(7):1788-1798Ferreira DMS; Castro RE; Machado MV; Evangelista T; Silvestre A; Costa A; Coutinho J; Carepa F; Cortez-Pinto H; Rodrigues CMP
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2010;299(4):G887-G897Castro RE; Ferreira DMS; Zhang X; Borralho PM; Sarver AL; Zeng Y; Steer CJ; Kren BT; Rodrigues CMP
All other publications
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
- Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
- Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314Correia JC; Ferreira DMS; Ruas JL
- Corrigendum: CELL. 2015;160(1-2):351Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
- Review: FEBS JOURNAL. 2014;281(11):2503-2524Ferreira DMS; Simao AL; Rodrigues CMP; Castro RE
- Review: CURRENT PHARMACEUTICAL DESIGN. 2010;16(25):2851-2864Castro RE; Santos MMM; Gloria PMC; Ribeiro CJA; Ferreira DMS; Xavier JM; Moreira R; Rodrigues CMP
Employments
- Assistant Senior Lecturer, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-
- Assistant Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2018-2024