Dimitris Kanellis

About me
Publications
Public outreach and news

About me

Interested in interpreting biological patterns in cancer. From bench to
desk-side, equally excited for wet lab techniques and data analytics.
Bsc Biology, AUTH, Thessaloniki, GR
Msc 'The molecular Basis of Human Diseases', Medical School, UOC, Heraklion,
GR
PhD in 'Inflammation-associated Carcinogenesis' IMBB/FORTH, Heraklion, GR

Research

Studying cancer vulnerabilities emerging from aberrant post-transcriptional
events.

Articles

Article: CELL DEATH AND DIFFERENTIATION. 2023;30(7):1666-1678

Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.

Kanellis DC; Zisi A; Skrott Z; Lemmens B; Espinoza JA; Kosar M; Björkman A; Li X; Arampatzis S; Bartkova J; Andújar-Sánchez M; Fernandez-Capetillo O; Mistrik M; Lindström MS; Bartek J
Article: NEURO-ONCOLOGY. 2023;25(6):1058-1072

Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth.

Zisi A; Kanellis DC; Moussaud S; Karlsson I; Carén H; Bräutigam L; Bartek J; Lindström MS
Article: CELL REPORTS. 2023;42(1):111979

MDC1 maintains active elongation complexes of RNA polymerase II.

Pappas G; Munk SHN; Watanabe K; Thomas Q; Gál Z; Gram HH; Lee M; Gómez-Cabello D; Kanellis DC; Olivares-Chauvet P; Larsen DH; Gregersen LH; Maya-Mendoza A; Galanos P; Bartek J
Article: SCIENCE ADVANCES. 2021;7(32):eabf7561

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.

Kanellis DC; Espinoza JA; Zisi A; Sakkas E; Bartkova J; Katsori A-M; Boström J; Dyrskjøt L; Broholm H; Altun M; Elsässer SJ; Lindström MS; Bartek J
Article: PLOS BIOLOGY. 2021;19(5):e3001263

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors.

Corman A; Kanellis DC; Michalska P; Häggblad M; Lafarga V; Bartek J; Carreras-Puigvert J; Fernandez-Capetillo O
Article: GENES & DEVELOPMENT. 2020;34(15-16):1065-1074

Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution.

Björkman A; Johansen SL; Lin L; Schertzer M; Kanellis DC; Katsori A-M; Christensen ST; Luo Y; Andersen JS; Elsässer SJ; Londono-Vallejo A; Bartek J; Schou KB
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity.

Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Hühn D; Watanabe K; Helleday T; Lindström MS; Bartek J
Article: ONCOGENE. 2016;35(19):2496-2505

Apolipoprotein A-I inhibits experimental colitis and colitis-propelled carcinogenesis.

Gkouskou KK; Ioannou M; Pavlopoulos GA; Georgila K; Siganou A; Nikolaidis G; Kanellis DC; Moore S; Papadakis KA; Kardassis D; Iliopoulos I; McDyer FA; Drakos E; Eliopoulos AG
Article: ONCOGENE. 2015;34(19):2516-2526

Physical and functional interaction of the TPL2 kinase with nucleophosmin.

Kanellis DC; Bursac S; Tsichlis PN; Volarevic S; Eliopoulos AG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1470-E1479

TPL2 kinase is a suppressor of lung carcinogenesis.

Gkirtzimanaki K; Gkouskou KK; Oleksiewicz U; Nikolaidis G; Vyrla D; Liontos M; Pelekanou V; Kanellis DC; Evangelou K; Stathopoulos EN; Field JK; Tsichlis PN; Gorgoulis V; Liloglou T; Eliopoulos AG

All other publications

Letter: LEUKEMIA. 2024;38(3):663-666

The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia.

Miliara S; Cozzi E; Zhong X; Chan I; Ekwall K; Lehmann S; Lennartsson A; Bartek J; Kanellis DC
Review: CANCER LETTERS. 2011;304(2):80-89

Tpl2 kinase signal transduction in inflammation and cancer.

Vougioukalaki M; Kanellis DC; Gkouskou K; Eliopoulos AG

About me

Research

Articles

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