David Schmidt

About me
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About me

I'm a specialist trainee in pediatrics and pediatric hemostasis, Astrid Lindgren Children's Hospital, and associate researcher at the Department of Women's and Children's Health (KBH), Karolinska Institutet. My interests are studies on the intersection of laboratory biomedicine and epidemiology in hemostasis and thrombosis (blood clotting).

I like to approach clinical challenges through a holistic framework which features continuous flow from challenge to research and implementation. For my future, I aspire to participate in collaborative, excellent translational clinical research, combining basic and clinical sciences, while assuring societal relevance and impact as core principles.

Education
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PhD, Leiden University/Sanquin Landsteiner Laboratory - Amsterdam UMC (2022)
MD/MSc, Utrecht University (2016)
BSc Biomedical Sciences/Molecular Medicine, Maastricht University (2012, cum laude)

Awards and Scholarships
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2023 Aroseniusfonden Grant, Swedish Association for Bleeding Disorders (FBIS)
2022 Stipend Svenska Läkaresällskap - Swedish Society for Thrombosis and Hemostasis (SSTH)
2021 Young Investigator Award, International Society for Thrombosis and Hemostasis (Philadelphia)
2019 Abstract Award, American Society for Hematology (Orlando)
2018 Abstract Award, American Society for Hematology (San Diego)
2018 Young Investigator Award, European Congress for Thrombosis and Hemostasis (Marseille)
2018 Abstract Award, Nordic Coagulation Meeting (Stockholm)
2017 Abstract Award, Sanquin Science Symposium (Amsterdam)
2017 Young Investigator Award, International Society for Thrombosis and Hemostasis (Berlin)
2016 - 2020 Doctoral research scholarship, Studienstiftung des Deutschen Volkes
2012 - 2016 Student scholarship, Studienstiftung des Deutschen Volkes

Research

* Diagnostic accuracy studies in coagulopathies and platelet disorders
* Clinical and molecular prognosis in childhood immune thrombocytopenia
* Statistical learning and penalized regression (LASSO, ridge, Elastic Net)

Articles

Article: THROMBOSIS AND HAEMOSTASIS. 2024;124(01):32-39
Clinical Implications of Discrepancy between One-Stage Clotting and Chromogenic Factor IX Activity in Hemophilia B
Schmidt DE; Truedsson A; Stralfors A; Hojbjerg JA; Soutari N; Holmstrom M; Ranta S; Letelier A; Bowyer A; Ljung R; Antovic J; Bruzelius M
Journal article: BLOOD. 2023;142:3955
ITGB1-Expressing Effector Memory CD4+T-Cell Response Associates with Clinical Recovery in Childhood Immune Thrombocytopenia
Schmidt DE; Heitink-Polle K; Nicolet BP; Porcelijn L; Bruin M; Van der Schoot E; Kapur R; Vidarsson G; De Haas M
Article: ISCIENCE. 2023;26(9):107619
Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines.
Van Coillie J; Pongracz T; Šuštić T; Wang W; Nouta J; Le Gars M; Keijzer S; Linty F; Cristianawati O; Keijser JBD; Visser R; van Vught LA; Slim MA; van Mourik N; Smit MJ; Sander A; Schmidt DE; Steenhuis M; Rispens T; Nielsen MA; Mordmüller BG; Vlaar APJ; Ellen van der Schoot C; Roozendaal R; Wuhrer M; Vidarsson G; UMC COVID-19 S3/HCW study group; Fatebenefratelli-Sacco Infectious Diseases Physici; Radboud University Medical Center (RUMC) and COUGH
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1225603
Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia.
Szittner Z; Bentlage AEH; Temming AR; Schmidt DE; Visser R; Lissenberg-Thunnissen S; Mok JY; van Esch WJE; Sonneveld ME; de Graaf EL; Wuhrer M; Porcelijn L; de Haas M; van der Schoot CE; Vidarsson G
Article: HAEMOPHILIA. 2022;28(6):1054-1061
Long-term joint outcomes in adolescents with moderate or severe haemophilia A
Schmidt DE; Michalopoulou A; Fischer K; Motwani J; Andersson NG; Pergantou H; Ranta S
Article: SCIENTIFIC REPORTS. 2021;11(1):24045
A functional spleen contributes to afucosylated IgG in humans.
Wojcik I; Schmidt DE; de Neef LA; Rab MAE; Meek B; de Weerdt O; Wuhrer M; van der Schoot CE; Zwaginga JJ; de Haas M; Falck D; Vidarsson G
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021;19(4):1071-1081
Biological stratification of clinical disease courses in childhood immune thrombocytopenia
Schmidt DE; Heitink-Polle KMJ; Mertens B; Porcelijn L; Kapur R; van Der Schoot CE; Vidarsson G; van Der Bom JG; Bruin MCA; de Haas M
Journal article: ANNALS OF BLOOD. 2021;6(0):3
Intravenous immunoglobulins (IVIg) in childhood immune thrombocytopenia: towards personalized medicine—a narrative review
Schmidt DE; Heitink-Pollé KMJ; Bruin MCA; de Haas M
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021;19(1):121-130
A clinical prediction score for transient versus persistent childhood immune thrombocytopenia
Schmidt DE; Wendtland Edslev P; Heitink-Polle KMJ; Mertens B; Bruin MCA; Kapur R; Vidarsson G; van der Schoot CE; Porcelijn L; van der Bom JG; Rosthoj S; de Haas M
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(01):27-35
Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays
Stralfors A; Mikovic D; Schmidt D; Onelov L; Soutari NMH; Berndtson M; Chaireti R; Holmstrom M; Antovic JP; Bruzelius M
Article: TH OPEN. 2020;4(3):e178-e188
Diagnostic Accuracy in Acute Venous Thromboembolism: Comparing D-Dimer, Thrombin Generation, Overall Hemostatic Potential, and Fibrin Monomers.
Farm M; Antovic A; Schmidt DE; Bark N; Soutari N; Siddiqui AJ; Holmström M; Pruner I; Antovic JP
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(5):1210-1220
Anti-platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications
Schmidt DE; Heitink-Polle KMJ; Porcelijn L; van der Schoot CE; Vidarsson G; Bruin MCA; de Haas M
Article: SCIENTIFIC REPORTS. 2020;10(1):3051
IgG-Fc glycosylation before and after rituximab treatment in immune thrombocytopenia.
Schmidt DE; de Haan N; Sonneveld ME; Porcelijn L; van der Schoot CE; de Haas M; Zwaginga J-J; Wuhrer M; Vidarsson G
Article: BLOOD ADVANCES. 2019;3(13):2003-2012
Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms
Schmidt DE; Heitink-Polle KMJ; Laarhoven AG; Bruin MCA; Veldhuisen B; Nagelkerke SQ; Kuijpers TW; Porcelijn L; van der Schoot CE; Vidarsson G; de Haas M
Article: THROMBOSIS RESEARCH. 2019;178:34-40
Correlation of thromboelastography and thrombin generation assays in warfarin-treated patients
Schmidt DE; Chaireti R; Bruzelius M; Holmstrom M; Antovic J; Agren A
Article: HAEMATOLOGICA. 2019;104(2):403-416
Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets.
Rijkers M; Schmidt D; Lu N; Kramer CSM; Heidt S; Mulder A; Porcelijn L; Claas FHJ; Leebeek FWG; Jansen AJG; Jongerius I; Zeerleder SS; Vidarsson G; Voorberg J; de Haas M
Article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION. 2017;77(6):397-405
Relative effects of plasma, fibrinogen concentrate, and factor XIII on ROTEM coagulation profiles in an in vitro model of massive transfusion in trauma
Schmidt DE; Halmin M; Wikman A; Ostlund A; Agren A
Article: THROMBOSIS AND HAEMOSTASIS. 2017;117(8):1528-1533
Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease
Schmidt DE; Bruzelius M; Majeed A; Odeberg J; Holmstrom M; Agren A
Article: HAEMOPHILIA. 2017;23(2):309-318
A prospective diagnostic accuracy study evaluating rotational thromboelastometry and thromboelastography in 100 patients with von Willebrand disease
Schmidt DE; Majeed A; Bruzelius M; Odeberg J; Holmstrom M; Agren A
Article: THROMBOSIS AND HAEMOSTASIS. 2017;117(1):75-85
Monitoring of coagulation factor therapy in patients with von Willebrand disease type 3 using a microchip flow chamber system
Agren A; Holmstrom M; Schmidt DE; Hosokawa K; Blomback M; Hjemdahl P
Article: NETHERLANDS HEART JOURNAL. 2016;24(12):722-729
CC chemokine ligands in patients presenting with stable chest pain: association with atherosclerosis and future cardiovascular events.
Versteylen MO; Manca M; Joosen IA; Schmidt DE; Das M; Hofstra L; Crijns HJ; Biessen EA; Kietselaer BL
Article: TRENDS IN CARDIOVASCULAR MEDICINE. 2015;25(7):578-587
Circulating endothelial cells in coronary artery disease and acute coronary syndrome.
Schmidt DE; Manca M; Hoefer IE
Article: THROMBOSIS RESEARCH. 2015;135(5):1007-1011
Detection of elevated INR by thromboelastometry and thromboelastography in warfarin treated patients and healthy controls
Schmidt DE; Holmstrom M; Majeed A; Naslin D; Wallen H; Agren A
Article: BLOOD COAGULATION AND FIBRINOLYSIS. 2015;26(1):81-87
Thrombin generation in a patient with an acquired high-titre factor V inhibitor
Schmidt DE; Steinhagen F; Schnabel C; Spath B; Holstein K; Fiedler W; Bokemeyer C; Renne T; Langer F
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All other publications

Review: TRANSFUSION MEDICINE REVIEWS. 2020;34(4):258-269
Evolution and Utility of Antiplatelet Autoantibody Testing in Patients with Immune Thrombocytopenia.
Porcelijn L; Schmidt DE; Oldert G; Hofstede-van Egmond S; Kapur R; Zwaginga JJ; de Haas M
Preprint: MEDRXIV. 2020
Age at Diagnosis Shapes the Prognosis of Childhood Immune Thrombocytopenia
Schmidt DE; Edslev PW; Heitink-Pollé KMJ; Kapur R; Porcelijn L; van der Schoot CE; Vidarsson G; Bruin MCA; Rosthøj S; de Haas M
Review: VOX SANGUINIS. 2020;115(4):323-333
Anti-platelet antibody immunoassays in childhood immune thrombocytopenia: a systematic review
Schmidt DE; Lakerveld AJ; Heitink-Polle KMJ; Bruin MCA; Vidarsson G; Porcelijn L; de Haas M
Letter: HAEMATOLOGICA. 2020;105(4):e172-e174
Anti-glycoprotein Ibα autoantibodies do not impair circulating thrombopoietin levels in immune thrombocytopenia patients.
Porcelijn L; Schmidt DE; van der Schoot CE; Vidarsson G; de Haas M; Kapur R
Meeting abstract: BLOOD. 2019;134:2376
A Clinical Prediction Score for Course of Disease in Newly Diagnosed Childhood Immune Thrombocytopenia
Schmidt D; Heitink-Polle KMJ; van der Schoot CE; Porcelijn L; Vidarsson G; Bruin M; van der Bom JG; De Haas M
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2237
Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine.
Nagelkerke SQ; Schmidt DE; de Haas M; Kuijpers TW
Meeting abstract: BLOOD. 2018;132:1145
Identification of Self-Limiting Pediatric Immune Thrombocytopenia at Diagnosis
Schmidt D; Heitink-Polle K; Mertens B; Laarhoven AG; Porcelijn L; Veldhuisen B; van der Schoot CE; Vidarsson G; van der Bom JG; Bruin M; De Haas M

Employments

Resident Pediatrics, Astrid Lindgren Children's Hospital, Karolinska University Hospital, 2020-
Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2023-2026
Affiliated to Research, Women's and Children's Health, Karolinska Institute, 2020-2023

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