David Lane

About me
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About me

Professor of Tumour Supressor Biology.

Articles

Article: MOLECULAR PHARMACEUTICS. 2025;22(6):3479-3490
Engineered Peptide Coacervates Enable Efficient Intracellular Delivery of the MYC Inhibitor omoMYC
Cerrato CP; Krkoska M; Sun Y; Liano-Pons J; Neo QY; Vosselman T; Alzrigat M; Vojtesek B; Lane DP; Henriksson MA; Miserez A; Landreh M
Article: SCIENTIFIC REPORTS. 2025;15(1):1000
Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools
Spiegelberg D; Hwang L-A; Pua KH; Kumar SC; Koh XY; Koh XH; Selvaraju RK; Sabapathy K; Nestor M; Lane D
Article: STRUCTURE. 2024;32(11):2160-2167.e2
AlphaFold with conformational sampling reveals the structural landscape of homorepeats
Bonet ADF; Ranyai S; Aswad L; Lane DP; Arsenian-Henriksson M; Landreh M; Lama D
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2024;146(28):19555-19565
Controlling Drug Partitioning in Individual Protein Condensates through Laser-Induced Microscale Phase Transitions
Leppert A; Feng J; Railaite V; Pessatti TB; Cerrato CP; Morman C; Osterholz H; Lane DP; Maia FRNC; Linder MB; Rising A; Landreh M
Article: ISCIENCE. 2024;27(6):109862
MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
Ingelshed K; Melssen MM; Kannan P; Chandramohan A; Partridge AW; Jiang L; Wermeling F; Lane DP; Nestor M; Spiegelberg D
Article: NATURE COMMUNICATIONS. 2024;15(1):1865
A druggable conformational switch in the c-MYC transactivation domain
Lama D; Vosselman T; Sahin C; Liano-Pons J; Cerrato CP; Nilsson L; Teilum K; Lane DP; Landreh M; Arsenian Henriksson M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51(3):768-778
p53 stabilisation potentiates [¹⁷⁷Lu]Lu-DOTATATE treatment in neuroblastoma xenografts
Berglund H; Salomonsson SL; Mohajershojai T; Gago FJF; Lane DP; Nestor M
Article: NATURE COMMUNICATIONS. 2024;15(1):489
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Chandramohan A; Josien H; Yuen TY; Duggal R; Spiegelberg D; Yan L; Juang Y-CA; Ge L; Aronica PG; Kaan HYK; Lim YH; Peier A; Sherborne B; Hochman J; Lin S; Biswas K; Nestor M; Verma CS; Lane DP; Sawyer TK; Garbaccio R; Henry B; Kannan S; Brown CJ; Johannes CW; Partridge AW
Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10542
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays
Kasper SH; Otten S; Squadroni B; Orr-Terry C; Kuang Y; Mussallem L; Ge L; Yan L; Kannan S; Verma CS; Brown CJ; Johannes CW; Lane DP; Chandramohan A; Partridge AW; Roberts LR; Josien H; Therien AG; Hett EC; Howell BJ; Peier A; Ai X; Cassaday J
Article: ANALYTICAL CHEMISTRY. 2023;95(29):10869-10872
Monitoring Disassembly and Cargo Release of Phase-Separated Peptide Coacervates with Native Mass Spectrometry
Cerrato CPP; Leppert A; Sun Y; Lane DPP; Arsenian-Henriksson M; Miserez A; Landreh M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(13):e2219978120
Proteasome inhibitor bortezomib stabilizes and activates p53 in hematopoietic stem/progenitors and double-negative T cells in vivo
Xue Y; San Luis B; Dress RJ; Murad KBA; Ginhoux F; Barker N; Lane D
Article: NATURE COMMUNICATIONS. 2023;14(1):1726
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Ho TLF; Lee MY; Goh HC; Ng GYN; Lee JJH; Kannan S; Lim YT; Zhao T; Lim EKH; Phua CZJ; Lee YF; Lim RYX; Ng PJH; Yuan J; Chan DKH; Lieske B; Chong CS; Lee KC; Lum J; Cheong WK; Yeoh KG; Tan KK; Sobota RM; Verma CS; Lane DP; Tam WL; Venkitaraman AR
Article: SCIENTIFIC REPORTS. 2023;13(1):4583
MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia
Lerma Clavero A; Boqvist PL; Ingelshed K; Bosdotter C; Sedimbi S; Jiang L; Wermeling F; Vojtesek B; Lane DP; Kannan P
Article: PNAS NEXUS. 2023;2(2):pgac303
A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1
Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmae M; Chen G; Elofsson A; Allison TM; Arsenian-Henriksson M; Johansson J; Lane DP; Hallberg BM; Landreh M
Article: SCIENTIFIC REPORTS. 2022;12(1):22564
Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy
Koh XY; Koh XH; Spiegelberg D; Jha P; Nestor M; Hwang L-A; Tan BX; Lane DP
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
Article: NATURE COMMUNICATIONS. 2022;13(1):4854
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
Frosi Y; Lin Y-C; Jiang S; Ramlan SR; Hew K; Engman AH; Pillai A; Yeung K; Cheng YX; Cornvik T; Nordlund P; Goh M; Lama D; Gates ZP; Verma CS; Thean D; Lane DP; Asial I; Brown CJ
Article: STRUCTURE. 2022;30(5):733-742.e7
A "spindle and thread"mechanism unblocks p53 translation N-terminal disorder
Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:883083
An Automated Quantification Tool for Angiogenic Sprouting From Endothelial Spheroids
Kannan P; Schain M; Lane DP
Article: CELL CHEMICAL BIOLOGY. 2022;29(4):572-585.e8
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
Liang YY; Bacanu S; Sreekumar L; Ramos AD; Dai L; Michaelis M; Cinatl J; Seki T; Cao Y; Coffill CR; Lane DP; Prabhu N; Nordlund P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(10):e2113233119
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity
Wang Y-H; Ho TLF; Hariharan A; Goh HC; Wong YL; Verkaik NS; Lee MY; Tam WL; van Gent DC; Venkitaraman AR; Sheetz MP; Lane DP
Article: CANCER RESEARCH. 2022;82(1):36-45
CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
Jiang L; Ingelshed K; Shen Y; Boddul SV; Iyer VS; Kasza Z; Sedimbi S; Lane DP; Wermeling F
Article: BIOMOLECULES. 2021;11(11):1695
p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids
Lundsten S; Berglund H; Jha P; Krona C; Hariri M; Nelander S; Lane DP; Nestor M
Article: AUTOPHAGY. 2021;17(11):3577-3591
CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response
He C; Wang S; Zhou C; He M; Wang J; Ladds M; Lianoudaki D; Sedimbi SK; Lane DP; Westerberg LS; Li S; Karlsson MCI
Article: NATURE COMMUNICATIONS. 2021;12(1):5720
A general approach to protein folding using thermostable exoshells
Sadeghi S; Deshpande S; Mavelli GV; Aksoyoglu A; Bafna J; Winterhalter M; Kini RM; Lane DP; Drum CL
Article: BIOMOLECULES. 2021;11(7):1056
Can Glycosylation Mask the Detection of MHC Expressing p53 Peptides by T Cell Receptors?
Thanh BN; Lane DP; Verma CS
Article: CANCERS. 2021;13(12):2985
Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment
Bhatta B; Luz I; Krueger C; Teo FX; Lane DP; Sabapathy K; Cooks T
Article: PHARMACEUTICAL RESEARCH. 2021;38(5):843-850
Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides
Desai TJ; Habulihaz B; Cannon JR; Chandramohan A; Kaan HYK; Sadruddin A; Yuen TY; Johannes C; Thean D; Brown CJ; Lane DP; Partridge AW; Evers R; Sawyer TK; Hochman J
Article: JCI INSIGHT. 2021;6(6):140273
Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells
Kritikou JS; Oliveira MMS; Record J; Saeed MB; Nigam SM; He M; Keszei M; Wagner AK; Brauner H; Sendel A; Sedimbi SK; Rentouli S; Lane DP; Snapper SB; Karre K; Vandenberghe P; Orange JS; Westerberg LS
Article: ACS CHEMICAL BIOLOGY. 2021;16(2):293-309
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay
Peier A; Ge L; Boyer N; Frost J; Duggal R; Biswas K; Edmondson S; Hermes JD; Yan L; Zimprich C; Sadruddin A; Kaan HYK; Chandramohan A; Brown CJ; Thean D; Lee XE; Yuen TY; Ferrer-Gago FJ; Johannes CW; Lane DP; Sherborne B; Corona C; Robers MB; Sawyer TK; Partridge AW
Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2021;1865(1):129775
Conformational ordering of intrinsically disordered peptides for targeting translation initiation
Brown CJ; Verma CS; Lane DP; Lama D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(52):17935-17949
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology
Ladds MJGW; Popova G; Pastor-Fernandez A; Kannan S; van Leeuwen IMM; Hakansson M; Walse B; Tholander F; Bhatia R; Verma CS; Lane DP; Lain S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: ACS MEDICINAL CHEMISTRY LETTERS. 2020;11(10):1993-2001
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits
Ng S; Juang Y-C; Chandramohan A; Kaan HYK; Sadruddin A; Yuen TY; Ferrer-Gago FJ; Lee XC; Liew X; Johannes CW; Brown CJ; Kannan S; Aronica PG; Berglund NA; Verma CS; Liu L; Stoeck A; Sawyer TK; Partridge AW; Lane DP
Article: FRONTIERS IN ONCOLOGY. 2020;10:1717
The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
Spiegelberg D; Mortensen ACL; Palupi KD; Micke P; Wong J; Vojtesek B; Lane DP; Nestor M
Article: CELL REPORTS. 2020;32(2):107897
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
Johansson P; Krona C; Kundu S; Doroszko M; Baskaran S; Schmidt L; Vinel C; Almstedt E; Elgendy R; Elfineh L; Gallant C; Lundsten S; Gago FJF; Hakkarainen A; Sipila P; Haggblad M; Martens U; Lundgren B; Frigault MM; Lane DP; Swartling FJ; Uhrbom L; Nestor M; Marino S; Nelander S
Article: FEBS JOURNAL. 2020;287(13):2823-2833
High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry
Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
Article: CHEMICAL SCIENCE. 2020;11(21):5577-5591
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability
Kannan S; Aronica PGA; Ng S; Lian DTG; Frosi Y; Chee S; Jiang S; Yuen TY; Sadruddin A; Kaan HYK; Chandramohan A; Wong JH; Tan YS; Chang ZW; Ferrer-Gago FJ; Arumugam P; Han Y; Chen S; Renia L; Brown CJ; Johannes CW; Henry B; Lane DP; Sawyer TK; Verma CS; Partridge AW
Article: NATURE METHODS. 2020;17(5):505-508
Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins
Gault J; Liko I; Landreh M; Shutin D; Bolla JR; Jefferies D; Agasid M; Yen H-Y; Ladds MJGW; Lane DP; Khalid S; Mullen C; Remes PM; Huguet R; McAlister G; Goodwin M; Viner R; Syka JEP; Robinson CV
Article: NATURE COMMUNICATIONS. 2020;11(1):2086
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Kong LR; Ong RW; TariD TZ; Salleh NABM; Thangavelu M; Chan JV; Koh LYJ; Periyasamy G; Lau JA; Le TBU; Wang L; Lee M; Kannan S; Verma CS; Lim CM; Chng WJ; Lane DP; Venkitaraman A; Hung HT; Cheok CF; Goh BC
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(8):3915-3934
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Popova G; Ladds MJGW; Johansson L; Saleh A; Larsson J; Sandberg L; Sahlberg SH; Qian W; Gullberg H; Garg N; Gustavsson A-L; Haraldsson M; Lane D; Yngve U; Lain S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(16):9054-9063
Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses
Sedimbi SK; Hagglof T; Garimella MG; Wang S; Duhlin A; Coelho A; Ingelshed K; Mondoc E; Malin SG; Holmdahl R; Lane DP; Leadbetter EA; Karlsson MCI
Article: NANOMATERIALS. 2020;10(4):E783-783
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
Lundsten S; Hernandez VA; Gedda L; Saren T; Brown CJ; Lane DP; Edwards K; Nestor M
Article: EJNMMI RESEARCH. 2020;10(1):38
Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2
Mortensen ACL; Morin E; Brown CJ; Lane DP; Nestor M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(11):5791-5800
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
Lim S; Khoo R; Peh KM; Teo J; Chang SC; Ng S; Beilhartz GL; Melnyk RA; Johannes CW; Brown CJ; Lane DP; Henry B; Partridge AW
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020;59(9):3523-3528
A Mass-Spectrometry-Based Approach to Distinguish Annular and Specific Lipid Binding to Membrane Proteins
Bolla JR; Corey RA; Sahin C; Gault J; Hummer A; Hopper JTS; Lane DP; Drew D; Allison TM; Stansfeld PJ; Robinson CV; Landreh M
Article: CHEMISTRY-A EUROPEAN JOURNAL. 2020;26(2):379-383
Functionalized Resins for the Synthesis of Peptide Alcohols
Ferrer-Gago FJ; Koh LQ; Lane DP
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2020;476:112683
The quantification of antibody elements and receptors subunit expression using qPCR: The design of VH, VL, CH, CL, FcR subunits primers for a more holistic view of the immune system
Ling W-L; Ng Y-L; Wipat A; Lane DP; Gan SK-E
Article: MOLECULES. 2019;24(24):E4586-4586
Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides
Diller DJ; Swanson J; Bayden AS; Brown CJ; Thean D; Lane DP; Partridge AW; Sawyer TK; Audie J
Article: SCIENTIFIC REPORTS. 2019;9(1):17933
Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci
Frosi Y; Inoue K; Ramlan SR; Lane DP; Watanabe T; Brown CJ
Article: ONCOGENE. 2019;38(48):7342-7356
Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase
Koh XY; Koh XH; Hwang L-A; Ferrer FJ; Rahmat SAB; Lama D; Lane DP
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(23):E5996-5996
The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
Kannan S; Partridge AW; Lane DP; Verma CS
Article: FRONTIERS IN ONCOLOGY. 2019;9:923
The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
Mortensen ACL; Spiegelberg D; Brown CJ; Lane DP; Nestor M
Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2019;59(7):3316-3329
Characterization of Hydration Properties in Structural Ensembles of Biomolecules
Pradhan MR; Nguyen MN; Kannan S; Fox SJ; Kwoh CK; Lane DP; Verma CS
Article: CANCER RESEARCH. 2019;79(14):3595-3607
Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo
Xue Y; Barker N; Hoon S; He P; Thakur T; Abdeen SR; Maruthappan P; Ghadessy FJ; Lane DP
Article: CHEMICAL SCIENCE. 2019;10(26):6457-6466
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
Yuen TY; Brown CJ; Xue Y; Tan YS; Gago FJF; Lee XE; Neo JY; Thean D; Kaan HYK; Partridge AW; Verma CS; Lane DP; Johannes CW
Article: MOLECULES. 2019;24(12):E2292-2292
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties
Partridge AW; Kaan HYK; Juang Y-C; Sadruddin A; Lim S; Brown CJ; Ng S; Thean D; Ferrer F; Johannes C; Yuen TY; Kannan S; Aronica P; Tan YS; Pradhan MR; Verma CS; Hochman J; Chen S; Wan H; Ha S; Sherborne B; Lane DP; Sawyer TK
Article: BMC BIOLOGY. 2019;17(1):40
Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly
Frosi Y; Usher R; Lian DTG; Lane DP; Brown CJ
Article: BRITISH JOURNAL OF CANCER. 2019;120(7):728-745
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment
Abdel-Fatah TMA; Broom RJ; Lu J; Moseley PM; Huang B; Li L; Liu S; Chen L; Ma RZ; Cao W; Wang X; Li Y; Perry JK; Aleskandarany M; Nolan CC; Rakha EA; Lobie PE; Chan SYT; Ellis IO; Hwang L-A; Lane DP; Green AR; Liu D-X
Article: SCIENTIFIC REPORTS. 2019;9(1):4913
Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides
Pal A; Neo K; Rajamani L; Ferrer FJ; Lane DP; Verma CS; Mortellaro A
Article: NEURO-ONCOLOGY. 2019;21(4):474-485
Radiation-induced astrocyte senescence is rescued by Δ133p53
Turnquist C; Beck JA; Horikawa I; Obiorah IE; Von Muhlinen N; Vojtesek B; Lane DP; Grunseich C; Chahine JJ; Ames HM; Smart DD; Harris BT; Harris CC
Article: CHEMICAL SCIENCE. 2019;10(8):2489-2500
Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein
Lama D; Liberatore A-M; Frosi Y; Nakhle J; Tsomaia N; Bashir T; Lane DP; Brown CJ; Verma CS; Auvin S
Article: NUCLEIC ACIDS RESEARCH. 2019;47(4):1637-1652
Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket
Pradhan MR; Siau JW; Kannan S; Nguyen MN; Ouaray Z; Kwoh CK; Lane DP; Ghadessy F; Verma CS
Article: SENSORS AND ACTUATORS B-CHEMICAL. 2019;279:79-86
Ultrasensitive dynamic light scattering based nanobiosensor for rapid anticancer drug screening
Zheng XT; Goh WL; Yeow P; Lane DP; Ghadessy FJ; Tan YN
Article: CANCER RESEARCH. 2018;78(17):5084-5093
The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors
Spiegelberg D; Mortensen AC; Lundsten S; Brown CJ; Lane DP; Nestor M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(9):4115-4131
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive
Keszei M; Record J; Kritikou JS; Wurzer H; Geyer C; Thiemann M; Drescher P; Brauner H; Kocher L; James J; He M; Baptista MAP; Dahlberg CIM; Biswas A; Lain S; Lane DP; Song W; Putsep K; Vandenberghe P; Snapper SB; Westerberg LS
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2018;31(7-8):301-312
Synthetic ¹⁰FN3-based mono- and bivalent inhibitors of MDM2/X function
Lau S-Y; Siau JW; Sobota RM; Wang C-I; Zhong P; Lane DP; Ghadessy FJ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2018;26(10):2807-2815
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges
Sawyer TK; Partridge AW; Kaan HYK; Juang Y-C; Lim S; Johannes C; Yuen TY; Verma C; Kannan S; Aronica P; Tan YS; Sherborne B; Ha S; Hochman J; Chen S; Surdi L; Peier A; Sauvagnat B; Dandliker PJ; Brown CJ; Ng S; Ferrer F; Lane DP
Article: ONCOGENE. 2018;37(18):2379-2393
p53 isoforms regulate premature aging in human cells
von Muhlinen N; Horikawa I; Alam F; Isogaya K; Lissa D; Vojtesek B; Lane DP; Harris CC
Article: PLOS ONE. 2018;13(4):e0195956
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Ladds MJGW; Pastor-Fernandez A; Popova G; van Leeuwen IMM; Eng KE; Drummond CJ; Johansson L; Svensson R; Westwood NJ; McCarthy AR; Tholander F; Popa M; Lane DP; McCormack E; McInerney GM; Bhatia R; Lain S
Article: NATURE COMMUNICATIONS. 2018;9(1):1107
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Farnegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Article: CELL CHEMICAL BIOLOGY. 2018;25(3):309-317.e4
Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
Costeira-Paulo J; Gault J; Popova G; Ladds MJGW; van Leeuwen IMM; Sarr M; Olsson A; Lane DP; Lain S; Marklund EG; Landreh M
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:469
Effect of VH-VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding
Ling W-L; Lua W-H; Poh J-J; Yeo JY; Lane DP; Gan SK-E
Article: PROTEIN SCIENCE. 2018;27(2):523-530
Evidence for allosteric effects on p53 oligomerization induced by phosphorylation
Muller P; Chan JM; Simoncik O; Fojta M; Lane DP; Hupp T; Vojtesek B
Article: SCIENTIFIC REPORTS. 2018;8(1):718
The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding
Lua W-H; Ling W-L; Yeo JY; Poh J-J; Lane DP; Gan SK-E
Article: CELL REPORTS. 2018;22(1):299-312
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Hwang L-A; Phang BH; Liew OW; Iqbal J; Koh XH; Koh XY; Othman R; Xue Y; Richards AM; Lane DP; Sabapathy K
Article: ONCOTARGET. 2017;8(68):112825-112840
Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53
Chan JV; Koh DXP; Liu Y; Joseph TL; Lane DP; Verma CS; Tan YS
Article: PLOS ONE. 2017;12(12):e0189379
Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
Chee SMQ; Wongsantichon J; Siau J; Thean D; Ferrer F; Robinson RC; Lane DP; Brown CJ; Ghadessy FJ
Article: SCIENTIFIC REPORTS. 2017;7(1):15600
Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations
Yadahalli S; Li J; Lane DP; Gosavi S; Verma CS
Article: BMC BIOLOGY. 2017;15(1):108
A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53
Wong JH; Alfatah M; Sin MF; Sim HM; Verma CS; Lane DP; Arumugam P
Article: EUROPACE. 2017;19(10):1589-1623
Screening for atrial fibrillation: a European Heart Rhythm Association (EHRA) consensus document endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacin Cardiaca y Electrofisiologia (SOLAECE)
Mairesse GH; Moran P; Van Gelder IC; Elsner C; Rosenqvist M; Mant J; Banerjee A; Gorenek B; Brachmann J; Varma N; de Lima GG; Kalman J; Claes N; Lobban T; Lane D; Lip GYH; Boriani G; Fauchier L; Jung W; Savelieva I; Freedman B; Chen SA; Isa R; Turakhia M; Sapp JL
Article: CANCER RESEARCH. 2017;77(16):4342-4354
Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity
Zheng S; Koh XY; Goh HC; Rahmat SAB; Hwang L-A; Lane DP
Article: SCIENTIFIC REPORTS. 2017;7(1):1763
Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery
Thean D; Ebo JS; Luxton T; Lee XC; Yuen TY; Ferrer FJ; Johannes CW; Lane DP; Brown CJ
Article: ONCOGENE. 2017;36(14):2002-2013
The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage
Xue Y; Raharja A; Sim W; Wong ESM; Rahmat SAB; Lane DP
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2017;7(3):a026310
Exploiting the p53 Pathway for Therapy
Cheok CF; Lane DP
Article: STRUCTURE. 2017;25(1):188-194
Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
Lama D; Pradhan MR; Brown CJ; Eapen RS; Joseph TL; Kwoh C-K; Lane DP; Verma CS
Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. 2017;24(1):41-69
Pre-participation cardiovascular evaluation for athletic participants to prevent sudden death: Position paper from the EHRA and the EACPR, branches of the ESC. Endorsed by APHRS, HRS, and SOLAECE.
Mont L; Pelliccia A; Sharma S; Biffi A; Borjesson M; Brugada Terradellas J; Carré F; Guasch E; Heidbuchel H; La Gerche A; Lampert R; McKenna W; Papadakis M; Priori SG; Scanavacca M; Thompson P; Sticherling C; Viskin S; Wilson M; Corrado D; Reviewers; Lip GY; Gorenek B; Blomström Lundqvist C; Merkely B; Hindricks G; Hernández-Madrid A; Lane D; Boriani G; Narasimhan C; Marquez MF; Haines D; Mackall J; Manuel Marques-Vidal P; Corra U; Halle M; Tiberi M; Niebauer J; Piepoli M
Article: EUROPACE. 2017;19(1):139-163
Pre-participation cardiovascular evaluation for athletic participants to prevent sudden death: Position paper from the EHRA and the EACPR, branches of the ESC. Endorsed by APHRS, HRS, and SOLAECE.
Mont L; Pelliccia A; Sharma S; Biffi A; Borjesson M; Terradellas JB; Carré F; Guasch E; Heidbuchel H; Gerche AL; Lampert R; McKenna W; Papadakis M; Priori SG; Scanavacca M; Thompson P; Sticherling C; Viskin S; Wilson M; Corrado D; Lip GYH; Gorenek B; Lundqvist CB; Merkely B; Hindricks G; Hernández-Madrid A; Lane D; Boriani G; Narasimhan C; Marquez MF; Haines D; Mackall J; Marques-Vidal PM; Corra U; Halle M; Tiberi M; Niebauer J; Piepoli M
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2016;84(10):1443-1461
Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain
Ouaray Z; ElSawy KM; Lane DP; Essex JW; Verma C
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2016;7(17):3452-3457
Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design
Tan YS; Reeks J; Brown CJ; Thean D; Gago FJF; Yuen TY; Goh ETL; Lee XEC; Jennings CE; Joseph TL; Lakshminarayanan R; Lane DP; Noble MEM; Verma CS
Article: CELL DEATH AND DIFFERENTIATION. 2016;23(9):1515-1528
p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration
Turnquist C; Horikawa I; Foran E; Major EO; Vojtesek B; Lane DP; Lu X; Harris BT; Harris CC
Article: SCIENTIFIC REPORTS. 2016;6:23750
Long range recognition and selection in IDPs: the interactions of the C-terminus of p53
Kannan S; Lane DP; Verma CS
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2016;84(2):254-266
Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins
Pradhan MR; Pal A; Hu Z; Kannan S; Keong KC; Lane DP; Verma CS
Article: GENES & DEVELOPMENT. 2016;30(3):281-292
The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
Coffill CR; Lee AP; Siau JW; Chee SM; Joseph TL; Tan YS; Madhumalar A; Tay B-H; Brenner S; Verma CS; Ghadessy FJ; Venkatesh B; Lane DP
Article: JOURNAL OF PHYSICAL CHEMISTRY B. 2016;120(2):320-328
Recognition Dynamics of p53 and MDM2: Implications for Peptide Design
ElSawy KM; Lane DP; Verma CS; Caves LSD
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2016;29(1):11-21
Enhanced antigen detection in immunohistochemical staining using a 'digitized' chimeric antibody
Eng H-Y; Wang C-I; Xue Y; Lee C-Y; Zulkifli SB; Chiam P-C; Ghadessy FJ; Lane DP
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2015;83(12):2240-2250
R248Q mutation-Beyond p53-DNA binding
Ng JWK; Lama D; Lukman S; Lane DP; Verma CS; Sim AYL
Article: ONCOGENE. 2015;34(48):5933-5941
Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish
Chua JS; Liew HP; Guo L; Lane DP
Article: BIOCHEMISTRY. 2015;54(42):6535-6544
Gating by Tryptophan 73 Exposes a Cryptic Pocket at the Protein-Binding Interface of the Oncogenic eIF4E Protein
Lama D; Brown CJ; Lane DP; Verma CS
Article: ONCOLOGY REPORTS. 2015;34(4):1692-1700
Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity
Voon Y-L; Ahmad M; Wong P-F; Husaini R; Ng WT-W; Leong C-O; Lane DP; Khoo AS-B
Article: JOURNAL OF MATERIALS CHEMISTRY B. 2015;3(29):5933-5937
A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells
Geng J; Goh WL; Zhang C; Lane DP; Liu B; Ghadessy F; Tan YN
Article: ONCOTARGET. 2015;6(20):17968-17980
Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
Goh AM; Xue Y; Leushacke M; Li L; Wong JS; Chiam PC; Rahmat SAB; Mann MB; Mann KM; Barker N; Lozano G; Terzian T; Lane DP
Article: SCIENTIFIC REPORTS. 2015;5:12116
Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays
Tan BX; Brown CJ; Ferrer FJ; Yuen TY; Quah ST; Chan BH; Jansson AE; Teo HL; Nordlund P; Lane DP
Article: CELL DEATH AND DIFFERENTIATION. 2015;22(7):1081-1093
A unique role for p53 in the regulation of M2 macrophage polarization
Li L; Ng DSW; Mah W-C; Almeida FF; Rahmat SA; Rao VK; Leow SC; Laudisi F; Peh MT; Goh AM; Lim JSY; Wright GD; Mortellaro A; Taneja R; Ginhoux F; Lee CG; Moore PK; Lane DP
Article: CELL RESEARCH. 2015;25(3):351-369
p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage
Gong L; Gong H; Pan X; Chang C; Ou Z; Ye S; Yin L; Yang L; Tao T; Zhang Z; Liu C; Lane DP; Peng J; Chen J
Article: CELL CYCLE. 2015;14(2):179-188
A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2
ElSawy KM; Sim A; Lane DP; Verma CS; Caves LSD
Article: NPJ BREAST CANCER. 2015;1:15012
A search for synergy in the binding kinetics of Trastuzumab and Pertuzumab whole and F(ab) to Her2
Lua W-H; Gan SK-E; Lane DP; Verma CS
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2015;83(1):153-168
mAb806 binding to epidermal growth factor receptor: a computational study
Ng YZ; Kannan S; Lane DP; Fuentes G; Verma CS
Article: BLOOD TRANSFUSION. 2014;12(4):608-610
Mixed field reactions in ABO and Rh typing chimerism likely resulting from twin haematopoiesis.
Sharpe C; Lane D; Cote J; Hosseini-Maaf B; Goldman M; Olsson ML; Hult AK
Article: CELL DEATH AND DIFFERENTIATION. 2014;21(9):1377-1387
Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response
Marcel V; Fernandes K; Terrier O; Lane DP; Bourdon J-C
Article: NATURE COMMUNICATIONS. 2014;5:4706
Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence
Horikawa I; Fujita K; Jenkins LMM; Hiyoshi Y; Mondal AM; Vojtesek B; Lane DP; Appella E; Harris CC
Article: PLOS ONE. 2014;9(8):e104914
Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2
Chee SMQ; Wongsantichon J; Tng QS; Robinson R; Joseph TL; Verma C; Lane DP; Brown CJ; Ghadessy FJ
Article: CELL CYCLE. 2014;13(14):2200-2210
Isg15 controls p53 stability and functions
Huang Y-F; Wee S; Gunaratne J; Lane DP; Bulavin DV
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(7):3263-3273
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging
Zhu Y; Demidov ON; Goh AM; Virshup DM; Lane DP; Bulavin DV
Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2014;10(4):1753-1761
Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design
Sim AYL; Joseph T; Lane DP; Verma C
Article: JOURNAL OF BIOMOLECULAR SCREENING. 2014;19(4):516-525
The Fluorescent Two-Hybrid Assay to Screen for Protein-Protein Interaction Inhibitors in Live Cells Targeting the Interaction of p53 with Mdm2 and Mdm4
Yurlova L; Derks M; Buchfellner A; Hickson I; Janssen M; Morrison D; Stansfield I; Brown CJ; Ghadessy FJ; Lane DP; Rothbauer U; Zolghadr K; Krausz E
Article: ONCOTARGET. 2014;5(4):933-943
High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
Tan BX; Khoo KH; Lim TM; Lane DP
Article: CHEMICAL SCIENCE. 2014;5(5):1804-1809
Functionalised staple linkages for modulating the cellular activity of stapled peptides
Lau YH; de Andrade P; Quah S-T; Rossmann M; Laraia L; Skoeld N; Sum TJ; Rowling PJE; Joseph TL; Verma C; Hyvoenen M; Itzhaki LS; Venkitaraman AR; Brown CJ; Lane DP; Spring DR
Article: CELL CYCLE. 2013;12(24):3727-3735
On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein
ElSawy KM; Verma CS; Lane DP; Caves LSD
Article: SCIENTIFIC REPORTS. 2013;3:3451
Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces
Lama D; Quah ST; Verma CS; Lakshminarayanan R; Beuerman RW; Lane DP; Brown CJ
Article: BIOSCIENCE REPORTS. 2013;33(6):e00086-U172
A comparison and optimization of methods and factors affecting the transformation of Escherichia coli
Chan W-T; Verma CS; Lane DP; Gan SK-E
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(12):5247-5257
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
Mondal AM; Horikawa I; Pine SR; Fujita K; Morgan KM; Vera E; Mazur SJ; Appella E; Vojtesek B; Blasco MA; Lane DP; Harris CC
Article: PLOS ONE. 2013;8(11):e80221
Mapping the Structural and Dynamical Features of Multiple p53 DNA Binding Domains: Insights into Loop 1 Intrinsic Dynamics
Lukman S; Lane DP; Verma CS
Article: EUROPACE. 2013;15(11):1540-1556
Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference.
Kirchhof P; Breithardt G; Aliot E; Al Khatib S; Apostolakis S; Auricchio A; Bailleul C; Bax J; Benninger G; Blomstrom-Lundqvist C; Boersma L; Boriani G; Brandes A; Brown H; Brueckmann M; Calkins H; Casadei B; Clemens A; Crijns H; Derwand R; Dobrev D; Ezekowitz M; Fetsch T; Gerth A; Gillis A; Gulizia M; Hack G; Haegeli L; Hatem S; Häusler KG; Heidbüchel H; Hernandez-Brichis J; Jais P; Kappenberger L; Kautzner J; Kim S; Kuck K-H; Lane D; Leute A; Lewalter T; Meyer R; Mont L; Moses G; Mueller M; Münzel F; Näbauer M; Nielsen JC; Oeff M; Oto A; Pieske B; Pisters R; Potpara T; Rasmussen L; Ravens U; Reiffel J; Richard-Lordereau I; Schäfer H; Schotten U; Stegink W; Stein K; Steinbeck G; Szumowski L; Tavazzi L; Themistoclakis S; Thomitzek K; Van Gelder IC; von Stritzky B; Vincent A; Werring D; Willems S; Lip GYH; Camm AJ
Article: BIOSENSORS & BIOELECTRONICS. 2013;47:421-428
A generic scaffold for conversion of peptide ligands into homogenous biosensors
Nirantar SR; Yeo KS; Chee S; Lane DP; Ghadessy FJ
Article: MARINE GEOLOGY. 2013;343:15-28
Quantifying overwash flux in barrier systems: An example from Martha's Vineyard, Massachusetts, USA
Carruthers EA; Lane DP; Evans RL; Donnelly JP; Ashton AD
Article: ONCOGENE. 2013;32(34):4009-4016
Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish
Guo L; Liew HP; Camus S; Goh AM; Chee LL; Lunny DP; Lane EB; Lane DP
Article: GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS. 2013;14(8):2993-3008
Tropical cyclone wind speed constraints from resultant storm surge deposition: A 2500 year reconstruction of hurricane activity from St. Marks, FL
Brandon CM; Woodruff JD; Lane DP; Donnelly JP
Article: ONCOTARGET. 2013;4(7):1019-1036
Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth
Wong JS; Warbrick E; Vojtesk B; Hill J; Lane DP
Article: ONCOGENE. 2013;32(29):3461-3469
The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage
Nicol SM; Bray SE; Black HD; Lorimore SA; Wright EG; Lane DP; Meek DW; Coates PJ; Fuller-Pace FV
Article: ONCOGENE. 2013;32(25):3101-3110
C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances
Muller P; Ruckova E; Halada P; Coates PJ; Hrstka R; Lane DP; Vojtesek B
Article: CELL RESEARCH. 2013;23(5):620-634
Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation
Tao T; Shi H; Guan Y; Huang D; Chen Y; Lane DP; Chen J; Peng J
Article: ONCOGENE. 2013;32(17):2150-2160
The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression.
Bernard H; Garmy-Susini B; Ainaoui N; Van Den Berghe L; Peurichard A; Javerzat S; Bikfalvi A; Lane DP; Bourdon JC; Prats A-C
Article: ACS CHEMICAL BIOLOGY. 2013;8(3):506-512
Stapled Peptides with Improved Potency and Specificity That Activate p53
Brown CJ; Quah ST; Jong J; Goh AM; Chiam PC; Khoo KH; Choong ML; Lee MA; Yurlova L; Zolghadr K; Joseph TL; Verma CS; Lane DP
Article: ONCOGENE. 2013;32(10):1252-1265
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
Muller PAJ; Trinidad AG; Timpson P; Morton JP; Zanivan S; van den Berghe PVE; Nixon C; Karim SA; Caswell PT; Noll JE; Coffill CR; Lane DP; Sansom OJ; Neilsen PM; Norman JC; Vousden KH
Article: CELL CYCLE. 2013;12(3):394-404
On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins
ElSawy KM; Verma CS; Joseph TL; Lane DP; Twarock R; Caves LSD
Article: CELL CYCLE. 2013;12(2):278-288
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
Chee JLY; Saidin S; Lane DP; Leong SM; Noll JE; Neilsen PM; Phua YT; Gabra H; Lim TM
Article: METHODS IN MOLECULAR BIOLOGY. 2013;962:15-29
Detecting p53 isoforms at protein level.
Marcel V; Khoury MP; Fernandes K; Diot A; Lane DP; Bourdon J-C
Article: METHODS IN MOLECULAR BIOLOGY. 2013;962:1-14
Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues.
Khoury MP; Marcel V; Fernandes K; Diot A; Lane DP; Bourdon J-C
Article: PLOS ONE. 2012;7(10):e47235
Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects
Zhou W; Quah ST; Verma CS; Liu Y; Lane DP; Brown CJ
Article: DISCOVERY MEDICINE. 2012;14(77):263-271
Seeking Synergy in p53 Transcriptional Activation for Cancer Therapy
Cheok CF; Lane DP
Article: TRANSCRIPTION. 2012;3(5):240-244
How p53 wields the scales of fate Arrest or death?
Goh AM; Lane DP
Article: PLOS ONE. 2012;7(8):e43985
Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations
Joseph TL; Lane DP; Verma CS
Article: JOURNAL OF VIROLOGY. 2012;86(16):8452-8460
Influenza A Viruses Control Expression of Proviral Human p53 Isoforms p53β and Δ133p53α
Terrier O; Marcel V; Cartet G; Lane DP; Lina B; Rosa-Calatrava M; Bourdon J-C
Article: HAEMOPHILIA. 2012;18:141-147
von Willebrand disease biology
Blomback M; Eikenboom J; Lane D; Denis C; Lillicrap D
Article: EMBO REPORTS. 2012;13(7):638-644
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
Coffill CR; Muller PAJ; Oh HK; Neo SP; Hogue K; Cheok CF; Vousden KH; Lane DP; Blackstock WP; Gunaratne J
Article: CELL CYCLE. 2012;11(12):2239-2247
Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding
Dastidar SG; Lane DP; Verma CS
Article: CELL DEATH AND DIFFERENTIATION. 2012;19(5):816-826
Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity
Marcel V; Petit I; Murray-Zmijewski F; de Rugy TG; Fernandes K; Meuray V; Diot A; Lane DP; Aberdam D; Bourdon J-C
Article: CELL CYCLE. 2012;11(8):1646-1655
The p53 isoforms are differentially modified by Mdm2
Camus S; Menendez S; Fernandes K; Kua N; Liu G; Xirodimas DP; Lane DP; Bourdon J-C
Article: GENES AND CANCER. 2012;3(3-4):320-324
Mdm2 in evolution.
Lane DP; Verma C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(5):1685-1690
Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity
Goh AM; Lim CY; Chiam PC; Li L; Mann MB; Mann KM; Menendez S; Lane DP
Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2012;8(1):314-321
Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development
ElSawy KM; Twarock R; Lane DP; Verma CS; Caves LSD
Article: ONCOTARGET. 2011;2(12):1203-1217
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
Neilsen PM; Noll JE; Suetani RJ; Schulz RB; Al-Ejeh F; Evdokiou A; Lane DP; Callen DF
Article: CELL CYCLE. 2011;10(24):4272-4279
Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
Lane DP; Madhumalar A; Lee AP; Tay B-H; Verma C; Brenner S; Venkatesh B
Article: THEORETICAL CHEMISTRY ACCOUNTS. 2011;130(4-6):1145-1154
Systematic mutational analysis of an ubiquitin ligase (MDM2)-binding peptide: computational studies
Liu Y; Lane DP; Verma CS
Article: DISCOVERY MEDICINE. 2011;12(63):107-117
New Insights into p53 Based Therapy
Lane DP; Brown CJ; Verma C; Cheok CF
Article: CELL CYCLE. 2011;10(12):1978-1987
NPMc⁺ AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anti-cancer compounds
Lew QJ; Tan CH; Gurumurthy M; Chu KL; Cheong N; Lane DP; Chao S-H
Article: CELL CYCLE. 2011;10(7):1100-1108
MDM4 downregulates p53 transcriptional activity and response to stress during differentiation
Menendez S; Goh AM; Camus S; Ng KW; Kua N; Badal V; Lane DP
Article: CELL DEATH AND DIFFERENTIATION. 2011;18(2):248-258
p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage.
Aoubala M; Murray-Zmijewski F; Khoury MP; Fernandes K; Perrier S; Bernard H; Prats A-C; Lane DP; Bourdon J-C
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;405(3):736-753
Stabilizing the eIF4G1 α-Helix Increases Its Binding Affinity with eIF4E: Implications for Peptidomimetic Design Strategies
Brown CJ; Lim JJ; Leonard T; Lim HCA; Chia CSB; Verma CS; Lane DP
Article: BREAST CANCER RESEARCH. 2011;13(1):R7
p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
Bourdon J-C; Khoury MP; Diot A; Baker L; Fernandes K; Aoubala M; Quinlan P; Purdie CA; Jordan LB; Prats A-C; Lane DP; Thompson AM
Article: CELL CYCLE. 2011;10(1):82-89
Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding Simulations reveal complexities of modulation
Dastidar SG; Raghunathan D; Nicholson J; Hupp TR; Lane DP; Verma CS
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;404(5):819-831
A Novel Unstructured Scaffold Based on 4EBP1 Enables the Functional Display of a Wide Range of Bioactive Peptides
See HY; Lane DP
Article: NATURE CELL BIOLOGY. 2010;12(12):1205-1212
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence
Fujita K; Horikawa I; Mondal AM; Jenkins LMM; Appella E; Vojtesek B; Bourdon J-C; Lane DP; Harris CC
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2010;2(12):a000893
p53 Research: The Past Thirty Years and the Next Thirty Years
Lane D; Levine A
Article: ONCOTARGET. 2010;1(7):639-650
Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
Rao B; van Leeuwen IMM; Higgins M; Campbell J; Thompson AM; Lane DP; Lain S
Article: CELL CYCLE. 2010;9(22):4560-4568
Stapled peptides in the p53 pathway Computer simulations reveal novel interactions of the staples with the target protein
Joseph TL; Lane D; Verma C
Article: AGING-US. 2010;2(11):748
The p53 inducing drug dosage may determine quiescence or senescence
Lane DP; Verma C; Fang CC
Article: CHEMISTRY AND BIOLOGY. 2010;17(10):1111-1121
Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.
Wang S; Griffiths G; Midgley CA; Barnett AL; Cooper M; Grabarek J; Ingram L; Jackson W; Kontopidis G; McClue SJ; McInnes C; McLachlan J; Meades C; Mezna M; Stuart I; Thomas MP; Zheleva DI; Lane DP; Jackson RC; Glover DM; Blake DG; Fischer PM
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2010;2(9):a001222
p53-based Cancer Therapy
Lane DP; Cheok CF; Lain S
Article: CELL DEATH AND DIFFERENTIATION. 2010;17(9):1486-1500
Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53
Cheok CF; Kua N; Kaldis P; Lane DP
Article: CELL CYCLE. 2010;9(15):3030-3038
Development of a novel multiplex in vitro binding assay to profile p53-DNA interactions
Goh W; Lane D; Ghadessy F
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2010;53(11):4367-4378
Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Wang S; Midgley CA; Scaërou F; Grabarek JB; Griffiths G; Jackson W; Kontopidis G; McClue SJ; McInnes C; Meades C; Mezna M; Plater A; Stuart I; Thomas MP; Wood G; Clarke RG; Blake DG; Zheleva DI; Lane DP; Jackson RC; Glover DM; Fischer PM
Article: CELL CYCLE. 2010;9(10):1998-2007
Detection of the 113p53 protein isoform A p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish
Guo L; Chua J; Vijayakumar D; Lee KC; Lim K; Eng H; Ghadessy F; Coomber D; Lane DP
Article: CELL CYCLE. 2010;9(6):1167-1181
Differential binding of p53 and nutlin to MDM2 and MDMX Computational studies
Joseph TL; Madhumalar A; Brown CJ; Lane DP; Verma C
Article: THEORETICAL CHEMISTRY ACCOUNTS. 2010;125(3-6):621-635
Forces mediating protein-protein interactions: a computational study of p53 "approaching" MDM2
Dastidar SG; Madhumalar A; Fuentes G; Lane DP; Verma CS
Article: CELL CYCLE. 2010;9(4):748-754
The Mdm2 and p53 genes are conserved in the Arachnids
Lane DP; Cheok CF; Brown CJ; Madhumalar A; Ghadessy FJ; Verma C
Article: CELL CYCLE. 2010;9(3):540-547
Mdm2 and p53 are highly conserved from placozoans to man
Lane DP; Cheok CF; Brown C; Madhumalar A; Ghadessy FJ; Verma C
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;395(4):871-883
Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting
Brown CJ; Dastidar SG; See HY; Coomber DW; Ortiz-Lombardia M; Verma C; Lane DP
Article: ONCOGENE. 2010;29(3):432-441
MdmX is a substrate for the deubiquitinating enzyme USP2a.
Allende-Vega N; Sparks A; Lane DP; Saville MK
Article: CELL CYCLE. 2009;8(23):3943-3952
Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-X_L
Wan KF; Wang S; Brown CJ; Yu VC; Entzeroth M; Lane DP; Lee MA
Article: NATURE CELL BIOLOGY. 2009;11(9):1135-1142
p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Fujita K; Mondal AM; Horikawa I; Nguyen GH; Kumamoto K; Sohn JJ; Bowman ED; Mathe EA; Schetter AJ; Pine SR; Ji H; Vojtesek B; Bourdon J-C; Lane DP; Harris CC
Article: CELL CYCLE. 2009;8(17):2810-2818
Specific activation of the p53 pathway by low dose actinomycin D A new route to p53 based cyclotherapy
Choong ML; Yang H; Lee MA; Lane DP
Article: CELL CYCLE. 2009;8(17):2828-2836
Design of a novel MDM2 binding peptide based on the p53 family
Arumugam M; Jun LH; Brown CJ; Lane D; Verma C
Article: EMBO JOURNAL. 2009;28(14):2100-2113
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
Lee E-W; Lee M-S; Camus S; Ghim J; Yang M-R; Oh W; Ha N-C; Lane DP; Song J
Article: CELL CYCLE. 2009;8(14):2247-2254
Ubiquitination of HEXIM1 by HDM2
Lau J; Lew QJ; Diribarne G; Michels AA; Dey A; Bensaude O; Lane DP; Chao S-H
Article: CELL CYCLE. 2009;8(12):1905-1911
Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site
Brown CJ; Verma CS; Walkinshaw MD; Lane DP
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(9):2673-2682
Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity
Medda F; Russell RJM; Higgins M; McCarthy AR; Campbell J; Slawin AMZ; Lane DP; Lain S; Westwood NJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(8):5030-5041
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53.
Dayal S; Sparks A; Jacob J; Allende-Vega N; Lane DP; Saville MK
Article: GENES & DEVELOPMENT. 2009;23(3):278-290
p53 isoform Δ113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish
Chen J; Ng SM; Chang C; Zhang Z; Bourdon J-C; Lane DP; Peng J
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(2):465-472
Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.
Appleyard MVCL; O'Neill MA; Murray KE; Paulin FEM; Bray SE; Kernohan NM; Levison DA; Lane DP; Thompson AM
Article: CELL CYCLE. 2009;8(1):137-148
Dimerization of the core domain of the p53 family A computational study
Madhumalar A; Jun LH; Lane DP; Verma CS
Article: CELL CYCLE. 2008;7(23):3759-3767
Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NFκB activity Implications for cancer therapy
Dey A; Wong E; Kua N; Teo HL; Tergaonkar V; Lane D
Article: CELL CYCLE. 2008;7(21):3417-3427
Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen
Staples OD; Hollick JJ; Campbell J; Higgins M; McCarthy AR; Appleyard V; Murray KE; Baker L; Thompson A; Ronseaux S; Slawin AMZ; Lane DP; Westwood NJ; Lain S
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2008;18(21):5771-5773
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl
Janssen CO; Lim S; Lo EP; Wan KF; Yu VC; Lee MA; Ng SB; Everett MJ; Buss AD; Lane DP; Boyce RS
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2008;130(41):13514-13515
Multiple peptide conformations give rise to similar binding affinities: Molecular simulations of p53-MDM2
Dastidar SG; Lane DP; Verma CS
Article: BMC CANCER. 2008;8:281
MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.
Paulin FEM; O'Neill M; McGregor G; Cassidy A; Ashfield A; Ali CW; Munro AJ; Baker L; Purdie CA; Lane DP; Thompson AM
Article: ONCOGENE. 2008;27(24):3371-3383
Chaperone-dependent stabilization and degradation of p53 mutants
Muller P; Hrstka R; Coomber D; Lane DP; Vojtesek B
Article: CANCER CELL. 2008;13(5):454-463
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
Lain S; Hollick JJ; Campbell J; Staples OD; Higgins M; Aoubala M; McCarthy A; Appleyard V; Murray KE; Baker L; Thompson A; Mathers J; Holland SJ; Stark MJR; Pass G; Woods J; Lane DP; Westwood NJ
Article: JOURNAL OF MOLECULAR BIOLOGY. 2008;378(2):302-317
Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription
Gurumurthy M; Tan CH; Ng R; Zeiger L; Lau J; Lee J; Dey A; Philp R; Li Q; Lim TM; Price DH; Lane DP; Chao S-H
Article: CLINICAL CANCER RESEARCH. 2008;14(6):1659-1668
Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin
Avery-Kiejda KA; Zhang XD; Adams LJ; Scott RJ; Vojtesek B; Lane DP; Hersey P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;367(2):271-276
Scotin: A new p63 target gene expressed during epidermal differentiation.
Zocchi L; Bourdon JC; Codispoti A; Knight R; Lane DP; Melino G; Terrinoni A
Article: CELL CYCLE. 2008;7(5):608-610
The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides
Brown CJ; Srinivasan D; Jun LH; Coomber D; Verma CS; Lane DP
Article: CELL DEATH AND DIFFERENTIATION. 2008;15(2):263-273
R-Roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis:: implications in cancer therapy
Dey A; Wong ET; Cheok CF; Tergaonkar V; Lane DP
Article: ONCOGENE. 2008;27(5):629-640
Detection of the p53 response in zebrafish embryos using new monoclonal antibodies
Lee K-C; Goh WLP; Xu M; Kua N; Lunny D; Wong JS; Coomber D; Vojtesek B; Lane EB; Lane DP
Article: CELL CYCLE. 2008;7(1):112-119
Regulation of the p14ARF promoter by DNA methylation
Badal V; Menendez S; Coomber D; Lane DP
Article: MOLECULAR CANCER RESEARCH. 2007;5(11):1133-1145
Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination
Cheok CF; Dey A; Lane DP
Article: CELL CYCLE. 2007;6(21):2604-2611
Modulation of the p53-MDM2 interaction by phosphorylation of Thr18 - A computational study
Lee HJ; Srinivasan D; Coomber D; Lane DP; Verma CS
Article: CELL CYCLE. 2007;6(18):2219-2226
Substrate specificity of cyclins determined by electrostatics
Lee HJ; Chua GH; Krishnan A; Lane DP; Verma CS
Article: CELL CYCLE. 2007;6(17):2178-2185
Nutlin-3 inhibits the NFκB pathway in a p53-dependent manner implications in lung cancer therapy
Dey A; Wong ET; Bist P; Tergaonkar V; Lane DP
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;371(5):1238-1248
Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization
Fen CX; Coomber DW; Lane DP; Ghadessy FJ
Article: ONCOGENE. 2007;26(28):4059-4070
Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6
Camus S; Menendez S; Cheok CF; Stevenson LF; Lain S; Lane DP
Article: ONCOGENE. 2007;26(11):1517-1521
The p53 knowledgebase: an integrated information resource for p53 research
Lim YP; Lim TT; Chan YL; Song ACM; Yeo BH; Vojtesek B; Coomber D; Rajagopal G; Lane D
Article: EMBO JOURNAL. 2007;26(4):976-986
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.
Stevenson LF; Sparks A; Allende-Vega N; Xirodimas DP; Lane DP; Saville MK
Article: CANCER RESEARCH. 2006;66(6):2928-2936
Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene.
Dudgeon C; Kek C; Demidov ON; Saito S-I; Fernandes K; Diot A; Bourdon J-C; Lane DP; Appella E; Fornace AJ; Bulavin DV
Article: GENES & DEVELOPMENT. 2005;19(23):2900-2911
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.
Chen J; Ruan H; Ng SM; Gao C; Soo HM; Wu W; Zhang Z; Wen Z; Lane DP; Peng J
Article: JOURNAL OF PATHOLOGY. 2005;207(3):251-259
Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry.
Nenutil R; Smardova J; Pavlova S; Hanzelkova Z; Muller P; Fabian P; Hrstka R; Janotova P; Radina M; Lane DP; Coates PJ; Vojtesek B
Article: GENES & DEVELOPMENT. 2005;19(18):2122-2137
p53 isoforms can regulate p53 transcriptional activity.
Bourdon J-C; Fernandes K; Murray-Zmijewski F; Liu G; Diot A; Xirodimas DP; Saville MK; Lane DP
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;115(5):701-710
Pilot screening programme for small molecule activators of p53
Berkson RG; Hollick JJ; Westwood NJ; Woods JA; Lane DP; Lain S
Article: CLINICAL CANCER RESEARCH. 2005;11(13):4875-4887
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Raynaud FI; Whittaker SR; Fischer PM; McClue S; Walton MI; Barrie SE; Garrett MD; Rogers P; Clarke SJ; Kelland LR; Valenti M; Brunton L; Eccles S; Lane DP; Workman P
Article: CANCER RESEARCH. 2005;65(12):5399-5407
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
MacCallum DE; Melville J; Frame S; Watt K; Anderson S; Gianella-Borradori A; Lane DP; Green SR
Article: BLOOD. 2005;105(11):4484-4491
A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.
Alvi AJ; Austen B; Weston VJ; Fegan C; MacCallum D; Gianella-Borradori A; Lane DP; Hubank M; Powell JE; Wei W; Taylor AMR; Moss PAH; Stankovic T
Article: SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND. 2005;3(3):197-205
P53 in cancer: a paradigm for modern management of cancer.
Steele RJC; Lane DP
Article: EMBO JOURNAL. 2005;24(3):543-553
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.
Bates GJ; Nicol SM; Wilson BJ; Jacobs A-MF; Bourdon J-C; Wardrop J; Gregory DJ; Lane DP; Perkins ND; Fuller-Pace FV
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(6):1871-1876
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Kontopidis G; Wu S-Y; Zheleva DI; Taylor P; McInnes C; Lane DP; Fischer PM; Walkinshaw MD
Article: MOLECULAR CANCER THERAPEUTICS. 2005;4(1):125-139
Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse.
Nutley BP; Raynaud FI; Wilson SC; Fischer PM; Hayes A; Goddard PM; McClue SJ; Jarman M; Lane DP; Workman P
Article: NEW SCIENTIST. 2004;184(2478):38-41
Dark angel
Lane D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(48):50157-50166
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.
Woods YL; Xirodimas DP; Prescott AR; Sparks A; Lane DP; Saville MK
Article: BRITISH JOURNAL OF CANCER. 2004;91(8):1488-1494
Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level
Karlsson GB; Jensen A; Stevenson LF; Woods YL; Lane DP; Sorensen MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(40):42169-42181
Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.
Saville MK; Sparks A; Xirodimas DP; Wardrop J; Stevenson LF; Bourdon J-C; Woods YL; Lane DP
Article: CELL. 2004;118(1):83-97
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
Xirodimas DP; Saville MK; Bourdon J-C; Hay RT; Lane DP
Article: TRENDS IN PHARMACOLOGICAL SCIENCES. 2004;25(7):343-346
Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets?
Fischer PM; Lane DP
Article: CHEMISTRY AND BIOLOGY. 2004;11(4):525-534
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
McInnes C; Wang S; Anderson S; O'Boyle J; Jackson W; Kontopidis G; Meades C; Mezna M; Thomas M; Wood G; Lane DP; Fischer PM
Article: MOLECULAR CANCER THERAPEUTICS. 2004;3(3):353-362
Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis.
Raynaud FI; Fischer PM; Nutley BP; Goddard PM; Lane DP; Workman P
Article: STRUCTURE. 2003;11(12):1537-1546
Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.
Kontopidis G; Andrews MJI; McInnes C; Cowan A; Powers H; Innes L; Plater A; Griffiths G; Paterson D; Zheleva DI; Lane DP; Green S; Walkinshaw MD; Fischer PM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(21):18720-18729
Oligomerization of the human ARF tumor suppressor and its response to oxidative stress
Menéndez S; Khan Z; Coomber DW; Lane DP; Higgins M; Koufali MM; Laín S
Article: STRUCTURE. 2003;11(4):399-410
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.
Wu SY; McNae I; Kontopidis G; McClue SJ; McInnes C; Stewart KJ; Wang S; Zheleva DI; Marriage H; Lane DP; Taylor P; Fischer PM; Walkinshaw MD
Article: BRITISH JOURNAL OF CANCER. 2003;88(4):636-643
Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein
Menéndez S; Higgins M; Berkson RG; Edling C; Lane DP; Laín S
Article: FEBS LETTERS. 2003;536(1-3):220-224
Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6
Camus S; Higgins M; Lane DP; Lain S
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;102(5):463-468
In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).
McClue SJ; Blake D; Clarke R; Cowan A; Cummings L; Fischer PM; MacKenzie M; Melville J; Stewart K; Wang S; Zhelev N; Zheleva D; Lane DP
Article: CHEMICAL BIOLOGY & DRUG DESIGN. 2002;60(5):257-270
Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A.
Zheleva DI; McInnes C; Gavine A-L; Zhelev NZ; Fischer PM; Lane DP
Article: ONCOGENE. 2002;21(43):6624-6632
Cell type-specific responses of human cells to inhibition of replication licensing.
Shreeram S; Sparks A; Lane DP; Blow JJ
Article: FEBS LETTERS. 2002;528(1-3):207-211
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.
Xirodimas DP; Chisholm J; Desterro JMS; Lane DP; Hay RT
Article: HISTOPATHOLOGY. 2002;41(3A):165-171
The assessment of proliferating cell nuclear antigen (PCNA)immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis.
Woods AL; Hall PA; Shepherd NA; Hanby AM; Waseem NH; Lane DP; Levison DA
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(17):6170-6182
Hypophosphorylation of Mdm2 augments p53 stability.
Blattner C; Hay T; Meek DW; Lane DP
Article: JOURNAL OF CELL BIOLOGY. 2002;158(2):235-246
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane.
Bourdon J-C; Renzing J; Robertson PL; Fernandes KN; Lane DP
Article: EMBO REPORTS. 2001;2(11):1029-1034
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.
Stad R; Little NA; Xirodimas DP; Frenk R; van der Eb AJ; Lane DP; Saville MK; Jochemsen AG
Article: ONCOGENE. 2001;20(48):7096-7097
Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice.
Coates PJ; Lorimore SA; Rigat BA; Lane DP; Wright EG
Article: ONCOGENE. 2001;20(36):4972-4983
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
Xirodimas D; Saville MK; Edling C; Lane DP; Laín S
Article: CANCER LETTERS. 2001;166(2):215-221
Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice.
Schumacher U; Adam E; Feldhaus S; Katoh M; Lane DP
Article: EXPERIMENTAL CELL RESEARCH. 2001;265(2):242-251
Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts.
Mattock H; Jares P; Zheleva DI; Lane DP; Warbrick E; Blow JJ
Article: EXPERIMENTAL CELL RESEARCH. 2001;265(2):234-241
Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein.
Mattock H; Lane DP; Warbrick E
Article: GENE THERAPY. 2001;8(4):274-281
Tumour-specific therapeutic adenovirus vectors: repression of transgene expression in healthy cells by endogenous p53.
Lipinski KS; Djeha AH; Krausz E; Lane DP; Searle PF; Mountain A; Wrighton CJ
Article: MOLECULAR CARCINOGENESIS. 2000;29(4):251-262
p53 is phosphorylated at the carboxyl terminus and promotes the differentiation of human HaCaT keratinocytes
Paramio JM; Segrelles C; Laín S; Gómez-Casero E; Lane DP; Lane EB; Jorcano JL
Article: NATURE. 2000;408(6810):307-310
Surfing the p53 network.
Vogelstein B; Lane D; Levine AJ
Article: MOLECULAR AND CELLULAR BIOLOGY. 2000;20(22):8458-8467
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
Rodriguez MS; Desterro JMP; Lain S; Lane DP; Hay RT
Article: CARCINOGENESIS. 2000;21(9):1631-1638
Defective nuclear localization of p53 protein in a Chinese hamster cell line is associated with the formation of stable cytoplasmic protein multimers in cells with gene amplification.
Ottaggio L; Bozzo S; Moro F; Sparks A; Campomenosi P; Miele M; Bonatti S; Fronza G; Lane DP; Abbondandolo A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(15):8501-8506
Activation of p53 in cervical carcinoma cells by small molecules
Hietanen S; Lain S; Krausz E; Blattner C; Lane DP
Article: SURGICAL ONCOLOGY-OXFORD. 2000;9(1):13-16
Gene therapy for gastric cancer: problems and prospects.
Steele RJ; Lane DP
Article: CURRENT BIOLOGY. 2000;10(13):793-796
Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.
Herbert TP; Fåhraeus R; Prescott A; Lane DP; Proud CG
Article: BIOCHEMISTRY. 2000;39(25):7388-7397
A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: affinity, stoichiometry, and thermodynamics.
Zheleva DI; Zhelev NZ; Fischer PM; Duff SV; Warbrick E; Blake DG; Lane DP
Article: ONCOGENE. 2000;19(19):2312-2323
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo.
Midgley CA; Desterro JM; Saville MK; Howard S; Sparks A; Hay RT; Lane DP
Article: FEBS LETTERS. 2000;472(1):93-98
Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA.
Burch LR; Midgley CA; Currie RA; Lane DP; Hupp TR
Article: FEBS LETTERS. 1999;463(1-2):179-184
Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein.
Cohen PA; Hupp TR; Lane DP; Daniels DA
Article: EMBO JOURNAL. 1999;18(22):6455-6461
SUMO-1 modification activates the transcriptional response of p53
Rodriguez MS; Desterro JMP; Lain S; Midgley CA; Lane DP; Hay RT
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(39):28042-28049
Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling.
Xirodimas DP; Lane DP
Article: EXPERIMENTAL CELL RESEARCH. 1999;248(2):457-472
An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
Laín S; Midgley C; Sparks A; Lane EB; Lane DP
Article: MOLECULAR AND CELLULAR BIOLOGY. 1999;19(5):3704-3713
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53.
Blattner C; Sparks A; Lane D
Article: EMBO JOURNAL. 1999;18(8):2106-2118
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.
Fåhraeus R; Lane DP
Article: ONCOGENE. 1999;18(1):189-199
Comparative study of the p53-mdm2 and p53-MDMX interfaces.
Böttger V; Böttger A; Garcia-Echeverria C; Ramos YF; van der Eb AJ; Jochemsen AG; Lane DP
Article: JOURNAL OF PATHOLOGY. 1999;187(1):138-146
New approaches to cancer therapies.
Fåhraeus R; Fischer P; Krausz E; Lane DP
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(25):14675-14680
Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability.
Nikolova PV; Henckel J; Lane DP; Fersht AR
Article: CARCINOGENESIS. 1998;19(12):2115-2120
Differential expression of p53, p21waf1/cip1 and hdm2 dependent on DNA damage in Bloom's syndrome fibroblasts.
Collister M; Lane DP; Kuehl BL
Article: ONCOGENE. 1998;17(19):2445-2456
Characterization of a new intrabody directed against the N-terminal region of human p53.
Cohen PA; Mani JC; Lane DP
Article: NUCLEIC ACIDS RESEARCH. 1998;26(17):3925-3932
PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain.
Warbrick E; Heatherington W; Lane DP; Glover DM
Article: LANCET. 1998;351:17-20
The promise of molecular oncology
Lane D
Article: ONCOGENE. 1998;16(5):587-596
Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule
Fåhraeus R; Laín S; Ball KL; Lane DP
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;275(4):575-588
The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability.
Hansen S; Lane DP; Midgley CA
Article: INTERVIROLOGY. 1998;41(1):10-16
Epitope mapping of antibodies recognising the N-terminal domain of simian virus large tumour antigen.
Lindner K; Mole SE; Lane DP; Kenny MK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(26):14338-14342
Thermodynamic stability of wild-type and mutant p53 core domain.
Bullock AN; Henckel J; DeDecker BS; Johnson CM; Nikolova PV; Proctor MR; Lane DP; Fersht AR
Article: CURRENT BIOLOGY. 1997;7(11):860-869
Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.
Böttger A; Böttger V; Sparks A; Liu WL; Howard SF; Lane DP
Article: TRENDS IN BIOCHEMICAL SCIENCES. 1997;22(10):372-374
MDM2--arbiter of p53's destruction.
Lane DP; Hall PA
Article: ONCOGENE. 1997;15(10):1179-1189
p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.
Midgley CA; Lane DP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(31):19471-19479
HSP70 binding sites in the tumor suppressor protein p53.
Fourie AM; Hupp TR; Lane DP; Sang BC; Barbosa MS; Sambrook JF; Gething MJ
Article: ONCOGENE. 1997;15(2):237-244
Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential.
Mundt M; Hupp T; Fritsche M; Merkle C; Hansen S; Lane D; Groner B
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;269(5):744-756
Molecular characterization of the hdm2-p53 interaction.
Böttger A; Böttger V; Garcia-Echeverria C; Chène P; Hochkeppel HK; Sampson W; Ang K; Howard SF; Picksley SM; Lane DP
Article: ONCOGENE. 1997;14(19):2313-2321
Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair.
Warbrick E; Lane DP; Glover DM; Cox LS
Article: JOURNAL OF PATHOLOGY. 1997;181(4):426-433
APC expression in normal human tissues.
Midgley CA; White S; Howitt R; Save V; Dunlop MG; Hall PA; Lane DP; Wyllie AH; Bubb VJ
Article: CURRENT BIOLOGY. 1997;7(3):R144-R147
Tumor suppressors: a developing role for p53?
Hall PA; Lane DP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(9):5765-5773
Ku selectively transfers between DNA molecules with homologous ends.
Bliss TM; Lane DP
Article: CURRENT BIOLOGY. 1997;7(1):71-80
Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21(WAF1)
Ball KL; Lain S; Fahraeus R; Smythe C; Lane DP
Article: ONCOGENE. 1996;13(12):2575-2587
The p53 response to ionising radiation in adult and developing murine tissues.
MacCallum DE; Hupp TR; Midgley CA; Stuart D; Campbell SJ; Harper A; Walsh FS; Wright EG; Balmain A; Lane DP; Hall PA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(48):30922-30928
Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70.
Hansen S; Midgley CA; Lane DP; Freeman BC; Morimoto RI; Hupp TR
Article: ONCOGENE. 1996;13(10):2141-2147
Identification of novel mdm2 binding peptides by phage display.
Böttger V; Böttger A; Howard SF; Picksley SM; Chène P; Garcia-Echeverria C; Hochkeppel HK; Lane DP
Article: ONCOGENE. 1996;12(11):2461-2466
Epitope analysis of the murine p53 tumour suppressor protein.
Lane DP; Stephen CW; Midgley CA; Sparks A; Hupp TR; Daniels DA; Greaves R; Reid A; Vojtesek B; Picksley SM
Article: METHODS. 1996;9(3):494-507
Phage Peptide Libraries.
Daniels DA; Lane DP
Article: JOURNAL OF CELL SCIENCE. 1996;109 ( Pt 5):1105-1112
Oxidative stress is involved in the UV activation of p53.
Renzing J; Hansen S; Lane DP
Article: FEBS JOURNAL. 1996;237(3):854-861
Human and plant proliferating-cell nuclear antigen have a highly conserved binding site for the p53-inducible gene product p21WAF1.
Ball KL; Lane DP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(16):9573-9578
Two pathways for base excision repair in mammalian cells.
Frosina G; Fortini P; Rossi O; Carrozzino F; Raspaglio G; Cox LS; Lane DP; Abbondandolo A; Dogliotti E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(9):4954-4960
Modification of an N-terminal regulatory domain of T antigen restores p53-T antigen complex formation in the absence of an essential metal ion cofactor.
Kernohan NM; Hupp TR; Lane DP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(7):3917-3924
Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group.
Hansen S; Hupp TR; Lane DP
Article: ACTA ONCOLOGICA. 1996;35(4):429-434
The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target.
Picksley SM; Spicer JF; Barnes DM; Lane DP
Article: CELL. 1995;83(2):237-245
Small peptides activate the latent sequence-specific DNA binding function of p53.
Hupp TR; Sparks A; Lane DP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(30):18165-18174
Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.
Hupp TR; Lane DP
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;6(6):1319-1323
The expression of p53 tumor-suppressor protein during progression of gastric and colorectal carcinomas.
Starzynska T; Bromley M; Lane D; Stern P
Article: BRITISH JOURNAL OF CANCER. 1995;71(6):1253-1256
Absence of p53 autoantibodies in a significant proportion of breast cancer patients.
Vojtesek B; Kovarik J; Dolezalova H; Nenutil R; Havlis P; Brentani RR; Lane DP
Article: EMBO JOURNAL. 1995;14(9):2099-2105
A direct effect of activated human p53 on nuclear DNA replication.
Cox LS; Hupp T; Midgley CA; Lane DP
Article: BRITISH JOURNAL OF CANCER. 1995;71(5):1013-1017
Prognostic significance of p53 overexpression in primary breast cancer; a novel luminometric immunoassay applicable on steroid receptor cytosols.
Borg A; Lennerstrand J; Stenmark-Askmalm M; Fernö M; Brisfors A; Ohrvik A; Stål O; Killander D; Lane D; Brundell J
Article: JOURNAL OF CELL SCIENCE. 1995;108 ( Pt 5):1843-1848
Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo.
Midgley CA; Owens B; Briscoe CV; Thomas DB; Lane DP; Hall PA
Article: CURRENT BIOLOGY. 1995;5(3):275-282
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.
Warbrick E; Lane DP; Glover DM; Cox LS
Article: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 1995;347(1319):83-87
On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage.
Lane DP; Midgley CA; Hupp TR; Lu X; Vojtesek B; Picksley SM
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All other publications

Corrigendum: NATURE COMMUNICATIONS. 2025;16(1):1617
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists (vol 15, 489, 2024)
Chandramohan A; Josien H; Yuen TY; Duggal R; Spiegelberg D; Yan L; Juang Y-CA; Ge L; Aronica PG; Kaan HYK; Lim YH; Peier A; Sherborne B; Hochman J; Lin S; Biswas K; Nestor M; Verma CS; Lane DP; Sawyer TK; Garbaccio R; Henry B; Kannan S; Brown CJ; Johannes CW; Partridge AW
Editorial comment: CANCER DISCOVERY. 2024;14(2):211-213
Mutant p53 Gain-of-Function in the Spotlight: Are We Suffering a GOF Delusion?
Lane DP
Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):5019
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (vol 14, 5019, 2023)
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Faernegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Letter: NANO LETTERS. 2023;23(12):5836-5841
Liquid-Liquid Phase Separation Primes Spider Silk Proteins for Fiber Formation via a Conditional Sticker Domain
Leppert A; Chen G; Lama D; Sahin C; Railaite V; Shilkova O; Arndt T; Marklund EG; Lane DP; Rising A; Landreh M
Editorial comment: CANCER DISCOVERY. 2023;13(1):14-16
Covalent Rescue of Mutant p53
Lane DP; Verma CS
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(23):e156513
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive (vol 128, pg 4115, 2018)
Keszei M; Record J; Kritikou JS; Wurzer H; Geyer C; Thiemann M; Drescher P; Brauner H; Kocher L; James J; He M; Baptista MAP; Dahlberg CIM; Biswas A; Lane DP; Song W; Putsep K; Vandenberghe P; Snapper SB; Westerberg LS
Corrigendum: CELL REPORTS. 2021;36(6):109498
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.
Hwang L-A; Phang BH; Liew OW; Iqbal J; Koh XH; Koh XY; Othman R; Xue Y; Richards AM; Lane DP; Sabapathy K
Corrigendum: PHARMACEUTICAL RESEARCH. 2021;38(4):735-736
Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides (Mar, 10.1007/s11095-021-03005-z, 2021)
Desai TJ; Habulihaz B; Cannon JR; Chandramohan A; Kaan HYK; Sadruddin A; Yuen TY; Johannes C; Thean D; Brown CJ; Lane DP; Partridge AW; Evers R; Sawyer TK; Hochman J
Corrigendum: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(12):1105
Understanding p53 functions through p53 antibodies (vol 11, pg 317, 2019)
Sabapathy K; Lane DP
Review: JOURNAL OF PATHOLOGY. 2019;249(3):274-285
Intratumour heterogeneity of p53 expression; causes and consequences
Xue Y; San Luis B; Lane DP
Editorial comment: SCIENCE. 2019;365(6453):539-540
How to lose tumor suppression
Lane DP
Editorial comment: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(4):265-266
p53: updates on mechanisms, biology and therapy (II)
Lane DP; Verma CS
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(4):317-329
Understanding p53 functions through p53 antibodies
Sabapathy K; Lane DP
Editorial comment: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(3):185-186
p53: updates on mechanisms, biology and therapy (I)
Lane DP; Verma CS
Editorial comment: CRISPR JOURNAL. 2018;1(4):258-260
Guardian of Genome Editing
Ho T; Lane DP
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):11110
The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding (vol 8, 718, 2018)
Lua W-H; Ling W-L; Yeo JY; Poh J-J; Lane DP; Gan SK-E
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):2071
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Farnegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Review: NATURE REVIEWS CLINICAL ONCOLOGY. 2018;15(1):13-30
Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
Sabapathy K; Lane DP
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2017;9(1):3-15
Anatomy of Mdm2 and Mdm4 in evolution
Tan BX; Liew HP; Chua JS; Ghadessy FJ; Tan YS; Lane DP; Coffill CR
Review: DRUG DISCOVERY TODAY. 2016;21(10):1642-1653
Stapled peptide design: principles and roles of computation
Tan YS; Lane DP; Verma CS
Corrigendum: NATURE REVIEWS DRUG DISCOVERY. 2014;13(4):314
Drugging the p53 pathway: understanding the route to clinical efficacy (vol 13, pg 217, 2014)
Khoo KH; Verma CS; Lane DP
Review: NATURE REVIEWS DRUG DISCOVERY. 2014;13(3):217-236
Drugging the p53 pathway: understanding the route to clinical efficacy
Hoe KK; Verma CS; Lane DP
Other: CELL CYCLE. 2012;11(8):1488-1489
Stress, specificity and the NEDD8 proteome
Lane DP
Review: EUROPACE. 2012;14(1):8-27
Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options-a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
Kirchhof P; Lip GYH; Van Gelder IC; Bax J; Hylek E; Kaab S; Schotten U; Wegscheider K; Boriani G; Brandes A; Ezekowitz M; Diener H; Haegeli L; Heidbuchel H; Lane D; Mont L; Willems S; Dorian P; Aunes-Jansson M; Blomstrom-Lundqvist C; Borentain M; Breitenstein S; Brueckmann M; Cater N; Clemens A; Dobrev D; Dubner S; Edvardsson NG; Friberg L; Goette A; Gulizia M; Hatala R; Horwood J; Szumowski L; Kappenberger L; Kautzner J; Leute A; Lobban T; Meyer R; Millerhagen J; Morgan J; Muenzel F; Nabauer M; Baertels C; Oeff M; Paar D; Polifka J; Ravens U; Rosin L; Stegink W; Steinbeck G; Vardas P; Vincent A; Walter M; Breithardt G; Camm AJ
Corrigendum: NATURE REVIEWS CLINICAL ONCOLOGY. 2011;8(10):568
Translating p53 into the clinic (vol 8, pg 25, 2011)
Cheok CF; Verma CS; Baselga J; Lane DP
Review: NATURE REVIEWS CLINICAL ONCOLOGY. 2011;8(1):25-37
Translating p53 into the clinic
Cheok CF; Verma CS; Baselga J; Lane DP
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2011;32(1):53-62
Reactivation of p53: from peptides to small molecules
Brown CJ; Cheok CF; Verma CS; Lane DP
Review: JOURNAL OF PATHOLOGY. 2011;223(2):116-126
The role of mutant p53 in human cancer
Goh AM; Coffill CR; Lane DP
Corrigendum: CELL CYCLE. 2010;9(19):4031
Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site (vol 8, pg 1905, 2009)
Brown CJ; Verma CS; Walkinshaw MD; Lane DP
Editorial comment: CANCER CELL. 2010;18(3):201-202
SNPing Away at Cancer
Goh AM; Lane DP
Editorial comment: JOURNAL OF PATHOLOGY. 2010;220(4):401-403
p53 transcriptional pathways in breast cancer: the good, the bad and the complex
Thompson AM; Lane DP
Published conference paper: BMC GENOMICS. 2010;11(Suppl 1):S5
Differences in the transactivation domains of p53 family members: a computational study
Mavinahalli JN; Madhumalar A; Beuerman RW; Lane DP; Verma C
Review: SEMINARS IN CANCER BIOLOGY. 2010;20(1):3-9
Modulating the p53 pathway
Dey A; Lane DP; Verma CS
Published conference paper: BMC BIOINFORMATICS. 2009;10(Suppl 15):S6
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
Dastidar SG; Lane DP; Verma CS
Review: NATURE REVIEWS CANCER. 2009;9(12):862-873
Awakening guardian angels: drugging the p53 pathway
Brown CJ; Lain S; Verma CS; Fersht AR; Lane DP
Review: NATURE REVIEWS DRUG DISCOVERY. 2008;7(12):1031-1040
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
Dey A; Tergaonkar V; Lane DP
Other: CELL CYCLE. 2008;7(21):3287-3291
Targeting a nucleolar SUMO protease for degradation A mechanism by which ARF induces SUMO conjugation
Xirodimas DP; Lane DP
Review: DRUG DEVELOPMENT RESEARCH. 2008;69(6):289-296
New Developments in Small Molecules Targeting p53 Pathways in Anticancer Therapy
Cheok CF; Lane DP
Review: BRITISH JOURNAL OF CANCER. 2008;98(1):4-8
Updates on p53: modulation of p53 degradation as a therapeutic approach
Dey A; Verma CS; Lane DP
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2007;8(4):275-283
p53 in health and disease
Vousden KH; Lane DP
Editorial comment: NATURE BIOTECHNOLOGY. 2006;24(2):163-164
Designer combination therapy for cancer
Lane D
Review: BRITISH JOURNAL OF CANCER. 2005;92(3):434-444
P53 abnormalities and outcomes in colorectal cancer: a systematic review
Munro AJ; Lain S; Lane DP
Review: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2005;70:489-497
Exploiting the p53 pathway for the diagnosis and therapy of human cancer.
Lane DP
Review: NATURE REVIEWS CANCER. 2004;4(9):727-737
Transcription - guarding the genome by sensing DNA damage.
Ljungman M; Lane DP
Editorial comment: CARCINOGENESIS. 2004;25(7):1077-1081
Anthony Dipple Carcinogenesis Award. p53 from pathway to therapy.
Lane D
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2004;350(26):2711-2712
Curing cancer with p53.
Lane D
Editorial comment: NATURE. 2004;427(6977):789-790
Turning the key on p53.
Lane DP; Fischer PM
Review: MINI-REVIEWS IN MEDICINAL CHEMISTRY. 2003;3(3):257-270
The p53-Mdm2 pathway: targets for the development of new anticancer therapeutics.
Zheleva DI; Lane DP; Fischer PM
Editorial comment: CELL DEATH AND DIFFERENTIATION. 2003;10(4):397-399
p53: 25 years of research and more questions to answer.
Bourdon JC; Laurenzi VD; Melino G; Lane D
Review: HEMATOLOGY JOURNAL. 2003;4(4):233-247
Exploiting the p53 pathway for cancer diagnosis and therapy.
Woods YL; Lane DP
Review: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2003;3(1):57-69
Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.
McInnes C; Andrews MJI; Zheleva DI; Lane DP; Fischer PM
Editorial comment: TRENDS IN CELL BIOLOGY. 2002;12(12):541-542
'Mind the gap'.
Lane DP
Review: TRENDS IN MOLECULAR MEDICINE. 2002;8(4):S38-S42
Therapeutic exploitation of the p53 pathway
Lane DP; Lain S
Review: JOURNAL OF MOLECULAR BIOLOGY. 2001;313(4):711-731
Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.
Liu WL; Midgley C; Stephen C; Saville M; Lane DP
Review: BIOCONJUGATE CHEMISTRY. 2001;12(6):825-841
Cellular delivery of impermeable effector molecules in the form of conjugates with peptides capable of mediating membrane translocation.
Fischer PM; Krausz E; Lane DP
Editorial comment: NATURE. 2001;414(6859):25-27
How cells choose to die.
Lane D
Review: CURRENT MEDICINAL CHEMISTRY. 2000;7(12):1213-1245
Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics.
Fischer PM; Lane DP
Review: BIOCHEMICAL JOURNAL. 2000;352 Pt 1(Pt 1):1-17
Strategies for manipulating the p53 pathway in the treatment of human cancer.
Hupp TR; Lane DP; Ball KL
Editorial comment: CHEMICAL BIOLOGY & DRUG DESIGN. 2000;55(2):163-172
Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector Penetratin.
Fischer PM; Zhelev NZ; Wang S; Melville JE; Fåhraeus R; Lane DP
Review: EXPERIMENTAL CELL RESEARCH. 1999;253(2):315-324
Accumulating active p53 in the nucleus by inhibition of nuclear export: A novel strategy to promote the p53 tumor suppressor function
Laín S; Xirodimas D; Lane DP
Editorial comment: JOURNAL OF PATHOLOGY. 1999;187(1):2-3
Preface to molecular and cellular themes in cancer research
Hall PA; Lane DP
Review: BJS-BRITISH JOURNAL OF SURGERY. 1998;85(11):1460-1467
The p53 tumour suppressor gene.
Steele RJ; Thompson AM; Hall PA; Lane DP
Editorial comment: NATURE MEDICINE. 1998;4(9):1012-1013
Killing tumor cells with viruses--a question of specificity.
Lane DP
Editorial comment: NATURE. 1998;394(6694):616-617
Awakening angels.
Lane D
Editorial comment: JOURNAL OF PATHOLOGY. 1996;180(1):1-5
p53--integrating the complexity.
Hall PA; Meek D; Lane DP
Other: COMPTES RENDUS BIOLOGIES. 1995;318(11):1173-1179
Cancer: the translation of advances in basic science to human therapy. 22-27 July 1995. La fondation des Treilles, Tourtour France.
Review: BIOESSAYS. 1995;17(6):501-508
Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.
Cox LS; Lane DP
Other: ONCOGENE. 1995;10(9):1865-1868
p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts.
Renzing J; Lane DP
Review: JOURNAL OF MOLECULAR BIOLOGY. 1995;248(1):58-78
Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions.
Stephen CW; Helminen P; Lane DP
Editorial comment: NATURE GENETICS. 1995;9(3):221-222
The dominating effect of mutant p53.
Hann BC; Lane DP
Other: ONCOGENE. 1995;10(2):389-393
Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.
Vojtesek B; Dolezalova H; Lauerova L; Svitakova M; Havlis P; Kovarik J; Midgley CA; Lane DP
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Professor, Senior, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2025-2025
Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2020-2024

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