Daniel Hägerstrand

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About me

(2015) Magnus Bergvalls stiftelse
(2014) Magnus Bergvalls stiftelse
(2014) Karolinska Institutets Forskningsstiftelser
(2014) Best poster together with PhD student Min Guo at the Winterviken
retreat for the depart of Oncology-Pathology, KI
(2008-2009) Sweden-American foundation post doc scholarship, 300000 SEK
(2007-2013) Harvard Medical School, Department of Medical Oncology,
Dana-Farber Cancer Institute, William Hahn lab, Boston, USA
(2007) PhD in experimental tumor biology, Department of Oncology-Pathology,
Karolinska Institutet (KI), Cancer Center Karoliska (CCK) “Molecular
determinants of glioma subsets with distinct histology or sensitivity to
signal transduction inhibitors”, supervisor Professor Arne Östman,
Stockholm, Sweden
(2001) Master of Science in Biology at Uppsala University, Uppsala, Sweden

Articles

Article: LEUKEMIA. 2024;38(11):2429-2442
The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia
Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Santos TDP; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
Article: LEUKEMIA. 2024;38(6):1287-1298
IκBε deficiency accelerates disease development in chronic lymphocytic leukemia
Bordini J; Lenzi C; Frenquelli M; Morabito A; Pseftogas A; Belloni D; Mansouri L; Tsiolas G; Perotta E; Ranghetti P; Gandini F; Genova F; Hagerstrand D; Gavriilidis G; Keisaris S; Pechlivanis N; Davi F; Kay NE; Langerak AW; Pospisilova S; Scarfo L; Makris A; Psomopoulos FE; Stamatopoulos K; Rosenquist R; Campanella A; Ghia P
Journal article: HEMASPHERE. 2022;6(Suppl):1167-1168
P1282: DISEASE‐SPECIFIC U1 SPLICEOSOMAL RNA MUTATIONS IN MATURE B‐CELL NEOPLASMS
Nadeu F; Shuai S; Clot G; Hilton LK; Diaz‐Navarro A; Martín S; Royo R; Baumann T; Kulis M; López‐Oreja I; Cossio M; Lu J; Ljungström V; Young E; Plevova K; Knisbacher BA; Lin Z; Hahn CK; Bousquets P; Alcoceba M; González M; Colado E; Aymerich M; Terol MJ; Rivas‐Delgado A; Enjuanes A; Ruiz‐Gaspà S; Chatzikonstantinou T; Hägerstrand D; Jylhä C; Skaftason A; Mansouri L; Stranska K; Doubek M; van Gastel‐Mol EJ; Davis Z; Walewska R; Scarfò L; Trentin L; Visentin A; Parikh SA; Rabe KG; Moia R; Armand M; Rossi D; Davi F; Gaidano G; Kay NE; Shanafelt T; Ghia P; Oscier D; Langerak AW; Beà S; López‐Guillermo A; Neuberg D; Wu CJ; Getz G; Pospisilova S; Stamatopoulos K; Rosenquist R; Huber W; Zenz T; Colomer D; Martín‐Subero JI; Delgado J; Morin RD; Stein LD; Puente XS; Campo E
Article: SCIENTIFIC REPORTS. 2022;12(1):9838
Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes
Keller M; Blom M; Conze LL; Guo M; Hagerstrand D; Aspenstrom P
Article: CANCER REPORTS. 2022;5(5):e1498
The association between Annexin A2 and epithelial cell adhesion molecule in breast cancer cells
Al-Qahtani SM; Gadalla SE; Guo M; Ericsson C; Hagerstrand D; Nister M
Article: ONCOGENE. 2021;40(32):5066-5080
SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma
Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
Article: GLIA. 2020;68(2):316-327
Astrocytes enhance glioblastoma growth
Mega A; Nilsen MH; Leiss LW; Tobin NP; Miletic H; Sleire L; Strell C; Nelander S; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
Article: NEURO-ONCOLOGY ADVANCES. 2020;2(1):vdaa061
Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity
Guo M; van Vliet M; Zhao J; de Stahl TD; Lindstrom MS; Cheng H; Heller S; Nister M; Hagerstrand D
Article: CLINICAL CANCER RESEARCH. 2019;25(12):3702-3717
A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjoberg E; Meyrath M; Milde L; Herrera M; Lovrot J; Hagerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Andy CE; Augsten M; Ostman A
Journal article: NEURO-ONCOLOGY. 2018;20(suppl_6):vi263-vi264
TMIC-35. ASTROCYTE-DEPENDENT ENHANCEMENT OF GLIOBLASTOMA GROWTH AS A CANDIDATE THERAPEUTIC TARGET
Mega A; Leiss L; Nilsen MH; Tobin N; Sleire L; Strell C; Liu J; Nekhotiaeva N; Eriksson A; Nelander S; Uhrbom L; Krona C; Hägerstrand D; Enger PØ; Nistér M; Östman A
Article: CANCER RESEARCH. 2018;78(20):5901-5916
Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nister M; Lindstrom MS; Hagerstrand D
Journal article: ESMO OPEN. 2018;3(Suppl 2):a359-A360
PO-336 Identification of SOX2 and SFRP2 as opposing regulators of glioblastoma heterogeneous subtypes
Guo M; Nister M; Hagerstrand D
Journal article: NEURO-ONCOLOGY. 2017;19(suppl_6):vi248
TMIC-24. ASTROCYTE-DEPENDENT ENHANCEMENT OF GLIOBLASTOMA GROWTH AS A CANDIDATE THERAPEUTIC TARGET
Mega A; Nilsen MH; Leiss LW; Sleire L; Liu J; Nelander S; Uhrbom L; Krona C; Hägerstrand D; Enger PØ; Nistér M; Östman A
Article: ONCOTARGET. 2017;8(49):84671-84684
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderen C; Hoglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hagerstrand D; Berglund UW; Helleday T; Brautigam L
Article: ONCOTARGET. 2016;7(45):72431-72442
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status
Roodakker KR; Elsir T; Edqvist P-HD; Hagerstrand D; Carison J; Lysiak M; Henriksson R; Ponten F; Rosell J; Soderkvist P; Stupp R; Tchougounova E; Nister M; Malmstrom A; Smits A
Article: ONCOGENE. 2015;34(2):209-216
TRAF2 is an NF-κB-activating oncogene in epithelial cancers
Shen RR; Zhou AY; Kim E; O'Connell JT; Hagerstrand D; Beroukhim R; Hahn WC
Article: CANCER DISCOVERY. 2013;3(9):1044-1057
Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers
Hagerstrand D; Tong A; Schumacher SE; Ilic N; Shen RR; Cheung HW; Vazquez F; Shrestha Y; Kim SY; Giacomelli AO; Rosenbluh J; Schinzel AC; Spardy NA; Barbie DA; Mermel CH; Weir BA; Garraway LA; Tamayo P; Mesirov JP; Beroukhim R; Hahn WC
Article: NEURO-ONCOLOGY. 2011;13(11):1178-1191
Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile
Hagerstrand D; He X; Lindh MB; Hoefs S; Hesselager G; Ostman A; Nister M
Article: ANTI-CANCER DRUGS. 2010;21(8):759-765
Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents
Uecker A; Sicker M; Beckers T; Mahboobi S; Hagerstrand D; Ostman A; Bohmer F-D
Article: NEURO-ONCOLOGY. 2010;12(9):967-975
PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541
Hagerstrand D; Lindh MB; Pena C; Garcia-Echeverria C; Nister M; Hofmann F; Ostman A
Article: NEURO-ONCOLOGY. 2008;10(1):2-9
Gene expression analyses of grade II gliomas and identification of rPTPβ/ζ as a candidate oligodendroglioma marker
Haegerstrand D; Smits A; Eriksson A; Sigurclarclottir S; Olofsson T; Hartman M; Nister M; Kalimo H; Oetman A
Article: ONCOGENE. 2006;25(35):4913-4922
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures
Hagerstrand D; Hesselager G; Achterberg S; Bolin UW; Kowanetz M; Kastemar M; Heldin C-H; Isaksson A; Nister M; Ostman A
Journal article: EJC SUPPLEMENTS. 2004;2(8):30
89 Gene expression profiling of cancer associated fibroblasts
Micke P; Sundquist C; Hägerstrand D; Scheidl S; Lindahl P; Pontén F; Heldin CH; Ostman A
Journal article: EJC SUPPLEMENTS. 2004;2(8):109
363 Targeting of PDGF receptors; combination effects in various solid tumors and identification of a PDGF dependent brain tumor subset
Östman A; Hägerstrand D; Pietras K; Furuhashi M; Wu Y; Hicklin DJ; Buchdunger E; Abe M; Nister M; Baranowska-Kortylewicz J; Heldin C-H
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All other publications

Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Data from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjöberg E; Meyrath M; Milde L; Herrera M; Lövrot J; Hägerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Chevigné A; Augsten M; Östman A
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Figure S1 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Figure S3 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S3 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Data from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjöberg E; Meyrath M; Milde L; Herrera M; Lövrot J; Hägerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Chevigné A; Augsten M; Östman A
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S1 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Figure S2 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjöberg E; Meyrath M; Milde L; Herrera M; Lövrot J; Hägerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Chevigné A; Augsten M; Östman A
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S4 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S3 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S1 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S4 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure Legends from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjöberg E; Meyrath M; Milde L; Herrera M; Lövrot J; Hägerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Chevigné A; Augsten M; Östman A
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S2 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Table S2 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Figure S2 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Figure S1 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Figure S3 from Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Figure Legends from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjöberg E; Meyrath M; Milde L; Herrera M; Lövrot J; Hägerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Chevigné A; Augsten M; Östman A
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Sjöberg E; Meyrath M; Milde L; Herrera M; Lövrot J; Hägerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Chevigné A; Augsten M; Östman A
Corrigendum: ONCOGENE. 2021;40(32):5153
SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma (May, 10.1038/s41388-021-01825-2, 2021)
Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
Corrigendum: ONCOTARGET. 2020;11(8):827
Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderén C; Höglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hägerstrand D; Berglund UW; Helleday T; Bräutigam L
Conference publication: NEURO-ONCOLOGY. 2018;20:263-264
ASTROCYTE-DEPENDENT ENHANCEMENT OF GLIOBLASTOMA GROWTH AS A CANDIDATE THERAPEUTIC TARGET
Mega A; Leiss L; Nilsen MH; Tobin N; Sleire L; Strell C; Liu J; Nekhotiaeva N; Eriksson A; Nelander S; Uhrbom L; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
Conference publication: NEURO-ONCOLOGY. 2017;19:248
ASTROCYTE-DEPENDENT ENHANCEMENT OF GLIOBLASTOMA GROWTH AS A CANDIDATE THERAPEUTIC TARGET
Mega A; Nilsen MH; Leiss LW; Sleire L; Liu J; Nelander S; Uhrbom L; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
Meeting abstract: CANCER RESEARCH. 2016;76:2385
Understanding the dynamic interplay between genetically different cancer cell clones in glioblastoma
Guo M; Heller S; Thorslund J; Orre L; Lehtio J; Nister M; Hagerstrand D
Meeting abstract: NEURO-ONCOLOGY. 2014;16:v122-v123
PRO-MIGRATORY AND -PROLIFERATIVE EFFECTS OF ASTROCYTES ON GBM CELLS
Mega A; Sleire L; Hagerstrand D; Enger PO; Nister M; Ostman A
Thesis / dissertation: 2007
Molecular determinants of glioma subsets with distinct histology or sensitivity to signal transduction inhibitors
Hägerstrand, Daniel
Conference publication: ANNALS OF ONCOLOGY. 2007;18:45
Analyses of roles of gene expression and PTEN-PI3K-AKT pathway in determination of sensitivity to the IGF-1 receptor inhibitor NVP-AEW541 in high grade glioma cell cultures
Hagerstrand D; Bradic M; Garcia-Echeverria C; Nister M; Hofmann F; Ostman A
Conference publication: ANNALS OF ONCOLOGY. 2005;16:21
PDGF receptors as cancer drug targets
Ostman A; Pietras K; Hägerstrand D; Furuhashi M; Abe M; Robinson S; Wu Y; Hicklin DJ; Baranowska-Kortylewicz J; Nister M; Heldin CH; Rubin K
Conference publication: ANNALS OF ONCOLOGY. 2005;16:43
Characterization of the sensitivity of high grade glioma cultures to inhibitors of PDGF- and IGF1-receptors
Bradic M; Hägerstrand D
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Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2007

About me

Articles

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Degrees and Education

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