Craig Wheelock

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Articles

Journal article: CHEMICAL REVIEWS. 2024
The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.
Revol-Cavalier J; Quaranta A; Newman JW; Brash AR; Hamberg M; Wheelock CE
Journal article: SCIENCE IMMUNOLOGY. 2024;9(102):eadl1467
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis
Bohnacker S; Henkel FDR; Hartung F; Geerlof A; Riemer S; Prodjinotho UF; Salah EB; Mourao ASD; Bohn S; Teder T; Thomas D; Gurke R; Boeckel C; Ud-Dean M; Koenig A-C; Quaranta A; Alessandrini F; Lechner A; Spitzlberger B; Kabat AM; Pearce E; Haeggstroem JZ; Hauck SM; Wheelock CE; Jakobsson P-J; Sattler M; Voehringer D; Feige MJ; da Costa CP; Bieren JE-V
Article: ANNALS OF THE AMERICAN THORACIC SOCIETY. 2024;21(12):1715-1722
Impact of Short-Term Diesel Exhaust Exposure on Prothrombotic Markers in Chronic Obstructive Pulmonary Disease: A Randomized, Double-Blind, Crossover Study.
Ryu MH; Hur SA; Afshar T; Kolmert J; Zurita J; Wheelock CE; Carlsten C
Article: EUROPEAN RESPIRATORY JOURNAL. 2024;:2400298
Body mass index trajectories from birth to early adulthood and lung function development.
Wang G; Hallberg J; Merid SK; Kumar A; Klevebro S; Habchi B; Chaleckis R; Wheelock CE; Hernandez-Pacheco N; Ekström S; Janson C; Kull I; Bergström A; Melén E
Article: ANALYTICAL CHEMISTRY. 2024;96(45):17950-17959
Development of a Desorption Electrospray Ionization-Multiple-Reaction-Monitoring Mass Spectrometry (DESI-MRM) Workflow for Spatially Mapping Oxylipins in Pulmonary Tissue
Smith MJ; Nie M; Adner M; Safholm J; Wheelock CE
Journal article: EBIOMEDICINE. 2024;109:105400
Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition
Dahlin M; Wheelock CE; Prast-Nielsen S
Article: EUROPEAN RESPIRATORY JOURNAL. 2024;64(5):2400207
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics.
Zounemat Kermani N; Chung KF; Macis G; Santini G; Clemeno FAA; Versi A; Sun K; Abdel-Aziz MI; Andersson LI; Auffray C; Badi Y; Bakke P; Brightling C; Brinkman P; Caruso M; Chanez P; De Meulder B; Djukanovic R; Fabbri L; Fowler SJ; Horvath I; Howarth P; James AJ; Kolmert J; Kraft M; Li C-X; Maitland-van der Zee AH; Malerba M; Papi A; Rabe K; Sanak M; Shaw DE; Singh D; Sparreman Mikus M; van Den Berge M; Wheelock AM; Wheelock CE; Yasinska V; Guo Y-K; Wagers S; Barnes PJ; Bush A; Sterk PJ; Dahlen S-E; Adcock IM; Siddiqui S; Montuschi P; U-BIOPRED and ATLANTIS Study Groups
Journal article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2024;35(11):e14267
Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling
Virkud YV; Styles JN; Kelly RS; Patil SU; Ruiter B; Smith NP; Clish C; Wheelock CE; Celedon JC; Litonjua AA; Bunyavanich S; Weiss ST; Baker ES; Lasky-Su JA; Shreffler WG
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2024;249:116378
Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticals
Perez-Cova M; Bedia C; Checa A; Meister I; Tauler R; Wheelock CE; Jaumot J
Article: NATURE COMMUNICATIONS. 2024;15(1):8562
Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
Torta F; Hoffmann N; Burla B; Alecu I; Arita M; Bamba T; Bennett SAL; Bertrand-Michel J; Bruegger B; Cala MP; Camacho-Munoz D; Checa A; Chen M; Chocholouskova M; Cinel M; Chu-Van E; Colsch B; Coman C; Connell L; Sousa BC; Dickens AM; Fedorova M; Eiriksson FF; Gallart-Ayala H; Ghorasaini M; Giera M; Guan XL; Haid M; Hankemeier T; Harms A; Hoering M; Holcapek M; Hornemann T; Hu C; Hulsmeier AJ; Huynh K; Jones CM; Ivanisevic J; Izumi Y; Koefeler HC; Lam SM; Lange M; Lee JC; Liebisch G; Lippa K; Lopez-Clavijo AF; Manzi M; Martinefski MR; Math RGH; Mayor S; Meikle PJ; Monge ME; Moon MH; Muralidharan S; Nicolaou A; Nguyen-Tran T; O'Donnell VB; Oresic M; Ramanathan A; Riols F; Saigusa D; Schock TB; Schwartz-Zimmermann H; Shui G; Singh M; Takahashi M; Thorsteinsdottir M; Tomiyasu N; Tournadre A; Tsugawa H; Tyrrell VJ; van der Gugten G; Wakelam MO; Wheelock CE; Wolrab D; Xu G; Xu T; Bowden JA; Ekroos K; Ahrends R; Wenk MR
Article: ENVIRONMENTAL SCIENCE: ADVANCES. 2024;3(10):1426-1437
Pregnancy complications and birth outcomes following low-level exposure to per- and polyfluoroalkyl substances in the vitamin D antenatal asthma reduction trial
Begum S; Prince N; Minguez-Alarcon L; Chen Y; Soeteman DI; Fangal V; Huang M; Wheelock C; Mendez K; Litonjua AA; Weiss ST; Lasky-Su J; Kelly RS
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2024;416(25):5485-5496
Cohort-based strategies as an in-house tool to evaluate and improve phenotyping robustness of LC-MS/MS lipidomics platforms
Zohrer B; Gomez C; Jaumot J; Idborg H; Torekov SS; Wheelock AM; Wheelock CE; Checa A
Article: JAMA DERMATOLOGY. 2024;160(10):1082-1090
Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis
Chen L; Brustad N; Luo Y; Wang T; Ali M; Ebrahimi P; Schoos A-MM; Vahman N; Lovric M; Rasmussen MA; Kolmert J; Wheelock CE; Lasky-Su JA; Stokholm J; Bonnelykke K; Chawes B
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;154(3):670-678
Urinary eicosanoid levels in early life and risk of atopic disease in childhood
Chen L; Brustad N; Kim M; Luo Y; Wang T; Ali M; Prince N; Chen Y; Chu S; Begum S; Mendez K; Kelly RS; Schoos A-M; Rasmussen MA; Zurita J; Kolmert J; Stokholm J; Litonjua A; Weiss ST; Bonnelykke K; Wheelock CE; Lasky-Su J; Chawes B
Article: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2024;72(32):18247-18256
Fungicide Metabolite MS2 Spectral Libraries for Comprehensive Human Biomonitoring
Chaleckis R; Ito Y; Wasada H; Wheelock CE; Oishi H; Tomizawa M; Kamijima M
Article: MED. 2024;:S2666-6340(24)00304-0
Bilirubin metabolism in early life and respiratory health during preschool age: A combined analysis of two independent birth cohorts.
Kim M; Brustad N; Eliasen AU; Ali M; Wang T; Rasmussen MA; Ernst M; Hougaard D; Litonjua AA; Wheelock CE; Kelly RS; Chen Y; Prince N; Townsend PA; Stokholm J; Weiss ST; Bønnelykke K; Lasky-Su J; Chawes B
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(3):288-297
Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults Results of the SoMOSA Study
Djukanovic R; Brinkman P; Kolmert J; Gomez C; Schofield J; Brandsma J; Shapanis A; Skipp PJS; Postle A; Wheelock C; Dahlen S-E; Sterk PJ; Brown T; Jackson DJ; Mansur A; Pavord I; Patel M; Brightling C; Siddiqui S; Bradding P; Sabroe I; Saralaya D; Chishimba L; Porter J; Robinson D; Fowler S; Howarth PH; Little L; Oliver T; Hill K; Stanton L; Allen A; Ellis D; Griffiths G; Harrison T; Akenroye A; Lasky-Su J; Heaney L; Chaudhuri R; Kurukulaaratchy R
Article: NATURE COMMUNICATIONS. 2024;15(1):6256
NMNAT2 is a druggable target to drive neuronal NAD production
Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
Article: CELL REPORTS MEDICINE. 2024;5(7):101629
Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids
Fiorenza M; Checa A; Sandsdal RM; Jensen SBK; Juhl CR; Noer MH; Bogh NP; Lundgren JR; Janus C; Stallknecht BM; Holst JJ; Madsbad S; Wheelock CE; Torekov SS
Article: SCIENTIFIC REPORTS. 2024;14(1):15444
Metabolomics-based search for lung cancer markers among patients with different smoking status
Klupczynska-Gabryszak A; Daskalaki E; Wheelock CE; Kasprzyk M; Dyszkiewicz W; Grabicki M; Brajer-Luftmann B; Pawlak M; Kokot ZJ; Matysiak J
Article: ERJ OPEN RESEARCH. 2024;10(4):00931-2023
Untargeted metabolomic analysis reveals different metabolites associated with response to mepolizumab and omalizumab in asthma
Nopsopon T; Chen Y; Chen Q; Wheelock CE; Weiss ST; McGeachie M; Lasky-Su J; Akenroye A
Article: EBIOMEDICINE. 2024;102:105025
Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma
Mendez KM; Begum S; Tiwari A; Sharma R; Chen Q; Kelly RS; Prince N; Huang M; Kachroo P; Chu SH; Chen Y; Lee-Sarwar K; Broadhurst DI; Reinke SN; Gerson R; Clish C; Avila L; Celedon JC; Wheelock CE; Weiss ST; McGeachie M; Lasky-Sua JA
Article: RESPIRATORY RESEARCH. 2024;25(1):86
Large airway T cells in adults with former bronchopulmonary dysplasia
Gao J; Um-Bergstrom P; Pourbazargan M; Berggren-Brostrom E; Li C; Merikallio H; Kaarteenaho R; Reinke NS; Wheelock CE; Melen E; Anders L; Wheelock AM; Rassidakis G; Ortiz-Villalon C; Skold MC
Article: JOURNAL OF NUTRITION. 2024;154(2):395-402
A Walnut-Enriched Diet for 2 Years Changes the Serum Oxylipin Profile in Healthy Older Persons
Cofan M; Checa A; Serra-Mir M; Roth I; Valls-Pedret C; Lopez-Illamola A; Domenech M; Rajaram S; Lazaro I; Sabate J; Ros E; Wheelock CE; Sala-Vila A
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2024;170:106789
A single extraction 96-well method for LC-MS/MS quantification of urinary eicosanoids, steroids and drugs
Sieminska J; Kolmert J; Zurita J; Benkestock K; Revol-Cavalier J; Niklinski J; Reszec J; Dahlen S-E; Ciborowski M; Wheelock CE
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;79(2):404-418
Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors
Chen Y; Checa A; Zhang P; Huang M; Kelly RS; Kim M; Chen Y-CS; Lee-Sarwar KA; Prince N; Mendez KM; Begum S; Kachroo P; Chu SH; Stokholm J; Bonnelykke K; Litonjua AA; Bisgaard H; Weiss ST; Chawes BL; Wheelock CE; Lasky-Su JA
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;152(6):1646-1657.e11
Maternal vitamin D-related metabolome and offspring risk of asthma outcomes
Kim M; Brustad N; Ali M; Gurdeniz G; Arendt M; Litonjua AA; Wheelock CE; Kelly RS; Chen Y; Prince N; Guo F; Zhou X; Stokholm J; Bonnelykke K; Weiss ST; Bisgaard H; Lasky J; Chawes B
Article: NATURE METABOLISM. 2023;5(10):1747-1764
Glutarate regulates T cell metabolism and anti-tumour immunity
Minogue E; Cunha PP; Wadsworth BJ; Grice GL; Sah-Teli SK; Hughes R; Bargiela D; Quaranta A; Zurita J; Antrobus R; Velica P; Barbieri L; Wheelock CE; Koivunen P; Nathan JA; Foskolou IP; Johnson RS
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(10):2039-2051.e10
Correspondence: Jakob D. Wikstrom, . E-mail: jakob.wikstrom@ki.se
Manchanda M; Torres M; Inuossa F; Bansal R; Kumar R; Hunt M; Wheelock CE; Bachar-Wikstrom E; Wikstrom JD
Article: ERJ OPEN RESEARCH. 2023;9(5):00269-02023
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
Yasinska V; Gomez C; Kolmert J; Ericsson M; Pohanka A; James A; Andersson LI; Sparreman-Mikus M; Sousa AR; Riley JH; Bates S; Bakke PS; Kermani NZ; Caruso M; Chanez P; Fowler SJ; Geiser T; Howarth PH; Horvath I; Krug N; Montuschi P; Sanak M; Behndig A; Shaw DE; Knowles RG; Dahlen B; Maitland-van der Zee A-H; Sterk PJ; Djukanovic R; Adcock IM; Chung KF; Wheelock CE; Dahlen S-E; Jonsson EW
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023;208(2):142-154
Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk
Abdel-Aziz MI; Thorsen J; Hashimoto S; Vijverberg SJH; Neerincx AH; Brinkman P; van Aalderen W; Stokholm J; Rasmussen MA; Roggenbuck-Wedemeyer M; Vissing NH; Mortensen MS; Brejnrod AD; Fleming LJ; Murray CS; Fowler SJ; Frey U; Bush A; Singer F; Hedlin G; Nordlund B; Shaw DE; Chung KF; Adcock IM; Djukanovic R; Auffray C; Bansal AT; Sousa AR; Wagers SS; Chawes BL; Bonnelykke K; Sorensen SJ; Kraneveld AD; Sterk PJ; Roberts G; Bisgaard H; Maitland-van der Zee AH
Article: SCIENTIFIC REPORTS. 2023;13(1):10461
Elevated third trimester corticosteroid levels are associated with fewer offspring infections
Prince N; Kelly RS; Chu SH; Kachroo P; Chen Y; Mendez KM; Begum S; Bisgaard H; Bonnelykke K; Kim M; Levy O; Litonjua AA; Wheelock CE; Weiss ST; Chawes BL; Lasky-Su JA
Article: CHEMOSPHERE. 2023;324:138228
Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism
Prince N; Begum S; Minguez-Alarcon L; Genard-Walton M; Huang M; Soeteman DI; Wheelock C; Litonjua AA; Weiss ST; Kelly RS; Lasky-Su J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;194:308-315
Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19
Pawelzik S-C; Arnardottir H; Sarajlic P; Mahdi A; Vigor C; Zurita J; Zhou B; Kolmert J; Galano J-M; Religa D; Durand T; Wheelock CE; Back M
Article: THE LANCET RESPIRATORY MEDICINE. 2023;11(1):55-64
Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study
Kole TM; Vanden Berghe E; Kraft M; Vonk JM; Nawijn MC; Siddiqui S; Sun K; Fabbri LM; Rabe KF; Chung KF; Nicolini G; Papi A; Brightling C; Singh D; van der Molen T; Dahlen S-E; Agusti A; Faner R; Wedzicha JA; Donaldson GC; Adcock IM; Lahousse L; Kerstjens HAM; van den Berge M
Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s251
416 The overwhelming omics in psoriasis, a systematic review
Torres M; Silberberg G; Wheelock C; Bachar-Wikstrom E; Wikstrom JD
Article: MOLECULAR NUTRITION AND FOOD RESEARCH. 2022;66(24):e2200351
The FADS1 rs174550 Genotype Modifies the n-3 and n-6 PUFA and Lipid Mediator Responses to a High Alpha-Linolenic Acid and High Linoleic Acid Diets
Meuronen T; Lankinen MA; Kolmert J; Laaksonen VDM; Sallinen T; Agren J; Virtanen KA; Laakso M; Wheelock CE; Pihlajamaki J; Schwab U
Article: METABOLITES. 2022;12(11):1108
Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts
Prince N; Kim M; Kelly RS; Diray-Arce J; Bonnelykke K; Chawes BL; Huang M; Levy O; Litonjua AA; Stokholm J; Wheelock CE; Bisgaard H; Weiss ST; Lasky-Su JA
Journal article: CIRCULATION. 2022;146(Suppl_1):a12842
Abstract 12842: Adipose Tissue Derived Ceramides Regulate the Myocardial Redox State and Predict Cardiovascular Outcomes
Polkinghorne MD; Akawi N; Badi I; Checa A; Kotanidis C; Akoumianakis I; Antonopoulos AS; Krasopoulos G; Sayeed R; Walcot N; Channon KM; Wheelock C; Antoniades C
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2022;934:175257
Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor
Safholm J; Abma W; Bankova LG; Boyce JA; Al-Ameri M; Orre A-C; Wheelock CE; Dahlen S-E; Adner M
Article: JOURNAL OF EXTRACELLULAR BIOLOGY. 2022;1(11):e66
Comparative and integrated analysis of plasma extracellular vesicle isolation methods in healthy volunteers and patients following myocardial infarction.
Paget D; Checa A; Zöhrer B; Heilig R; Shanmuganathan M; Dhaliwal R; Johnson E; Jørgensen MM; Bæk R; Oxford Acute Myocardial Infarction Study (OxAMI); Wheelock CE; Channon KM; Fischer R; Anthony DC; Choudhury RP; Akbar N
Article: ANALYTICAL CHEMISTRY. 2022;94(42):14618-14626
Development of a Chiral Supercritical Fluid Chromatography-Tandem Mass Spectrometry and Reversed-Phase Liquid Chromatography-Tandem Mass Spectrometry Platform for the Quantitative Metabolic Profiling of Octadecanoid Oxylipins
Quaranta A; Zohrer B; Revol-Cavalier J; Benkestock K; Balas L; Oger C; Keyes GS; Wheelock AM; Durand T; Galano J-M; Ramsden CE; Hamberg M; Wheelock CE
Article: ELIFE. 2022;11:e78861
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
Kuo A; Checa A; Niaudet C; Jung B; Fu Z; Wheelock CE; Singh SA; Aikawa M; Smith LE; Proia RL; Hla T
Article: EUROPEAN JOURNAL OF NUTRITION. 2022;61(7):3707-3718
The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism
Vaittinen M; Lankinen MA; Kakela P; Agren J; Wheelock CE; Laakso M; Schwab U; Pihlajamaki J
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(9):e895
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial
Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock CE; Back M
Article: EBIOMEDICINE. 2022;83:104236
Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort
Sevelsted A; Gurdeniz G; Rago D; Pedersen C-ET; Lasky-Su JA; Checa A; Zhang P; Wheelock CE; Normann SS; Kristensen DM; Rasmussen MA; Schullehner J; Sdougkou K; Martin JW; Stokholm J; Bonnelykke K; Bisgaard H; Chawes B
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(9):2677-2687
Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang X; Ronnberg E; Safholm J; Thulasingam M; Trauelsen M; Schwartz TW; Wheelock CE; Dahlen S-E; Nilsson G; Haeggstrom JZ
Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2022;56(11):7107-7118
Urinary Eicosanoid Levels Reflect Allergen and Diesel Exhaust Coexposure and Are Linked to Impaired Lung Function
Ryu MH; Gomez C; Yuen ACY; Brook JR; Wheelock CE; Carlsten C
Article: EUROPEAN RESPIRATORY JOURNAL. 2022;59(6):2101733
Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study
Reinke SN; Naz S; Chaleckis R; Gallart-Ayala H; Kolmert J; Kermani NZ; Tiotiu A; Broadhurst DI; Lundqvist A; Olsson H; Strom M; Wheelock AM; Gomez C; Ericsson M; Sousa AR; Riley JH; Bates S; Scholfield J; Loza M; Baribaud F; Bakke PS; Caruso M; Chanez P; Fowler SJ; Geiser T; Howarth P; Horvath I; Krug N; Montuschi P; Behndig A; Singer F; Musial J; Shaw DE; Dahlen B; Hu S; Lasky-Su J; Sterk PJ; Chung KF; Djukanovic R; Dahlen S-E; Adcock IM; Wheelock CE
Article: NATURE MEDICINE. 2022;28(4):814-822
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
Kachroo P; Stewart ID; Kelly RS; Stav M; Mendez K; Dahlin A; Soeteman DI; Chu SH; Huang M; Cote M; Knilhtila HM; Lee-Sarwar K; McGeachie M; Wang A; Wu AC; Virkud Y; Zhang P; Wareham NJ; Karlson EW; Wheelock CE; Clish C; Weiss ST; Langenberg C; Lasky-Su JA
Article: MUCOSAL IMMUNOLOGY. 2022;15(3):515-524
Mild COVID-19 imprints a long-term inflammatory eicosanoid-and chemokine memory in monocyte-derived macrophages
Bohnacker S; Hartung F; Henkel F; Quaranta A; Kolmert J; Priller A; Ud-Dean M; Giglberger J; Kugler LM; Pechtold L; Yazici S; Lechner A; Erber J; Protzer U; Lingor P; Knolle P; Chaker AM; Schmidt-Weber CB; Wheelock CE; Esser-von Bieren J
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205(4):397-411
Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma
Tiotiu A; Badi Y; Kermani NZ; Sanak M; Kolmert J; Wheelock CE; Hansbro PM; Dahlen S-E; Sterk PJ; Djukanovic R; Guo Y; Mumby S; Adcock IM; Chung KF
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205(3):288-299
Metabo-Endotypes of Asthma Reveal Differences in Lung Function Discovery and Validation in Two TOPMed Cohorts
Kelly RS; Mendez KM; Huang M; Hobbs BD; Clish CB; Gerszten R; Cho MH; Wheelock CE; McGeachie MJ; Chu SH; Celedon JC; Weiss ST; Lasky-Su J
Article: EUROPEAN RESPIRATORY JOURNAL. 2022;59(2):2100142
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
Mikus MS; Kolmert J; Andersson LI; Ostling J; Knowles RG; Gomez C; Ericsson M; Thorngren J-O; Khoonsari PE; Dahlen B; Kupczyk M; De Meulder B; Auffray C; Bakke PS; Beghe B; Bel EH; Caruso M; Chanez P; Chawes B; Fowler SJ; Gaga M; Geiser T; Gjomarkaj M; Horvath I; Howarth PH; Johnston SL; Joos G; Krug N; Montuschi P; Musial J; Nizankowska-Mogilnicka E; Olsson HK; Papi A; Rabe KF; Sandstrom T; Shaw DE; Siafakas NM; Uhlen M; Riley JH; Bates S; Middelveld RJM; Wheelock CE; Chung KF; Adcock IM; Sterk PJ; Djukanovic R; Nilsson P; Dahlen S-E; James A
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):89-101
Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma
Badi YE; Pavel AB; Pavlidis S; Riley JH; Bates S; Kermani NZ; Knowles R; Kolmert J; Wheelock CE; Worsley S; Uddin M; Alving K; Bakke PS; Behndig A; Caruso M; Chanez P; Fleming LJ; Fowler SJ; Frey U; Howarth P; Horvath I; Krug N; Maitland-van der Zee AH; Montuschi P; Roberts G; Sanak M; Shaw DE; Singer F; Sterk PJ; Djukanovic R; Dahlen S-E; Guo Y-K; Chung KF; Guttman-Yassky E; Adcock IM
Journal article: CIRCULATION. 2021;144(Suppl_2):a13393
Abstract 13393: Liraglutide Improves Myocardial Redox State in Humans by Regulating the Adipose Tissue-Derived Long-Chain Ceramides
Akawi N; Checa A; Akoumianakis I; Farid S; Srivastava V; Krasopoulos G; Channon KM; Wheelock C; Torekov SS; antoniades C
Journal article: F1000RESEARCH. 2021;10:elixir-1129
ELIXIR and Toxicology: a community in development
Martens M; Stierum R; Schymanski EL; Evelo CT; Aalizadeh R; Aladjov H; Arturi K; Audouze K; Babica P; Berka K; Bessems J; Blaha L; Bolton EE; Cases M; Damalas DΕ; Dave K; Dilger M; Exner T; Geerke DP; Grafström R; Gray A; Hancock JM; Hollert H; Jeliazkova N; Jennen D; Jourdan F; Kahlem P; Klanova J; Kleinjans J; Kondic T; Kone B; Lynch I; Maran U; Cuesta SM; Ménager H; Neumann S; Nymark P; Oberacher H; Ramirez N; Remy S; Rocca-Serra P; Salek RM; Sallach B; Sansone S-A; Sanz F; Sarimveis H; Sarntivijai S; Schulze T; Slobodnik J; Spjuth O; Tedds J; Thomaidis N; Weber RJM; van Westen GJP; Wheelock CE; Williams AJ; Witters H; Zdrazil B; Županič A; Willighagen EL
Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY LETTERS. 2021;8(10):839-852
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective
Zhang P; Carlsten C; Chaleckis R; Hanhineva K; Huang M; Isobe T; Koistinen VM; Meister I; Papazian S; Sdougkou K; Xie H; Martin JW; Rappaport SM; Tsugawa H; Walker DI; Woodruff TJ; Wright RO; Wheelock CE
Article: CIRCULATION. 2021;144(12):961-982
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis
Edgar L; Akbar N; Braithwaite AT; Krausgruber T; Gallart-Ayala H; Bailey J; Corbin AL; Khoyratty TE; Chai JT; Alkhalil M; Rendeiro AF; Ziberna K; Arya R; Cahill TJ; Bock C; Laurencikiene J; Crabtree MJ; Lemieux ME; Riksen NP; Netea MG; Wheelock CE; Channon KM; Ryden M; Udalova IA; Carnicer R; Choudhury RP
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2021;907:174282
Prostaglandin D₂ inhibits mediator release and antigen induced bronchoconstriction in the Guinea pig trachea by activation of DP₁ receptors
Safholm J; Abma W; Liu J; Balgoma D; Fauland A; Kolmert J; Wheelock CE; Adner M; Dahlen S-E
Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(8):85001
Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery
Chung MK; Rappaport SM; Wheelock CE; Vy KN; van der Meer TP; Miller GW; Vermeulen R; Patel CJ
Article: EXPERIMENTAL EYE RESEARCH. 2021;209:108646
Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip
Abdalkader R; Chaleckis R; Wheelock CE; Kamei K-I
Article: ANALYTICAL SCIENCES. 2021;37(7):1049-1052
Untargeted LC-MS Metabolomics for the Analysis of Micro-scaled Extracellular Metabolites from Hepatocytes
Abdalkader R; Chaleckis R; Meister I; Zhang P; Wheelock CE; Kamei K-I
Article: CHEST. 2021;160(1):53-64
Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort
Alahmadi FH; Simpson AJ; Gomez C; Ericsson M; Thorngren J-O; Wheelock CE; Shaw DE; Fleming LJ; Roberts G; Riley J; Bates S; Sousa AR; Knowles R; Bansal AT; Corfield J; Pandis I; Sun K; Bakke PS; Caruso M; Chanez P; Dahlen B; Horvath I; Krug N; Montuschi P; Singer F; Wagers S; Adcock IM; Djukanovic R; Chung KF; Sterk PJ; Dahlen S-E; Fowler SJ
Article: ENVIRONMENTAL RESEARCH. 2021;197:111169
Low-level exposure to polycyclic aromatic hydrocarbons is associated with reduced lung function among Swedish young adults
Alhamdow A; Zettergren A; Kull I; Hallberg J; Andersson N; Ekstrom S; Berglund M; Wheelock CE; Essig YJ; Krais AM; Georgelis A; Lindh CH; Melen E; Bergstrom A
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2021;77(20):2494-2513
Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease
Akawi N; Checa A; Antonopoulos AS; Akoumianakis I; Daskalaki E; Kotanidis CP; Kondo H; Lee K; Yesilyurt D; Badi I; Polkinghorne M; Akbar N; Lundgren J; Chuaiphichai S; Choudhury R; Neubauer S; Channon KM; Torekov SS; Wheelock CE; Antoniades C
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2021;1866(5):158886
COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells
Johnsson A-K; Ronnberg E; Fuchs D; Kolmert J; Safholm J; Claesson H-E; Hamberg M; Wheelock CE; Nilsson G; Dahlen S-E
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(4):594-603
Selective inhibition of prostaglandin D₂ biosynthesis in human mast cells to overcome need for multiple receptor antagonists: Biochemical consequences
Johnsson A-K; Choi J-H; Ronnberg E; Fuchs D; Kolmert J; Hamberg M; Dahlen B; Wheelock CE; Dahlen S-E; Nilsson G
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(7):853-863
Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype
Rago D; Pedersen C-ET; Huang M; Kelly RS; Gurdeniz G; Brustad N; Knihtila H; Lee-Sarwar KA; Morin A; Rasmussen MA; Stokholm J; Bonnelykke K; Litonjua AA; Wheelock CE; Weiss ST; Lasky-Su J; Bisgaard H; Chawes BL
Article: ANALYTICAL CHEMISTRY. 2021;93(12):5248-5258
High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology
Meister I; Zhang P; Sinha A; Skold CM; Wheelock AM; Izumi T; Chaleckis R; Wheelock CE
Journal article: REVUE DES MALADIES RESPIRATOIRES ACTUALITES. 2021;13(1):68
Rôle des mastocytes dans l’asthme sévère : analyse de données transcriptomiques dans la cohorte U-BIOPRED
Tiotiu A; Badi Y; Kermani N; Hansbro P; Wheelock C; Dahlen SE; Guo YK; Sterk P; Djukanovic R; Adcock I; Chung KF
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(1):37-53
Urinary Leukotriene E₄ and Prostaglandin D₂ Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation A Clinical Observational Study
Kolmert J; Gomez C; Balgoma D; Sjodin M; Bood J; Konradsen JR; Ericsson M; Thorngren J-O; James A; Mikus M; Sousa AR; Riley JH; Bates S; Bakke PS; Pandis I; Caruso M; Chanez P; Fowler SJ; Geiser T; Howarth P; Horvath I; Krug N; Montuschi P; Sanak M; Behndig A; Shaw DE; Knowles RG; Holweg CTJ; Wheelock AM; Dahlen B; Nordlund B; Alving K; Hedlin G; Chung KF; Adcock IM; Sterk PJ; Djukanovic R; Dahlen S-E; Wheelock CE
Article: F1000RESEARCH. 2021;10:ELIXIR-1129
ELIXIR and Toxicology: a community in development.
Martens M; Stierum R; Schymanski EL; Evelo CT; Aalizadeh R; Aladjov H; Arturi K; Audouze K; Babica P; Berka K; Bessems J; Blaha L; Bolton EE; Cases M; Damalas DΕ; Dave K; Dilger M; Exner T; Geerke DP; Grafström R; Gray A; Hancock JM; Hollert H; Jeliazkova N; Jennen D; Jourdan F; Kahlem P; Klanova J; Kleinjans J; Kondic T; Kone B; Lynch I; Maran U; Martinez Cuesta S; Ménager H; Neumann S; Nymark P; Oberacher H; Ramirez N; Remy S; Rocca-Serra P; Salek RM; Sallach B; Sansone S-A; Sanz F; Sarimveis H; Sarntivijai S; Schulze T; Slobodnik J; Spjuth O; Tedds J; Thomaidis N; Weber RJM; van Westen GJP; Wheelock CE; Williams AJ; Witters H; Zdrazil B; Županič A; Willighagen EL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin
Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: JOURNAL OF HEPATOLOGY. 2020;73(4):817-828
Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis
Lopez-Vicario C; Checa A; Urdangarin A; Aguilar F; Alcaraz-Quiles J; Caraceni P; Amoros A; Pavesi M; Gomez-Cabrero D; Trebicka J; Oettl K; Moreau R; Planell N; Arroyo V; Wheelock CE; Claria J
Article: EUROPEAN RESPIRATORY REVIEW. 2020;29(157):200134
Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment
Zheng X; Mansouri S; Krager A; Grimminger F; Seeger W; Pullamsetti SS; Wheelock CE; Savai R
Article: CIRCULATION. 2020;142(8):776-789
Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis
Artiach G; Carracedo M; Plunde O; Wheelock CE; Thul S; Sjovall P; Franco-Cereceda A; Laguna-Fernandez A; Arnardottir H; Back M
Article: ANALYTICAL CHEMISTRY. 2020;92(16):11310-11317
Correlation-Based Deconvolution (CorrDec) To Generate High-Quality MS2 Spectra from Data-Independent Acquisition in Multisample Studies
Tada I; Chaleckis R; Tsugawa H; Meister I; Zhang P; Lazarinis N; Dahlen B; Wheelock CE; Arita M
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2020;149:106428
Lipoxin A₄ reduces house dust mite and TNFα-induced hyperreactivity in the mouse trachea
Abma W; Noreby M; Wheelock CE; Dahlen S-E; Adner M; Safholm J
Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2020;98:33-40
"Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury"
Heredia Martinez A; Rosa Diez G; Ferraris V; Coccia PA; Ferraris JR; Checa A; Wheelock CE; Lundberg JO; Weitzberg E; Carlstrom M; Krmar RT
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(4):976-984
Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C₄
Tang X; Fuchs D; Tan S; Trauelsen M; Schwartz TW; Wheelock CE; Li N; Haeggstrom JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2020;1865(4):158611
Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent process
Fuchs D; Tang X; Johnsson A-K; Dahlen S-E; Hamberg M; Wheelock CE
Article: CELL METABOLISM. 2020;31(2):375-390.e11
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Ryden M
Article: EUROPEAN RESPIRATORY JOURNAL. 2020;55(2):1900544
Exhaled volatile organic compounds as markers for medication use in asthma
Brinkman P; Ahmed WM; Gomez C; Knobel HH; Weda H; Vink TJ; Nijsen TM; Wheelock CE; Dahlen S-E; Montuschi P; Knowles RG; Vijverberg SJ; Maitland-van der Zee AH; Sterk PJ; Fowler SJ
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:1968
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
Moller SH; Mellergaard M; Madsen M; Bermejo AV; Jepsen SD; Hansen MH; Hogh RI; Aldana BI; Desler C; Rasmussen LJ; Sustarsic EG; Gerhart-Hines Z; Daskalaki E; Wheelock CE; Hiron TK; Lin D; O'Callaghan CA; Wandall HH; Andresen L; Skov S
Article: ISCIENCE. 2019;21:188-204
MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma
Oliynyk G; Ruiz-Perez MV; Sainero-Alcolado L; Dzieran J; Zirath H; Gallart-Ayala H; Wheelock CE; Johansson HJ; Nilsson R; Lehtio J; Arsenian-Henriksson M
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(5):1198-1213
IL-17-high asthma with features of a psoriasis immunophenotype
Oestling J; van Geest M; Schofield JPR; Jevnikar Z; Wilson S; Ward J; Lutter R; Shaw DE; Bakke PS; Caruso M; Dahlen S-E; Fowler SJ; Horvath I; Krug N; Montuschi P; Sanak M; Sandstrom T; Sun K; Pandis I; Auffray C; Sousa AR; Guo Y; Adcock IM; Howarth P; Chung KF; Bigler J; Sterk PJ; Skipp PJ; Djukanovic R; Vaarala O; Ahmed H; Auffray C; Bakke P; Bansal AT; Baribaud F; Bates S; Bel EH; Bigler J; Bisgaard H; Boedigheimer MJ; Bonnelykke K; Brandsma J; Brinkman P; Bucchioni E; Burg D; Bush A; Caruso M; Chaiboonchoe A; Chanez P; Chung KF; Compton CH; Corfield J; D'Amico A; Dahlen SE; De Meulder B; Djukanovic R; Erpenbeck VJ; Erzen D; Fichtner K; Fitch N; Fleming LJ; Formaggio E; Fowler SJ; Frey U; Gahlemann M; Geiser T; Guo Y; Hashimoto S; Haughney J; Hedlin G; Hekking PW; Higenbottam T; Hohlfeld JM; Holweg C; Horvath I; Howarth P; James AJ; Knowles R; Knox AJ; Krug N; Lefaudeux D; Loza MJ; Lutter R; Manta A; Masefield S; Matthews JG; Mazein A; Meiser A; Middelveld RJM; Miralpeix M; Montuschi P; Mores N; Murray CS; Musial J; Myles D; Pahus L; Pandis I; Pavlidis S; Powell P; Pratico G; Valls MP; Rao N; Riley J; Roberts A; Roberts G; Rowe A; Sandstrom T; Seibold W; Selby A; Shaw DE; Sigmund R; Singer F; Skipp PJ; Sousa AR; Sterk PJ; Sun K; Thornton B; van Aalderen WM; van Geest M; Vestbo J; Vissing NH; Wagener AH; Wagers SS; Weiszhart Z; Wheelock CE; Wilson SJ
Article: METABOLITES. 2019;9(11):E251-251
Creating a Reliable Mass Spectral-Retention Time Library for All Ion Fragmentation-Based Metabolomics
Tada I; Tsugawa H; Meister I; Zhang P; Shu R; Katsumi R; Wheelock CE; Arita M; Chaleckis R
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0085
5893Adipose tissue secreted ceramides and related sphingolipids - potential modulators of vascular redox signalling in cardiovascular disease
Akawi N; Checa A; Kotanidis C; Akoumianakis I; Daskalakis E; Herdamn L; Wheelock C; Antoniades C
Article: METABOLITES. 2019;9(10):E212-212
Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD
Naz S; Bhat M; Stahl S; Forsslund H; Skold CM; Wheelock AM; Wheelock CE
Article: AMERICAN JOURNAL OF PHYSIOLOGY - RENAL PHYSIOLOGY. 2019;317(3):F529-F539
Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients
Mortensen LA; Bistrup C; Stubbe J; Carlstrom M; Checa A; Wheelock CE; Palarasah Y; Bladbjerg EM; Thiesson HC; Jensen BL
Article: SCIENTIFIC REPORTS. 2019;9(1):12150
Exhaustion of CD4+T-cells mediated by the Kynurenine Pathway in Melanoma
Pour SR; Morikawa H; Kiani N; Yang M; Azimi A; Shafi G; Shang M; Baumgartner R; Ketelhuth DFJ; Kamleh MA; Wheelock CE; Lundqvist A; Hansson J; Tegner J
Article: NATURE COMMUNICATIONS. 2019;10(1):3081
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
Carlstrom KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(1):70-82
Stratification of asthma phenotypes by airway proteomic signatures
Schofield JPR; Burg D; Nicholas B; Strazzeri F; Brandsma J; Staykova D; Folisi C; Bansal AT; Xian Y; Guo Y; Rowe A; Corfield J; Wilson S; Ward J; Lutter R; Shaw DE; Bakke PS; Caruso M; Dahlen S-E; Fowler SJ; Horvath I; Howarth P; Krug N; Montuschi P; Sanak M; Sandstrom T; Sun K; Pandis I; Riley J; Auffray C; De Meulder B; Lefaudeux D; Sousa AR; Adcock IM; Chung KF; Sterk PJ; Skipp PJ; Djukanovic R; Ahmed H; Allen D; Badorrek P; Ballereau S; Baribaud F; Batuwitage MK; Bedding A; Behndig AF; Berglind A; Berton A; Bigler J; Boedigheimer MJ; Bonnelykke K; Brinkman P; Bush A; Campagna D; Casaulta C; Chaiboonchoe A; Davison T; De Meulder B; Delin I; Dennison P; Dodson P; El Hadjam L; Erzen D; Faulenbach C; Fichtner K; Fitch N; Formaggio E; Gahlemann M; Galffy G; Garissi D; Garret T; Gent J; Guillmant-Farry E; Henriksson E; Hoda U; Hohlfeld JM; Hu X; James A; Johnson K; Jullian N; Kerry G; Klueglich M; Knowles R; Konradsen JR; Kretsos K; Krueger L; Lantz A-S; Larminie C; Latzin P; Lefaudeux D; Lemonnier N; Lowe LA; Lutter R; Manta A; Mazein A; McEvoy L; Menzies-Gow A; Mores N; Murray CS; Nething K; Nihlen U; Niven R; Nordlund B; Nsubuga S; Pellet J; Pison C; Pratico G; Puig Valls M; Riemann K; Rocha JP; Rossios C; Santini G; Saqi M; Scott S; Sehgal N; Selby A; Soderman P; Sogbesan A; Spycher F; Stephan S; Stokholm J; Sunther M; Szentkereszty M; Tamasi L; Tariq K; Valente S; van Aalderen WM; van Drunen CM; Van Eyll J; Vyas A; Yu W; Zetterquist W; Zolkipli Z; Zwinderman AH; Adriaens N; Aliprantis A; Alving K; Bakke P; Balgoma D; Barber C; Baribaud F; Bates S; Bautmans A; Beleta J; Bochenek G; Brandsma J; Braun A; Burg D; Carayannopoulos L; Rocha JPCDP; Chaleckis R; D'Amico A; De Alba J; De Lepeleire I; Dekker T; Dijkhuis A; Draper A; Edwards J; Emma R; Ericsson M; Flood B; Gallart H; Gomez C; Gove K; Gozzard N; Haughney J; Hewitt L; Hohlfeld J; Holweg C; Hu R; Hu S; Kamphuis J; Kennington EJ; Kerry D; Knobel H; Kolmert J; Kots M; Kuo S; Kupczyk M; Lambrecht B; Lone-Latif S; Loza MJ; Marouzet L; Martin J; Masefield S; Mathon C; Meah S; Meiser A; Metcalf L; Mikus M; Miralpeix M; Monk P; Naz S; Nicholas B; Nilsson P; Ostling J; Pacino A; Palkonen S; Pavlidis S; Pennazza G; Petren A; Pink S; Postle A; Powell P; Rahman-Amin M; Rao N; Ravanetti L; Ray E; Reinke S; Reynolds L; Riley J; Robberechts M; Roberts A; Russell K; Rutgers M; Santoninco M; Schoelch C; Schofield JPR; Sjodin M; Skipp PJ; Smids B; Smith C; Smith J; Smith KM; Staykova D; Sun K; Thorngren J-O; Thornton B; Thorsen J; van de Pol M; van Geest M; Versnel J; Vink A; Wald F; Walker S; Ward J; Weiszhart Z; Wetzel K; Wheelock CE; Wiegman C; Williams S; Wilson SJ; Woodcock A; Yang X; Yeyasingham E; Prins J-B; Gahlemann M; Visintin L; Evans H; Puhl M; Buzermaniene L; Hudson V; Bond L; de Boer P; Widdershoven G; Sigmund R; Roberts A; Supple D; Hamerlijnck D; Negus J; Kamphuis J; Sergison L; Visintin L; de Boer P; Onstein S; MacNee W; Bernardini R; Bont L; Wecksell P-A; de Boer P; Gahlemann M; Sigmund R
Article: CANCER LETTERS. 2019;452:71-78
Metabolomics of neonatal blood spots reveal distinct phenotypes of pediatric acute lymphoblastic leukemia and potential effects of early-life nutrition
Petrick LM; Schiffman C; Edmands WMB; Yano Y; Perttula K; Whitehead T; Metayer C; Wheelock CE; Arora M; Grigoryan H; Carlsson H; Dudoit S; Rappaport SM
Article: METABOLITES. 2019;9(6):E106-106
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium
Zhang P; Arora M; Chaleckis R; Isobe T; Jain M; Meister I; Melen E; Perzanowski M; Torta F; Wenk MR; Wheelock CE
Article: JOURNAL OF LIPID RESEARCH. 2019;60(6):1164-1173
Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping
Gomez C; Gonzalez-Riano C; Barbas C; Kolmert J; Ryu MH; Carlsten C; Dahlen S-E; Wheelock CE
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(6):2202-2214.e5
Cytokine-induced endogenous production of prostaglandin D₂ is essential for human group 2 innate lymphoid cell activation
Maric J; Ravindran A; Mazzurana L; Van Acker A; Rao A; Kokkinou E; Ekoff M; Thomas D; Fauland A; Nilsson G; Wheelock CE; Dahlen S-E; Ferreiros N; Geisslinger G; Friberg D; Heinemann A; Konya V; Mjosberg J
Article: CANCER LETTERS. 2019;444:1-8
Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1
Lukic A; Wahlund CJE; Gomez C; Brodin D; Samuelsson B; Wheelock CE; Gabrielsson S; Radmark O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(2):577-590
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar Z; Ostling J; Calven J; Thorn K; Israelsson E; Oberg L; Singhania A; Lau LCK; Wilson SJ; Ward JA; Chauhan A; Sousa AR; De Meulder B; Loza MJ; Baribaud F; Sterk PJ; Chung KF; Sun K; Guo Y; Adcock IM; Payne D; Dahlen B; Chanez P; Shaw DE; Krug N; Hohlfeld JM; Sandstrom T; Djukanovic R; James A; Hinks TSC; Howarth PH; Vaarala O; van Geest M; Olsson H
Article: METHODS IN MOLECULAR BIOLOGY. 2019;2049:233-245
Metabolomic Analysis of Yeast and Human Cells: Latest Advances and Challenges.
Chaleckis R; Ohashi K; Meister I; Naz S; Wheelock CE
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:636
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
Bergqvist F; Ossipova E; Idborg H; Raouf J; Checa A; Englund K; Englund P; Khoonsari PE; Kultima K; Wheelock CE; Larsson K; Korotkova M; Jakobsson P-J
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2019;109(1):165-175
Inflammatory response to dietary linoleic acid depends on FADS1 genotype
Lankinen MA; Fauland A; Shimizu B-I; Agren J; Wheelock CE; Laakso M; Schwab U; Pihlajamaki J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients
Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Ronnelid J; Oke V; Grosso G; Kvarnstrom M; Larsson A; Wheelock CE; Syvanen A-C; Ronnblom L; Kultima K; Persson H; Graslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J
Article: ANALYTICA CHIMICA ACTA. 2018;1037:338-350
The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability
Daskalaki E; Pillon NJ; Krook A; Wheelock CE; Checa A
Article: RESPIRATORY RESEARCH. 2018;19(1):236
Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study
Sjodin MOD; Checa A; Yang M; Dahlen S-E; Wheelock AM; Eklund A; Grunewald J; Wheelock CE
Article: ANALYTICAL CHEMISTRY. 2018;90(22):13400-13408
OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma
Reinke SN; Galindo-Prieto B; Skotare T; Broadhurst DI; Singhania A; Horowitz D; Djukanovic R; Hinks TSC; Geladi P; Trygg J; Wheelock CE
Article: CIRCULATION. 2018;138(16):1693-1705
ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages
Laguna-Fernandez A; Checa A; Carracedo M; Artiach G; Petri MH; Baumgartner R; Forteza MJ; Jiang X; Andonova T; Walker ME; Dalli J; Arnardottir H; Gistera A; Thul S; Wheelock CE; Paulsson-Berne G; Ketelhuth DFJ; Hansson GK; Back M
Article: JOURNAL OF LIPID RESEARCH. 2018;59(10):2025-2033
An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids
Fuchs D; Hamberg M; Skold CM; Wheelock AM; Wheelock CE
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;142(4):1080-1089
Leukotriene E₄ induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor
Lazarinis N; Bood J; Gomez C; Kolmert J; Lantz A-S; Gyllfors P; Davis A; Wheelock CE; Dahlen S-E; Dahlen B
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):388-398
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy
Mahdi A; Kovamees O; Checa A; Wheelock CE; von Heijne M; Alvarsson M; Pernow J
Article: JOURNAL OF LIPID RESEARCH. 2018;59(10):2001-2017
MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines
Burla B; Arita M; Arita M; Bendt AK; Cazenave-Gassiot A; Dennis EA; Ekroos K; Han X; Ikeda K; Liebisch G; Lin MK; Loh TP; Meikle PJ; Oresic M; Quehenberger O; Shevchenko A; Torta F; Wakelam MJO; Wheelock CE; Wenk MR
Article: ANALYTICAL CHEMISTRY. 2018;90(17):10239-10248
Lipid Mediator Quantification in Isolated Human and Guinea Pig Airways: An Expanded Approach for Respiratory Research
Kolmert J; Fauland A; Fuchs D; Safholm J; Gomez C; Adner M; Dahlen S-E; Wheelock CE
Article: CELL DEATH AND DISEASE. 2018;9(9):846
Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment
Dyczynski M; Vesterlund M; Bjorklund A-C; Zachariadis V; Janssen J; Gallart-Ayala H; Daskalaki E; Wheelock CE; Lehtio J; Grander D; Tamm KP; Nilsson R
Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2018;137:20-29
Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model
Kolmert J; Pineiro-Hermida S; Hamberg M; Gregory JA; Lopez IP; Fauland A; Wheelock CE; Dahlen S-E; Pichel JG; Adner M
Journal article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2018;33(suppl_1):i600
SP748TREATMENT WITH SPIRONOLACTONE FOR 1 YEAR DOES NOT IMPROVE NITRIC OXIDE METABOLISM IN RENAL TRANSPLANT PATIENTS
Mortensen LA; Bistrup C; Jensen B; Stubbe J; Carlström M; Checa A; Wheelock C; Thiesson H
Article: EUROPEAN RESPIRATORY JOURNAL. 2018;51(5):1701930
Integration of multi-omics datasets enables molecular classification of COPD
Li C-X; Wheelock CE; Skold CM; Wheelock AM
Article: PEDIATRIC NEPHROLOGY. 2018;33(4):639-649
Changes in arterial pressure and markers of nitric oxide homeostasis and oxidative stress following surgical correction of hydronephrosis in children
Al-Mashhadi A; Checa A; Wahlin N; Neveus T; Fossum M; Wheelock CE; Karanikas B; Stenberg A; Persson AEG; Carlstrom M
Article: JOURNAL OF PROTEOME RESEARCH. 2018;17(2):870-878
Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics
Kamleh MA; McLeod O; Checa A; Baldassarre D; Veglia F; Gertow K; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Silveira A; Orvik J; Hamsten A; Wheelock CE
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(2):710-721
Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance
Petrus P; Bialesova L; Checa A; Kerr A; Naz S; Backdahl J; Gracia A; Toft S; Dahlman-Wright K; Heden P; Dahlman I; Wheelock CE; Arner P; Mejhert N; Gao H; Ryden M
Article: FOOD AND FUNCTION. 2018;9(1):463-475
Aronia-citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine
Alejandra Garcia-Flores L; Medina S; Gomez C; Wheelock CE; Cejuela R; Miguel Martinez-Sanz J; Oger C; Galano J-M; Durand T; Hernandez-Saez A; Ferreres F; Gil-Izquierdo A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(1):E273-273
Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System
Wefers C; Duiveman-de Boer T; Zusterzeel PLM; Massuger LFAG; Fuchs D; Torensma R; Wheelock CE; de Vries IJM
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1730:45-58
LC-MS-Based Metabolomics of Biofluids Using All-Ion Fragmentation (AIF) Acquisition.
Chaleckis R; Naz S; Meister I; Wheelock CE
Article: PLOS ONE. 2018;13(9):e0203874
Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort
Emma R; Bansal AT; Kolmert J; Wheelock CE; Dahlen S-E; Loza MJ; De Meulder B; Lefaudeux D; Auffray C; Dahlen B; Bakke PS; Chanez P; Fowler SJ; Horvath I; Montuschi P; Krug N; Sanak M; Sandstrom T; Shaw DE; Fleming LJ; Djukanovic R; Howarth PH; Singer F; Sousa AR; Sterk PJ; Cortield J; Pandis I; Chung KF; Adcock IM; Lutter R; Fabbella L; Caruso M
Article: NATURE METHODS. 2017;14(12):1171-1174
Deciphering lipid structures based on platform-independent decision rules
Hartler J; Triebl A; Ziegl A; Troetzmueller M; Rechberger GN; Zeleznik OA; Zierler KA; Torta F; Cazenave-Gassiot A; Wenk MR; Fauland A; Wheelock CE; Armando AM; Quehenberger O; Zhang Q; Wakelam MJO; Haemmerle G; Spener F; Koefeler HC; Thallinger GG
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2275-2288
Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma
Bowden JA; Heckert A; Ulmer CZ; Jones CM; Koelmel JP; Abdullah L; Ahonen L; Alnouti Y; Armando AM; Asara JM; Bamba T; Barr JR; Bergquist J; Borchers CH; Brandsma J; Breitkopf SB; Cajka T; Cazenave-Gassiot A; Checa A; Cinel MA; Colas RA; Cremers S; Dennis EA; Evans JE; Fauland A; Fiehn O; Gardner MS; Garrett TJ; Gotlinger KH; Han J; Huang Y; Neo AH; Hyotylainen T; Izumi Y; Jiang H; Jiang H; Jiang J; Kachman M; Kiyonami R; Klavins K; Klose C; Kofeler HC; Kolmert J; Koal T; Koster G; Kuklenyik Z; Kurland IJ; Leadley M; Lin K; Maddipati KR; McDougall D; Meikle PJ; Mellett NA; Monnin C; Moseley MA; Nandakumar R; Oresic M; Patterson R; Peake D; Pierce JS; Post M; Postle AD; Pugh R; Qiu Y; Quehenberger O; Ramrup P; Rees J; Rembiesa B; Reynaud D; Roth MR; Sales S; Schuhmann K; Schwartzman ML; Serhan CN; Shevchenko A; Somerville SE; John-Williams LS; Surma MA; Takeda H; Thakare R; Thompson JW; Torta F; Triebl A; Troetzmueller M; Ubhayasekera SJK; Vuckovic D; Weir JM; Welti R; Wenk MR; Wheelock CE; Yao L; Yuan M; Zhao XH; Zhou S
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2017;174(22):4043-4054
Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E^-/- mice
Petri MH; Laguna-Fernandez A; Arnardottir H; Wheelock CE; Perretti M; Hansson GK; Back M
Article: REDOX BIOLOGY. 2017;13:522-527
Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity
Peleli M; Flacker P; Zhuge Z; Gomez C; Wheelock CE; Persson AEG; Carlstrom M
Article: THE FASEB JOURNAL. 2017;31(10):4370-4381
GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures
Lukic A; Larssen P; Fauland A; Samuelsson B; Wheelock CE; Gabrielsson S; Radmark O
Article: SCIENTIFIC REPORTS. 2017;7(1):12180
Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae
Ohashi K; Chaleckis R; Takaine M; Wheelock CE; Yoshida S
Article: LUPUS. 2017;26(10):1023-1033
Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study
Checa A; Idborg H; Zandian A; Sar DG; Surowiec I; Trygg J; Svenungsson E; Jakobsson P-J; Nilsson P; Gunnarsson I; Wheelock CE
Article: ANALYTICAL CHEMISTRY. 2017;89(15):7933-7942
Development of a Liquid Chromatography High Resolution Mass Spectrometry Metabolomics Method with High Specificity for Metabolite Identification Using All Ion Fragmentation Acquisition
Naz S; Gallart-Ayala H; Reinke SN; Mathon C; Blankley R; Chaleckis R; Wheelock CE
Article: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2017;1861(8):2099-2111
Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase
Mittal M; Hasan M; Balagunaseelan N; Fauland A; Wheelock C; Radmark O; Haeggstrom JZ; Rinaldo-Matthis A
Article: EUROPEAN RESPIRATORY JOURNAL. 2017;49(6):1602322
Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD
Naz S; Kolmert J; Yang M; Reinke SN; Kamleh MA; Snowden S; Heyder T; Levanen B; Erle DJ; Skold CM; Wheelock AM; Wheelock CE
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(6):1797-1807
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
Lefaudeux D; De Meulder B; Loza MJ; Peffer N; Rowe A; Baribaud F; Bansal AT; Lutter R; Sousa AR; Corfield J; Pandis I; Bakke PS; Caruso M; Chanez P; Dahlen S-E; Fleming LJ; Fowler SJ; Horvath I; Krug N; Montuschi P; Sanak M; Sandstrom T; Shaw DE; Singer F; Sterk PJ; Roberts G; Adcock IM; Djukanovic R; Auffray C; Chung KF
Article: REDOX BIOLOGY. 2017;11:205-212
New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
Gonzalez-Pena D; Checa A; de Ancos B; Wheelock CE; Sanchez-Moreno C
Article: EUROPEAN RESPIRATORY JOURNAL. 2017;49(3):1601740
Metabolomics analysis identifies different metabotypes of asthma severity
Reinke SN; Gallart-Ayala H; Gomez C; Checa A; Fauland A; Naz S; Kamleh MA; Djukanovic R; Hinks TSC; Wheelock CE
Article: REPRODUCTION, FERTILITY AND DEVELOPMENT. 2017;29(3):544-556
Peri-ovulatory endocrine regulation of the prostanoid pathways in the bovine uterus at early dioestrus
Oliveira ML; D'Alexandri FL; Pugliesi G; Van Hoeck V; Mesquita FS; Membrive CMB; Negrao JA; Wheelock CE; Binelli M
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2017;(120)
A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
Roci I; Gallart-Ayala H; Watrous J; Jain M; Wheelock CE; Nilsson R
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2017;(120)
A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
Roci I; Gallart-Ayala H; Watrous J; Jain M; Wheelock CE; Nilsson R
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(11):3952-3958
Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus
Kovamees O; Shemyakin A; Checa A; Wheelock CE; Lundberg JO; Ostenson C-G; Pernow J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;99:87-98
Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation
Hezel M; Peleli M; Liu M; Zollbrecht C; Jensen BL; Checa A; Giulietti A; Wheelock CE; Lundberg JO; Weitzberg E; Carlstrom M
Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion
Paquin-Proulx D; Gibbs A; Bachle SM; Checa A; Introini A; Leeansyah E; Wheelock CE; Nixon DF; Broliden K; Tjernlund A; Moll M; Sandberg JK
Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2016;58:1-9
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia
Carlstrom M; Cananau C; Checa A; Wide K; Sartz L; Svensson A; Wheelock CE; Westphal S; Bekassy Z; Barany P; Lundberg JO; Hansson S; Weitzberg E; Krmar RT
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(7):e003868
Genetic Abrogation of Adenosine A₃ Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension
Yang T; Zollbrecht C; Winerdal ME; Zhuge Z; Zhang X-M; Terrando N; Checa A; Sallstrom J; Wheelock CE; Winqvist O; Harris RA; Larsson E; Persson AEG; Fredholm BB; Carlstrom M
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;71(7):944-956
Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice
Frei RB; Luschnig P; Parzmair GP; Peinhaupt M; Schranz S; Fauland A; Wheelock CE; Heinemann A; Sturm EM
Article: EUROPEAN RESPIRATORY JOURNAL. 2016;47(6):1645-1656
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
Balgoma D; Yang M; Sjodin M; Snowden S; Karimi R; Levanen B; Merikallio H; Kaarteenaho R; Palmberg L; Larsson K; Erle DJ; Dahlen S-E; Dahlen B; Skold CM; Wheelock AM; Wheelock CE
Article: ANALYTICAL CHEMISTRY. 2016;88(5):2707-2713
Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells
Roci I; Gallart-Ayala H; Schmidt A; Watrous J; Jain M; Wheelock CE; Nilsson R
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;137(3):833-843
Activated prostaglandin D₂ receptors on macrophages enhance neutrophil recruitment into the lung
Jandl K; Stacher E; Balint Z; Sturm EM; Maric J; Peinhaupt M; Luschnig P; Aringer I; Fauland A; Konya V; Dahlen S-E; Wheelock CE; Kratky D; Olschewski A; Marsche G; Schuligoi R; Heinemann A
Article: JOURNAL OF INTERNAL MEDICINE. 2016;279(3):293-308
Gene expression signatures, pathways and networks in carotid atherosclerosis
Perisic L; Aldi S; Sun Y; Folkersen L; Razuvaev A; Roy J; Lengquist M; Akesson S; Wheelock CE; Maegdefessel L; Gabrielsen A; Odeberg J; Hansson GK; Paulsson-Berne G; Hedin U
Article: SCIENTIFIC REPORTS. 2015;5:15740
Lipid mediator profile in vernix caseosa reflects skin barrier development
Checa A; Holm T; Sjodin MOD; Reinke SN; Alm J; Scheynius A; Wheelock CE
Article: MULTIPLE SCLEROSIS JOURNAL. 2015;21(10):1271-1279
Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis
Checa A; Khademi M; Sar DG; Haeggstroem JZ; Lundberg JO; Piehl F; Olsson T; Wheelock CE
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(3):272-279
Urinary excretion of lipid mediators in response to repeated eucapnic voluntary hyperpnea in asthmatic subjects
Bood JR; Sundblad B-M; Delin I; Sjodin M; Larsson K; Anderson SD; Wheelock CE; Dahlen S-E; Dahlen B
Article: REDOX BIOLOGY. 2015;5:234-242
Effects of long-term dietary nitrate supplementation in mice
Hezel MP; Liu M; Schiffer TA; Larsen FJ; Checa A; Wheelock CE; Carlstrom M; Lundberg JO; Weitzberg E
Article: SCIENTIFIC REPORTS. 2015;5:12017
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
Checa A; Xu N; Sar DG; Haeggstrom JZ; Stahle M; Wheelock CE
Article: CHEST. 2015;147(2):397-405
The Effect of Omega-3 Fatty Acids on Bronchial Hyperresponsiveness, Sputum Eosinophilia, and Mast Cell Mediators in Asthma
Brannan JD; Bood J; Alkhabaz A; Balgoma D; Otis J; Delin I; Dahlen B; Wheelock CE; Nair P; Dahlen S-E; O'Byrne PM
Article: JOURNAL OF PROTEOME RESEARCH. 2015;14(1):557-566
LC-MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment
Kamleh MA; Snowden SG; Grapov D; Blackburn GJ; Watson DG; Xu N; Stahle M; Wheelock CE
Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2014;7(6):955-964
High-Dose Simvastatin Exhibits Enhanced Lipid-Lowering Effects Relative to Simvastatin/Ezetimibe Combination Therapy
Snowden SG; Grapov D; Settergren M; D'Alexandri FL; Haeggstrom JZ; Fiehn O; Hyotylainen T; Pedersen TL; Newman JW; Oresic M; Pernow J; Wheelock CE
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2014;190(9):981-988
Network Analysis in the Investigation of Chronic Respiratory Diseases
Diez D; Agusti A; Wheelock CE
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(2):306-313
Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma
Daham K; James A; Balgoma D; Kupczyk M; Billing B; Lindeberg A; Henriksson E; FitzGerald GA; Wheelock CE; Dahlen S-E; Dahlen B
Article: STEM CELLS AND DEVELOPMENT. 2014;23(14):1582-1593
Cord Blood Mesenchymal Stem Cells Suppress DC-T Cell Proliferation via Prostaglandin B2
van den Berk LCJ; Jansen BJH; Snowden S; Siebers-Vermeulen KGC; Gilissen C; Koegler G; Figdor CG; Wheelock CE; Torensma R
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2014;99(4):843-850
Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
Larsen FJ; Schiffer TA; Ekblom B; Mattsson MP; Checa A; Wheelock CE; Nystrom T; Lundberg JO; Weitzberg E
Article: EUROPEAN RESPIRATORY JOURNAL. 2014;43(2):453-463
Lipid mediator profiles differ between Lung compartments in asthmatic and healthy humans
Larsson N; Lundstrom SL; Pinto R; Rankin G; Karimpour M; Blomberg A; Sandstrom T; Pourazar J; Trygg J; Behndig AF; Wheelock CE; Nording ML
Article: JOURNAL OF IMMUNOLOGY. 2013;191(6):3090-3099
Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
Nasi A; Fekete T; Krishnamurthy A; Snowden S; Rajnavoelgyi E; Catrina AI; Wheelock CE; Vivar N; Rethi B
Article: ANALYTICAL CHEMISTRY. 2013;85(16):7866-7874
Quantification of Lipid Mediator Metabolites in Human Urine from Asthma Patients by Electrospray Ionization Mass Spectrometry: Controlling Matrix Effects
Balgoma D; Larsson J; Rokach J; Lawson JA; Daham K; Dahlen B; Dahlen S-E; Wheelock CE
Article: MOLECULAR NUTRITION AND FOOD RESEARCH. 2013;57(8):1378-1389
Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids
Lundstrom SL; Yang J; Brannan JD; Haeggstrom JZ; Hammock BD; Nair P; O'Byrne P; Dahlen S-E; Wheelock CE
Article: JOURNAL OF LIPID RESEARCH. 2013;54(1):116-126
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations
Lundstrom SL; Saluja R; Adner M; Haeggstrom JZ; Nilsson G; Wheelock CE
Article: ANALYTICAL CHEMISTRY. 2012;84(16):7064-7071
Building Multivariate Systems Biology Models
Kirwan GM; Johansson E; Kleemann R; Verheij ER; Wheelock AM; Goto S; Trygg J; Wheelock CE
Article: BMC MEDICAL GENOMICS. 2012;5:27
Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics
Diez D; Goto S; Fahy JV; Erle DJ; Woodruff PG; Wheelock AM; Wheelock CE
Article: PLOS ONE. 2012;7(3):e33780
Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen Provocation
Lundstrom SL; Yang J; Kallberg HJ; Thunberg S; Gafvelin G; Haeggstrom JZ; Gronneberg R; Grunewald J; van Hage M; Hammock BD; Eklund A; Wheelock AM; Wheelock CE
Article: ATHEROSCLEROSIS. 2011;215(2):411-416
12-and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebroyascular symptoms
Gertow K; Nobili E; Folkersen L; Newman JW; Pedersen TL; Ekstrand J; Swedenborg J; Kuehn H; Wheelock CE; Hansson GK; Hedin U; Haeggstrom JZ; Gabrielsen A
Journal article: CURRENT CARDIOVASCULAR RISK REPORTS. 2011;5(1):52-61
Systems Biology Approaches for Investigating the Relationship Between Lipids and Cardiovascular Disease
Kirwan GM; Diez D; Haeggström JZ; Goto S; Wheelock CE
Article: PLOS ONE. 2011;6(8):e23864
Asthmatics Exhibit Altered Oxylipin Profiles Compared to Healthy Individuals after Subway Air Exposure
Lundstrom SL; Levanen B; Nording M; Klepczynska-Nystrom A; Skold M; Haeggstrom JZ; Grunewald J; Svartengren M; Hammock BD; Larsson B-M; Eklund A; Wheelock AM; Wheelock CE
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(5):1032-1040.e4
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
Esser J; Gehrmann U; D'Alexandri FL; Hidalgo-Estevez AM; Wheelock CE; Scheynius A; Gabrielsson S; Radmark O
Article: ENVIRONMENTAL POLLUTION. 2010;158(6):2266-2272
Inhibition, recovery and oxime-induced reactivation of muscle esterases following chlorpyrifos exposure in the earthworm Lumbricus terrestris
Collange B; Wheelock CE; Rault M; Mazzia C; Capowiez Y; Sanchez-Hernandez JC
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):135-139
Advances in eicosanoid research, novel therapeutic implications
Haeggstrom JZ; Rinaldo-Matthis A; Wheelock CE; Wetterholm A
Article: BIOINFORMATICS. 2009;25(15):1978-1979
GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome
Folkersen L; Diez D; Wheelock CE; Haeggstrom JZ; Goto S; Eriksson P; Gabrielsen A
Article: METHODS IN MOLECULAR BIOLOGY. 2009;580:339-368
Bioinformatics strategies for the analysis of lipids.
Wheelock CE; Goto S; Yetukuri L; D'Alexandri FL; Klukas C; Schreiber F; Oresic M
Article: METHODS IN MOLECULAR BIOLOGY. 2009;579:161-187
HPLC/MS/MS-based approaches for detection and quantification of eicosanoids.
Lundström SL; D'Alexandri FL; Nithipatikom K; Haeggström JZ; Wheelock AM; Wheelock CE
Article: ENVIRONMENTAL POLLUTION. 2009;157(1):264-272
Tissue distribution, isozyme abundance and sensitivity to chlorpyrifos-oxon of carboxylesterases in the earthworm Lumbricus terrestris
Sanchez-Hernandez JC; Wheelock CE
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2009;17(1):149-164
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis
Harada T; Nakagawa Y; Wadkins RM; Potter PM; Wheelock CE
Article: BIOINFORMATICS. 2008;24(21):2564-2565
varDB: a pathogen-specific sequence database of protein families involved in antigenic variation
Hayes CN; Diez D; Joannin N; Honda W; Kanehisa M; Wahlgren M; Wheelock CE; Goto S
Article: JOURNAL OF MASS SPECTROMETRY. 2008;43(8):1053-1062
Substituted 3-phenylpropenoates and related analogs: electron ionization mass spectral fragmentation and density functional theory calculations
Wheelock CE; Colvin ME; Sanborn JR; Hammock BD
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2008;21(4):951-957
Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase.
Morisseau C; Newman JW; Wheelock CE; Hill Iii T; Morin D; Buckpitt AR; Hammock BD
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2008;21(3):583-590
Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice
Wheelock CE; Forshed J; Goto S; Hammock BD; Newman JW
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2008;16(4):2114-2130
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH)
Wheelock CE; Nishi K; Ying A; Jones PD; Colvin ME; Olmstead MM; Hammock BD
Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2007;41(23):7997-8003
Identification of endocrine disruptor biodegradation by integration of structure-activity relationship with pathway analysis.
Kadowaki T; Wheelock CE; Adachi T; Kudo T; Okamoto S; Tanaka N; Tonomura K; Tsujimoto G; Mamitsuka H; Goto S; Kanehisa M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2007;152(5):691-698
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
Hillard CJ; Ho W-S; Thompson J; Gauthier KM; Wheelock CE; Huang H; Hammock BD
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(40):15835-15840
PfEMP1-DBL1 α amino acid motifs in severe disease states of Plasmodium falciparum malaria
Normark J; Nilsson D; Ribacke U; Winter G; Moll K; Wheelock CE; Bayarugaba J; Kironde F; Egwang TG; Chen Q; Andersson B; Wahigren M
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;121(5):984-991
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.
Endsley MP; Aggarwal N; Isbell MA; Wheelock CE; Hammock BD; Falck JR; Campbell WB; Nithipatikom K
Article: METABOLOMICS. 2007;3(2):137-145
Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice
Wheelock CE; Goto S; Hammock BD; Newman JW
Article: MOLECULAR PHARMACOLOGY. 2007;71(3):713-723
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.
Wadkins RM; Hyatt JL; Edwards CC; Tsurkan L; Redinbo MR; Wheelock CE; Jones PD; Hammock BD; Potter PM
Article: BIOCHEMISTRY. 2006;45(13):4045-4057
Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta.
Wogulis M; Wheelock CE; Kamita SG; Hinton AC; Whetstone PA; Hammock BD; Wilson DK
Article: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. 2006;25(4):973-984
Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations.
Wheelock CE; Miller JL; Miller MJ; Phillips BM; Huntley SA; Gee SJ; Tjeerdema RS; Hammock BD
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2006;14(4):1143-1159
High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity.
Wheelock CE; Nakagawa Y; Harada T; Oikawa N; Akamatsu M; Smagghe G; Stefanou D; Iatrou K; Swevers L
Article: ANALYTICAL BIOCHEMISTRY. 2005;344(2):183-192
Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity.
Kang K-D; Jones PD; Huang H; Zhang R; Mostovich LA; Wheelock CE; Watanabe T; Gulyaeva LF; Hammock BD
Article: AQUATIC TOXICOLOGY. 2005;74(2):172-192
Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos.
Wheelock CE; Eder KJ; Werner I; Huang H; Jones PD; Brammell BF; Elskus AA; Hammock BD
Article: AQUATIC TOXICOLOGY. 2005;74(1):47-52
Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca.
Wheelock CE; Miller JL; Miller MJ; Phillips BM; Gee SJ; Tjeerdema RS; Hammock BD
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;332(4):1028-1033
A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells.
Nithipatikom K; Endsley MP; Isbell MA; Wheelock CE; Hammock BD; Campbell WB
Article: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. 2004;23(11):2699-2708
Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity.
Wheelock CE; Miller JL; Miller MJ; Gee SJ; Shan G; Hammock BD
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2004;430(2):247-255
Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis.
Stok JE; Goloshchapov A; Song C; Wheelock CE; Derbel MBH; Morisseau C; Hammock BD
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(28):29863-29869
Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes.
Stok JE; Huang H; Jones PD; Wheelock CE; Morisseau C; Hammock BD
Article: ECOLOGY AND SOCIETY. 2004;9(6)
Challenges in regulating pesticide mixtures
Lydy M; Belden J; Wheelock C; Hammock B; Denton D
Article: INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2003;33(12):1261-1273
Juvenile hormone (JH) esterase: why are you so JH specific?
Kamita SG; Hinton AC; Wheelock CE; Wogulis MD; Wilson DK; Wolf NM; Stok JE; Hock B; Hammock BD
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2003;11(23):5101-5116
Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors.
Wheelock CE; Nakagawa Y; Akamatsu M; Hammock BD
Article: ANALYTICAL BIOCHEMISTRY. 2003;315(2):208-222
Evaluation of α-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes
Wheelock CE; Wheelock Å; Zhang R; Stok JE; Morisseau C; Le Valley SE; Green CE; Hammock BD
Article: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. 2003;22(2):336-341
Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas).
Denton DL; Wheelock CE; Murray SA; Deanovic LA; Hammock BD; Hinton DE
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2002;45(25):5576-5593
Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors.
Wheelock CE; Colvin ME; Uemura I; Olmstead MM; Sanborn JR; Nakagawa Y; Jones AD; Hammock BD
Article: AQUATIC TOXICOLOGY. 2002;61(1-2):89-93
Effect of nutritional state on Hsp60 levels in the rotifer Brachionus plicatilis following toxicant exposure.
Wheelock CE; Baumgartner TA; Newman JW; Wolfe MF; Tjeerdema RS
Article: BIOCHEMICAL PHARMACOLOGY. 2002;63(9):1599-1608
Structural refinement of inhibitors of urea-based soluble epoxide hydrolases.
Morisseau C; Goodrow MH; Newman JW; Wheelock CE; Dowdy DL; Hammock BD
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2001;14(12):1563-1572
Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility.
Wheelock CE; Severson TF; Hammock BD
Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2001;109(1):61-66
Evaluation of fish models of soluble epoxide hydrolase inhibition.
Newman JW; Denton DL; Morisseau C; Koger CS; Wheelock CE; Hinton DE; Hammock BD
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2000;8(11):2663-2673
3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues.
Nakagawa Y; Wheelock CE; Morisseau C; Goodrow MH; Hammock BG; Hammock BD
Article: ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. 1999;36(3):281-287
Hsp60-induced tolerance in the rotifer Brachionus plicatilis exposed to multiple environmental contaminants.
Wheelock CE; Wolfe MF; Olsen H; Tjeerdema RS; Sowby ML
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All other publications

Book chapter: METHODS IN MOLECULAR BIOLOGY. 2025;p. 315-339
Quantification of Octadecanoids in Human Plasma Using Chiral Supercritical Fluid Chromatography-Tandem Mass Spectrometry.
Salamin O; Wheelock CE
Corrigendum: NATURE COMMUNICATIONS. 2024;15(1):8143
NMNAT2 is a druggable target to drive neuronal NAD production (vol 15, 6256, 2024)
Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
Preprint: MEDRXIV. 2024;MEDRXIV
Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling.
Virkud YV; Styles JN; Kelly RS; Patil SU; Ruiter B; Smith NP; Clish C; Wheelock CE; Celedón JC; Litonjua AA; Bunyavanich S; Weiss ST; Baker ES; Lasky-Su JA; Shreffler WG
Letter: METABOLOMICS. 2024;20(3):60
Workshop report - interdisciplinary metabolomic epidemiology: the pathway to clinical translation
Zanetti KA; Guo L; Husain D; Kelly RS; Lasky-Su J; Broadhurst D; Wheelock CE
Preprint: CHEMRXIV. 2024
Development of a desorption electrospray ionization –multiple-reaction-monitoring mass spectrometry (DESI-MRM) workflow for spatially mapping oxylipins in pulmonary tissue
Smith M; Nie M; Adner M; Säfholm J; Wheelock C
Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;209(8):903-904
A Lipid Map for Community-acquired Pneumonia with Sepsis Observation Is the First Step in Scientific Progress
Schenck EJ; Plataki M; Wheelock CE
Review: EUROPEAN RESPIRATORY REVIEW. 2023;32(170):230063
The re-emerging role of linoleic acid in paediatric asthma
Naughten S; Ecklu-Mensah G; Constantino G; Quaranta A; Escalante KS; Bai-Tong S; Gilbert J; Leibel S; Wheelock CE; Leibel S
Preprint: BIORXIV. 2023;BIORXIV
OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records.
Chen Q; Dwaraka VB; Carreras-Gallo N; Mendez K; Chen Y; Begum S; Kachroo P; Prince N; Went H; Mendez T; Lin A; Turner L; Moqri M; Chu SH; Kelly RS; Weiss ST; Rattray NJW; Gladyshev VN; Karlson E; Wheelock C; Mathé EA; Dahlin A; McGeachie MJ; Smith R; Lasky-Su JA
Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(4):378-396
Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification
Johansson A; Andreassen OA; Brunak S; Franks PW; Hedman H; Loos RJF; Meder B; Melen E; Wheelock CE; Jacobsson B
Preprint: AUTHOREA. 2023
Evidence of kinetic proofreading through allergen specific IgE at the human mast cell IgE receptor
Hoffmann HJ; Hjort C; Just J; Andersson LI; Wheelock C; Dahlén S-E; Würtzen PA; Christensen L
Corrigendum: CHEMOSPHERE. 2023;327:138420
Corrigendum to "Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism" [Chemosphere 324 (2023)138228].
Prince N; Begum S; Mínguez-Alarcón L; Génard-Walton M; Huang M; Soeteman DI; Wheelock C; Litonjua AA; Weiss ST; Kelly RS; Lasky-Su J
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023;207:a6148
Lipid Profiling Reveals Key Lipid Mediators in Cigarette Smoke-induced Experimental COPD
Rehman SF; Fuchs D; Budden KF; Quaranta A; Shukla SD; Horvat J; Wood LG; Wheelock CE; Hansbro PM
Editorial comment: ERJ OPEN RESEARCH. 2023;9(3):26-2023
Important steps towards a big change for lung health: a joint approach by the European Respiratory Society, the European Society of Radiology and their partners to facilitate implementation of the European Union's new recommendations on lung cancer screening
Ward B; Vasakova MK; Cordeiro CR; Yorgancioglu A; Chorostowska-Wynimko J; Blum TG; Kauczor H-U; Samarzija M; Henschke C; Wheelock C; Grigg J; Andersen ZJ; Koblizek V; Majek O; Odemyr M; Powell P; Seijo LM
Editorial comment: RESPIRATORY RESEARCH. 2023;24(1):15
Recognising the importance of chronic lung disease: a consensus statement from the Global Alliance for Chronic Diseases (Lung Diseases group)
Gould GS; Hurst JR; Trofor A; Alison JA; Fox G; Kulkarni MM; Wheelock CE; Clarke M; Kumar R
Review: CAMBRIDGE PRISMS: PRECISION MEDICINE. 2023;1:e15
Building a precision medicine infrastructure at a national level: The Swedish experience.
Edsjö A; Lindstrand A; Gisselsson D; Mölling P; Friedman M; Cavelier L; Johansson M; Ehrencrona H; Fagerqvist T; Strid T; Lovmar L; Jacobsson B; Johansson Å; Engstrand L; Wheelock CE; Sikora P; Wirta V; Fioretos T; Rosenquist R; Genomic Medicine Sweden (GMS)
Review: BIOCHEMICAL SOCIETY TRANSACTIONS. 2022;50(6):1569-1582
The octadecanoids: an emerging class of lipid mediators
Quaranta A; Revol-Cavalier J; Wheelock CE
Preprint: BIORXIV. 2022
Glutarate regulates T cell function and metabolism
Minogue E; Cunha P; Quaranta A; Zurita J; Teli SS; Wadsworth B; Hughes R; Grice G; Velica P; Bargiela D; Barbieri L; Wheelock C; Nathan J; Koivunen P; Foskolou I; Johnson R
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2897
Adipose tissue derived ceramides regulate myocardial redox state and predict cardiovascular outcomes
Polkinghorne M; Akawi N; Badi I; Checa A; Kotanidis C; Akoumianakis I; Antonopoulos A; Krasopoulos G; Sayeed R; Walcot N; Channon K; Wheelock C; Antoniades C
Letter: NATURE MEDICINE. 2022;28(10):1980-1982
Implementing precision medicine in a regionally organized healthcare system in Sweden
Fioretos T; Wirta V; Cavelier L; Berglund E; Friedman M; Akhras M; Botling J; Ehrencrona H; Engstrand L; Helenius G; Fagerqvist T; Gisselsson D; Gruvberger-Saal S; Gyllensten U; Heidenblad M; Hoglund K; Jacobsson B; Johansson M; Johansson A; Soller MJ; Landstrom M; Larsson P; Levin L-A; Lindstrand A; Lovmar L; Lyander A; Melin M; Nordgren A; Nordmark G; Molling P; Palmqvist L; Palmqvist R; Repsilber D; Sikora P; Stenmark B; Soderkvist P; Stranneheim H; Strid T; Wheelock CE; Wadelius M; Wedell A; Edsjo A; Rosenquist R
Review: EUROPEAN RESPIRATORY REVIEW. 2022;31(165):220038
Air pollution, metabolites and respiratory health across the life-course
Gruzieva O; Jeong A; He S; Yu Z; de Bont J; Pinho MGM; Eze IC; Kress S; Wheelock CE; Peters A; Vlaanderen J; de Hoogh K; Scalbert A; Chadeau-Hyam M; Vermeulen RCH; Gehring U; Probst-Hensch N; Melen E
Conference publication: ISEE CONFERENCE ABSTRACTS. 2022;2022(1)
Exploring the exposome across the life-course; air pollution, metabolomics and lung function
Gruzieva O; Jeong A; He S; Yu Z; de Bont J; Pinho MG; Eze IC; Kress S; Wheelock CE; Peters A; Vlaanderen J; de Hoogh K; Scalbert A; Chadeau-Hyam M; Vermeulen RCH; Gehring U; Probst-Hensch N; Melén E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2022;60:2519
Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperreactivity through alternative activation of the CysLT1 receptor
Safholm J; Abma W; Wheelock CE; Dahlen S; Adner M
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2022;60:3378
Soluble epoxide hydrolase inhibition alleviates inflammation in cigarette smoke-induced experimental COPD irrespective of dietary fat content
Rehman SF; Budden KF; Quaranta A; Fuchs D; Shukla SD; Brown A; Alemao C; Balachandra L; Gomez H; Kumar V; Idrees S; Horvat J; Wood LG; Wheelock C; Hansbro PM
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2022;60:3787
Plasma steroid metabolite profiles are strongly associated with childhood respiratory infection proneness (CRIP)
Prince N; Kim M; Kelly R; Bisgaard H; Wheelock C; Chawes B; Lasky-Su J
Meeting abstract: EUROPEAN RESPIRATORY JOURNAL. 2022;60:3889
Suppressive effect of corticosteroid treatment on urinary levels of androgens and cortisol in mild and severe asthma
Yasinska V; Gomez C; Kolmert J; James A; Andersson LI; Dahlen B; Wheelock CE; Dahlen S; Wikstrom-Jonsson E
Corrigendum: NATURE MEDICINE. 2022;28(8):1723
Author Correction: Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma.
Kachroo P; Stewart ID; Kelly RS; Stav M; Mendez K; Dahlin A; Soeteman DI; Chu SH; Huang M; Cote M; Knihtilä HM; Lee-Sarwar K; McGeachie M; Wang A; Wu AC; Virkud Y; Zhang P; Wareham NJ; Karlson EW; Wheelock CE; Clish C; Weiss ST; Langenberg C; Lasky-Su JA
Preprint: RESEARCH SQUARE. 2022
Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid
Dong C; Liu J; Quaranta A; Jing X; Nie M; Wheelock C; Murrell B; Coquet J; Bowden T; Engstrand T; Adner M
Editorial comment: EUROPEAN RESPIRATORY JOURNAL. 2022;60(2):2200102
Metabolomics in pulmonary medicine: extracting the most from your data
Reinke SN; Chaleckis R; Wheelock CE
Conference publication: HEART. 2022;108:A143-A144
ADIPOSE TISSUE DERIVED CERAMIDES REGULATE MYOCARDIAL REDOX STATE AND PREDICT CARDIOVASCULAR OUTCOMES
Polkinghorne M; Akawi N; Badi I; Checa A; Kotanidis C; Akoumianakis I; Antonopoulos A; Krasopoulos G; Sayeed R; Walcot N; Channon KM; Wheelock C; Antoniades C
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205:a1976
Increased Cytotoxic T Cells in the Large Airways in Adults Born Prematurely with a History of Bronchopulmonary Dysplasia
Gao J; Um-Bergstrom PJ; Pourbazargan M; Berggren-Brostrom E; Li C; Merikallio H; Riitta K; Reinke S; Wheelock CE; Melen E; Linden A; Wheelock AM; Rassidaki G; Ortiz-Villalon C; Skold CM
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205:a3481
Driving Metabolomic Signatures for Clinical Asthma Subtypes: Important Distinctions Leading to Personalized Treatment in the TOPMed Initiative
Mendez K; Prince N; Cote M; Huang M; Kelly RS; Kachroo P; Chu S; Soeteman D; Knihtila H; Wheelock CE; Clish C; Weiss ST; Lasky-Su JA
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205:a3579
The Thromboxane A2 Pathway, as Assessed by Urinary Eicosanoids, Is Increased After Acute Controlled Exposure to Diesel Exhaust in Participants with COPD
Ryu M; Kolmert J; Zurita J; Wheelock CE; Carlsten C
Preprint: MEDRXIV. 2022
Comparative and Integrated Analysis of Plasma Extracellular Vesicles Isolations Methods in Healthy Volunteers and Patients Following Myocardial Infarction
Paget D; Checa A; Zöhrer B; Heilig R; Shanmuganathan M; Dhaliwal R; Johnson E; Jørgensen MM; Bæk R; Study OAMI; Wheelock CE; Channon KM; Fischer R; Anthony DC; Choudhury RP; Akbar N
Corrigendum: MUCOSAL IMMUNOLOGY. 2022;15(4):798
Correction to: Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages.
Bohnacker S; Hartung F; Henkel F; Quaranta A; Kolmert J; Priller A; Ud-Dean M; Giglberger J; Kugler LM; Pechtold L; Yazici S; Lechner A; Erber J; Protzer U; Lingor P; Knolle P; Chaker AM; Schmidt-Weber CB; Wheelock CE; Esser-von Bieren J
Preprint: BIORXIV. 2022
Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis
Kuo A; Checa A; Niaudet C; Jung B; Fu Z; Wheelock CE; Singh SA; Aikawa M; Smith LE; Proia RL; Hla T
Preprint: CHEMRXIV. 2022
Development of a chiral SFC-MS/MS and reversed-phase LC-MS/MS platform for the quantitative metabolic profiling of octadecanoid oxylipins
Quaranta A; Zöhrer B; Revol-Cavalier J; Benkestock K; Balas L; Oger C; Keyes GS; Wheelock ÅM; Durand T; Galano J-M; Ramsden CE; Hamberg M; Wheelock CE
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S251
The overwhelming omics in psoriasis, a systematic review
Torres M; Silberberg G; Wheelock C; Bachar-Wikstrom E; Wikstrom JD
Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2022;63(7)
Targeting NMNAT2 for neuroprotection in glaucoma
Williams PA; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
Preprint: MEDRXIV. 2021
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: a single-blind randomized controlled trial
Arnardottir H; Pawelzik S-C; Sarajlic P; Quaranta A; Kolmert J; Religa D; Wheelock C; Bäck M
Conference publication: 2021;:oa4117
Late Breaking Abstract - Monocyte-derived macrophages display an inflammatory memory several months post SARS-CoV-2 infection
Bohnacker S; Hartung F; Henkel F; Quaranta A; Kolmert J; Priller A; Lingor P; Chaker A; Knolle P; Schmidt-Weber C; Wheelock C; Esser-von Bieren J
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2021;58:oa1290
The carnitine pathway is dysregulated in asthma in an oral corticosteroid-independent mechanism
Reinke S; Naz S; Kermani N; Chaleckis R; Kolmert J; Strom M; Wheelock A; Djukanovic R; Chung F; Adcock I; Dahlen S-E; Wheelock C
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(7):2270-2273
Distinct effects of antigen and Compound 48/80 in the guinea pig trachea
Liu J; Kolmert J; Safholm J; Johnsson A-K; Zurita J; Wheelock CE; Dahlen S-E; Nilsson G; Adner M
Editorial comment: METABOLITES. 2021;11(6):346
Metabolomics in the Identification of Biomarkers of Asthma
Villasenor A; Eguiluz-Gracia I; Moreira A; Wheelock CE; Escribese MM
Review: METABOLOMICS. 2021;17(5):45
A strategy for advancing for population-based scientific discovery using the metabolome: the establishment of the Metabolomics Society Metabolomic Epidemiology Task Group
Lasky-Su J; Kelly RS; Wheelock CE; Broadhurst D
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):a4327
Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function
Kelly RS; Mendez K; Huang M; Clish C; Gerszten R; Wheelock CE; Cho MH; Kraft P; Hobbs BD; Celedon JC; Weiss ST; Lasky-Su JA
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):a1381
Metabolomic Analysis of Asthma Phenotypes across Multiple Cohorts
Mendez K; Cote M; Huang M; Kelly RS; Kachroo P; Chu SH; Soeteman DI; Reinke SN; Wheelock CE; Celedon JC; Clish CB; Weiss ST; Lasky-Su JA
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):a1385
Temporal Fluctuation of Systemic Markers in Urine During a Nasal Rhinovirus Challenge in Healthy and Asthmatic Subjects
Sinha A; Wheelock CE; Binbin X; Frey U; Sterk PJ; Lutter R; Chaleckis R
Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):1204-1205
Exposure to Active and Passive Tobacco Smoke on Urinary Eicosanoid Metabolites in Type 2 Asthma Reply
Kolmert J; Dahlen S-E; Wheelock CE
Preprint: RESEARCH SQUARE. 2021
Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function: Discovery and validation in two TOPMed Cohorts
Kelly R; Mendez K; Huang M; Hobbs B; Clish C; Gerszten R; Cho M; Wheelock C; McGeachie M; Chu S; Celedon J; Weiss S; Lasky-Su J
Preprint: RESEARCH SQUARE. 2021
The systematic use of metabolomic epidemiology, biobanks, and electronic medical records for precision medicine initiatives in asthma: findings suggest new guidelines to optimize treatment
Kachroo P; Stewart I; Kelly R; Stav M; Mendez K; Dahlin A; Soeteman D; Chu S; Huang M; Cote M; Knilhtilä H; Lee-Sarwar K; McGeachie M; Wang A; Wu A; Virkud Y; Zhang P; Wareham N; Karlson E; Wheelock C; Clish C; Weiss S; Langenberg C; Lasky-Su J
Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(3):853-856
AsthmaMap: An interactive knowledge repository for mechanisms of asthma
Mazein A; Ivanova O; Balaur I; Ostaszewski M; Berzhitskaya V; Serebriyskaya T; Ligon T; Hasenauer J; De Meulder B; Overall RW; Roy L; Knowles RG; Wheelock CE; Dahlen S-E; Chung KF; Adcock IM; Roberts G; Djukanovic R; Pellet J; Gawron P; Balling R; Maitland-van der Zee AH; Schneider R; Sterk PJ; Auffray C
Preprint: BIORXIV. 2021
Spatiotemporal Determination of Metabolite Activities in Multiple Corneal Epithelium Barriers on a Chip
Abdalkader R; Chaleckis R; Wheelock C; Kamei K-I
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(1):380-383
Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics
Zounemat Kermani N; Saqi M; Agapow P; Pavlidis S; Kuo C; Tan KS; Mumby S; Sun K; Loza M; Baribaud F; Sousa AR; Riley J; Wheelock AM; Wheelock CE; De Meulder B; Schofield J; Sanchez-Ovando S; Simpson JL; Baines KJ; Wark PA; Auffray C; Dahlen S-E; Sterk PJ; Djukanovic R; Adcock IM; Guo Y-K; Chung KF
Preprint: CHEMRXIV. 2020
High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology
Meister I; Zhang P; Sinha A; Sköld M; Wheelock Å; Izumi T; Chaleckis R; Wheelock C
Preprint: CHEMRXIV. 2020
High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology
Meister I; Zhang P; Sinha A; Sköld CM; Wheelock ÅM; Izumi T; Chaleckis R; Wheelock CE
Published conference paper: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2020;151:106474
Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction
Ambaw YA; Fuchs D; Raida M; Mazengia NT; Torta F; Wheelock CE; Wenk MR; Tong L
Preprint: AUTHOREA. 2020
Inhalation of allergen and diesel exhaust increases urinary eicosanoids associated with impaired lung function and airway hyperresponsiveness: a randomized, double-blinded, human crossover study
Ryu MH; Gómez C; Yuen A; Wheelock C; Carlsten C
Review: METABOLITES. 2020;10(11):E454-454
Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health
Oresic M; McGlinchey A; Wheelock CE; Hyotylainen T
Preprint: BIORXIV. 2020
Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites fromhepatocytes
Abdalkader R; Chaleckis R; Meister I; Zhang P; Wheelock C; Kamei K-I
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:3827
Differential mast cell activation by transcriptomic signature analysis in the U-BIOPRED severe asthma cohort
Tiotiu A; Badi Y; Kermani NZ; Hansbro P; Wheelock C; Dahlen S-E; Guo Y-K; Sterk P; Djukanovic R; Adcock I; Chung FK
Meeting abstract: EUROPEAN RESPIRATORY JOURNAL. 2020;56:2046
Mepolizumab decreases urinary excretion of LTE4 in severe asthma
Yasinska V; Kolmert J; Zurita J; Quaranta A; Bossios A; Lazarinis N; Dahlen B; Wheelock CE; Dahlen S-E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:627
COX-1 driven biosynthesis of PGD2 during activation of human mast cells prevents formation of other prostanoids
Johnsson A; Choi J-H; Ronnberg E; Fuchs D; Kolmert J; Hamberg M; Dahlen B; Wheelock CE; Dahlen S-E; Nilsson G
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:1246
Urinary metabolomics-profiling of the U-BIOPRED asthma study identified biochemical clusters associated with asthma severity
Wheelock C; Reinke S; Kolmert J; Naz S; Chaleckis R; Sterk P; Chung F; Adcock I; Djukanovic R; Dahlen S-E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:5246
Urinary metabolomics identifies molecular signatures associated with bronchopulmonary dysplasia (BPD) and birth-term
Wheelock C; Meister I; Gomez C; Chaleckis R; Zhang P; Strom M; Um-Bergstrom P; Brostrom E; Melen E; Skold M; Wheelock A
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:2043
Different patterns of mast cell activation and smooth muscle contractions by MRGPRX2 agonist and antigen in guinea pig trachea
Liu J; Kolmert J; Safholm J; Wheelock CE; Dahlen S-E; Nilsson G; Adner M
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2020;56:2897
A novel protective role of prostaglandin D2 in antigen-induced bronchoconstriction
Safholm J; Abma W; Liu J; Balgoma D; Kolmert J; Fauland A; Wheelock CE; Adner M; Dahlen S-E
Review: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2020;160:102156
Abnormal n-6 fatty acid metabolism in cystic fibrosis contributes to pulmonary symptoms
Wheelock CE; Strandvik B
Review: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2020;159:102143
Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial
Meuronen T; Lankinen MA; Fauland A; Shimizu B-I; de Mello VD; Laaksonen DE; Wheelock CE; Erkkila AT; Schwab US
Preprint: BIORXIV. 2020
Oral pyruvate prevents glaucomatous neurodegeneration
Williams P; Harder J; Guymer C; Wood J; Daskalaki E; Chidlow G; Cardozo B; Foxworth N; Cochran K; Ouellette T; Wheelock C; Casson R; John S
Editorial comment: EUROPEAN RESPIRATORY JOURNAL. 2020;55(2):1902064
The role of gene-environment interactions in lung disease: the urgent need for the exposome
Wheelock CE; Rappaport SM
Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2020;177(11):2581-2582
IL-13 and IL-4 induce 5-HT-mediated airway hyperreactivity in mouse trachea
Abma W; Safholm J; Wheelock C; Dahlen S-E; Adner M
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2019;54:oa3802
Late Breaking Abstract - Matrix metalloproteinases in serum and sputum reflect distinct processes of relevance to asthma
James A; Gomez C; Thorngren J-O; Ericsson M; Kolmert J; Wheelock C; Knowles R; Adcock I; Dahlen S-E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2019;54:oa3805
Baseline and longitudinal urinary eicosanoid profiles for molecular sub-phenotyping in the U-BIOPRED study
Kolmert J; Gomez C; Lefaudeux D; De Meulder B; Pandis I; Djukanovic R; Sterk P; Adcook I; Dahlen B; Dahlen S-E; Wheelock CE
Conference publication: 2019;:pa4349
Alterations in measures of systemic inflammation among adults born preterm
Gao J; Um-Bergström P; Pourbazargan M; Berggren-Broström E; Merikallio H; Kaarteenaho R; Reinke S; Wheelock C; Melén E; Lindén A; Wheelock A; Sköld M
Review: METABOLITES. 2019;9(6):E117-117
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective
Chu SH; Huang M; Kelly RS; Benedetti E; Siddiqui JK; Zeleznik OA; Pereira A; Herrington D; Wheelock CE; Krumsiek J; McGeachie M; Moore SC; Kraft P; Mathe E; Lasky-Su J
Letter: EUROPEAN RESPIRATORY JOURNAL. 2019;53(6):1900453
Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
Perotin J-M; Schofield JPR; Wilson SJ; Ward J; Brandsma J; Strazzeri F; Bansal A; Yang X; Rowe A; Corfield J; Lutter R; Shaw DE; Bakke PS; Caruso M; Dahlen B; Fowler SJ; Horvath I; Howarth P; Krug N; Montuschi P; Sanak M; Sandstrom T; Sun K; Pandis I; Auffray C; De Meulder B; Lefaudeux D; Riley JH; Sousa AR; Dahlen S-E; Adcock IM; Chung KF; Sterk PJ; Skipp PJ; Collins JE; Davies DE; Djukanovic R; Adcock IM; Ahmed H; Auffray C; Bakke P; Banssal AT; Baribaud F; Bates S; Bel EH; Bigler J; Bisgaard H; Boedigheimer MJ; Bonnelykke K; Brandsma J; Brinkman P; Bucchioni E; Burg D; Bush A; Caruso M; Chaiboonchoe A; Chanez P; Chung KF; Compton CH; Corfield J; D'Amico A; Dahlen SE; De Meulder B; Djukanovic R; Erpenbeck VJ; Erzen D; Fichtner K; Fitch N; Fleming LJ; Formaggio E; Fowler SJ; Frey U; Gahlemann M; Geiser T; Guo Y; Hashimoto S; Haughney J; Hedlin G; Hekking PW; Higenbottam T; Hohlfeld JM; Holweg C; Horvath I; Howarth P; James AJ; Knowles R; Knox AJ; Krug N; Lefaudeux D; Loza MJ; Lutter R; Manta A; Masefield S; Matthews JG; Mazein A; Meiser A; Middelveld RJM; Miralpeix M; Montuschi P; Mores N; Murray CS; Musial J; Myles D; Pahus L; Pandis I; Pavlidis S; Powell P; Pratico G; Puig Valls M; Rao N; Riley J; Roberts A; Roberts G; Rowe A; Sandstrom T; Seibold W; Selby A; Shaw DE; Sigmund R; Singer F; Skipp PJ; Sousa AR; Sterk PJ; Sun K; Thornton B; van Aalderen WM; van Geest M; Vestbo J; Vissing NH; Wagener AH; Wagers SS; Weiszhart Z; Wheelock CE; Wilson SJ; Aliprantis A; Allen D; Alving K; Badorrek P; Balgoma D; Ballereau S; Barber C; Batuwitage MK; Bautmans A; Bedding A; Behndig AF; Beleta J; Berglind A; Berton A; Bochenek G; Braun A; Campagna D; Carayannopoulos L; Casaulta C; Chaleckis R; Dahlen B; Davison T; De Alba J; De Lepeleire I; Dekker T; Delin I; Dennison P; Dijkhuis A; Dodson P; Dyson K; Edwards J; El Hadjam L; Emma R; Ericsson M; Faulenbach C; Flood B; Galffy G; Gallart H; Garissi D; Gent J; de Verdier MG; Gibeon D; Gomez C; Gove K; Guillmant-Farry E; Henriksson E; Hewitt L; Hoda U; Hu R; Hu S; Hu X; Jeyasingham E; Johnson K; Jullian N; Kamphuis J; Kennington EJ; Kerry D; Kerry G; Klueglich M; Knobel H; Kolmert J; Konradsen JR; Kots M; Kretsos K; Krueger L; Kuo S; Kupczyk M; Lambrecht B; Lantz A-S; Larminie C; Larsson LX; Latzin P; Lazarinis N; Lemonnier N; Lone-Latif S; Lowe LA; Manta A; Marouzet L; Martin J; Mathon C; McEvoy L; Meah S; Menzies-Gow A; Metcalf L; Mikus M; Monk P; Naz S; Nething K; Nicholas B; Nihlen U; Nilsson P; Niven R; Nordlund B; Nsubuga S; Ostling J; Pacino A; Palkonen S; Pellet J; Pennazza G; Petren A; Pink S; Pison C; Postle A; Rahman-Amin M; Ravanetti L; Ray E; Reinke S; Reynolds L; Riemann K; Robberechts M; Rocha JP; Rossios C; Russell K; Rutgers M; Santini G; Santoninco M; Saqi M; Schoelch C; Schofield JPR; Scott S; Sehgal N; Sjodin M; Smids B; Smith C; Smith J; Smith KM; Soderman P; Sogbessan A; Spycher F; Staykova D; Stephan S; Stokholm J; Strandberg K; Sunther M; Szentkereszty M; Tamasi L; Tariq K; Thorngren J-O; Thorsen J; Valente S; van de Pol M; van Drunen CM; Van Eyll J; Versnel J; Vink A; von Garnier C; Vyas A; Wald F; Walker S; Ward J; Wetzel K; Wiegman C; Williams S; Yang X; Yeyasingham E; Yu W; Zetterquist W; Zolkipli Z; Zwinderman AH; Prins J-B; Gahlemann M; Visintin L; Evans H; Puhl M; Buzermaniene L; Hudson V; Bond L; de Boer P; Widdershoven G; Sigmund R; Roberts A; Supple D; Hamerlijnck D; Negus J; Kamphuis J; Sergison L; Visintin L; de Boer P; Onstein S; MacNee W; Bernardini R; Bont L; Wecksell P-A; de Boer P; Gahlemann M; Sigmund R; Draper A; Gozzard N
Conference publication: HEART. 2019;105:A161-A162
UNTARGETED METABOLOMICS INTERROGATION OF ADIPOSE TISSUE SECRETOME FROM PARTICIPANTS OF THE OXFORD COHORT FOR HEART, VESSELS & FAT HIGHLIGHTED CERAMIDES AS POTENTIAL ADIPOKINES MODULATING VASCULAR REDOX SIGNALLING IN CARDIOVASCULAR DISEASE
Akawi N; Checa A; Kotanidis C; Akoumianakis I; Daskalakis E; Wheelock C; Antoniades C
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;199:a7090
Lipid Mediator-Based Molecular Profiling Identified 5 Distinct Asthma Sub-Phenotypes in the U-BIOPRED Study
Dahlen SK; Kolmert J; Gomez C; Djukanovic R; Dahlen BU; Sterk PJ; De Meulder B; Adcock IM; Wheelock C
Editorial comment: EUROPEAN RESPIRATORY JOURNAL. 2019;53(3):1900217
Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration
Agusti A; Faner R; Donaldson G; Heuvelin E; Breyer-Kohansal R; Melen E; Maitland-van der Zee AH; Vestbo J; Allinson JP; Vanfleteren LEGW; van den Berge M; Adcock IM; Lahousse L; Brusselle G; Wedzicha JA; Alter P; Barbe F; Brightling CE; Breyer M-K; Burghuber OC; Casas M; Chung KF; Cosio BG; Crispi F; de Batlle J; Fitting J-W; Garcia J; Hallberg J; Hartl S; Jarvis D; Mathioudakis A; Nicod L; Papi A; Ritchie A; Sigsgaard T; Sterk PJ; Ullman A; Vellve K; Vogelmeier C; Wheelock AM; Wheelock CE; Spanevello A
Review: CURRENT OPINION IN BIOTECHNOLOGY. 2019;55:44-50
Challenges, progress and promises of metabolite annotation for LC-MS-based metabolomics
Chaleckis R; Meister I; Zhang P; Wheelock CE
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74(2):406-411
Treatable traits in the European U-BIOPRED adult asthma cohorts
Simpson AJ; Hekking P-P; Shaw DE; Fleming LJ; Roberts G; Riley JH; Bates S; Sousa AR; Bansal AT; Pandis I; Sun K; Bakke PS; Caruso M; Dahlen B; Dahlen S-E; Horvath I; Krug N; Montuschi P; Sandstrom T; Singer F; Adcock IM; Wagers SS; Djukanovic R; Chung KF; Sterk PJ; Fowler SJ; Adcock IM; Ahmed H; Auffray C; Bakke P; Bansal AT; Baribaud F; Bates S; Bel EH; Bigler J; Bisgaard H; Boedigheimer MJ; Bonnelykke K; Brandsma J; Brinkman P; Bucchioni E; Burg D; Bush A; Caruso M; Chaiboonchoe A; Chanez P; Chung FK; Compton CH; Corfield J; D'Amico A; Dahlen B; Dahlen SE; De Meulder B; Djukanovic R; Erpenbeck VJ; Erzen D; Fichtner K; Fitch N; Fleming LJ; Formaggio E; Fowler SJ; Frey U; Gahlemann M; Geiser T; Goss V; Guo Y; Hashimoto S; Haughney J; Hedlin G; Hekking PW; Higenbottam T; Hohlfeld JM; Holweg C; Horvath I; Howarth P; James AJ; Knowles R; Knox AJ; Krug N; Lefaudeux D; Loza MJ; Lutter R; Manta A; Masefield S; Matthews JG; Mazein A; Meiser A; Middelveld RJM; Miralpeix M; Montuschi P; Mores N; Murray CS; Musial J; Myles D; Pahus L; Pandis I; Pavlidis S; Postle A; Powel P; Pratico G; Puig Valls M; Rao N; Riley J; Roberts A; Roberts G; Rowe A; Sandstrom T; Schofield JPR; Seibold W; Selby A; Shaw DE; Sigmund R; Singer F; Skipp PJ; Sousa AR; Sterk PJ; Sun K; van Aalderen WM; van Geest M; Vestbo J; Vissing NH; Wagener AH; Wagers SS; Weiszhart Z; Wheelock CE; Wilson SJ
Preprint: BIORXIV. 2019
Morse-clustering of a Topological Data Analysis Network Identifies Phenotypes of Asthma Based on Blood Gene Expression Profiles
Schofield JPR; Strazzeri F; Bigler J; Boedigheimer M; Adcock IM; Chung KF; Bansal A; Knowles R; Dahlen S-E; Wheelock CE; Sun K; Pandis I; Riley J; Auffray C; De Meulder B; Lefaudeux D; Ramanan D; Sousa AR; Sterk PJ; Ewing RM; Macarthur BD; Djukanovic R; Sanchez-Garcia R; Skipp PJ
Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(16):3021
LXA₄ reduces the TNF-α induced increase of 5-HT responsiveness in mouse trachea
Abma W; Safholm J; Wheelock C; Dahlen S; Adner M
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3626
Adipose tissue secreted ceramides and related sphingolipids - potential modulators of vascular redox signalling in cardiovascular disease
Akawi N; Checa A; Kotanidis C; Akoumianakis I; Daskalakis E; Herdamn L; Wheelock C; Antoniades C
Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(16):3037-3038
Characterisation of prostaglandin B2 responses in isolated human and guinea pig vascular and airway tissue
Safholm J; Lee T; Ting H; Wheelock C; Orre A; Bergman P; Al-Ameri M; Adner M; Dahlen S
Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2019;60(9)
Changes of eicosanoids after eyelid warming or thermopulsation treatment for Meibomian gland dysfunction (MGD)
Ambaw YA; Fuchs D; Torta F; Wheelock C; Wenk M; Tong L
Published conference paper: SCIENCE OF THE TOTAL ENVIRONMENT. 2018;644:1101-1109
Effect of psychiatric drugs on Daphnia magna oxylipin profiles
Garreta-Lara E; Checa A; Fuchs D; Tauler R; Lacorte S; Wheelock CE; Barata C
Meeting abstract: EUROPEAN RESPIRATORY JOURNAL. 2018;52:oa4920
Late Breaking Abstract - Elevated airway lymphocytes in adults born prematurely with a history of bronchopulmonary dysplasia
Gao J; Um-Bergstrom P; Pourbazargan M; Berggren-Brostrom E; Merikallio H; Kaarteenaho R; Reinke S; Wheelock CE; Melen E; Linden A; Wheelock AM; Skold CM
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2018;52:oa3582
Association between exhaled volatile organic compounds and urinary levels of oral corticosteroids within the U-BIOPRED Cohort
Brinkman P; Ahmed W; Gomez C; Knobel HH; Weda H; Vink TJ; Nijsen TM; Wheelock CE; Dahlen S-E; Montuschi P; Knowles RG; Vijverberg SJ; Maitland-Van der Zee AH; Sterk PJ; Fowler SJ
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2018;52:pa3992
Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort
Alahmadi F; Simpson A; Gomez C; Wheelock C; Shaw D; Fleming L; Roberts G; Riley J; Bates S; Sousa AR; Knowles R; Bansal A; Corfield J; Pandis I; Sun K; Bakke P; Caruso M; Chanez P; Dahlen B; Horvath I; Krug N; Montuschi P; Sandstrom T; Singer F; Wagers S; Adcock I; Djukanovic R; Chung K; Sterk PJ; Dahlen S-E; Fowler SJ
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2018;52:pa1044
Antigen challenge results in specific activation of pathways for arachidonic acid oxygenation
Safholm J; Balgoma D; Fauland A; Gomez C; Kolmert J; Adner M; Wheelock C; Dahlen S-E
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441
Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients
Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Erhardt S; Wheelock CE
Editorial comment: CLINICAL AND EXPERIMENTAL ALLERGY. 2018;48(8):916-918
AsthmaMap: An expert-driven computational representation of disease mechanisms
Mazein A; Knowles RG; Adcock I; Chung KF; Wheelock CE; Maitland-van der Zee AH; Sterk PJ; Auffray C
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2018;29(3):275-296
The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders
Araujo AC; Wheelock CE; Haeggstrom JZ
Conference publication: HEART. 2018;104:A111
DIABETES-INDUCED INNATE IMMUNE MEMORY DRIVES INFLAMMATION AND ATHEROSCLEROSIS, DESPITE RESTORATION OF NORMOGLYCAEMIA
Edgar L; Akbar N; Khoyratty T; Krausgruber T; Alkhalil M; Ziberna K; Arya R; Sousa Fialho MDL; Heather L; Bock C; Wheelock C; Udalova I; Carnicer R; Choudhury RP
Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2018;33
TREATMENT WITH SPIRONOLACTONE FOR 1 YEAR DOES NOT IMPROVE NITRIC OXIDE METABOLISM IN RENAL TRANSPLANT PATIENTS
Mortensen LA; Bistrup C; Jensen B; Stubbe J; Carlstrom M; Checa A; Wheelock C; Thiesson H
Editorial comment: LCGC EUROPE. 2018;31(4):222-224
The Benefits of Data Independent Acquisition in Metabolomics
Matheson A; Wheelock C
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018;197
Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma Within the U-BIOPRED Cohort
Brinkman P; Ahmed W; Gomez C; Knobel HH; Weda H; Vink TJ; Nijsen TM; Pennazza G; Santonico M; D'Amico A; Wheelock CE; Dahlen SE; Montuschi P; Vijverberg SJ; Maitland-van der Zee AH; Sterk PJ; Fowler SJ
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018;197
Time Series Fluctuation of Clinical and Molecular Markers in Healthy and Asthmatic Subjects Before and After Rhinovirus Inoculation
Sinha A; Binbin X; Delgado-Eckert E; Chaleckis R; Wheelock CC; Frey U; Lutter R; Sterk PJ
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2018;48:177
Effects of a walnut-enriched diet for 2 years on oxylipins derived from arachidonic and alpha-linolenic acids
Cofan M; Sala-Vila A; Checa A; Wheelock CE; Simoes T-MF; Serra-Mir M; Rajaram S; Sabate J; Ros E
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2018;197
Urinary Metabolomics-Based Sub-Phenotyping of the Large-Scale Multi-Omics U-BIOPRED Asthma Cohort Identified Tryptophan Dysregulation Associated with Asthma Severity
Wheelock C; Naz S; Reinke S; Olsson H; Lundqvist A; Chaleckis R; Kolmert J; Schofield J; Skipp P; Bigler J; Loza M; Baribaud F; Bakke P; Caruso M; Chanez P; Fowler SJ; Horvath I; Krug N; Montuschi P; Sanak M; Sandstrom T; Shaw D; Dahlen BU; Chung KF; Djukanovic R; Singer F; Sousa A; Bansal A; Sterk PJ; Dahlen S
Conference publication: 2017;:pa580
Increased serum MMP-3 in severe asthma is associated with oral steroid use; data from U-BIOPRED and BIOAIR cohorts
James A; Kolmert J; Wheelock C; Knowles R; Dahlén S-E; Thörngren J-O; Ericsson M; Gomez C
Conference publication: JOURNAL OF HEPATOLOGY. 2017;66(1):S142
Identification of new biomarkers of leukocyte dysfunction by lipidomics in patients with acute-on-chronic liver failure
Lopez-Vicario C; Checa A; Alcaraz-Quiles J; Titos E; Casulleras M; Flores-Costa R; Pavesi M; Duran-Gell M; Moreau R; Arroyo V; Wheelock CE; Claria J
Conference publication: NEUROENDOCRINOLOGY. 2017;105:306
SSA-, H1, H2-and Leukotriene Receptor Blockade Eliminates Handicapping Symptoms from Atypical Carcinoid Syndrome
Ekberg LK; Dahlen SE; Wheelock C; Kolmert J; Bood J; Dahlen B
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:pa876
Metabolomics profiling identifies female-selective upregulation of oxidative stress in individuals with COPD
Naz S; Kolmert J; Yang M; Skold M; Wheelock A; Wheelock C
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:oa4954
Non-invasive urinary lipid mediator excretion profiles identify sub-phenotypes of asthma in the U-BIOPRED study
Kolmert J; Gomez C; Lefaudeux D; DeMeulder B; James A; Auffray C; Wheelock C; Dahlen S-E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:oa1983
The CysLT₁ receptor antagonist montelukast inhibits mast cell activation induced by inhaled leukotriene E₄ in subjects with asthma
Lazarinis N; Bood J; Gomez C; Kolmert J; Safholm J; Lantz A-S; Henriksson E; Wheelock C; Dahlen S-E; Dahlen B
Meeting abstract: EUROPEAN RESPIRATORY JOURNAL. 2016;48:pp130
LSC Abstract - Prediction of COPD- and smoking status by network-based multi-'omics data fusion analysis
Li C-X; Naz S; Levanen B; Eldh M; Gabrielsson S; Erle DJ; Wheelock CE; Skold CM; Wheelock AM
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:275
DYSREGULATIONS IN THE SPHINGOLIPID PATHWAY IN SLE PATIENTS
Checa A; Idborg H; Sar DG; Jakobsson P-J; Wheelock CE; Gunnarsson I
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:A53
DYSREGULATIONS IN THE SPHINGOLIPID PATHWAY IN SLE PATIENTS
Checa A; Idborg H; Sar DG; Jakobsson PJ; Wheelock CE; Gunnarsson I
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193
Non-Invasive Sub-Phenotyping Of Asthma In The U-Biopred Study By Analysis Of Urinary Lipid Mediator Excretion Patterns
Wheelock CE; Kolmert J; Lefaudeux D; Sjodin M; Balgoma D; Sousa AR; Corfield J; Pandis I; Djukanovic R; Dahlen S-E
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;71:36
Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice
Frei-Winterleitner RB; Luschnig P; Parzmair GP; Peinhaupt M; Schranz S; Fauland A; Wheelock CE; Heinemann A; Sturm EM
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2015;46:pa851
LATE-BREAKING ABSTRACT: Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
Balgoma D; Yang M; Sjodin M; Snowden S; Karimi R; Levanen B; Merikallio H; Kaarteenaho R; Palmberg L; Larsson K; Erle D; Dahlen S-E; Dahlen B; Skold M; Wheelock A; Wheelock C
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2015;46:pa2545
The CysLT₁receptor antagonist montelukast blocks bronchoconstriction induced by inhaled leukotriene E₄ in subjects with asthma
Lazarinis N; Bood J; Wheelock C; Dahlen S-E; Dahlen B
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2015;46:pa4889
The first U-BIOPRED blood handprint of severe asthma
De Meulder B; Lefaudeux D; Bigler J; Loza MJ; Wheelock CE; Sousa AR; Corfield J; Baribaud F; Auffray C; Shaw DE; Horvath I; Musial J; Chanez P; Krug N; Montuschi P; Bakke PS; Singer F; Fowler SJ; Dahlen S-E; Sandstrom T; Sterk PJ; Chung KF; Adcock IM; Djukanovic R
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:829-830
EFFECT OF MPGES-1 TARGETING ON LIPID METABOLISM IN HUMAN CELLS
Korotkova M; Idborg H; Raouf J; Ossipova E; Checa A; Olsson P; Leclerc P; Oliynyk G; Wheelock C; Jakobsson P-J
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:A94
EFFECT OF MPGES-1 TARGETING ON LIPID METABOLISM IN HUMAN CELLS
Idborg H; Raouf J; Ossipova E; Checa A; Olsson P; Leclerc P; Oliynik G; Wheelock C; Jakobsson P-J; Korotkova M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:A53
SCREENING OF SPHINGOLIPIDS IN SLE - BEFORE AND AFTER TREATMENT
Idborg H; Checa A; Sar D; Jakobsson P-J; Wheelock C; Gunnarsson I
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2014;44
A new sensitive panel for in vivo monitoring of mast cell activation in urine samples
Bood J; Kolmert J; Gulen T; Delin I; Wheelock C; Dahlen B; Nilsson G; Dahlen S-E
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2014;189
Lipid Mediator Levels Evidence Gender-Specific Increases In Bronchoalveolar Lavage Fluid Of COPD Patients Relative To Healthy Smokers
Wheelock C; Balgoma D; Skold M; Wheelock A
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:95
Proteomics and metabolomics in the classification of SLE subsets
Jakobsson P-J; Svenungsson E; Idborg H; Nilsson P; Wheelock C; Gunnarsson I; Trygg J; Lehtio J; Koistinen IS
Editorial comment: MOLECULAR BIOSYSTEMS. 2013;9(11):2589-2596
Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine
Wheelock AM; Wheelock CE
Review: EUROPEAN RESPIRATORY JOURNAL. 2013;42(3):802-825
Application of 'omics technologies to biomarker discovery in inflammatory lung diseases
Wheelock CE; Goss VM; Balgoma D; Nicholas B; Brandsma J; Skipp PJ; Snowden S; Burg D; D'Amico A; Horvath I; Chaiboonchoe A; Ahmed H; Ballereau S; Rossios C; Chung KF; Montuschi P; Fowler SJ; Adcock IM; Postle AD; Dahlen S-E; Rowe A; Sterk PJ; Auffray C; Djukanovic R
Review: MOLECULAR NUTRITION AND FOOD RESEARCH. 2013;57(8):1359-1377
Quantitative metabolic profiling of lipid mediators
Balgoma D; Checa A; Sar DG; Snowden S; Wheelock CE
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2013;42
Lipid mediator levels evidence gender-specific increases in bronchoalveolar lavage fluid of COPD patients relative to healthy smokers
Wheelock C; Balgoma D; Grunewald J; Eklund A; Skold M; Wheelock A
Review: BIOANALYSIS. 2012;4(18):2265-2290
Application of metabolomics approaches to the study of respiratory diseases
Snowden S; Dahlen S-E; Wheelock CE
Conference publication: 2012;:a1414
Safety Of The COX-2 Inhibitor Etoricoxib In Allergen-Challenged Asthmatics
Daham K; Lindeberg A; James A; Henriksson E; Billing B; Kupczyk M; Balgoma D; Delin I; Wheelock CE; Dahlen S-EK; Dahlen B
Conference publication: 2012;:a2115
Altered Lipid Mediator Bronchoalveolar Lavage Profiles In Pigs After Induction Of Lung Injury
Larsson N; Lundstrom S; Claesson J; Lehtipalo S; Behndig AF; Pourazar J; Pinto R; Trygg J; Wheelock CE; Nording ML
Conference publication: 2012;:a1747
Divergent Lipid Mediator Profiles In Asthmatic And Healthy Subjects In Response To Diesel Exhaust Exposure
Nording ML; Lundstrom S; Larsson N; Sehlstedt M; Behndig AF; Blomberg A; Sandstrom T; Pourazar J; Pinto R; Trygg J; Wheelock CE
Conference publication: 2012;:a1417
Different Lung Compartments Evidence Divergent Lipid Mediator Profiles In Healthy And Asthmatic Subjects
Larsson N; Lundstrom S; Behndig AF; Blomberg A; Sandstrom T; Pourazar J; Pinto R; Trygg J; Wheelock CE; Nording ML
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2012;40:a4551
Gender differences in 5-and 12/15-lipoxygenases products in bronchoalveolar lavage fluid from healthy never-smokers, smoker and COPD patients
Balgoma D; Schold M; Grunewald J; Eklund A; Wheelock A; Wheelock C
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2012;40
Application of a new mass-spectrometric platform for determination of lipid mediators in urine reveals increased oxidative stress during allergen bronchoprovocation of subjects with atopic asthma
Balgoma D; Daham K; Larsson J; Lindeberg A; Dahlen B; Rokach J; Wheelock C; Dahlen S-E
Conference publication: INFLAMMATION RESEARCH. 2012;61:S67-S68
EICOSANOIDS: PERFORMING LIPIDOMICS ON ACTIVATED MAST CELLS
Nilsson G; Lundstrom S; Saluja R; Haeggstrom J; Wheelock C
Conference publication: REPRODUCTION IN DOMESTIC ANIMALS. 2012;47:479-480
Oxylipidomics of the cow uterus: effects of the peri-ovulatory endocrine milieu of the estrous cycle
Membrive CB; Scolari SC; Cardoso D; Martin I; Sales JN; Oliveira M; D'Alexandri FL; Mesquita FS; de Paula Nogueira G; Wheelock C; Dahle S-E; Binelli M
Review: CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2011;12(7):1026-1052
Lipid Mediator Profiling in Pulmonary Disease
Lundstrom SL; Balgoma D; Wheelock AM; Haeggstrom JZ; Dahlen S-E; Wheelock CE
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):158
12-AND 15-LIPOXYGENASES IN HUMAN CAROTID ATHEROSCLEROTIC LESIONS: ASSOCIATIONS WITH CEREBROVASCULAR SYMPTOMS
Gertow K; Nobili E; Folkersen L; Newman JW; Pedersen TL; Ekstrand J; Swedenborg J; Kuehn H; Wheelock CE; Hansson GK; Hedin U; Haeggstrom JZ; Gabrielsen A
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:a4447
Allergic Asthmatics Exhibit Altered Response In Oxylipin Profile As Compared To Healthy And Asthmatic Controls After Allergen Provocation
Lundstrom S; Yang J; Haeggstrom JZ; Hammock BD; Grunewald J; Nord M; van Hage M; Eklund A; Wheelock CE; Wheelock AM
Book chapter: DIFFICULT-TO-TREAT SEVERE ASTHMA. 2011;p.
Lipid mediators in severe asthma
Kupczyk M; Lundström S; Dahlén B; Balgoma D; Wheelock CE; Dahlén S-E
Book chapter: ANTICHOLINESTERASE PESTICIDES. 2011;p. 57-75
Carboxylesterases in the Metabolism and Toxicity of Pesticides
Jackson CJ; Oakeshott JG; Sanchez‐Hernandez JC; Wheelock CE
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;66:114
Detection of the urinary prostaglandin D2 metabolites in systemic mastocytosis
Gulen T; Larsson J; Balgoma D; Delin I; Wheelock C; Dahlen B; Hagglund H; Nilsson G; Dahlen S
Conference publication: 2010;:116-126
PHYLOGENETIC ANALYSIS OF LIPID MEDIATOR GPCRs
MIZUTANI S; TANAKA M; WHEELOCK CE; KANEHISA M; GOTO S
Published conference paper: ACTA TROPICA. 2010;114(3):144-151
varDB: A database of antigenic variant sequences-Current status and future prospects
Diez D; Hayes N; Joannin N; Normark J; Kanehisa M; Wahlgren M; Wheelock CE; Goto S
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2010;181:a2817
Difference In Oxylipin Levels And Exosome Content In Bronchoalveolar Lavage Fluid Of Asthmatics And Healthy Individuals In Response To Subway Air Exposure
Levanen B; Lundstrom SL; Paredes PT; Nording ML; Nystrom AK; Skold MC; Haeggstroem JZ; Grunewald J; Svartengren M; Hammock BD; Gabrielsson S; Larsson B; Eklund A; Wheelock CE; Erle DJ; Wheelock AM
Review: MOLECULAR BIOSYSTEMS. 2010;6(2):289-304
The use of network analyses for elucidating mechanisms in cardiovascular disease
Diez D; Wheelock AM; Goto S; Haeggstrom JZ; Paulsson-Berne G; Hansson GK; Hedin U; Gabrielsen A; Wheelock CE
Review: MOLECULAR BIOSYSTEMS. 2009;5(6):588-602
Systems biology approaches and pathway tools for investigating cardiovascular disease
Wheelock CE; Wheelock AM; Kawashima S; Diez D; Kanehisa M; van Erk M; Kleemann R; Haeggstrom JZ; Goto S
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;64:86
Saliva - a new matrix for eicosanoid biomarkers in allergy
Stark K; Boot M; Kupczyk M; Delin I; Wheelock C; Dahlen B; Dahlen S
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2008;11(11):799-802
From Genome to Proteome: Integration and proteome completion-8th Siena Meeting
Wheelock AM; Wheelock CE
Book chapter: PLANT PROTEOMICS. 2008;p. 105-125
Bioinformatics in Gel‐Based Proteomics
Wheelock ÅM; Wheelock CE
Conference publication: INTERNATIONAL JOURNAL FOR PARASITOLOGY. 2008;38:S26-S27
PfEMP1-DBL1 amino acid motifs in severe disease states of Plasmodium falciparum malaria.
Normark J; Nilsson D; Ribackel U; Winter G; Moll K; Wheelock CE; Bayarugaba J; Kironde F; Egwang TG; Chen Q; Andersson B; Wahlgren M
Review: REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. 2008;195:117-178
Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs)
Wheelock CE; Phillips BM; Anderson BS; Miller JL; Miller MJ; Hammock BD
Review: JOURNAL OF PESTICIDE SCIENCE. 2006;31(3):273-281
Structure-activity relationships and pathway analysis of biological degradation processes
Kadowaki T; Wheelock CE; Hattori M; Goto S; Kanehisa M
Review: JOURNAL OF PESTICIDE SCIENCE. 2006;31(3):263-272
Enlistment of omics technologies in the fight against malaria:: Panacea or Pandora's Box?
Hayes CN; Wheelock AM; Normark J; Wahlgren M; Goto S; Wheelock CE
Review: JOURNAL OF PESTICIDE SCIENCE. 2005;30(2):75-83
Overview of carboxylesterases and their role in the metabolism of insecticides
Wheelock CE; Shan G; Ottea J
Published conference paper: PEST MANAGEMENT SCIENCE. 2004;60(4):359-368
Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California.
McAbee RD; Kang K-D; Stanich MA; Christiansen JA; Wheelock CE; Inman AD; Hammock BD; Cornel AJ
Corrigendum: BIOORGANIC AND MEDICINAL CHEMISTRY. 2001;9(7):1941
3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues (vol 8, pg 2663, 2000)
Nakagawa Y; Wheelock CE; Morisseau C; Goodrow MH; Hammock BH; Hammock BD
Published conference paper: MARINE ENVIRONMENTAL RESEARCH. 1998;46(1-5):453-456
Characterization of hsp60 response in the rotifer, Brachionus plicatilis, exposed to multiple environmental contaminants
Wheelock CE; Wolfe MF; Olsen H; Tjeerdema RS
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Grants

Regulation of host defense by a helminthic glutamate dehydrogenase
Swiss National Science Foundation
1 January 2023 - 31 December 2026
Molecular phenotyping for precision pharmacotherapy of asthma
Swedish Research Council
1 January 2023 - 31 December 2026
POST-IONISATION AND FRAGMENTATION OF GAS-PHASE IONS FOR SINGLE ORGANISM ANALYSIS (PIFAGOR)
Swedish Research Council
1 January 2022 - 31 December 2025
Home monitoring and molecular phenotyping of patients with long-COVID for sub-grouping and follow-up of efficacy of interventions
Swedish Research Council
1 December 2021 - 30 November 2025
integrating Metabolism ENvironment and Diet for sub-phenotyping of obstructive lung disease (iMEND)
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2023
Hem-monitorering och molekylär fenotypning av patienter med långtids-COVID för subgruppering samt uppföljning av interventioner
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2021
Biological mechanisms behind health effects of air pollution exposure from childhood to adulthood
Swedish Research Council
1 January 2021 - 31 December 2024
integrating Metabolism ENvironment and Diet for sub-phenotyping of obstructive lung disease (iMEND)
Swedish Heart-Lung Foundation
1 January 2019 - 31 December 2021
Molecular phenotyping of endemic lung diseases (MORPHEUS)
Swedish Heart-Lung Foundation
1 January 2019 - 31 December 2021
Novel lipid mediators in the induction and resolution of chronic airway inflammation
Swedish Research Council
1 January 2017 - 31 December 2020
Clinical biomarkers for ROS-based anticancer therapy
Swedish Foundation for Strategic Research
1 January 2015 - 31 December 2019
An integrative systems biology approach to understanding inflammatory neurological diseases.
Canadian Institutes of Health Research
1 April 2014 - 30 June 2016

Employments

Principal Researcher, Institute of Environmental Medicine, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2009

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