Claudia Kutter

Claudia Kutter

Principal Researcher
Telephone: +46852482819
Visiting address: Tomtebodavägen 23A (Gamma4), 17165 Solna
Postal address: C1 Mikrobiologi, tumör- och cellbiologi, C1 SciLife Kutter, 171 77 Stockholm

About me

  • I received my PhD from the University of Basel, Switzerland. During my PhD, I worked on small RNA-mediated regulation of stem cell differentiation at the Friedrich Miescher Institute (Basel, Switzerland). As a postdoctoral researcher, I jointed Cancer Research UK and the University of Cambridge (Cambridge, UK) to study the evolution of noncoding RNAs using next-generation sequencing (NGS) methods. In 2016, I became a SciLifeLab and Wallenberg fellow at the Karolinska Institute (Department of Microbiology, Tumor and Cell Biology). I am leading my independent research group at the Science for Life Laboratory (SciLifeLab) in Stockholm (Sweden).

Research

  • *Deciphering genome functionality*
    Cells do not exist in one form and adapt quickly, especially in response to metabolic changes. My group studies how this reversible cell phenotype is
    controlled by a sophisticated entwined interaction between RNA (long noncoding, transfer and small RNAs) and RNA-binding proteins with a particular focus on liver diseases (from fatty liver to liver cancer).
    We have developed and used experimental and computational multi-omics approaches (bulk and single cell genomics, transcriptomics, CRISPR technology combined with cell-based assays) to understand the differences between healthy, reversible and diseased liver cell phenotypes.
    Our long term goal is to integrate RNA and their regulators in biomedical research not only for diagnosis and prognosis but also for therapeutic purposes.

    *Conference organiser*
    * EMBO workshop "RNA: Structure meets Function" [1]
    * Transposon symposium [2]
    * EpiChrom [3]
    * SciLifeLab seminar series [4]
    * Science & SciLifeLab prize [5]
    [1] http://meetings.embo.org/event/18-rna
    [2] https://transposonsymposium.wordpress.com/
    [3] https://www.scilifelab.se/wp-content/uploads/2017/07/epichrom-2017-proceedings.pdf
    [4] https://www.scilifelab.se/research/seminars-and-symposia/
    [5] http://scienceprize.scilifelab.se/

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