Christopher Sundling

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Articles

Article: JOURNAL OF INFECTIOUS DISEASES. 2025;232(1):e78-e88
Improved Detection of Extrapulmonary and Paucibacillary Pulmonary Tuberculosis by Xpert MTB Host Response in a Tuberculosis Low-Endemic, High-Resource Setting
Folkesson E; Froberg G; Sundling C; Schon T; Sodersten E; Bruchfeld J
Article: IMMUNITY. 2025;:S1074-7613(25)00283-3-2136.e5
Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity.
Lautenbach MJ; Wyss K; Yman V; Foroogh F; Satarvandi D; Mousavian Z; Sondén K; Wang J; Álvez MB; Bergström S; Nilsson P; Edfors F; Brodin P; Uhlén M; Sundling C; Färnert A
Article: IMMUNITY. 2025;58(6):1586-1597.e5
Antibody-Fab and-Fc features promote Mycobacterium tuberculosis restriction
Grace PS; Peters JM; Sixsmith J; Lu R; Irvine EB; Luedeman C; Fenderson BA; Vickers A; Slein MD; McKitrick T; Wei M-H; Cummings RD; Wallace A; Cavacini LA; Choudhary A; Proulx MK; Sundling C; Kallenius G; Reljic R; Ernst JD; Casadevall A; Locht C; Pinter A; Sassetti CM; Bryson BD; Fortune SM; Alter G
Journal article: BIORXIV. 2024;:2024.10.07.617070
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.
Grace PS; Peters JM; Sixsmith J; Lu R; Luedeman C; Fenderson BA; Vickers A; Slein MD; Irvine EB; McKitrick T; Wei M-H; Cummings RD; Wallace A; Cavacini LA; Choudhary A; Proulx MK; Sundling C; Källenius G; Reljic R; Ernst JD; Casadevall A; Locht C; Pinter A; Sasseti CM; Bryson BD; Fortune SM; Alter G
Article: PLOS MEDICINE. 2024;21(9):e1004452
HIV, malnutrition, and noncommunicable disease epidemics among tuberculosis-affected households in east and southern Africa: A cross-sectional analysis of the ERASE-TB cohort.
Calderwood CJ; Marambire ET; Larsson L; Banze D; Mfinanga A; Nhamuave C; Appalarowthu T; Mugava M; Ribeiro J; Towo PE; Madziva K; Dixon J; Held K; Minja LT; Mutsvangwa J; Khosa C; Heinrich N; Fielding K; Kranzer K; ERASE-TB consortium
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(8):e2350736
Regulation of B-cell function and expression of CD11c, T-bet, and FcRL5 in response to different activation signals
Kleberg L; Courey-Ghaouzi A-D; Lautenbach MJ; Farnert A; Sundling C
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(4):e2350784
Disease-specific plasma protein profiles in patients with fever after traveling to tropical areas
Sundling C; Yman V; Mousavian Z; Angenendt S; Foroogh F; von Horn E; Lautenbach MJ; Grunewald J; Faernert A; Sonden K
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2024;141:106984
Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease
Kallenius G; Correia-Neves M; Sundling C
Journal article: PLOS ONE. 2024;19(1):e0297828
Correction: Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis.
Cantera JL; Lillis LM; Peck RB; Moreau E; Schouten JA; Davis P; Zheng RB; Lowary TL; Drain PK; Andama A; Pinter A; Kawasaki M; Källenius G; Sundling C; Dobos KM; Flores D; Chatterjee D; Murphy E; Halas OR; Boyle DS
Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1454006
Estradiol-mediated enhancement of the human ectocervical epithelial barrier correlates with desmoglein-1 expression in the follicular menstrual phase
Bradley F; Stern A; Boger MF; Mousavian Z; Dethlefsen O; Kaldhusdal V; Lajoie J; Omollo K; Bergstrom S; Manberg A; Nilsson P; Kimani J; Burgener AD; Tjernlund A; Sundling C; Fowke KR; Broliden K
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1501700
Naturally acquired IgG responses to Plasmodium falciparum do not target the conserved termini of the malaria vaccine candidate Merozoite Surface Protein 2
Zerebinski J; Margerie L; Han NS; Moll M; Ritvos M; Jahnmatz P; Ahlborg N; Ngasala B; Rooth I; Sjoeberg R; Sundling C; Yman V; Faernert A; Plaza DF
Article: CELL REPORTS: METHODS. 2023;3(9):100574
A genomic platform for surveillance and antigen discovery in Plasmodium spp. using long-read amplicon sequencing
Plaza DF; Zerebinski J; Broumou I; Lautenbach MJ; Ngasala B; Sundling C; Farnert A
Article: NATURE COMMUNICATIONS. 2023;14(1):2164
Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19
Yu M; Charles A; Cagigi A; Christ W; osterberg B; Falck-Jones S; Azizmohammadi L; ahlberg E; Falck-Jones R; Svensson J; Nie M; Warnqvist A; Hellgren F; Lenart K; Arcoverde Cerveira R; Ols S; Lindgren G; Lin A; Maecker H; Bell M; Johansson N; Albert J; Sundling C; Czarnewski P; Klingstroem J; Faernert A; Lore K; Smed-Soerensen A
Article: IMMUNITY. 2023;56(3):635-652.e6
Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
Corcoran M; Chernyshev M; Mandolesi M; Narang S; Kaduk M; Ye K; Sundling C; Farnert A; Kreslavsky T; Bernhardsson C; Larena M; Jakobsson M; Hedestam GBK
Article: ISCIENCE. 2022;25(12):105652
A protein signature associated with active tuberculosis identified by plasma profiling and network-based analysis
Mousavian Z; Folkesson E; Froberg G; Foroogh F; Correia-Neves M; Bruchfeld J; Kallenius G; Sundling C
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
Preserved Mucosal-Associated Invariant T Cells in the Cervical Mucosa of HIV-Infected Women with Dominant Expression of the TRAV1-2-TRAJ20 T Cell Receptor α-Chain
Gibbs A; Healy K; Kaldhusdal V; Sundling C; Franzen-Boger M; Edfeldt G; Buggert M; Lajoie J; Fowke KR; Kimani J; Kwon DS; Andersson S; Sandberg JK; Broliden K; Davanian H; Chen MS; Tjernlund A
Article: BMJ OPEN. 2022;12(7):e060985
Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventional, longitudinal, multicountry cohort study
Marambire ET; Banze D; Mfinanga A; Mutsvangwa J; Mbunda TD; Ntinginya NE; Celso K; Kallenius G; Calderwood CJ; Geldmacher C; Held K; Appalarowthu T; Riess F; Panzner U; Heinrich N; Kranzer K
Article: CELL REPORTS. 2022;39(3):110709
Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria
Lautenbach MJ; Yman V; Silva CS; Kadri N; Broumou I; Chan S; Angenendt S; Sonden K; Plaza DF; Farnert A; Sundling C
Article: NATURE COMMUNICATIONS. 2022;13(1):331
Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure
Yman V; Tuju J; White MT; Kamuyu G; Mwai K; Kibinge N; Asghar M; Sundling C; Sonden K; Murungi L; Kiboi D; Kimathi R; Chege T; Chepsat E; Kiyuka P; Nyamako L; Osier FHA; Farnert A
Article: PLOS ONE. 2022;17(9):e0274415
Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis
Cantera JL; Lillis LM; Peck RB; Moreau E; Schouten JA; Davis P; Drain PK; Andama A; Pinter A; Kawasaki M; Kallenius G; Sundling C; Dobos KM; Flores D; Chatterjee D; Murphy E; Halas OR; Boyle DS
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:799306
Plasmodium falciparum-Specific Memory B-Cell and Antibody Responses Are Associated With Immunity in Children Living in an Endemic Area of Kenya
Jahnmatz P; Nyabundi D; Sundling C; Widman L; Mwacharo J; Musyoki J; Otieno E; Ahlborg N; Bejon P; Ndungu FM; Farnert A
Article: IMMUNITY. 2021;54(5):988-1001.e5
Positive selection of IgG⁺ over IgM⁺ B cells in the germinal center reaction
Sundling C; Lau AWY; Bourne K; Young C; Laurianto C; Hermes JR; Menzies RJ; Butt D; Krautler NJ; Zahra D; Suan D; Brink R
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1313
Generation of plasma cells and CD27^-IgD^- B cells during hantavirus infection is associated with distinct pathological findings
Kerkman PF; Dernstedt A; Tadala L; Mittler E; Dannborg M; Sundling C; Maleki KT; Tauriainen J; Tuiskunen-Back A; Wigren Bystrom J; Ocaya P; Thunberg T; Jangra RK; Roman-Sosa G; Guardado-Calvo P; Rey FA; Klingstrom J; Chandran K; Puhar A; Ahlm C; Forsell MNE
Article: PLOS ONE. 2021;16(1):e0245431
A longitudinal study of plasma BAFF levels in mothers and their infants in Uganda, and correlations with subsets of B cells
Ronnberg C; Lugaajju A; Nyman A; Hammar U; Bottai M; Lautenbach MJ; Sundling C; Kironde F; Persson KEM
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:727300
High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids
Silva CS; Sundling C; Folkesson E; Froberg G; Nobrega C; Canto-Gomes J; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Kallenius G
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2020;481:112792
Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers
Silva MH; Lepzien R; Ols S; Dahlberg B; Grunewald J; Lore K; Smed-Sorensen A; Correia-Neves M; Empadinhas N; Farnert A; Kallenius G; Sundling C
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2020;478:112715
Multiplex analysis of antigen-specific memory B cells in humans using reversed B-cell FluoroSpot
Jahnmatz P; Sundling C; Makower B; Sonden K; Farnert A; Ahlborg N
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(2):e20191155
Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses
Phad GE; Pushparaj P; Tran K; Dubrovskaya V; Adori M; Martinez-Murillo P; Bernat NV; Singh S; Dionne G; O'Dell S; Bhullar K; Narang S; Sorini C; Villablanca EJ; Sundling C; Murrell B; Mascola JR; Shapiro L; Pancera M; Martin M; Corcoran M; Wyatt RT; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:619398
Memory B-Cell Responses Against Merozoite Antigens After Acute Plasmodium falciparum Malaria, Assessed Over One Year Using a Novel Multiplexed FluoroSpot Assay
Jahnmatz P; Sundling C; Yman V; Widman L; Asghar M; Sonden K; Stenstrom C; Smedman C; Ndungu F; Ahlborg N; Farnert A
Article: JCI INSIGHT. 2019;4(9):126492
B cell profiling in malaria reveals expansion and remodeling of CD11c⁺ B cell subsets
Sundling C; Ronnberg C; Yman V; Asghar M; Jahnmatz P; Lakshmikanth T; Chen Y; Mikes J; Forsell MN; Sonden K; Achour A; Brodin P; Persson KEM; Farnert A
Article: BMC MEDICINE. 2019;17(1):22
Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure
Yman V; White MT; Asghar M; Sundling C; Sonden K; Draper SJ; Osier FHA; Farnert A
Article: JCI INSIGHT. 2018;3(5):97018
Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site
Cheng HD; Grimm SK; Gilman MSA; Gwom LC; Sok D; Sundling C; Donofrio G; Hedestam GBK; Bonsignori M; Haynes BF; Lahey TP; Maro I; von Reyn CF; Gorny MK; Zolla-Pazner S; Walker BD; Alter G; Burton DR; Robb ML; Krebs SJ; Seaman MS; Bailey-Kellogg C; Ackerman ME
Article: CELL. 2017;169(5):891-904.e15
Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability
Zhao X; Howell KA; He S; Brannan JM; Wec AZ; Davidson E; Turner HL; Chiang C-I; Lei L; Fels JM; Vu H; Shulenin S; Turonis AN; Kuehne AI; Liu G; Ta M; Wang Y; Sundling C; Xiao Y; Spence JS; Doranz BJ; Holtsberg FW; Ward AB; Chandran K; Dye JM; Qiu X; Li Y; Aman MJ
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(5):1259-1267
Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
Kraeutler NJ; Suan D; Butt D; Bourne K; Hermes JR; Chan TD; Sundling C; Kaplan W; Schofield P; Jackson J; Basten A; Christ D; Brink R
Article: JOURNAL OF IMMUNOLOGY. 2016;196(9):3729-3743
High-Resolution Longitudinal Study of HIV-1 Env Vaccine-Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence
Wang Y; Sundling C; Wilson R; O'Dell S; Chen Y; Dai K; Phad GE; Zhu J; Xiao Y; Mascola JR; Hedestam GBK; Wyatt RT; Li Y
Article: SCIENTIFIC REPORTS. 2016;6:20987
HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation
Dai K; Khan SN; Wang Y; He L; Guenaga J; Ingale J; Sundling C; O'Dell S; McKee K; Phad G; Corcoran M; Wilson R; Mascola JR; Zhu J; Li Y; Hedestam GBK; Wyatt RT
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:242-10
CD138 and CD31 Double-Positive Cells Comprise the Functional Antibody-Secreting Plasma Cell compartment in Primate Bone Marrow
Martinez-Murillo P; Pramanik L; Sundling C; Hultenby K; Wretenberg P; Spangberg M; Hedestam GBK
Article: MBIO. 2015;6(6):e01375-e01315
Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis
Dai K; He L; Khan SN; O'Dell S; McKee K; Tran K; Li Y; Sundling C; Morris CD; Mascola JR; Hedestam GBK; Wyatt RT; Zhu J
Article: JOURNAL OF IMMUNOLOGY. 2015;194(12):5903-5914
Diverse Antibody Genetic and Recognition Properties Revealed following HIV-1 Envelope Glycoprotein Immunization
Phad GE; Bernat NV; Feng Y; Ingale J; Murillo PAM; O'Dell S; Li Y; Mascola JR; Sundling C; Wyatt RT; Hedestam GBK
Article: SCIENTIFIC REPORTS. 2015;5:8925
Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation
Martinez P; Sundling C; O'Dell S; Mascola JR; Wyatt RT; Hedestam GBK
Article: PLOS PATHOGENS. 2014;10(8):e1004337
HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization
Navis M; Karen T; Bale S; Phad GE; Guenaga J; Wilson R; Soldemo M; McKee K; Sundling C; Mascola J; Li Y; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2014;408:137-141
A simple and safe technique for longitudinal bone marrow aspiration in cynomolgus and rhesus macaques
Spangberg M; Martinez P; Fredlund H; Hedestam GBK; Sundling C
Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3637-3644
Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization
Sundling C; Zhang Z; Phad GE; Sheng Z; Wang Y; Mascola JR; Li Y; Wyatt RT; Shapiro L; Hedestam GBK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):E738-E747
Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign
Tran K; Poulsen C; Guenaga J; de Val N; Wilson R; Sundling C; Li Y; Stanfield RL; Wilson IA; Ward AB; Hedestam GBK; Wyatt RT
Article: JOURNAL OF INFECTIOUS DISEASES. 2013;207(3):426-431
Immunization of Macaques With Soluble HIV Type 1 and Influenza Virus Envelope Glycoproteins Results in a Similarly Rapid Contraction of Peripheral B-Cell Responses After Boosting
Sundling C; Martinez P; Soldemo M; Spangberg M; Bengtsson KL; Stertman L; Forsell MNE; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;386(1-2):85-93
Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells
Sundling C; Phad G; Douagi I; Navis M; Hedestam GBK
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(142):142ra96
High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site
Sundling C; Li Y; Huynh N; Poulsen C; Wilson R; O'Dell S; Feng Y; Mascola JR; Wyatt RT; Hedestam GBK
Journal article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(142)
Neutralizing HIV
Sundling C; Li Y; Huynh N; Poulsen C; Wilson R; O'Dell S; Feng Y; Mascola JR; Wyatt RT; Hedestam GBK
Article: IMMUNOLOGY. 2011;134(3):257-269
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation
Gujer C; Sundling C; Seder RA; Hedestam GBK; Lore K
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;89(6):811-821
IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation
Gujer C; Sandgren KJ; Douagi I; Adams WC; Sundling C; Smed-Sorensen A; Seder RA; Hedestam GBK; Lore K
Article: JOURNAL OF VIROLOGY. 2010;84(18):9086-9095
Immunization with Wild-Type or CD4-Binding-Defective HIV-1 Env Trimers Reduces Viremia Equivalently following Heterologous Challenge with Simian-Human Immunodeficiency Virus
Sundling C; O'Dell S; Douagi I; Forsell MN; Morner A; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(9):2003-2017
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2010;84(4):1683-1695
Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates
Douagi I; Forsell MNE; Sundling C; O'Dell S; Feng Y; Dosenovic P; Li Y; Seder R; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):1991-2001
Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells
Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Hedestam GBK; Lore K
Article: JOURNAL OF VIROLOGY. 2009;83(2):540-551
Human Immunodeficiency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein
Moerner A; Douagi I; Forsell MNE; Sundling C; Dosenovic P; O'Dell S; Dey B; Kwong PD; Voss G; Thorstensson R; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF GENERAL VIROLOGY. 2008;89(Pt 12):2954-2964
CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization
Sundling C; Schon K; Morner A; Forsell MNE; Wyatt RT; Thorstensson R; Hedestam GBK; Lycke NY
Article: JOURNAL OF GENERAL VIROLOGY. 2007;88(Pt 10):2774-2779
Increased human immunodeficiency virus type 1 Env expression and antibody induction using an enhanced alphavirus vector
Forsell MNE; McInerney GM; Dosenovic P; Hidmark AS; Eriksson C; Liljestorm P; Grundner C; Hedestam GBK
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Employments

Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2023
Degree Of Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2013

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