Christopher Grigsby

About me
Publications
Grants
Public outreach and news

About me

Postdoctoral researcher since 2016 investigating the role of biomaterials in
direct cellular reprogramming for the treatment of neurodegenerative disease.
*Previously*
* PhD in Biomedical Engineering from Duke University [2007-2014]
* BS in Bioengineering from the University of California, Berkeley
[2001-2005]

Articles

Article: ADVANCED HEALTHCARE MATERIALS. 2023;12(27):e2301148
Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy
Geng H; Lupton EJ; Ma Y; Sun R; Grigsby CL; Brachi G; Li X; Zhou K; Stuckey DJ; Stevens MM
Article: ADVANCED MATERIALS. 2023;35(41):e2300305
Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering
Ritzau-Reid KI; Callens SJP; Xie R; Cihova M; Reumann D; Grigsby CL; Prados-Martin L; Wang R; Moore AC; Armstrong JPK; Knoblich JA; Stevens MM
Article: SMALL. 2022;18(36):e2202303
Polysaccharide-Polyplex Nanofilm Coatings Enhance Nanoneedle-Based Gene Delivery and Transfection Efficiency
Hachim D; Zhao J; Bhankharia J; Nunez-Toldra R; Brito L; Seong H; Becce M; Ouyang L; Grigsby CL; Higgins SG; Terracciano CM; Stevens MM
Journal article: CIRCULATION. 2021;144(Suppl_1):a10747
Abstract 10747: Genetic Enhancement of Epicardial Paracrine Signalling for Cardiac Regeneration
Brito L; Mylonaki I; Grigsby CL; Seong H; Higgins SG; Smart N; Noseda M; Rosenthal N; Harding S; Stevens M
Article: BIOMATERIALS SCIENCE. 2021;9(15):5175-5191
Enhanced efficiency of nonviral direct neuronal reprogramming on topographical patterns
Mattiassi S; Rizwan M; Grigsby CL; Zaw AM; Leong KW; Yim EKF
Article: ADVANCED FUNCTIONAL MATERIALS. 2020;30(42):2003710
An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
Ritzau-Reid KI; Spicer CD; Gelmi A; Grigsby CL; Ponder JFJ; Bemmer V; Creamer A; Vilar R; Serio A; Stevens MM
Article: ACS CENTRAL SCIENCE. 2020;6(5):695-703
Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation
Moroz-Omori EV; Satyapertiwi D; Ramel M-C; Hogset H; Sunyovszki IK; Liu Z; Wojciechowski JP; Zhang Y; Grigsby CL; Brito L; Bugeon L; Dallman MJ; Stevens MM
Article: ACS NANO. 2020;14(5):5711-5727
Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer
Blakney AK; Zhu Y; McKay PF; Bouton CR; Yeow J; Tang J; Hu K; Samnuan K; Grigsby CL; Shattock RJ; Stevens MM
Article: CELL REPORTS. 2020;31(5):107601
Srebf1 Controls Midbrain Dopaminergic Neurogenesis
Toledo EM; Yang S; Gyllborg D; van Wijk KE; Sinha I; Varas-Godoy M; Grigsby CL; Lonnerberg P; Islam S; Steffensen KR; Linnarsson S; Arenas E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986
Modeling the transport of nuclear proteins along single skeletal muscle cells
Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
Article: ACS NANO. 2014;8(10):10026-10034
Shape-Controlled Synthesis of Hybrid Nanomaterials via Three-Dimensional Hydrodynamic Focusing
Lu M; Yang S; Ho Y-P; Grigsby CL; Leong KW; Huang TJ
Article: ACS NANO. 2014;8(1):332-339
Three-Dimensional Hydrodynamic Focusing Method for Polyplex Synthesis
Lu M; Ho Y-P; Grigsby CL; Nawaz AA; Leong KW; Huang TJ
Article: SCIENTIFIC REPORTS. 2013;3:3155
Microfluidic Preparation of Polymer-Nucleic Acid Nanocomplexes Improves Nonviral Gene Transfer
Grigsby CL; Ho Y-P; Lin C; Engbersen JFJ; Leong KW
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2012;1(7):e32
Nonviral Direct Conversion of Primary Mouse Embryonic Fibroblasts to Neuronal Cells
Adler AF; Grigsby CL; Kulangara K; Wang H; Yasuda R; Leong KW
Article: JOURNAL OF CONTROLLED RELEASE. 2012;160(1):48-56
Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models
Loo Y; Grigsby CL; Yamanaka YJ; Chellappan MK; Jiang X; Mao H-Q; Leong KW
Article: CIRCULATION. 2011;124(17):1838-U159
Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy
Chen S; Law CS; Grigsby CL; Olsen K; Hong T-T; Zhang Y; Yeghiazarians Y; Gardner DG
Article: NANO LETTERS. 2011;11(5):2178-2182
Tuning Physical Properties of Nanocomplexes through Microfluidics-Assisted Confinement
Ho Y-P; Grigsby CL; Zhao F; Leong KW
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2010;122(5):326-332
A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation
Chen S; Law CS; Grigsby CL; Olsen K; Gardner DG
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(6):1647-1658
Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents
Chen S; Grigsby CL; Law CS; Ni X; Nekrep N; Olsen K; Humphreys MH; Gardner DG
Article: HYPERTENSION. 2008;52(6):1106-1112
Expression of the Vitamin D Receptor Is Increased in the Hypertrophic Heart
Chen S; Glenn DJ; Ni W; Grigsby CL; Olsen K; Nishimoto M; Law CS; Gardner DG
Article: KIDNEY INTERNATIONAL. 2007;72(3):300-306
Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells
Chen S; Olsen K; Grigsby C; Gardner DG
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All other publications

Editorial comment: NATURE MATERIALS. 2022;21(9):989-992
Ascendancy of semi-synthetic biomaterials from design towards democratization
Speidel AT; Grigsby CL; Stevens MM
Conference publication: TISSUE ENGINEERING PART A. 2022;28:S36-S37
POLYHYDROXYALKANOATES, NATURAL MATERIALS OF BACTERIAL ORIGIN, IDEAL FOR CARDIAC TISSUE ENGINEERING
Roy I; Dubey P; Majid Q; Fricker A; Gregory D; Grigsby C; Stevens MM; Terracciano C; Harding SE
Conference publication: TISSUE ENGINEERING PART A. 2022;28:S37
POLYSACCHARIDE-POLYPLEX ULTRATHIN COATINGS FOR NANONEEDLE-BASED GENE DELIVERY
Hachim D; Zhao J; Bhankharia J; Seong H; Brito L; Grigsby C; Becce M; Stevens M
Conference publication: CIRCULATION. 2021;144
Genetic Enhancement of Epicardial Paracrine Signalling for Cardiac Regeneration
Brito L; Mylonaki I; Grigsby CL; Seong H; Higgins SG; Smart N; Noseda M; Rosenthal N; Harding S; Stevens M
Conference publication: HUMAN GENE THERAPY. 2019;30(2):A9
Epicardial cell transfection with cationic polymeric nanocomplexes
Brito L; Mylonaki I; Moroz E; Grigsby C; Smart N; Rosenthal N; Harding SE; Stevens MM
Review: NANO TODAY. 2016;11(6):778-792
Microfluidic hydrodynamic focusing for synthesis of nanomaterials
Lu M; Ozcelik A; Grigsby CL; Zhao Y; Guo F; Leong KW; Huang TJ
Review: NANOMEDICINE. 2012;7(4):565-577
Understanding nonviral nucleic acid delivery with quantum dot-FRET nanosensors
Grigsby CL; Ho Y-P; Leong KW
Conference publication: CIRCULATION. 2011;124(21)
Induction of Modulatory Calcineurin Inhibitory Protein 1 as a Potential Mechanism Leading to Cardiac Hypertrophy in the Cardiomyocyte-Specific Vitamin D Receptor Gene-Deleted Mouse
Chen S; Law CS; Grigsby CL; Olsen K; Hong T-T; Zhang Y; Yeghiazarians Y; Gardner DG
Review: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2010;7(Suppl 1):S67-S82
Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery
Grigsby CL; Leong KW
Conference publication: HYPERTENSION. 2008;52(4):E47
Vitamin D-dependent suppression of rat aortic smooth muscle cell proliferation through key cell cycle phosphatase Cdc25A
Chen S; Law CS; Grigsby CL; Olsen K; Gardner DG
Review: HYPERTENSION. 2007;49(3):419-426
Molecular biology of the natriuretic peptide system - Implications for physiology and hypertension
Gardner DG; Chen S; Glenn DJ; Grigsby CL
Conference publication: HYPERTENSION. 2006;48(4):E58
NFAT5 mediates osmotic regulation of sgk1 gene transcription
Chen S; Nekrep N; Grigsby C; Olsen K; Gardner DG

Grants

Oral Factor VIII Gene Delivery: A Non-viral Therapy against Hemophilia A
American Heart Association
1 July 2010 - 30 June 2012

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