Christian Riedel

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About me

I am a group leader at the Department of Medicine, Huddinge. My lab works on the regulation of aging and age-related diseases.
Please click on the following links to our lab websites for more information:

https://ki.se/en/research/research-areas-centres-and-networks/research-groups/ageing-basic-mechanisms-and-interventions-christian-riedels-research-group

http://riedellab.org

Articles

Article: GENOMICS. 2024;116(4):110858

Cactus: A user-friendly and reproducible ATAC-Seq and mRNA-Seq analysis pipeline for data preprocessing, differential analysis, and enrichment analysis.

Salignon J; Millan-Ariño L; Garcia MU; Riedel CG
Article: NATURE COMMUNICATIONS. 2024;15(1):2320

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.

Emerson FJ; Chiu C; Lin LY; Riedel CG; Zhu M; Lee SS
Article: BMC BIOLOGY. 2024;22(1):48

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway.

Coschiera A; Yoshihara M; Lauter G; Ezer S; Pucci M; Li H; Kavšek A; Riedel CG; Kere J; Swoboda P
Article: CELL STRESS. 2023;7(12):105-111

A versatile method for the identification of senolytic compounds.

Annunziata C; Castoldi F; Jan S; Ang HX; Ristovska M; Melini S; Welch R; Riedel CG; Pietrocola F
Article: DEVELOPMENT. 2023;150(21):dev201755

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.

Robert VJ; Caron M; Gely L; Adrait A; Pakulska V; Couté Y; Chevalier M; Riedel CG; Bedet C; Palladino F
Journal article: DEVELOPMENT. 2023;150(21):dev201755

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.

Robert VJ; Caron M; Gely L; Adrait A; Pakulska V; Couté Y; Chevalier M; Riedel CG; Bedet C; Palladino F
Article: AGING-US. 2023;15(12):5240-5265

Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis.

Salignon J; Faridani OR; Miliotis T; Janssens GE; Chen P; Zarrouki B; Sandberg R; Davidsson P; Riedel CG
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(1):158-166

Beyond Chronological Age: A Multidimensional Approach to Survival Prediction in Older Adults.

Salignon J; Rizzuto D; Calderón-Larrañaga A; Zucchelli A; Fratiglioni L; Riedel CG; Vetrano DL
Article: AGING-US. 2022;14(2):530-543

Meeting Report: Aging Research and Drug Discovery

Meron E; Thaysen M; Angeli S; Antebi A; Barzilai N; Baur JA; Bekker-Jensen S; Birkisdottir M; Bischof E; Bruening J; Brunet A; Buchwalter A; Cabreiro F; Cai S; Chen BH; Ermolaeva M; Ewald CY; Ferrucci L; Florian MC; Fortney K; Freund A; Georgievskaya A; Gladyshev VN; Glass D; Golato T; Gorbunova V; Hoejimakers J; Houtkooper RH; Jager S; Jaksch F; Janssens G; Jensen MB; Kaeberlein M; Karsenty G; de Keizer P; Kennedy B; Kirkland JL; Kjaer M; Kroemer G; Lee K-F; Lemaitre J-M; Liaskos D; Longo VD; Lu Y-X; MacArthur MR; Maier AB; Manakanatas C; Mitchell SJ; Moskalev A; Niedernhofer L; Ozerov I; Partridge L; Passegue E; Petr MA; Peyer J; Radenkovic D; Rando TA; Rattan S; Riedel CG; Rudolph L; Ai R; Serrano M; Schumacher B; Sinclair DA; Smith R; Suh Y; Taub P; Trapp A; Trendelenburg A-U; Valenzano DR; Verburgh K; Verdin E; Vijg J; Westendorp RGJ; Zonari A; Bakula D; Zhavoronkov A; Scheibye-Knudsen M
Article: MOLECULAR METABOLISM. 2021;54:101329

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.

Casteels T; Zhang Y; Frogne T; Sturtzel C; Lardeau C-H; Sen I; Liu X; Hong S; Pauler FM; Penz T; Brandstetter M; Barbieux C; Berishvili E; Heuser T; Bock C; Riedel CG; Meyer D; Distel M; Hecksher-Sørensen J; Li J; Kubicek S
Article: CURRENT PROTOCOLS. 2021;1(7):e187

Chromatin Immunoprecipitation and Sequencing (ChIP-seq) Optimized for Application in Caenorhabditis elegans.

Sen I; Kavšek A; Riedel CG
Article: AGING-US. 2020;12(24):24484-24503

ARDD 2020: from aging mechanisms to interventions.

Mkrtchyan GV; Abdelmohsen K; Andreux P; Bagdonaite I; Barzilai N; Brunak S; Cabreiro F; de Cabo R; Campisi J; Cuervo AM; Demaria M; Ewald CY; Fang EF; Faragher R; Ferrucci L; Freund A; Silva-García CG; Georgievskaya A; Gladyshev VN; Glass DJ; Gorbunova V; de Grey A; He W-W; Hoeijmakers J; Hoffmann E; Horvath S; Houtkooper RH; Jensen MK; Jensen MB; Kane A; Kassem M; de Keizer P; Kennedy B; Karsenty G; Lamming DW; Lee K-F; MacAulay N; Mamoshina P; Mellon J; Molenaars M; Moskalev A; Mund A; Niedernhofer L; Osborne B; Pak HH; Parkhitko A; Raimundo N; Rando TA; Rasmussen LJ; Reis C; Riedel CG; Franco-Romero A; Schumacher B; Sinclair DA; Suh Y; Taub PR; Toiber D; Treebak JT; Valenzano DR; Verdin E; Vijg J; Young S; Zhang L; Bakula D; Zhavoronkov A; Scheibye-Knudsen M
Article: CURRENT PROTOCOLS IN PROTEIN SCIENCE. 2020;102(1):e114

Histone Purification Combined with High-Resolution Mass Spectrometry to Examine Histone Post-Translational Modifications and Histone Variants in Caenorhabditis elegans.

Millan-Ariño L; Yuan Z-F; Oomen ME; Brandenburg S; Chernobrovkin A; Salignon J; Körner L; Zubarev RA; Garcia BA; Riedel CG
Article: NATURE COMMUNICATIONS. 2020;11(1):138

DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes.

Sen I; Zhou X; Chernobrovkin A; Puerta-Cavanzo N; Kanno T; Salignon J; Stoehr A; Lin X-X; Baskaner B; Brandenburg S; Björkegren C; Zubarev RA; Riedel CG
Article: CELL REPORTS. 2019;27(2):467-480.e6

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging.

Janssens GE; Lin X-X; Millan-Ariño L; Kavšek A; Sen I; Seinstra RI; Stroustrup N; Nollen EAA; Riedel CG
Article: NATURE COMMUNICATIONS. 2018;9(1):4400

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.

Lin X-X; Sen I; Janssens GE; Zhou X; Fonslow BR; Edgar D; Stroustrup N; Swoboda P; Yates JR; Ruvkun G; Riedel CG
Article: CELL METABOLISM. 2015;22(1):151-163

The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.

Heimbucher T; Liu Z; Bossard C; McCloskey R; Carrano AC; Riedel CG; Tanasa B; Klammt C; Fonslow BR; Riera CE; Lillemeier BF; Kemphues K; Yates JR; O'Shea C; Hunter T; Dillin A
Article: NATURE CELL BIOLOGY. 2013;15(5):491-501

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

Riedel CG; Dowen RH; Lourenco GF; Kirienko NV; Heimbucher T; West JA; Bowman SK; Kingston RE; Dillin A; Asara JM; Ruvkun G
Article: CURRENT BIOLOGY. 2012;22(10):881-890

The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification.

Zhang C; Montgomery TA; Fischer SEJ; Garcia SMDA; Riedel CG; Fahlgren N; Sullivan CM; Carrington JC; Ruvkun G
Article: GENES & DEVELOPMENT. 2011;25(19):2079-2092

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.

Hayes GD; Riedel CG; Ruvkun G
Article: PLOS GENETICS. 2011;7(9):e1002235

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

Rizki G; Iwata TN; Li J; Riedel CG; Picard CL; Jan M; Murphy CT; Lee SS
Article: CELL CYCLE. 2010;9(20):4048-4049

Toward the mechanisms preventing merotelic kinetochore-microtubule attachments.

Riedel CG
Article: CELL CYCLE. 2010;9(13):2657-2662

Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

Rumpf C; Cipak L; Dudas A; Benko Z; Pozgajova M; Riedel CG; Ammerer G; Mechtler K; Gregan J
Article: NATURE. 2009;459(7250):1079-1U60

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.

Curran SP; Wu X; Riedel CG; Ruvkun G
Article: CURRENT BIOLOGY. 2007;17(14):1190-1200

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation.

Gregan J; Riedel CG; Pidoux AL; Katou Y; Rumpf C; Schleiffer A; Kearsey SE; Shirahige K; Allshire RC; Nasmyth K
Article: NATURE PROTOCOLS. 2007;2(5):1145-1151

Tandem affinity purification of functional TAP-tagged proteins from human cells.

Gregan J; Riedel CG; Petronczki M; Cipak L; Rumpf C; Poser I; Buchholz F; Mechtler K; Nasmyth K
Article: NATURE. 2006;441(7089):53-61

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Riedel CG; Katis VL; Katou Y; Mori S; Itoh T; Helmhart W; Gálová M; Petronczki M; Gregan J; Cetin B; Mudrak I; Ogris E; Mechtler K; Pelletier L; Buchholz F; Shirahige K; Nasmyth K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(45):37846-37852

Differential requirement for phospholipase D/Spo14 and its novel interactor Sma1 for regulation of exocytotic vesicle fusion in yeast meiosis.

Riedel CG; Mazza M; Maier P; Körner R; Knop M
Article: TRENDS IN BIOCHEMICAL SCIENCES. 2004;29(8):389-392

Is chromatin remodeling required to build sister-chromatid cohesion?

Riedel CG; Gregan J; Gruber S; Nasmyth K
Article: BIOTECHNIQUES. 2002;33(3):592-602

Improved version of the red fluorescent protein (drFP583/DsRed/RFP).

Knop M; Barr F; Riedel CG; Heckel T; Reichel C
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All other publications

Preprint: BIORXIV. 2023;BIORXIV

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.

Emerson FJ; Chiu C; Lin LY; Riedel CG; Zhu M; Lee SS
Preprint: BIORXIV. 2022

A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translation

Breusegem SY; Houghton J; Romero-Bueno R; Fragoso-Luna A; Kentistou KA; Ong KK; Janssen AFJ; Bright NA; Riedel CG; Perry JRB; Askjaer P; Larrieu D
Review: CURRENT GENOMICS. 2018;19(6):464-482

Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome.

Zhou X; Sen I; Lin X-X; Riedel CG
Book chapter: CHROMATIN REGULATION AND DYNAMICS. 2017;p. 95-116

Chapter 4 ATP-Dependent Chromatin Remodeling: From Development to Disease

Lezzerini M; Riedel CG
Other: CELL CYCLE. 2010;9(20):4048-4049

Toward the mechanisms preventing merotelic kinetochore-microtubule attachments.

Riedel CG

Grants

Discovery of new chromatin-related mechanisms that delay or prevent aging

Swedish Research Council

1 January 2024 - 31 December 2027
A new mechanism by which mitochondria modulate the outcomes of reduced insulin/IGF-like signaling and slow down the aging process

Novo Nordisk Foundation

1 January 2023 - 31 December 2024
Molecular Profiling and Novel Treatment Strategies of Vascular Ageing in Chronic Kidney Disease

Swedish Research Council

1 January 2022 - 31 December 2024
A new mechanism by which mitochondria modulate the outcomes of reduced insulin/IGF-like signaling and slow down the aging process

Novo Nordisk Foundation

1 January 2022 - 31 December 2022
New mechanistic insights into aging regulation by the transcription factor DAF-16/FOXO

Swedish Research Council

1 January 2020 - 31 December 2023
Disentangling complexity of health in aging: A new research environment to pave the road for individualized medicine

Swedish Research Council

1 December 2017 - 31 December 2022
Regulation of aging by DAF-16/FOXO, its cofactors, and the chromatin landscape

Swedish Research Council

1 January 2016 - 31 December 2019
Molecular mechanisms of longevity control

International Human Frontier Science Program Organization

1 May 2008 - 30 April 2011

Employments

Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Associate Professor, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 2024-
Professor, Chair of Nutritional Physiology, Faculty of Lifesciences, University of Bayreuth, 2023-2024
Assistant Professor, European Research Institute for the Biology of Ageing, University Medical Center Groningen, 2013-2015
Postdoctoral Fellow, Dept of Molecular Biology, Massachusetts General Hospital, 2007-2012

Degrees and Education

Molecular Biology, Research Institute of Molecular Pathology, 2006
Biochemistry, University of Tübingen, 2001

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