Christer Halldin

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2024;67(6):245-249
Validation of a good manufacturing practice procedure for the production of [¹¹C]AZD4747, a CNS penetrant KRAS^G12c inhibitor
Gonzalez MAC; Hognasbacka AA; Halldin C; Schou M
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2024;98(4):1391-1401
High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer's Disease Using [¹¹C]AZD2184
Mattsson P; Cselenyi Z; Moren AF; Freund-Levi Y; Wahlund L-O; Halldin C; Farde L
Article: CLINICAL CANCER RESEARCH. 2024;30(7):1338-1351
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1
Staniszewska AD; Pilger D; Gill SJ; Jamal K; Bohin N; Guzzetti S; Gordon J; Hamm G; Mundin G; Illuzzi G; Pike A; McWilliams L; Maglennon G; Rose J; Hawthorne G; Gonzalez MC; Halldin C; Johnstroem P; Schou M; Critchlow SE; Fawell S; Johannes JW; Leo E; Davies BR; Cosulich S; Sarkaria JN; O'Connor MJ; Hamerlik P
Article: PHARMACEUTICALS. 2024;17(2):250
Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[¹¹C]Methionine and [¹¹C]Choline
Mallapura H; Tanguy L; Mahfuz S; Bylund L; Langstrom B; Halldin C; Nag S
Article: MOLECULES. 2024;29(2):427
Synthesis of [¹¹C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non-Human Primate Brains Using Positron Emission Tomography
Nag S; Jia K; Arakawa R; Datta P; Scott D; Shaffer C; Moein MM; Hutchison M; Kaliszczak M; Halldin C
Article: EJNMMI RADIOPHARMACY AND CHEMISTRY. 2023;8(1):42
Microfluidic-based production of [⁶⁸Ga]Ga-FAPI-46 and [⁶⁸Ga]Ga-DOTA-TOC using the cassette-based iMiDEV™ microfluidic radiosynthesizer
Mallapura H; Ovdiichuk O; Jussing E; Thuy TA; Piatkowski C; Tanguy L; Collet-Defossez C; Langstrom B; Halldin C; Nag S
Article: NATURE COMMUNICATIONS. 2023;14(1):6750
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases
Smith R; Capotosti F; Schain M; Ohlsson T; Vokali E; Molette J; Touilloux T; Hliva V; Dimitrakopoulos IK; Puschmann A; Jogi J; Svenningsson P; Andreasson M; Sandiego C; Russell DS; Miranda-Azpiazu P; Halldin C; Stomrud E; Hall S; Bratteby K; Tampio L'Estrade E; Luthi-Carter R; Pfeifer A; Kosco-Vilbois M; Streffer J; Hansson O
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(20):3732-3736
Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [¹⁸F]FE-PE2I-OH for Translational Dopamine Transporter Imaging
Schou M; Amini N; Takano A; Arakawa R; Dahl K; Toth M; Svedberg M; Varrone A; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2023;64(10):1588-1593
Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain
Cook BE; Nag S; Arakawa R; Lin EY-S; Stratman N; Guckian K; Hering H; Lulla M; Choi J; Salinas C; Genung NE; Moren AF; Bolin M; Boscutti G; Plisson C; Martarello L; Halldin C; Kaliszczak MA
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(17):3206-3211
PET Evaluation of the Novel F-18 Labeled Reversible Radioligand [¹⁸F]GEH200449 for Detection of Monoamine Oxidase-B in the Non-Human Primate Brain
Varnas K; Nag S; Halldin C; Farde L
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(14):2560-2568
Development of a Novel [¹¹C]CO-Labeled Positron Emission Tomography Radioligand [¹¹C]BIO-1819578 for the Detection of O-GlcNAcase Enzyme Activity
Nag S; Bolin M; Datta P; Arakawa R; Moren AF; Maynaq YK; Lin E; Genung N; Hering H; Guckian K; Martarello L; Kaliszczak M; Halldin C
Article: MOVEMENT DISORDERS. 2023;38(7):1209-1222
Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial
Huttunen HJJ; Booms S; Sjogren M; Kerstens V; Johansson J; Holmnas R; Koskinen J; Kulesskaya N; Fazio P; Woolley M; Brady A; Williams J; Johnson D; Dailami N; Gray W; Levo R; Saarma M; Halldin C; Marjamaa J; Resendiz-Nieves J; Grubor I; Lind G; Eerola-Rautio J; Mertsalmi T; Andreasson M; Paul G; Rinne J; Kivisaari R; Bjartmarz H; Almqvist P; Varrone A; Scheperjans F; Widner H; Svenningsson P
Article: MOLECULES. 2023;28(12):4612
Characterization of a Novel M4 PAM PET Radioligand [11C]PF06885190 in Nonhuman Primates (NHP)
Nag S; Arakawa R; Jia Z; Lachapelle E; Zhang L; Maresca K; Chen L; Jahan M; Mccarthy T; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248
Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [¹¹C]AZ10419369 Positron Emission Tomography Study
Tangen A; Veldman ER; Svensson J; Tiger M; Nord M; Sorjonen K; Andersson M; Plaven-Sigray P; Varrone A; Halldin C; Varnas K; Borg J; Lundberg J
Article: EJNMMI RESEARCH. 2023;13(1):29
[¹⁸F]FE-PE2I DAT correlates with Parkinson's disease duration, stage, and rigidity/bradykinesia scores: a PET radioligand validation study
Kerstens VS; Fazio P; Sundgren M; Halldin C; Svenningsson P; Varrone A
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(2):258-268
Quantification of the purinergic P2X₇ receptor with [¹¹C]SMW139 improves through correction for brain-penetrating radiometabolites
Brumberg J; Aarnio R; Forsberg A; Marjamaki P; Kerstens V; Moein MM; Nag S; Wahlroos S; Kassiou M; Windhorst AD; Halldin C; Haaparanta-Solin M; Fazio P; Oikonen V; Rinne JO; Varrone A
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2023;66(1):641-656
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
Liu L; Johnson PD; Prime ME; Khetarpal V; Brown CJ; Anzillotti L; Bertoglio D; Chen X; Coe S; Davis R; Dickie AP; Esposito S; Gadouleau E; Giles PR; Greenaway C; Haber J; Halldin C; Haller S; Hayes S; Herbst T; Herrmann F; Hessmann M; Hsai MM; Khani Y; Kotey A; Lembo A; Mangette JE; Marriner GA; Marston RW; Mills MR; Monteagudo E; Forsberg-Moren A; Nag S; Orsatti L; Sandiego C; Schaertl S; Sproston J; Staelens S; Tookey J; Turner PA; Vecchi A; Veneziano M; Munoz-Sanjuan I; Bard J; Dominguez C
Article: NEUROIMAGE: CLINICAL. 2023;37:103347
Longitudinal DAT changes measured with [18F]FE-PE2I PET in patients with Parkinson?s disease; a validation study
Kerstens VS; Fazio P; Sundgren M; Brumberg J; Halldin C; Svenningsson P; Varrone A
Article: MOLECULES. 2022;27(24):8843
Production of [¹¹C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer
Mallapura H; Tanguy L; Langstrom B; Le Meunier L; Halldin C; Nag S
Article: JOURNAL OF NUCLEAR MEDICINE. 2022;63(12):1919-1924
First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B
Wakabayashi Y; Stenkrona P; Arakawa R; Yan X; Van Buskirk MG; Jenkins MD; Santamaria JAM; Maresca KP; Takano A; Liow J-S; Chappie TA; Varrone A; Nag S; Zhang L; Hughes ZA; Schmidt CJ; Doran SD; Mannes A; Zanotti-Fregonara P; Ooms M; Morse CL; Zoghbi SS; Halldin C; Pike VW; Innis RB
Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(10):1863-1868
In vivo correlation of serotonin transporter and 1B receptor availability in the human brain: a PET study
Svensson JE; Tiger M; Plaven-Sigray P; Halldin C; Schain M; Lundberg J
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2022;65(10-11):288-291
Simplified and accessible [¹⁸F]F-AraG synthesis procedure for preclinical PET
Hognasbacka AA; Gonzalez MAC; Halldin C; Schou M
Article: ACS CHEMICAL NEUROSCIENCE. 2022;13(14):2078-2083
Synthesis and Preclinical Evaluation of [¹¹C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor
Dahl K; Johnstrom P; Forsberg-Moren A; Gustafsson B; Miranda-Azpiazu P; Khani Y; Halldin C; Farde L; Elmore CS; Schou M
Article: SYNAPSE. 2022;76(7-8):e22235
Decreased 5-HT_1A binding in mild Alzheimer's disease-A positron emission tomography study
Mattsson P; Cselenyi Z; Andree B; Borg J; Nag S; Halldin C; Farde L
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022;42(4):630-641
Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography
Veldman ER; Varrone A; Varnas K; Svedberg MM; Cselenyi Z; Tiger M; Gulyas B; Halldin C; Lundberg J
Article: EJNMMI RESEARCH. 2022;12(1):13
Target occupancy study and whole-body dosimetry with a MAGL PET ligand [¹¹C]PF-06809247 in non-human primates
Arakawa R; Takano A; Nag S; Jia Z; Amini N; Maresca KP; Zhang L; Keliher EJ; Butler CR; Piro JR; Samad TA; Smith D; Nason D; O'Neil S; Trapa P; Fonseca KR; Litchfield J; McCarthy T; Carson RE; Halldin C
Article: ACS CHEMICAL NEUROSCIENCE. 2022;13(3):352-362
Development of C-11-Labeled ASEM Analogues for the Detection of Neuronal Nicotinic Acetylcholine Receptors (alpha 7-nAChR)
Nag S; Miranda-Azpiazu P; Jia Z; Datta P; Arakawa R; Moein MM; Yang Z; Tu Y; Lemoine L; Agren H; Nordberg A; Langstrom B; Halldin C
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240
Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
Plaven-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: ACS CHEMICAL NEUROSCIENCE. 2021;12(24):4580-4586
PET Imaging of VMAT2 with the Novel Radioligand [¹⁸F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [¹¹C]DTBZ and [¹⁸F]FE-DTBZ
Nag S; Jahan M; Toth M; Nakao R; Varrone A; Halldin C
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2021;64(16):12003-12021
[¹¹C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
Liu L; Johnson PD; Prime ME; Khetarpal V; Lee MR; Brown CJ; Chen X; Clark-Frew D; Coe S; Conlon M; Davis R; Ensor S; Esposito S; Moren AF; Gai X; Green S; Greenaway C; Haber J; Halldin C; Hayes S; Herbst T; Herrmann F; He-mann M; Hsai MM; Kotey A; Mangette JE; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Varnas K; Varrone A; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
Article: LAB ON A CHIP. 2021;21(11):2272-2282
Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production
Ovdiichuk O; Mallapura H; Pineda F; Hourtane V; Langstrom B; Halldin C; Nag S; Maskali F; Karcher G; Collet C
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):264
Serotonin transporter availability increases in patients recovering from a depressive episode
Svensson JE; Svanborg C; Plaven-Sigray P; Kaldo V; Halldin C; Schain M; Lundberg J
Article: MOLECULAR PSYCHIATRY. 2021;26(5):1647-1658
Serotonin transporter availability in adults with autism-a positron emission tomography study
Andersson M; Tangen A; Farde L; Bolte S; Halldin C; Borg J; Lundberg J
Article: NEURO-ONCOLOGY. 2021;23(4):687-696
Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study
Jucaite A; Stenkrona P; Cselenyi Z; De Vita S; Buil-Bruna N; Varnas K; Savage A; Varrone A; Johnstrom P; Schou M; Davison C; Sykes A; Reddy VP; Hoch M; Vazquez-Romero A; Moein MM; Halldin C; Merchant MS; Pass M; Farde L
Article: RSC ADVANCES. 2021;11(7):3942-3951
In silico studies of ASEM analogues targeting α7-nAChR and experimental verification
Zhou Y; Kuang G; Li J; Halldin C; Nordberg A; Langstrom B; Tu Y; Agren H
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(2):951
An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [¹¹C]PBR28 and [¹⁸F]flumazenil PET Imaging
Ghosh KK; Padmanabhan P; Yang C-T; Wang Z; Palanivel M; Ng KC; Lu J; Carlstedt-Duke J; Halldin C; Gulyas B
Article: BRITISH JOURNAL OF ANAESTHESIA. 2021;126(1):238-244
Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo
Varnas K; Finnema SJ; Johnstrom P; Arakawa R; Halldin C; Eriksson LI; Farde L
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(24):4398-4404
Synthesis and Autoradiography of Novel F-18 Labeled Reversible Radioligands for Detection of Monoamine Oxidase B
Nag S; Jia Z; Svedberg M; Jackson A; Ahmad R; Luthra S; Varnas K; Farde L; Halldin C
Article: MOLECULAR BRAIN. 2020;13(1):164
Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice
Vanan S; Zeng X; Chia SY; Varnas K; Jiang M; Zhang K; Saw WT; Padmanabhan P; Yu W-P; Zhou Z-D; Halldin C; Gulyas B; Tan E-K; Zeng L
Article: SYNAPSE. 2020;74(10):e22157
Autoradiographic mapping of synaptic vesicle glycoprotein 2A in non-human primate and human brain
Varnas K; Stepanov V; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2020;63(12):517-522
Development of a fully automated low-pressure [¹¹C]CO carbonylation apparatus
Ferrat M; El Khoury Y; Larsen P; Dahl K; Halldin C; Schou M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(10):2407-2416
High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson's disease cohort
Fazio P; Ferreira D; Svenningsson P; Halldin C; Farde L; Westman E; Varrone A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(10):2429-2439
PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [¹⁸F]PF-06684511
Arakawa R; Takano A; Stenkrona P; Stepanov V; Nag S; Jahan M; Gryback P; Bolin M; Chen L; Zhang L; He P; Villalobos A; McCarthy TJ; Halldin C; Varrone A
Article: EJNMMI RESEARCH. 2020;10(1):95
Reliability of dopamine transporter PET measurements with [¹⁸F]FE-PE2I in patients with Parkinson's disease
Kerstens VS; Fazio P; Sundgren M; Matheson GJ; Franzen E; Halldin C; Cervenka S; Svenningsson P; Varrone A
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(15):8608-8633
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
Liu L; Prime ME; Lee MR; Khetarpal V; Brown CJ; Johnson PD; Miranda-Azpiazu P; Chen X; Clark-Frew D; Coe S; Davis R; Dickie A; Ebneth A; Esposito S; Gadouleau E; Gai X; Galan S; Green S; Greenaway C; Giles P; Halldin C; Hayes S; Herbst T; Herrmann F; Hessmann M; Jia Z; Kiselyov A; Kotey A; Krulle T; Mangette JE; Marston RW; Menta S; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Svedberg M; Takano A; Taylor M; Thomas W; Toth M; Vaidya D; Vanras K; Weddell D; Wigginton I; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
Article: EJNMMI RESEARCH. 2020;10(1):59
Quantification and reliability of [¹¹C]VC-002 binding to muscarinic acetylcholine receptors in the human lung - a test-retest PET study in control subjects
Cselenyi Z; Jucaite A; Kristensson C; Stenkrona P; Ewing P; Varrone A; Johnstrom P; Schou M; Vazquez-Romero A; Moein MM; Bolin M; Siikanen J; Gryback P; Larsson B; Halldin C; Grime K; Eriksson UG; Farde L
Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):159
A randomized placebo-controlled PET study of ketamine′s effect on serotonin_1B receptor binding in patients with SSRI-resistant depression
Tiger M; Veldman ER; Ekman C-J; Halldin C; Svenningsson P; Lundberg J
Article: MOVEMENT DISORDERS. 2020;35(4):606-615
PET molecular imaging of phosphodiesterase 10A: An early biomarker of Huntington's disease progression
Fazio P; Fitzer-Attas CJ; Mrzljak L; Bronzova J; Nag S; Warner JH; Landwehrmeyer B; Al-Tawil N; Halldin C; Forsberg A; Ware J; Dilda V; Wood A; Sampaio C; Varrone A; Svenningsson P; Paucar M; Sundblom J; Nyholm D; Widner H; Heiberg A; Frich J; Nielsen J; Hjermind L; Roos R
Article: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2020;74(4):263-269
[¹¹C]raclopride positron emission tomography study of dopamine-D_2/3 receptor binding in patients with severe major depressive episodes before and after electroconvulsive therapy and compared to control subjects
Tiger M; Svensson J; Liberg B; Saijo T; Schain M; Halldin C; Farde L; Lundberg J
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2020;40(4):799-807
A PET study in healthy subjects of brain exposure of ¹¹C-labelled osimertinib - A drug intended for treatment of brain metastases in non-small cell lung cancer
Varrone A; Varnas K; Jucaite A; Cselenyi Z; Johnstrom P; Schou M; Vazquez-Romero A; Moein MM; Halldin C; Brown AP; Vishwanathan K; Farde L
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(7):1048-1057
Synthesis, Biodistribution, and Radiation Dosimetry of a Novel mGluR5 Radioligand: ¹⁸F-AZD9272
Nag S; Varnas K; Arakawa R; Jahan M; Schou M; Farde L; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2020;63(3):100-107
"In-loop" carbonylation-A simplified method for carbon-11 labelling of drugs and radioligands
Ferrat M; Dahl K; Halldin C; Schou M
Article: TALANTA. 2020;208:120449
New approach in radiometabolite analysis of positron emission tomography (PET) radioligands; lead-shielded microextraction by packed sorbent as a tool for in vivo radiometabolite analysis of [¹¹C]SMW139 in rat plasma
Moein MM; Toth M; Tari L; Varrone A; Abdel-Rehim M; Halldin C
Article: NEUROPHARMACOLOGY. 2020;162:107809
The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans
Varnas K; Cselenyi Z; Arakawa R; Nag S; Stepanov V; Moein MM; Johnstrom P; Kingston L; Elmore CS; Halldin C; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 2019;60(12):1818-1824
Performance Evaluation of a High-Resolution Nonhuman Primate PET/CT System
Sarnyai Z; Nagy K; Patay G; Molnar M; Rosenqvist G; Toth M; Takano A; Gulyas B; Major P; Halldin C; Varrone A
Article: EJNMMI RESEARCH. 2019;9(1):100
Potential for imaging the high-affinity state of the 5-HT_1B receptor: a comparison of three PET radioligands with differing intrinsic activity
Lindberg A; Arakawa R; Nogami T; Nag S; Schou M; Elmore CS; Farde L; Pike VW; Halldin C
Article: NEUROIMAGE. 2019;202:116143
Validity and reliability of extrastriatal [¹¹C]raclopride binding quantification in the living human brain
Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Article: CELLS. 2019;8(11):E1420-1420
The Effect of Sertoli Cells on Xenotransplantation and Allotransplantation of Ventral Mesencephalic Tissue in a Rat Model of Parkinson's Disease
Jhao Y-T; Chiu C-H; Chen C-FF; Chou T-K; Lin Y-W; Ju Y-T; Wu S-C; Yan R-F; Shiue C-Y; Chueh S-H; Halldin C; Cheng C-Y; Ma K-H
Article: NUCLEAR MEDICINE AND BIOLOGY. 2019;78-79:11-16
Development of a ¹⁸F-labeled PET radioligand for imaging 5-HT_1B receptors: [¹⁸F]AZ10419096
Lindberg A; Nag S; Schou M; Arakawa R; Nogami T; Moein MM; Elmore CS; Pike VW; Halldin C
Article: SCIENTIFIC REPORTS. 2019;9(1):14960
Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates
Eriksson O; Velikyan I; Haack T; Bossart M; Evers A; Laitinen I; Larsen PJ; Plettenburg O; Takano A; Halldin C; Antoni G; Johansson L; Pierrou S; Wagner M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338
Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [¹¹C]PBR28 HRRT PET study
Tuisku J; Plaven-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Bruck A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamaki P; Rissanen E; Sucksdorff M; Varrone A; Collste K; Gallezot J-D; Hillmer A; Huang Y; Hoglund CO; Johansson J; Jucaite A; Lampa J; Nabulsi N; Pittman B; Sandiego CM; Stenkrona P; Rinne J; Matuskey D; Cervenka S
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2019;62(18):8532-8543
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity
Zhang L; Butler CR; Maresca KP; Takano A; Nag S; Jia Z; Arakawa R; Piro JR; Samad T; Smith DL; Nason DM; O'Neil S; McAllister L; Schildknegt K; Trapa P; McCarthy TJ; Villalobos A; Halldin C
Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2019;59(9):3910-3918
Enhanced Sampling Simulations of Ligand Unbinding Kinetics Controlled by Protein Conformational Changes
Zhou Y; Zou R; Kuang G; Angstrom B; Halidin C; Agren H; Tu Y
Article: JOURNAL OF NEUROIMMUNOLOGY. 2019;334:577000
Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [¹¹C]PBR28 positron emission tomography
Forsberg A; Lampa J; Estelius J; Cervenka S; Farde L; Halldin C; Lekander M; Hoglund OC; Kosek E
Article: NEUROPSYCHOPHARMACOLOGY. 2019;44(10):1706-1713
Effect of clinically relevant doses of vortioxetine and citalopram on serotonergic PET markers in the nonhuman primate brain
Yang K-C; Stepanov V; Amini N; Martinsson S; Takano A; Bundgaard C; Bang-Andersen B; Sanchez C; Halldin C; Farde L; Finnema SJ
Article: ALZHEIMER'S AND DEMENTIA. 2019;15(8):1081-1103
A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies
Perani D; Iaccarino L; Lammertsma AA; Windhorst AD; Edison P; Boellaard R; Hansson O; Nordberg A; Jacobs AH
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2019;22(7):415-425
D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients
Stenkrona P; Matheson GJ; Halldin C; Cervenka S; Farde L
Article: NATURE MEDICINE. 2019;25(7):1131-1142
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease
Zeitler B; Froelich S; Marlen K; Shivak DA; Yu Q; Li D; Pearl JR; Miller JC; Zhang L; Paschon DE; Hinkley SJ; Ankoudinova I; Lam S; Guschin D; Kopan L; Cherone JM; Nguyen H-OB; Qiao G; Ataei Y; Mendel MC; Amora R; Surosky R; Laganiere J; Vu BJ; Narayanan A; Sedaghat Y; Tillack K; Thiede C; Gaertner A; Kwak S; Bard J; Mrzljak L; Park L; Heikkinen T; Lehtimaki KK; Svedberg MM; Haggkvist J; Tari L; Toth M; Varrone A; Halldin C; Kudwa AE; Ramboz S; Day M; Kondapalli J; Surmeier DJ; Urnov FD; Gregory PD; Rebar EJ; Munoz-Sanjuan I; Zhang HS
Article: JOURNAL OF NUCLEAR MEDICINE. 2019;60(7):992-997
Quantitative Analysis of ¹⁸F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain
Takano A; Chen L; Nag S; Brodney MA; Arakawa R; Chang C; Amini N; Doran SD; Dutra JK; McCarthy TJ; Nolan CE; O'Neill BT; Villalobos A; Zhang L; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2019;29(13):1624-1627
Synthesis and preclinical evaluation of [¹⁸F]FSL25.1188, a reversible PET radioligand for monoamine oxidase-B
Dahl K; Bernard-Gauthier V; Nag S; Varnas K; Narayanaswami V; Moein MM; Arakawa R; Vasdev N; Halldin C
Article: MOLECULAR IMAGING AND BIOLOGY. 2019;21(3):500-508
Characterization of [¹¹C]PXT012253 as a PET Radioligand for mGlu₄ Allosteric Modulators in Nonhuman Primates
Takano A; Nag S; Jia Z; Jahan M; Forsberg A; Arakawa R; Gryback P; Duvey G; Halldin C; Charvin D
Article: BRAIN RESEARCH. 2019;1711:140-145
In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [¹⁸F]MNI-659
Svedberg MM; Varnas K; Varrone A; Mitsios N; Mulder J; Gulyas B; Beaumont V; Munoz-Sanjuan I; Zaleska MM; Schmidt CJ; Halldin C; Mrzljak L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2019;22(4):278-285
Venlafaxine ER Blocks the Norepinephrine Transporter in the Brain of Patients with Major Depressive Disorder: a PET Study Using [¹⁸F]FMeNER-D₂
Arakawa R; Stenkrona P; Takano A; Svensson J; Andersson M; Nag S; Asami Y; Hirano Y; Halldin C; Lundberg J
Article: NUCLEAR MEDICINE AND BIOLOGY. 2019;70:1-13
Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT_1β receptors
Lindberg A; Lu S; Nag S; Schou M; Liow J-S; Zoghbi SS; Frankland MP; Gladding RL; Morse CL; Takano A; Amini N; Elmore CS; Lee YS; Innis RB; Halldin C; Pike VW
Article: NEUROIMAGE. 2019;188:102-110
Accuracy and reliability of [¹¹C]PBR28 specific binding estimated without the use of a reference region
Plaven-Sigray P; Schain M; Zanderigo F; Farde L; Halldin C; Forsberg A; Varrone A; Jucaite A; Cervenka S; Stenkrona P; Collste K; Kander M; Kosek E; Lampa J; Hoglund CO; Rabiner EA; Gunn RN; Ogden RT; Cervenk S
Article: CHEMISTRYSELECT. 2019;4(6):1846-1849
Rapid and Efficient Synthesis of ¹¹C-Labeled Benzimidazolones Using [¹¹C]Carbon Dioxide
Horkka K; Dahl K; Bergare J; Elmore CS; Halldin C; Schou M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(2):367-375
PET imaging of [¹¹C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding
Varnas K; Cselenyi Z; Jucaite A; Halldin C; Svenningsson P; Farde L; Varrone A
Article: EJNMMI RESEARCH. 2019;9(1):9
Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator
Schou M; Ewing P; Cselenyi Z; Friden M; Takano A; Halldin C; Farde L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2019;22(1):53-56
Serotonin and Norepinephrine Transporter Occupancy of Tramadol in Nonhuman Primate Using Positron Emission Tomography
Arakawa R; Takano A; Halldin C
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2019;75:72-83
Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation
Albrecht DS; Forsberg A; Sandstrom A; Bergan C; Kadetoff D; Protsenko E; Lampa J; Lee YC; Hoglund CO; Catana C; Cervenka S; Akeju O; Lekander M; Cohen G; Halldin C; Taylor N; Kim M; Hooker JM; Edwards RR; Napadow V; Kosek E; Loggia ML
Article: EJNMMI RESEARCH. 2018;8(1):113
The development of a GPR44 targeting radioligand [¹¹C]AZ12204657 for in vivo assessment of beta cell mass
Jahan M; Johnstrom P; Selvaraju RK; Svedberg M; Winzell MS; Bernstrom J; Kingston L; Schou M; Jia Z; Skrtic S; Johansson L; Korsgren O; Farde L; Halldin C; Eriksson O
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(461):eaam8434
GABA_A receptor availability is not altered in adults with autism spectrum disorder or in mouse models
Horder J; Andersson M; Mendez MA; Singh N; Tangen A; Lundberg J; Gee A; Halldin C; Veronese M; Bolte S; Farde L; Sementa T; Cash D; Higgins K; Spain D; Turkheimer F; Mick I; Selvaraj S; Nutt DJ; Lingford-Hughes A; Howes OD; Murphy DG; Borg J
Article: MOVEMENT DISORDERS. 2018;33(10):1619-1631
An mGlu4-Positive Allosteric Modulator Alleviates Parkinsonism in Primates
Charvin D; Di Paolo T; Bezard E; Gregoire L; Takano A; Duvey G; Pioli E; Halldin C; Medori R; Conquet F
Article: EJNMMI RESEARCH. 2018;8(1):74
[¹¹C]SCH23390 binding to the D₁-dopamine receptor in the human brain-a comparison of manual and automated methods for image analysis
Stenkrona P; Matheson GJ; Cervenka S; Sigray PP; Halldin C; Farde L
Article: MOLECULAR IMAGING AND BIOLOGY. 2018;20(4):615-622
A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[¹¹C]Rolipram
Takano A; Uz T; Garcia-Segovia J; Tsai M; Lahu G; Amini N; Nakao R; Jia Z; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2018;59(8):1275-1280
Whole-Body Biodistribution and Dosimetry of the Dopamine Transporter Radioligand ¹⁸F-FE-PE2I in Human Subjects
Lizana H; Johansson L; Axelsson J; Larsson A; Ogren M; Linder J; Halldin C; Varrone A; Mo SJ
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2018;57(31):9744-9748
Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO₂
Del Vecchio A; Caille F; Chevalier A; Loreau O; Horkka K; Halldin C; Schou M; Camus N; Kessler P; Kuhnast B; Taran F; Audisio D
Article: TRANSLATIONAL PSYCHIATRY. 2018;8(1):132
Serotonin concentration enhancers at clinically relevant doses reduce [¹¹C] AZ10419369 binding to the 5-HT_1B receptors in the nonhuman primate brain
Yang K-C; Takano A; Halldin C; Farde L; Finnema SJ
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45(9):1605-1617
Dual tracer tau PET imaging reveals different molecular targets for ¹¹C-THK5351 and ¹¹C-PBB3 in the Alzheimer brain
Chiotis K; Stenkrona P; Almkvist O; Stepanov V; Ferreira D; Arakawa R; Takano A; Westman E; Varrone A; Okamura N; Shimada H; Higuchi M; Halldin C; Nordberg A
Article: NEUROPHARMACOLOGY. 2018;135:455-463
The metabotropic glutamate receptor 5 radioligand [¹¹C]AZD9272 identifies unique binding sites in primate brain
Varnas K; Jureus A; Finnema SJ; Johnstrom P; Raboisson P; Amini N; Takano A; Stepanov V; Halldin C; Farde L
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2018;61(8):3296-3308
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain
Zhang L; Chen L; Dutra JK; Beck EM; Nag S; Takano A; Amini N; Arakawa R; Brodney MA; Buzon LM; Doran SD; Lanyon LF; McCarthy TJ; Bales KR; Nolan CE; O'Neill BT; Schildknegt K; Halldin C; Villalobos A
Article: MOVEMENT DISORDERS. 2018;33(4):592-599
Nigrostriatal dopamine transporter availability in early Parkinson's disease
Fazio P; Svenningsson P; Cselenyi Z; Halldin C; Farde L; Varrone A
Article: NUCLEAR MEDICINE AND BIOLOGY. 2018;57:12-19
Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates
Stepanov V; Takano A; Nakao R; Amini N; Miura S; Hasui T; Kimura H; Taniguchi T; Halldin C
Article: DIABETES. 2018;67(2):182-192
In Vivo Visualization of β-Cells by Targeting of GPR44
Eriksson O; Johnstrom P; Cselenyi Z; Jahan M; Selvaraju RK; Jensen-Waern M; Takano A; Winzell MS; Halldin C; Skrtic S; Korsgren O
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2018;68:146-157
Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [¹¹C]PBR28 PET study
Tamm S; Cervenka S; Forsberg A; Estelius J; Grunewald J; Gyllfors P; Karshikoff B; Kosek E; Lampa J; Lensmar C; Strand V; Akerstedt T; Halldin C; Ingvar M; Hoglund CO; Lekander M
Article: PLOS ONE. 2018;13(3):e0193770
Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study
Plaven-Sigray P; Matheson GJ; Gustavsson P; Stenkrona P; Halldin C; Farde L; Cervenka S
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2017;56(51):16218-16222
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis
McClure KF; Piotrowski DW; Petersen D; Wei L; Xiao J; Londregan AT; Kamlet AS; Dechert-Schmitt A-M; Raymer B; Ruggeri RB; Canterbury D; Limberakis C; Liras S; DaSilva-Jardine P; Dullea RG; Loria PM; Reidich B; Salatto CT; Eng H; Kimoto E; Atkinson K; King-Ahmad A; Scott D; Beaumont K; Chabot JR; Bolt MW; Maresca K; Dahl K; Arakawa R; Takano A; Halldin C
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2017;9(1):96
Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains
Lemoine L; Gillberg P-G; Svedberg M; Stepanov V; Jia Z; Huang J; Nag S; Tian H; Ghetti B; Okamura N; Higuchi M; Halldin C; Nordberg A
Article: EJNMMI RESEARCH. 2017;7(1):54
Test-retest reproducibility of [¹¹C]-Ldeprenyl-D2 binding to MAO-B in the human brain
Arakawa R; Stenkrona P; Takano A; Nag S; Maior RS; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;54:34-40
[¹¹C]AZ10419096-a full antagonist PET radioligand for imaging brain 5-HT_1B receptors
Lindberg A; Nag S; Schou M; Takano A; Matsumoto J; Amini N; Elmore CS; Farde L; Pike VW; Haildin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2017;60(13):624-628
Reduction of [¹¹C]CO₂ to [¹¹C]CO using solid supported zinc
Dahl K; Ulin J; Schou M; Halldin C
Article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2017;267:15-21
Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder - A pilot study.
Tangen Ä; Borg J; Tiger M; Varnäs K; Sorjonen K; Lindefors N; Halldin C; Lundberg J
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2017;20(9):683-691
Fenfluramine Reduces [¹¹C] Cimbi-36 Binding to the 5-HT_2A Receptor in the Nonhuman Primate Brain
Yang K-C; Stepanov V; Martinsson S; Ettrup A; Takano A; Knudsen GM; Halldin C; Farde L; Finnema SJ
Article: EJNMMI RESEARCH. 2017;7(1):66
Revisiting the Logan plot to account for non-negligible blood volume in brain tissue
Schain M; Fazio P; Mrzljak L; Amini N; Al-Tawil N; Fitzer-Attas C; Bronzova J; Landwehrmeyer B; Sampaio C; Halldin C; Varrone A
Article: NEUROIMAGE. 2017;155:344-353
Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [¹¹C] SCH-23390
Matheson GJ; Stenkrona P; Cselenyi Z; Plaven-Sigray P; Halldin C; Farde L; Cervenka S
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: NEUROIMAGE. 2017;152:330-339
Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D_2/3 receptors and sub-cortical volumes in the human basal ganglia: A PET study with ¹⁸F-MNI-659 and ¹¹C-raelopride with correction for partial volume effect
Fazio P; Schain M; Mrzljak L; Amini N; Nag S; Al-Tawil N; Fitzer-Attas CJ; Bronzova J; Landwehrmeyer B; Sampaio C; Halldin C; Varrone A
Article: NEUROPHARMACOLOGY. 2017;117:171-181
In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects
Delnomdedieu M; Forsberg A; Ogden A; Fazio P; Yu C-R; Stenkrona P; Duvvuri S; David W; Al-Tawil N; Vitolo OV; Amini N; Nag S; Halldin C; Varrone A
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(5):462-469
Extrastriatal dopamine D2-receptor availability in social anxiety disorder
Plaven-Sigray P; Hedman E; Victorsson P; Matheson GJ; Forsberg A; Djurfeldt DR; Ruck C; Halldin C; Lindefors N; Cervenka S
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1104
Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study
Jayaram-Lindstrom N; Guterstam J; Haggkvist J; Ericson M; Malmlof T; Schilstrom B; Halldin C; Cervenka S; Saijo T; Nordstrom A-L; Franck J
Article: JOURNAL OF NUCLEAR MEDICINE. 2017;58(4):617-622
Longitudinal Small-Animal PET Imaging of the zQ175 Mouse Model of Huntington Disease Shows In Vivo Changes of Molecular Targets in the Striatum and Cerebral Cortex
Haggkvist J; Toth M; Tari L; Varnas K; Svedberg M; Forsberg A; Nag S; Dominguez C; Munoz-Sanjuan I; Bard J; Wityak J; Varrone A; Halldin C; Mrzljak L
Article: ANNALS OF NEUROLOGY. 2017;81(4):572-582
The Immune Response of the Human Brain to Abdominal Surgery
Forsberg A; Cervenka S; Fagerlund MJ; Rasmussen LS; Zetterberg H; Harris HE; Stridh P; Christensson E; Granstrom A; Schening A; Dymmel K; Knave N; Terrando N; Maze M; Borg J; Varrone A; Halldin C; Blennow K; Farde L; Eriksson LI
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44(3):382-391
Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer's disease and elderly controls after oral administration of sembragiline
Sturm S; Forsberg A; Nave S; Stenkrona P; Seneca N; Varrone A; Comley RA; Fazio P; Jamois C; Nakao R; Ejduk Z; Al-Tawil N; Akenine U; Halldin C; Andreasen N; Ricci B
Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;46:50-53
Development of [¹¹C]/[³H-1]THK-5351-A potential novel carbon-11 tau imaging PET radioligand
Stepanov V; Svedberg M; Jia Z; Krasikova R; Lemoine L; Okamura N; Furumoto S; Mitsios N; Mulder J; Langstrom B; Nordberg A; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44(2):308-320
Characterization of [¹¹C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
Yang K-C; Stepanov V; Amini N; Martinsson S; Takano A; Nielsen J; Bundgaard C; Bang-Andersen B; Grimwood S; Halldin C; Farde L; Finnema SJ
Article: PSYCHOPHARMACOLOGY. 2017;234(4):707-716
GABA_A receptor occupancy by subtype selective GABA_Aα2,3 modulators: PET studies in humans
Jucaite A; Cselenyi Z; Lappalainen J; McCarthy DJ; Lee C-M; Nyberg S; Varnas K; Stenkrona P; Halldin C; Cross A; Farde L
Article: AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;7(6):246-254
Simplified estimation of binding parameters based on image-derived reference tissue models for dopamine transporter bindings in non-human primates using [18F]FE-PE2I and PET.
Odano I; Varrone A; Hosoya T; Sakaguchi K; Gulyás B; Padmanabhan P; Ghosh KK; Yang C-T; Guenther I; Wang Z; Serrano R; Chimon NG; Halldin C
Article: CURRENT RADIOPHARMACEUTICALS. 2017;10(1):35-40
Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1.
Igawa H; Stepanov V; Tari L; Okuda S; Yamamoto S; Kasai S; Nagisa Y; Haggkvist J; Svedberg M; Toth M; Takano A; Halldin C
Article: RSC ADVANCES. 2017;7(32):19787-19793
Characterization of the binding mode of the PET tracer [¹⁸F] ASEM to a chimera structure of the α7 nicotinic acetylcholine receptor
Kuang G; Zhou Y; Zou R; Halldin C; Nordberg A; Langstrom B; Agren H; Tu Y
Article: NEURON. 2016;92(6):1220-1237
Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models
Beaumont V; Zhong S; Lin H; Xu W; Bradaia A; Steidl E; Gleyzes M; Wadel K; Buisson B; Padovan-Neto FE; Chakroborty S; Ward KM; Harms JF; Beltran J; Kwan M; Ghavami A; Haggkvist J; Toth M; Halldin C; Varrone A; Schaab C; Dybowski JN; Elschenbroich S; Lehtimaki K; Heikkinen T; Park L; Rosinski J; Mrzljak L; Lavery D; West AR; Schmidt CJ; Zaleska MM; Munoz-Sanjuan I
Article: CHEMICAL COMMUNICATIONS. 2016;52(97):13963-13966
Efficient DBU accelerated synthesis of ¹⁸F-labelled trifluoroacetamides
Gomez AB; Gonzalez MAC; Lubcke M; Johansson MJ; Halldin C; Szabo KJ; Schou M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43(12):2255-2262
Guidelines to PET measurements of the target occupancy in the brain for drug development
Takano A; Varrone A; Gulyas B; Salvadori P; Gee A; Windhorst A; Vercouillie J; Bormans G; Lammertsma AA; Halldin C
Article: NEUROIMAGE. 2016;141:10-17
A human [¹¹C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor
Takano A; Stenkrona P; Stepanov V; Amini N; Martinsson S; Tsai M; Goldsmith P; Xie J; Wu J; Uz T; Halldin C; Macek TA
Article: PHYSICAL CHEMISTRY, CHEMICAL PHYSICS - PCCP. 2016;18(40):28003-28009
Theoretical study of the binding profile of an allosteric modulator NS-1738 with a chimera structure of the α7 nicotinic acetylcholine receptor
Kuang G; Wang X; Halldin C; Nordberg A; Langstrom B; Agren H; Tu Y
Article: JOURNAL OF NUCLEAR MEDICINE. 2016;57(10):1529-1534
Optimal Acquisition Time Window and Simplified Quantification of Dopamine Transporter Availability Using ¹⁸F-FE-PE2I in Healthy Controls and Parkinson Disease Patients
Sonni I; Fazio P; Sehain M; Halldin C; Svenningsson P; Farde L; Varrone A
Article: NEUROSCIENCE LETTERS. 2016;630:183-188
Amyloid binding properties of curcumin analogues in Alzheimer's disease postmortem brain tissue
Veldman ER; Jia Z; Halldin C; Svedberg MM
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2016;7(17):3313-3321
The Culprit Is in the Cave: The Core Sites Explain the Binding Profiles of Amyloid-Specific Tracers
Murugan NA; Halldin C; Nordberg A; Langstrom B; Agren H
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2016;358(3):464-471
Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676
Varnas K; Jureus A; Johnstrom P; Ahlgren C; Schott P; Schou M; Gruber S; Jerning E; Malmborg J; Halldin C; Afzelius L; Farde L
Article: MOLECULAR PSYCHIATRY. 2016;21(8):1077-1084
Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
Borg J; Cervenka S; Kuja-Halkola R; Matheson GJ; Jonsson EG; Lichtenstein P; Henningsson S; Ichimiya T; Larsson H; Stenkrona P; Halldin C; Farde L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(8):pyw023
Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [¹⁸F]Lu AF10628
Varnas K; Finnema SJ; Stepanov V; Takano A; Toth M; Svedberg M; Nielsen SM; Khanzhin NA; Juhl K; Bang-Andersen B; Halldin C; Farde L
Article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2016;253:36-42
Low serotonin_1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder
Tiger M; Farde L; Ruck C; Varrone A; Forsberg A; Lindefors N; Halldin C; Lundberg J
Article: CHEMISTRYSELECT. 2016;1(10):2498-2501
Alkyl Iodides and [¹¹C]CO in Nickel-Mediated Cross-Coupling Reactions: Successful Use of Alkyl Electrophiles containing a β Hydrogen Atom in Metal-Mediated [¹¹C]Carbonylation
Rahman O; Langstrom B; Halldin C
Article: SYNAPSE. 2016;70(6):253-263
Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [¹¹C]T-773 in nonhuman primates
Takano A; Stepanov V; Nakao R; Amini N; Gulyas B; Kimura H; Halldin C
Article: NEUROIMAGE. 2016;133:313-320
Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data
Fazio P; Schain M; Varnas K; Halldin C; Farde L; Varrone A
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2016;2016(16):2775-2777
Direct and Efficient (Carbonyl)cobalt-Mediated Aryl Acetylation Using [¹¹C] Methyl Iodide
Dahl K; Schou M; Halldin C
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2016;54:149-157
In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects
Kanegawa N; Collste K; Forsberg A; Schain M; Arakawa R; Jucaite A; Lekander M; Hoglund CO; Kosek E; Lampa J; Halldin C; Farde L; Varrone A; Cervenka S
Article: BRAIN STRUCTURE AND FUNCTION. 2016;221(3):1279-1290
Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking
Toth M; Little P; Arnberg F; Haggkvist J; Mulder J; Halldin C; Gulyas B; Holmin S
Article: JOURNAL OF NUCLEAR MEDICINE. 2016;57(2):315-320
In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, ¹⁸F-Labeled Deuterated Fluorodeprenyl
Nag S; Fazio P; Lehmann L; Kettschau G; Heinrich T; Thiele A; Svedberg M; Amini N; Leesch S; Catafau AM; Hannestad J; Varrone A; Halldin C
Article: NEUROPHARMACOLOGY. 2016;101:519-530
A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates
Hjorth S; Karlsson C; Jucaite A; Varnas K; Hamren UW; Johnstrom P; Gulyas B; Donohue SR; Pike VW; Halldin C; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43(1):173-183
Test-retest reproducibility of [¹¹C]PBR28 binding to TSPO in healthy control subjects
Collste K; Forsberg A; Varrone A; Amini N; Aeinehband S; Yakushev I; Halldin C; Farde L; Cervenka S
Article: EJNMMI PHYSICS. 2015;2(Suppl 1):A90
Biocompatible branched copolymer nanoparticles prepared by RAFT polymerization as MRI/PET bimodal tracers.
Yang C-T; Tao H; Jackson AW; Chandrasekharan P; Padmanabhan P; Gulyás B; Halldin C
Article: PSYCHOPHARMACOLOGY. 2015;232(21-22):4159-4167
Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [¹¹C]MADAM PET study
Finnema SJ; Halldin C; Bang-Andersen B; Bundgaard C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2015;42(11):893-898
Synthesis of ([¹¹C]carbonyl)raclopride and a comparison with ([¹¹C]methyl)raclopride in a monkey PET study
Rahman O; Takano A; Amini N; Dahl K; Kanegawa N; Langstrom B; Farde L; Halldin C
Article: BRAIN. 2015;138(Pt 9):2687-2700
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease
Jucaite A; Svenningsson P; Rinne JO; Cselenyi Z; Varnas K; Johnstrom P; Amini N; Kirjavainen A; Helin S; Minkwitz M; Kugler AR; Posener JA; Budd S; Halldin C; Varrone A; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42(10):1507-1511
β-Amyloid binding in elderly subjects with declining or stable episodic memory function measured with PET and [¹¹C]AZD2184
Mattsson P; Forsberg A; Persson J; Nyberg L; Nilsson L-G; Halldin C; Farde L
Article: BRAIN STRUCTURE AND FUNCTION. 2015;220(5):3043-3051
Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease: a preliminary investigation in the postmortem human brain
Gulyas B; Sovago J; Gomez-Mancilla B; Jia Z; Szigeti C; Gulya K; Schumacher M; Maguire RP; Gasparini F; Halldin C
Article: MOLECULAR IMAGING AND BIOLOGY. 2015;17(4):445-449
Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [¹¹C]T-773
Toth M; Haggkvist J; Stepanov V; Takano A; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Gulyas B; Halldin C
Article: SYNAPSE. 2015;69(7):365-374
5-HT_1B receptor imaging and cognition: A positron emission tomography study in control subjects and parkinson's disease patients
Varrone A; Svenningsson P; Marklund P; Fatouros-Bergman H; Forsberg A; Halldin C; Nilsson L-G; Farde L
Article: SYNAPSE. 2015;69(7):345-355
Evaluation of a novel PDE10A PET radioligand, [¹¹C]T-773, in nonhuman primates: Brain and whole body PET and brain autoradiography
Takano A; Stepanov V; Gulyas B; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42(7):1119-1132
Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
Rodriguez-Vieitez E; Ni R; Gulyas B; Toth M; Haeggkvist J; Halldin C; Voytenko L; Marutle A; Nordberg A
Article: NUCLEAR MEDICINE AND BIOLOGY. 2015;42(6):555-560
Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing
Johnstrom P; Bergman L; Varnas K; Malmquist J; Halldin C; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2015;58(5):220-225
An evaluation of a high-pressure ¹¹CO carbonylation apparatus
Dahl K; Itsenko O; Rahman O; Ulin J; Sjoberg C-O; Sandblom P; Larsson L-A; Schou M; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2015;58(5):202-208
Development of a series of novel carbon-11 labeled PDE10A inhibitors
Stepanov V; Miura S; Takano A; Amini N; Nakao R; Hasui T; Nakashima K; Taniguchi T; Kimura H; Kuroita T; Halldin C
Article: NEUROPHARMACOLOGY. 2015;92:44-48
In vivo occupancy of the 5-HT_1A receptor by a novel pan 5-HT_1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography
Comley RA; van der Aart J; Gulyas B; Garnier M; Iavarone L; Halldin C; Rabiner EA
Article: JOURNAL OF NUCLEAR MEDICINE. 2015;56(5):714-720
Quantitative Analysis of ¹⁸F-(E)-N-(3-Iodoprop-2-Enyl)-2β-Carbofluoroethoxy-3β-(4′-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease
Fazio P; Svenningsson P; Forsberg A; Jonsson EG; Amini N; Nakao R; Nag S; Halldin C; Farde L; Varrone A
Article: NUCLEAR MEDICINE AND BIOLOGY. 2015;42(4):387-394
Synthesis and biological evaluation of [¹¹C]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver
Jahan M; Johnstrom P; Nag S; Takano A; Korsgren O; Johansson L; Halldin C; Eriksson O
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(10):pyv036
Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates
Schou M; Varnas K; Lundquist S; Nakao R; Amini N; Takano A; Finnema SJ; Halldin C; Farde L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(3):1339-1346
Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients
Paul G; Zachrisson O; Varrone A; Almqvist P; Jerling M; Lind G; Rehncrona S; Linderoth B; Bjartmarz H; Shafer LL; Coffey R; Svensson M; Mercer KJ; Forsberg A; Halldin C; Svenningsson P; Widner H; Frisen J; Palhagen S; Haegerstrand A
Article: SYNAPSE. 2015;69(3):172-181
Validation of [¹¹C]ORM-13070 as a PET Tracer for Alpha_2c-Adrenoceptors in the Human Brain
Lehto J; Hirvonen MM; Johansson J; Kemppainen J; Luoto P; Naukkarinen T; Oikonen V; Arponen E; Rouru J; Sallinen J; Scheinin H; Vuorilehto L; Finnema SJ; Halldin C; Rinne JO; Scheinin M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42(3):438-446
Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [¹⁸F]FEMPA in Alzheimer's disease patients and control subjects
Varrone A; Oikonen V; Forsberg A; Joutsa J; Takano A; Solin O; Haaparanta-Solin M; Nag S; Nakao R; Al-Tawil N; Wells LA; Rabiner EA; Valencia R; Schultze-Mosgau M; Thiele A; Vollmer S; Dyrks T; Lehmann L; Heinrich T; Hoffmann A; Nordberg A; Halldin C; Rinne JO
Article: NEUROIMAGE. 2015;106:47-54
Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women - a PET study
Jovanovic H; Kocoska-Maras L; Radestad AF; Halldin C; Borg J; Hirschberg AL; Nordstrom A-L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2015;42(2):146-154
Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A
Harada A; Suzuki K; Miura S; Hasui T; Kamiguchi N; Ishii T; Taniguchi T; Kuroita T; Takano A; Stepanov V; Halldin C; Kimura H
Article: PLOS ONE. 2015;10(5):e0125917
Positron Emission Tomography studies with [¹¹C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation
Toth M; Doorduin J; Haggkvist J; Varrone A; Amini N; Halldin C; Gulyas B
Article: PLOS ONE. 2015;10(9):e0137160
[¹¹C]MADAM Used as a Model for Understanding the Radiometabolism of Diphenyl Sulfide Radioligands for Positron Emission Tomography (PET)
Gourand F; Amini N; Jia Z; Stone-Elander S; Guilloteau D; Barre L; Halldin C
Article: RSC ADVANCES. 2015;5(108):88886-88889
¹¹C-carbonylation reactions using gas-liquid segmented microfluidics
Dahl K; Schou M; Ulin J; Sjoberg C-O; Farde L; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu081
Amphetamine Decreases α_2C-Adrenoceptor Binding of [¹¹C]ORM-13070: A PET Study in the Primate Brain
Finnema SJ; Hughes ZA; Haaparanta-Solin M; Stepanov V; Nakao R; Vamas K; Varrone A; Arponen E; Marjamaki P; Pohjanoksa K; Vuorilehto L; Babalola PA; Solin O; Grimwood S; Sallinen J; Farde L; Scheinin M; Halldin C
Article: EJNMMI RESEARCH. 2014;4(1):64
ABC transporter-dependent brain uptake of the 5-HT_1B receptor radioligand [¹¹C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig
Toth M; Haggkvist J; Varrone A; Finnema SJ; Doorduin J; Tokunaga M; Higuchi M; Gulyas B; Halldin C
Article: SCIENCE TRANSLATIONAL MEDICINE. 2014;6(263):263ra158
The gut microbiota influences blood-brain barrier permeability in mice
Braniste V; Al-Asmakh M; Kowal C; Anuar F; Abbaspour A; Toth M; Korecka A; Bakocevic N; Ng LG; Kundu P; Gulyas B; Halldin C; Hultenby K; Nilsson H; Hebert H; Volpe BT; Diamond B; Pettersson S
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2014;41(11):2175-2185
EANM guideline for the preparation of an Investigational Medicinal Product Dossier (IMPD)
Todde S; Windhorst AD; Behe M; Bormans G; Decristoforo C; Faivre-Chauvet A; Ferrari V; Gee AD; Gulyas B; Halldin C; Peitl PK; Koziorowski J; Mindt TL; Sollini M; Vercouillie J; Ballinger JR; Elsinga PH
Article: NEUROINFORMATICS. 2014;12(4):551-562
Evaluation of Two Automated Methods for PET Region of Interest Analysis
Schain M; Varnas K; Cselenyi Z; Halldin C; Farde L; Varrone A
Article: SYNAPSE. 2014;68(10):480-483
No correlation between serotonin and its metabolite 5-HIAA in the cerebrospinal fluid and [(11) C]AZ10419369 binding measured with PET in healthy volunteers.
Tiger M; Svenningsson P; Nord M; Jabre S; Halldin C; Lundberg J
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2014;98:140-143
Determination of plasma protein binding of positron emission tomography radioligands by high-performance frontal analysis
Amini N; Nakao R; Schou M; Halldin C
Article: PSYCHIATRY RESEARCH. 2014;223(2):164-170
Reduced 5-HT_1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder
Tiger M; Ruck C; Forsberg A; Varrone A; Lindefors N; Halldin C; Farde L; Lundberg J
Article: JOURNAL OF NUCLEAR MEDICINE. 2014;55(7):1164-1170
¹⁸F-MCL-524, an ¹⁸F-Labeled Dopamine D₂ and D₃ Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study
Finnema SJ; Stepanov V; Nakao R; Sromek AW; Zhang T; Neumeyer JL; George SR; Seeman P; Stabin MG; Jonsson C; Farde L; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2014;41(6):501-506
A radiometabolite study of the serotonin transporter PET radioligand [¹¹C]MADAM
Gourand F; Emond P; Bergstroem JP; Takano A; Gulyas B; Guilloteau D; Barre L; Halldin C
Article: NEUROBIOLOGY OF AGING. 2014;35(4):867-875
Positron emission tomography imaging of 5-hydroxytryptamine_1B receptors in Parkinson's disease
Varrone A; Svenningsson P; Forsberg A; Varnas K; Tiger M; Nakao R; Halldin C; Nilsson L-G; Farde L
Article: MOLECULAR IMAGING AND BIOLOGY. 2014;16(2):173-179
Synthesis, Radiolabeling, and In Vivo Pharmacokinetic Evaluation of the Amyloid Beta Radioligand [¹¹C]AZD4694 in Nonhuman Primates
Schou M; Varnas K; Sandell J; Johnstrom P; Cselenyi Z; Svensson S; Nakao R; Amini N; Bergman L; Sumic A; Gulyas B; Lindstrom-Boo E; Halldin C; Farde L
Article: NUCLEAR MEDICINE COMMUNICATIONS. 2014;35(3):231-237
Reproducibility of PET measurement for presynaptic dopaminergic functions using L-[β-¹¹C]DOPA and [¹⁸F]FE-PE2I in humans
Suzuki M; Ito H; Kodaka F; Takano H; Kimura Y; Fujiwara H; Sasaki T; Takahata K; Nogami T; Nagashima T; Nengaki N; Kawamura K; Zhang M-R; Varrone A; Halldin C; Okubo Y; Suhara T
Article: SYNAPSE. 2014;68(3):89-97
Low Brain CB1 Receptor Occupancy by a Second Generation CB1 Receptor Antagonist TM38837 in Comparison With Rimonabant in Nonhuman Primates: A PET Study
Takano A; Gulyas B; Varnaes K; Little PB; Noerregaard PK; Jensen NO; Elling CE; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2014;41(2):301-307
Test-retest reliability of [¹¹C]AZ10419369 binding to 5-HT_1B receptors in human brain
Nord M; Finnema SJ; Schain M; Halldin C; Farde L
Article: TRANSLATIONAL PSYCHIATRY. 2014;4(1):e342
A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques
Yamanaka H; Yokoyama C; Mizuma H; Kurai S; Finnema SJ; Halldin C; Doi H; Onoe H
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2014;2014(2):307-310
Improved Yields for the Palladium-Mediated ¹¹C-Carbonylation Reaction Using Microwave Technology
Dahl K; Schou M; Rahman O; Halldin C
Article: NEUROIMAGE. 2014;84:733-741
In vitro and in vivo evaluation of ¹¹C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB₁ receptors
Tsujikawa T; Zoghbi SS; Hong J; Donohue SR; Jenko KJ; Gladding RL; Halldin C; Pike VW; Innis RB; Fujita M
Article: NEUROIMAGE. 2014;84:342-353
Characterization of [¹¹C]Cimbi-36 as an agonist PET radioligand for the 5-HT_2A and 5-HT_2C receptors in the nonhuman primate brain
Finnema SJ; Stepanov V; Ettrup A; Nakao R; Amini N; Svedberg M; Lehmann C; Hansen M; Knudsen GM; Halldin C
Article: NEUROIMAGE. 2013;82:160-169
A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066-Estimating occupancy in the absence of a reference region
Kadgedal M; Cselenyi Z; Nyberg S; Raboisson P; Stahle L; Stenkrona P; Varnas K; Halldin C; Hooker AC; Karlsson MO
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(10):2235-2244
Norepinephrine transporter occupancy in the human brain after oral administration of quetiapine XR
Nyberg S; Jucaite A; Takano A; Kagedal M; Cselenyi Z; Halldin C; Farde L
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2013;21(21):6634-6641
Development of a novel fluorine-18 labeled deuterated fluororasagiline ([¹⁸F]fluororasagiline-D₂) radioligand for PET studies of monoamino oxidase B (MAO-B)
Nag S; Lehmann L; Kettschau G; Toth M; Heinrich T; Thiele A; Varrone A; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2013;54(10):1825-1832
Performance Evaluation of the Small-Animal nanoScan PET/MRI System
Nagy K; Toth M; Major P; Patay G; Egri G; Haggkvist J; Varrone A; Farde L; Halldin C; Gulyas B
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(10):1190-1198
5-HTT and 5-HT_1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects
Stenkrona P; Halldin C; Lundberg J
Article: ANALYTICAL CHEMISTRY. 2013;85(18):8728-8734
Simultaneous Determination of Protein-Free and Total Positron Emission Tomography Radioligand Concentrations in Plasma Using High-Performance Frontal Analysis Followed by Mixed Micellar Liquid Chromatography: Application to [¹¹C]PBR28 in Human Plasma
Nakao R; Amini N; Halldin C
Article: TALANTA. 2013;113:130-134
Improved radiometabolite analysis procedure for positron emission tomography (PET) radioligands using a monolithic column coupled with direct injection micellar/high submicellar liquid chromatography
Nakao R; Halldin C
Article: SYNAPSE. 2013;67(9):586-595
The dopamine D₁ receptor agonist (S)-[¹¹C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentrationa positron emission tomography examination in the monkey brain
Finnema SJ; Bang-Andersen B; Jorgensen M; Christoffersen CT; Gulyas B; Wikstrom HV; Farde L; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(7):1577-1586
Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain
Nord M; Finnema SJ; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2013;40(6):747-754
Radiosynthesis and evaluation of new α₁-adrenoceptor antagonists as PET radioligands for brain imaging
Airaksinen AJ; Finnema SJ; Balle T; Varnas K; Bang-Andersen B; Gulyas B; Farde L; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2013;40(5):658-663
A simplified radiometabolite analysis procedure for PET radioligands using a solid phase extraction with micellar medium
Nakao R; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2013;33(7):1058-1065
Arterial input function derived from pairwise correlations between PET-image voxels
Schain M; Benjaminsson S; Varnas K; Forsberg A; Halldin C; Lansner A; Farde L; Varrone A
Article: CEPHALALGIA. 2013;33(10):853-860
A PET study with [¹¹C]AZ10419369 to determine brain 5-HT_1B receptor occupancy of zolmitriptan in healthy male volunteers
Varnas K; Jucaite A; McCarthy DJ; Stenkrona P; Nord M; Halldin C; Farde L; Kanes S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(6):1231-1239
AZD5213: a novel histamine H₃ receptor antagonist permitting high daytime and low nocturnal H₃ receptor occupancy, a PET study in human subjects
Jucaite A; Takano A; Bostrom E; Jostell K-G; Stenkrona P; Halldin C; Segerdahl M; Nyberg S
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(6):921-931
In vivo imaging of the ¹⁸-kDa translocator protein (TSPO) with [¹⁸F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients
Varrone A; Mattsson P; Forsberg A; Takano A; Nag S; Gulyas B; Borg J; Boellaard R; Al-Tawil N; Eriksdotter M; Zimmermann T; Schultze-Mosgau M; Thiele A; Hoffmann A; Lammertsma AA; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2013;40(4):547-553
Palladium mediated ¹¹C-cyanation and characterization in the non-human primate brain of the novel mGluR5 radioligand [¹¹C]AZD9272
Andersson JD; Seneca N; Truong P; Wensbo D; Raboisson P; Farde L; Halldin C
Article: SYNAPSE. 2013;67(5):258-264
Brain uptake and distribution of the dopamine D3/D2 receptor partial agonist [11C]cariprazine: An in vivo positron emission tomography study in nonhuman primates
Toth M; Varrone A; Steiger C; Laszlovszky I; Horvath A; Kiss B; Gyertyan I; Adham N; Halldin C; Gulyas B
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(4):763-769
Effects of amphetamine on the human brain opioid system - a positron emission tomography study
Guterstam J; Jayaram-Lindstrom N; Cervenka S; Frost JJ; Farde L; Halldin C; Franck J
Article: EJNMMI RESEARCH. 2013;3(1):30
In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [¹⁸F]FEDAA1106
Takano A; Piehl F; Hillert J; Varrone A; Nag S; Gulyas B; Stenkrona P; Villemagne VL; Rowe CC; Macdonell R; Al Tawil N; Kucinski T; Zimmermann T; Schultze-Mosgau M; Thiele A; Hoffmann A; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2013;40(3):410-414
Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate
Schou M; Varnas K; Jucaite A; Gulyas B; Halldin C; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):580-593
Low background and high contrast PET imaging of amyloid-β with [¹¹C]AZD2995 and [¹¹C]AZD2184 in Alzheimer's disease patients
Forsberg A; Jureus A; Cselenyi Z; Eriksdotter M; Freund-Levi Y; Jeppsson F; Swahn B-M; Sandell J; Julin P; Schou M; Andersson J; Johnstrom P; Varnas K; Halldin C; Farde L; Svensson S
Article: NEUROIMAGE. 2013;69:78-86
Graphic plot analysis for estimating binding potential of translocator protein (TSPO) in positron emission tomography studies with [¹⁸F]FEDAA1106
Ikoma Y; Takano A; Varrone A; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):574-579
Test-retest reproducibility of dopamine D_2/3 receptor binding in human brain measured by PET with [¹¹C]MNPA and [¹¹C]raclopride
Kodaka F; Ito H; Kimura Y; Fujie S; Takano H; Fujiwara H; Sasaki T; Nakayama K; Halldin C; Farde L; Suhara T
Article: JOURNAL OF CHROMATOGRAPHY A. 2013;1281:54-59
"Mixed" anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands
Nakao R; Halldin C
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2013;2013(7):1228-1231
Palladium-Mediated [¹¹C]Carbonylation at Atmospheric Pressure: A General Method Using Xantphos as Supporting Ligand
Dahl K; Schou M; Amini N; Halldin C
Article: PSYCHOPHARMACOLOGY. 2013;226(1):147-153
SERT and NET occupancy by venlafaxine and milnacipran in nonhuman primates: a PET study
Takano A; Halldin C; Farde L
Article: BRAIN RESEARCH BULLETIN. 2013;91:46-51
In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB₁ receptor antagonist radioligand [¹²⁵I]SD7015 in CB₁ knock-out and wildtype mouse
Mathe D; Horvath I; Szigeti K; Donohue SR; Pike VW; Jia Z; Ledent C; Palkovits M; Freund TF; Halldin C; Gulyas B
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2013;405(4):1303-1310
Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [¹¹C]flumazenil, [¹⁸F]FE-PE2I, and [¹¹C]PBR28
Amini N; Nakao R; Schou M; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(2):228-237
Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT
Schain M; Toth M; Cselenyi Z; Arakawa R; Halldin C; Farde L; Varrone A
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2013;21(1):186-195
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity
Nag S; Kettschau G; Heinrich T; Varrone A; Lehmann L; Gulyas B; Thiele A; Keller E; Halldin C
Article: JOURNAL OF CHROMATOGRAPHY A. 2012;1266:76-83
Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection
Nakao R; Schou M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(11):1794-1801
Preclinical Characterization of a Novel Class of ¹⁸F-Labeled PET Tracers for Amyloid-β
Brockschnieder D; Schmitt-Willich H; Heinrich T; Varrone A; Gulyas B; Toth M; Andersson J; Boemer U; Krause S; Friebe M; Dinkelborg L; Halldin C; Dyrks T
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2012;55(13):460-462
Radiolabeling of two 11C-labeled formylating agents and their application in the preparation of [11C]benzimidazole
Schou M; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2012;55(13):455-459
Radiofluorination and reductive amination using a microfluidic device
Dahl K; Schou M; Halldin C
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2012;320(1-2):110-117
Evolution of microglial activation in ischaemic core and pen-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [¹¹C]vinpocetine
Gulyas B; Toth M; Schain M; Airaksinen A; Vas A; Kostulas K; Lindstrom P; Hillert J; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(8):1167-1172
Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder
Lundberg J; Tiger M; Landen M; Halldin C; Farde L
Article: EJNMMI RESEARCH. 2012;2(1):37
Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[¹¹ C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([¹¹ C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
Fuchigami T; Takano A; Gulyas B; Jia Z; Finnema SJ; Andersson JD; Nakao R; Magata Y; Haratake M; Nakayama M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(7):1065-1073
Quantification of Dopamine Transporter in Human Brain Using PET with ¹⁸F-FE-PE2I
Sasaki T; Ito H; Kimura Y; Arakawa R; Takano H; Seki C; Kodaka F; Fujie S; Takahata K; Nogami T; Suzuki M; Fujiwara H; Takahashi H; Nakao R; Fukumura T; Varrone A; Halldin C; Nishikawa T; Suhara T
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2012;55(6):206-210
An efficient one-step radiosynthesis of [18F]FE-PE2I, a PET radioligand for imaging of dopamine transporters
Stepanov V; Krasikova R; Raus L; Loog O; Hiltunen J; Halldin C
Article: TRANSLATIONAL PSYCHIATRY. 2012;2(5):e120
Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder
Cervenka S; Hedman E; Ikoma Y; Djurfeldt DR; Ruck C; Halldin C; Lindefors N
Article: BRAIN RESEARCH. 2012;1453:56-63
Signal transduction pathway activity compensates dopamine D₂/D₃ receptor density changes in Parkinson's disease: a preliminary comparative human brain receptor autoradiography study with [³H]raclopride and [³⁵S]GTPγS
Szabolcs F; Katalin N; Jia Z; Tibor H; Varrone A; Halldin C; Laszlo C; Gulyas B
Article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2012;895:116-122
Rapid and sensitive measurement of PET radioligands in plasma by fast liquid chromatography/radiometric detection
Nakao R; Schou M; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2012;20(9):3065-3071
Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)
Nag S; Lehmann L; Kettschau G; Heinrich T; Thiele A; Varrone A; Gulyas B; Halldin C
Article: EJNMMI RESEARCH. 2012;2:15
Kinetic analysis and test-retest variability of the radioligand [¹¹C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
Jucaite A; Cselenyi Z; Arvidsson A; Ahlberg G; Julin P; Varnas K; Stenkrona P; Andersson J; Halldin C; Farde L
Article: BRAIN RESEARCH BULLETIN. 2012;87(6):504-510
The decrease of dopamine D₂/D₃ receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB₁ cannabinoid receptors in Parkinson's disease: A preliminary autoradiographic study with the selective dopamine D₂/D₃ antagonist [³H]raclopride and the novel CB₁ inverse agonist [¹²⁵I]SD7015
Farkas S; Nagy K; Jia Z; Harkany T; Palkovits M; Donohou SR; Pike VW; Halldin C; Mathe D; Csiba L; Gulyas B
Article: ANALYTICAL CHEMISTRY. 2012;84(7):3222-3230
Direct Plasma Metabolite Analysis of Positron Emission Tomography Radioligands by Micellar Liquid Chromatography with Radiometric Detection
Nakao R; Schou M; Halldin C
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2012;227(4):1663-1669
Pharmacokinetic analysis of plasma curves obtained after i.v. injection of the PET radioligand [11C] raclopride provides a likely explanation for rapid radioligand metabolism
Sestini S; Halldin C; Mansi L; Castagnoli A; Farde L
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32(4):685-695
Confirmation of fenfluramine effect on 5-HT_1B receptor binding of [¹¹C]AZ10419369 using an equilibrium approach
Finnema SJ; Varrone A; Hwang T-J; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2012;39(3):315-323
Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-[¹⁸F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography
Jahan M; Nag S; Krasikova R; Weber U; Muhs A; Pfeifer A; Spenger C; Willbold D; Gulyas B; Halldin C
Article: SYNAPSE. 2012;66(4):323-330
In vivo evaluation in cynomolgus monkey brain and metabolism of [18F]fluorodeprenyl: A new MAO-B pet radioligand
Nag S; Varrone A; Toth M; Thiele A; Kettschau G; Heinrich T; Lehmann L; Halldin C
Article: QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012
New developments of dopaminergic imaging in Parkinson's disease.
Varrone A; Halldin C
Article: QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012;56(1):68-82
New developments of dopaminergic imaging in Parkinson's disease
Varrone A; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(3):415-424
Clinical Validation of ¹⁸F-AZD4694, an Amyloid-β-Specific PET Radioligand
Cselenyi Z; Jonhagen ME; Forsberg A; Halldin C; Julin P; Schou M; Johnstrom P; Varnas K; Svensson S; Farde L
Article: NEUROIMAGE. 2012;60(1):800-807
Quantification of serotonin transporter availability with [¹¹C]MADAM - A comparison between the ECAT HRRT and HR systems
Schain M; Toth M; Cselenyi Z; Stenkrona P; Halldin C; Farde L; Varrone A
Article: NEUROIMAGE. 2012;59(4):3582-3593
Quantitative PET analyses of regional [¹¹C]PE2I binding to the dopamine transporter - Application to juvenile myoclonic epilepsy
Odano I; Varrone A; Savic I; Ciumas C; Karlsson P; Jucaite A; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2012;39(2):295-303
Simplified quantification and whole-body distribution of [¹⁸F]FE-PE2I in nonhuman primates: prediction for human studies
Varrone A; Gulyas B; Takano A; Stabin MG; Jonsson C; Halldin C
Article: NEUROCHEMISTRY INTERNATIONAL. 2012;60(3):286-291
[¹²⁵I]SD-7015 reveals fine modalities of CB₁ cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease
Farkas S; Nagy K; Palkovits M; Kovacs GG; Jia Z; Donohue S; Pike V; Halldin C; Mathe D; Harkany T; Gulyas B; Csiba L
Article: CURRENT RADIOPHARMACEUTICALS. 2012;5(1):19-28
Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.
Gulyas B; Toth M; Vas A; Shchukin E; Kostulas K; Hillert J; Halldin C
Article: JOURNAL OF NEUROIMAGING. 2012;22(1):28-32
A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry
Comley RA; Cervenka S; Palhagen SE; Panagiotidis G; Matthews JC; Lai RY; Halldin C; Farde L; Nichols TE; Whitcher BJ
Article: NEUROCHEMISTRY INTERNATIONAL. 2012;60(2):153-162
Distribution and binding of ¹⁸F-labeled and ¹²⁵I-labeled analogues of ACI-80, a prospective molecular imaging biomarker of disease: A whole hemisphere post mortem autoradiography study in human brains obtained from Alzheimer's disease patients
Gulyas B; Spenger C; Beliczai Z; Gulya K; Kasa P; Jahan M; Jia Z; Weber U; Pfeifer A; Muhs A; Willbold D; Halldin C
Article: PLOS ONE. 2012;7(7):e41457
Development of a Small D-Enantiomeric Alzheimer's Amyloid-β Binding Peptide Ligand for Future In Vivo Imaging Applications
Funke SA; Bartnik D; Glueck JM; Piorkowska K; Wiesehan K; Weber U; Gulyas B; Halldin C; Pfeifer A; Spenger C; Muhs A; Willbold D
Article: EJNMMI RESEARCH. 2011;1(1):33
Decreased defluorination using the novel beta-cell imaging agent [¹⁸F]FE-DTBZ-d4 in pigs examined by PET
Jahan M; Eriksson O; Johnstrom P; Korsgren O; Sundin A; Johansson L; Halldin C
Article: PSYCHOPHARMACOLOGY. 2011;218(3):579-587
Occupancy of dopamine D₂ and D₃ and serotonin 5-HT_1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography
Seneca N; Finnema SJ; Laszlovszky I; Kiss B; Horvath A; Pasztor G; Kapas M; Gyertyan I; Farkas S; Innis RB; Halldin C; Gulyas B
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2011;54(14):847-854
Synthesis of a delta opioid agonist in [2H6], [2H4], [11C], and [14C] labeled forms
Elmore CS; Brush K; Schou M; Palmer W; Dorff PN; Powell ME; Hoesch V; Hall JE; Hudzik T; Halldin C; Dantzman CL
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38(11):2058-2065
Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [¹⁸F]FEDAA1106: a human whole-body PET study
Takano A; Gulyas B; Varrone A; Karlsson P; Sjoholm N; Larsson S; Jonsson C; Odh R; Sparks R; Al Tawil N; Hoffmann A; Zimmermann T; Thiele A; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(10):1357-1366
Comparison of D₂ dopamine receptor occupancy after oral administration of quetiapine fumarate immediate-release and extended-release formulations in healthy subjects
Nord M; Nyberg S; Brogren J; Jucaite A; Halldin C; Farde L
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2011;54(20):7023-7029
Synthesis of Three Novel Fluorine-18 Labeled Analogues of L-Deprenyl for Positron Emission Tomography (PET) studies of Monoamine Oxidase B (MAO-B)
Nag S; Lehmann L; Heinrich T; Thiele A; Kettschau G; Nakao R; Gulyas B; Halldin C
Article: HUMAN BRAIN MAPPING. 2011;32(10):1626-1636
Extrastriatal Dopamine D₂ Receptor Binding in Huntington's Disease
Esmaeilzadeh M; Farde L; Karlsson P; Varrone A; Halldin C; Waters S; Tedroff J
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(8):1313-1321
Imaging of the Striatal and Extrastriatal Dopamine Transporter with ¹⁸F-LBT-999: Quantification, Biodistribution, and Radiation Dosimetry in Nonhuman Primates
Varrone A; Stepanov V; Nakao R; Toth M; Gulyas B; Emond P; Deloye JB; Vercouillie J; Stabin MG; Jonsson C; Guilloteau D; Halldin C
Article: PSYCHOPHARMACOLOGY. 2011;216(2):279-286
NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo
Takano A; Nag S; Gulyas B; Halldin C; Farde L
Article: NEUROIMAGE. 2011;56(3):1111-1121
Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [¹¹C]vinpocetine
Gulyas B; Vas A; Toth M; Takano A; Varrone A; Cselenyi Z; Schain M; Mattsson P; Halldin C
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2011;54(8):2961-2970
N-(4-Cyanotetrahydro-2H-pyran-4-yl) and N-(1-Cyanocyclohexyl) Derivatives of 1,5-Diarylpyrazole-3-carboxamides Showing High Affinity for 18 kDa Translocator Protein and/or Cannabinoid Receptors
Donohue SR; Dannals RF; Halldin C; Pike VW
Article: ACS CHEMICAL NEUROSCIENCE. 2011;2(2):82-89
The "Specific" P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)
Kannan P; Telu S; Shukla S; Ambudkar SV; Pike VW; Halldin C; Gottesman MM; Innis RB; Hall MD
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(6):2593-2598
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
Kannan P; Brimacombe KR; Kreisl WC; Liow J-S; Zoghbi SS; Telu S; Zhang Y; Pike VW; Halldin C; Gottesman MM; Innis RB; Hall MD
Article: NUCLEAR MEDICINE AND BIOLOGY. 2011;38(2):261-272
Development of a PET radioligand for the central 5-HT_1B receptor: radiosynthesis and characterization in cynomolgus monkeys of eight radiolabeled compounds
Andersson JD; Pierson ME; Finnema SJ; Gulyas B; Heys R; Elmore CS; Farde L; Halldin C
Article: PSYCHOPHARMACOLOGY. 2011;213(2-3):533-545
Dose-dependent binding of AZD3783 to brain 5-HT_1B receptors in non-human primates and human subjects: a positron emission tomography study with [¹¹C]AZ10419369
Varnas K; Nyberg S; Karlsson P; Pierson ME; Kagedal M; Cselenyi Z; McCarthy D; Xiao A; Zhang M; Halldin C; Farde L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(1):83-89
Effect of risperidone on high-affinity state of dopamine D₂ receptors: a PET study with agonist ligand [¹¹C](R)-2-CH₃O-N-n-propylnorapomorphine
Kodaka F; Ito H; Takano H; Takahashi H; Arakawa R; Miyoshi M; Okumura M; Otsuka T; Nakayama K; Halldin C; Farde L; Suhara T
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(1):132-139
Kinetic Analysis and Quantification of the Dopamine Transporter in the Nonhuman Primate Brain with ¹¹C-PE2I and ¹⁸F-FE-PE2I
Varrone A; Toth M; Steiger C; Takano A; Guilloteau D; Ichise M; Gulyas B; Halldin C
Article: NEUROCHEMISTRY INTERNATIONAL. 2011;58(1):60-68
Activated MAO-B in the brain of Alzheimer patients, demonstrated by [¹¹C]-L-deprenyl using whole hemisphere autoradiography
Gulyas B; Pavlova E; Kasa P; Gulya K; Bakota L; Varszegi S; Keller E; Horvath MC; Nag S; Hermecz I; Magyar K; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2011;31(1):113-123
Quantitative analysis of [¹¹C]AZ10419369 binding to 5-HT_1B receptors in human brain
Varnas K; Nyberg S; Halldin C; Varrone A; Takano A; Karlsson P; Andersson J; McCarthy D; Smith M; Pierson ME; Soderstrom J; Farde L
Article: SYNAPSE. 2010;64(10):733-741
Radiosynthesis of the Candidate β-Amyloid Radioligand [¹¹C]AZD2184: Positron Emission Tomography Examination and Metabolite Analysis in Cynomolgus Monkeys
Andersson JD; Varnas H; Cselenyi Z; Gulyas B; Wensbo D; Finnema SJ; Swahn B-M; Svensson S; Nyberg S; Farde L; Halldin C
Article: SYNAPSE. 2010;64(9):699-703
Dopamine β-Hydroxylase-Deficient Mice Have Normal Densities of D₂ Dopamine Receptors in the High-Affinity State Based on In Vivo PET Imaging and In Vitro Radioligand Binding
Skinbjerg M; Seneca N; Liow J-S; Hong J; Weinshenker D; Pike VW; Halldin C; Sibley DR; Innis RB
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(8):1499-1506
Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB₁ receptors using positron emission tomography
Terry GE; Hirvonen J; Liow J-S; Seneca N; Tauscher JT; Schaus JM; Phebus L; Felder CC; Morse CL; Pike VW; Halldin C; Innis RB
Article: SYNAPSE. 2010;64(7):573-577
Fenfluramine-Induced Serotonin Release Decreases [¹¹C]AZ10419369 Binding to 5-HT_1B-Receptors in the Primate Brain
Finnema SJ; Varrone A; Hwang TJ; Gulyas B; Pierson ME; Halldin C; Farde L
Article: PSYCHOPHARMACOLOGY. 2010;210(3):331-336
Norepinephrine transporter occupancy by antidepressant in human brain using positron emission tomography with (S,S)-[¹⁸F]FMeNER-D₂
Sekine M; Arakawa R; Ito H; Okumura M; Sasaki T; Takahashi H; Takano H; Okubo Y; Halldin C; Suhara T
Article: DRUG METABOLISM AND DISPOSITION. 2010;38(6):917-922
N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier
Kannan P; Brimacombe KR; Zoghbi SS; Liow J-S; Morse C; Taku AK; Pike VW; Halldin C; Innis RB; Gottesman MM; Hall MD
Article: SYNAPSE. 2010;64(6):478-485
PET Studies of D2-Receptor Binding in Striatal and Extrastriatal Brain Regions: Biochemical Support In Vivo for Separate Dopaminergic Systems in Humans
Cervenka S; Varrone A; Fransen E; Halldin C; Farde L
Article: NEUROCHEMISTRY INTERNATIONAL. 2010;56(6-7):789-798
The norepinephrine transporter (NET) radioligand (S,S)-[¹⁸F]FMeNER-D₂ shows significant decreases in NET density in the human brain in Alzheimer's disease: A post-mortem autoradiographic study
Gulyas B; Brockschnieder D; Nag S; Pavlova E; Kasa P; Beliczai Z; Legradi A; Gulya K; Thiele A; Dyrks T; Halldin C
Article: NEUROIMAGE. 2010;50(4):1402-1407
D₂ dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model
Skinbjerg M; Liow J-S; Seneca N; Hong J; Lu S; Thorsell A; Heilig M; Pike VW; Halldin C; Sibley DR; Innis RB
Article: NEUROSCIENCE. 2010;167(1):104-110
AGE-RELATED REDUCTION IN DOPAMINE D1 RECEPTORS IN THE HUMAN BRAIN: FROM LATE CHILDHOOD TO ADULTHOOD, A POSITRON EMISSION TOMOGRAPHY STUDY
Jucaite A; Forssberg H; Karlsson P; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2010;37(3):357-363
In vivo and in vitro characterization of [¹⁸F]-FE-(+)-DTBZ as a tracer for beta-cell mass
Eriksson O; Jahan M; Johnstrom P; Korsgren O; Sundin A; Halldin C; Johansson L
Article: NEUROIMAGE. 2010;50(1):323-328
Association between striatal and extrastriatal dopamine D2-receptor binding and social desirability
Cervenka S; Gustavsson JP; Halldin C; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 2010;51(1):112-120
Imaging and Quantitation of Cannabinoid CB₁ Receptors in Human and Monkey Brains Using ¹⁸F-Labeled Inverse Agonist Radioligands
Terry GE; Hirvonen J; Liow J-S; Zoghbi SS; Gladding R; Tauscher JT; Schaus JM; Phebus L; Felder CC; Morse CL; Donohue SR; Pike VW; Halldin C; Innis RB
Article: NEUROIMAGE. 2009;48(2):362-370
Quantitation of cannabinoid CB₁ receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
Terry GE; Liow J-S; Zoghbi SS; Hirvonen J; Farris AG; Lerner A; Tauscher JT; Schaus JM; Phebus L; Felder CC; Morse CL; Hong JS; Pike VW; Halldin C; Innis RB
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(11):1885-1891
Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[¹⁸F]FMeNER-D₂ and (S,S)-[¹¹C]MeNER
Takano A; Gulyas B; Varrone A; Halldin C
Article: NEUROIMAGE. 2009;48(2):398-404
Modulation of striatal dopamine D1 binding by cognitive processing
Karlsson S; Nyberg L; Karlsson P; Fischer H; Thilers P; MacDonald S; Brehmer Y; Rieckmann A; Halldin C; Farde L; Backman L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(11):1859-1863
Detection of amyloid in Alzheimer's disease with positron emission tomography using [¹¹C]AZD2184
Nyberg S; Jonhagen ME; Cselenyi Z; Halldin C; Julin P; Olsson H; Freund-Levi Y; Andersson J; Varnas K; Svensson S; Farde L
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2009;19(21):6209-6212
Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors
Donohue SR; Varnas K; Jia Z; Gulyas B; Pike VW; Halldin C
Article: SYNAPSE. 2009;63(10):871-880
In Vitro Autoradiography and In Vivo Evaluation in Cynomolgus Monkey of [¹⁸F]FE-PE2I, a New Dopamine Transporter PET Radioligand
Varrone A; Steiger C; Schou M; Takano A; Finnema SJ; Guilloteau D; Gulyas B; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2009;19(16):4843-4845
Synthesis, radiolabeling and preliminary in vivo evaluation of [¹⁸F]FE-PE2I, a new probe for the dopamine transporter
Schou M; Steiger C; Varrone A; Guilloteau D; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(8):1308-1314
Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[¹⁸F]FMeNER-D₂
Takano A; Gulyas B; Varrone A; Maguire RP; Halldin C
Article: SYNAPSE. 2009;63(7):621-624
Arrestin3 Mediates D₂ Dopamine Receptor Internalization
Skinbjerg M; Ariano MA; Thorsell A; Heilig M; Halldin C; Innis RB; Sibley DR
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(6):783-792
Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT_1A receptor binding in humans
Borg J; Henningsson S; Saijo T; Inoue M; Bah J; Westberg L; Lundberg J; Jovanovic H; Andree B; Nordstrom A-L; Halldin C; Eriksson E; Farde L
Article: EXPERIMENTAL NEUROLOGY. 2009;218(1):83-91
Activation of glucocorticoid receptors increases 5-HT_2A receptor levels
Trajkovska V; Kirlegaard L; Krey G; Marcussen AB; Thomsen MS; Chourbaji S; Brandwein C; Ridder S; Halldin C; Gass P; Knudsen GM; Aznar S
Article: SYNAPSE. 2009;63(6):462-475
Pharmacological Characterization of 2-Methoxy-N-Propylnorapomorphine's Interactions with D₂ and D₃ Dopamine Receptors
Skinbjerg M; Namkung Y; Halldin C; Innis RB; Sibley DR
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2009;52(5-6):158-165
A two-step one-pot radiosynthesis of the potent dopamine D₂/D₃ agonist PET radioligand [¹¹C]MNPA
Steiger C; Finnema SJ; Raus L; Schou M; Nakao R; Suzuki K; Pike VW; Wikstrom HV; Halldin C
Article: SYNAPSE. 2009;63(5):378-389
Dopamine D_2/3 Receptor Occupancy of Apomorphine in the Nonhuman Primate Brain-A Comparative PET Study With [¹¹C]Raclopride and [¹¹C]MNPA
Finnema SJ; Halldin C; Bang-Andersen B; Gulyas B; Bundgaard C; Wikstrom HV; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 2009;50(5):703-710
Quantitative PET Analysis of the Dopamine D₂ Receptor Agonist Radioligand ¹¹C-(R)-2-CH₃O-N-n-Propylnorapomorphine in the Human Brain
Otsuka T; Ito H; Halldin C; Takahashi H; Takano H; Arakawa R; Okumura M; Kodaka F; Miyoshi M; Sekine M; Seki C; Nakao R; Suzuki K; Finnema S; Hirayasu Y; Suhara T; Farde L
Article: PSYCHIATRY RESEARCH. 2009;172(1):31-37
5-HT_1A receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [¹¹C] WAY100635 and [¹¹C] MADAM PET
Jovanovic H; Karlsson P; Cerin A; Halldin C; Nordstrom A-L
Article: NEUROIMAGE. 2009;45(3):891-902
[¹⁸F]Flumazenil binding to central benzodiazepine receptor studies by PET - Quantitative analysis and comparisons with [¹¹C]flumazenil
Odano I; Halldin C; Karlsson P; Varrone A; Airaksinen AJ; Krasikova RN; Farde L
Article: JOURNAL OF NEUROSCIENCE. 2009;29(6):1887-1896
Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system.
Tokunaga M; Seneca N; Shin R-M; Maeda J; Obayashi S; Okauchi T; Nagai Y; Zhang M-R; Nakao R; Ito H; Innis RB; Halldin C; Suzuki K; Higuchi M; Suhara T
Article: APPLIED RADIATION AND ISOTOPES. 2009;67(1):73-78
A fully automated one-pot synthesis of [carbonyl-¹¹C]WAY-100635 for clinical PET applications
Krasikova RN; Andersson J; Truong P; Nag S; Shchukin EV; Halldin C
Article: APPLIED RADIATION AND ISOTOPES. 2009;67(1):106-110
In-target produced [¹¹C]methane: Increased specific radioactivity
Andersson J; Truong P; Halldin C
Article: NEUROCHEMISTRY INTERNATIONAL. 2009;54(1):28-36
A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system
Gulyas B; Makkai B; Kasa P; Gulya K; Bakota L; Varszegi S; Beliczai Z; Andersson J; Csiba L; Thiele A; Dyrks T; Suhara T; Suzuki K; Higuchi M; Halldin C
Article: SYNAPSE. 2009;63(1):22-30
Evaluation of [¹¹C]PipISB and [¹⁸F]PipISB in Monkey as Candidate Radioligands for Imaging Brain Cannabinoid Type-1 Receptors In Vivo
Finnema SJ; Donohue SR; Zoghbi SS; Brown AK; Gulyas B; Innis RB; Halldin C; Pike VW
Article: MOLECULAR IMAGING AND BIOLOGY. 2009;11(1):23-30
Investigation of the Metabolites of (S,S)-[¹¹C] MeNER in Humans, Monkeys and Rats
Schou M; Zoghbi SS; Shetty HU; Shchukin E; Liow J-S; Hong J; Andree BA; Gulyas B; Farde L; Innis RB; Pike VW; Halldin C
Article: NEUROCHEMISTRY INTERNATIONAL. 2008;53(6-8):181-183
Immunohistoblot analysis on whole human hemispheres from normal and Alzheimer diseased brains
Beliczai Z; Varszegi S; Gulyas B; Halldin C; Kasa P; Gulya K
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(11):2144-2151
Guideline to regulations for radiopharmaceuticals in early phase clinical trials in the EU
Verbruggen A; Coenen HH; Deverre J-R; Guilloteau D; Langstrom B; Salvadori PA; Halldin C
Article: SYNAPSE. 2008;62(10):756-763
Occupancy of dopamine D_2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [¹¹C]MNPA
Seneca N; Zoghbi SS; Skinbjerg M; Liow J-S; Hong J; Sibley DR; Pike VW; Halldin C; Innis RB
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2008;51(18):5833-5842
Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging
Donohue SR; Krushinski JH; Pike VW; Chernet E; Phebus L; Chesterfield AK; Felder CC; Halldin C; Schaus JM
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2008;51(18):5608-5616
Discovery and labeling of high-affinity 3,4-diarylpyrazolines as candidate radioligands for in vivo imaging of cannabinoid subtype-1 (CB₁) receptors
Donohue SR; Pike VW; Finnema SJ; Truong P; Andersson J; Gulyas B; Halldin C
Article: NEUROLOGY. 2008;71(11):788-794
Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy
Ciumas C; Wahlin T-BR; Jucaite A; Lindstrom P; Halldin C; Savic I
Article: SYNAPSE. 2008;62(9):700-709
Kinetic brain analysis and whole-body imaging in monkey of [¹¹C]MNPA:: A dopamine agonist radioligand
Seneca N; Skinbjerg M; Zoghbi SS; Liow J-S; Gladding RL; Hong J; Kannan P; Tuan E; Sibley DR; Halldin C; Pike VW; Innis RB
Article: NEUROIMAGE. 2008;42(2):474-482
Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[¹⁸F]FMeNER-D₂
Takano A; Varrone A; Gulyas B; Karlsson P; Tauscher J; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11(5):671-678
Age-related diurnal effect on D₂ receptor binding: a preliminary PET study
Cervenka S; Halldin C; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 2008;49(8):1270-1276
Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-¹⁸F-FMeNER-D₂
Arakawa R; Okurnura M; Ito H; Seki C; Takahashi H; Takano H; Nakao R; Suzuki K; Okubo Y; Halldin C; Suhara T
Article: NEUROIMAGE. 2008;41(3):690-698
Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB₁ receptors in rodents
Terry G; Liow J-S; Chernet E; Zoghbi SS; Phebus L; Felder CC; Tauscher J; Schaus JM; Pike VW; Halldin C; Innis RB
Article: NEUROIMAGE. 2008;41(3):1075-1085
[¹¹C]AZ10419369:: A selective 5-HT_1B receptor radioligand suitable for positron emission tomography (PET).: Characterization in the primate brain
Pierson ME; Andersson J; Nyberg S; McCarthy DJ; Finnema SJ; Varnas K; Takano A; Karlsson P; Gulyas B; Medd AM; Lee C-M; Powell ME; Heys JR; Potts W; Seneca N; Mrzljak L; Farde L; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2008;16(13):6467-6473
[¹¹C]cyclopropyl-FLB 457:: A PET radioligand for low densities of dopamine D₂ receptors
Airaksinen AJ; Nag S; Finnema SJ; Mukherjee J; Chattopadhyay S; Gulyas B; Farde L; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2008;28(5):1059-1069
Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [¹¹C]PE2I:: quantitative modeling and test-retest reproducibility
Hirvonen J; Johansson J; Teras M; Oikonen V; Lumme V; Virsu P; Roivainen A; Nagren K; Halldin C; Farde L; Hietala J
Article: NEUROIMAGE. 2008;40(3):1287-1295
Associations between dopamine D2-receptor binding and cognitive performance indicate functional compartmentalization of the human striatum
Cervenka S; Backman L; Cselenyi Z; Halldin C; Farde L
Article: TETRAHEDRON LETTERS. 2008;49(17):2789-2791
A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3-dipolar cycloaddition
Donohue SR; Halldin C; Pike VW
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2008;51(3-4):146-152
Radiolabeling of a high potency cannabinoid subtype-1 receptor ligand, N-(4-fluoro-benzyl)-4-(3-(piperidin-1-yl)-indole-1-sulfonyl)benzamide (PipISB), with carbon-11 or fluorine-18
Donohue SR; Halldin C; Schou M; Hong J; Phebus L; Chernet E; Hitchcock SA; Gardinier KM; Ruley KM; Krushinski JH; Schaus J; Pike VW
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2008;11(2):163-171
PET analysis of the 5-HT_2A receptor inverse agonist ACP-103 in human brain
Nordstrom A-L; Mansson M; Jovanovic H; Karlsson P; Halldin C; Farde L; Vanover KE; Hacksell U; Brann MR; Davis RE; Weiner DM
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(3):630-636
Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[¹⁸F]FMeNER-D₂:: a human whole-body PET study
Takano A; Halldin C; Varrone A; Karlsson P; Sjoeholm N; Stubbs JB; Schou M; Airaksinen AJ; Tauscher J; Gulyas B
Article: NEUROIMAGE. 2008;39(3):1408-1419
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
Jovanovic H; Lundberg J; Karlsson P; Cerin A; Saijo T; Varrone A; Halldin C; Nordstrom A-L
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2008;264(1-2):9-17
Functional neuroimaging in multiple sclerosis with radiolabelled glia markers:: Preliminary comparative PET studies with [¹¹C]vinpocetine and [¹¹C]PK11195 in patients
Vas A; Shchukin Y; Karrenbauer VD; Cselenyi Z; Kostulas K; Hillert J; Savic I; Takano A; Halldin C; Gulyas B
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(1):153-157
Imaging the norepinephrine transporter with positron emission tomography:: initial human studies with (S,S)-[¹⁸F]FMeNER-D₂
Takano A; Gulyas B; Varrone A; Karlsson P; Schou M; Airaksinen AJ; Vandenhende F; Tauscher J; Halldin C
Article: NEUROPSYCHOPHARMACOLOGY. 2008;33(2):259-269
The PET radioligand [¹¹C]MePPEP binds reversibly and with high specific signal to cannabinoid CB₁ receptors in nonhuman primate brain
Yasuno F; Brown AK; Zoghbi SS; Krushinski JH; Chernet E; Tauscher J; Schaus JM; Phebus LA; Chesterfield AK; Felder CC; Gladding RL; Hong J; Halldin C; Pike VW; Innis RB
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2008;51(1-2):1-5
Radiosynthesis of [¹¹C]ximelagatran via palladium catalyzed [¹¹C]cyanation
Airaksinen AJ; Andersson J; Truong P; Karlsson O; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2007;10(6):777-785
PET measurement of serotonin transporter occupancy: a comparison of escitalopram and citalopram
Lundberg J; Christophersen JS; Petersen KB; Loft H; Halldin C; Farde L
Article: PSYCHOPHARMACOLOGY. 2007;195(3):425-433
A PET study on regional coexpression of 5-HT_1A receptors and 5-HTT in the human brain
Lundberg J; Borg J; Halldin C; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34(10):1670-1682
Synthesis and initial evaluation of [¹¹C](R)-RWAY in monkey -: a new, simply labeled antagonist radioligand for imaging brain 5-HT_1A receptors with PET
McCarron JA; Zoghbi SS; Shetty HU; Vermeulen ES; Wikstrom HV; Ichise M; Yasuno F; Halldin C; Innis RB; Pike VW
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2007;50(7-8):716-723
One-step radiosynthesis of [¹⁸F]LBT-999:: a selective radioligand for the visualization of the dopamine transporter with PET
Dolle F; Helfenbein J; Hinnen F; Mavel S; Mincheva Z; Saba W; Schoellhorn-Peyronneau M-A; Valette H; Garreau L; Chalon S; Halldin C; Madelmont J-C; Deloye J-B; Bottlaender M; Le Gailliard J; Guilloteau D; Emond P
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34(5):667-678
Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [¹¹C]PE2I
Shetty HU; Zoghbi SS; Liow J-S; Ichise M; Hong J; Musachio JL; Halldin C; Seidel J; Innis RB; Pike VW
Article: APPLIED RADIATION AND ISOTOPES. 2007;65(3):293-300
Synthesis of ³H-labeled N-(3-iodoprop-2E-enyl)-2β-carbomethoxy-3β(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments
Stepanov V; Schou M; Jarv J; Halldin C
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2007;50(4):848-855
N-(5-fluoro-2-phenoxyphenyl)-N-(2-[¹³¹I]iodo-5-methoxybenzyl)acetamide:: A potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain
Zhang M-R; Kumata K; Maeda J; Haradahira T; Noguchi J; Suhara T; Halldin C; Suzuki K
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2007;15(2):616-625
Synthesis of ¹¹C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET
Schou M; Pike VW; Sovago J; Gulyas B; Gallagher PT; Dobson DR; Walter MW; Rudyk H; Farde L; Halldin C
Article: SYNAPSE. 2007;61(1):17-23
[¹¹C]LBT-999:: A suitable radioligand for investigation of extra-striatal dopamine transporter with PET
Saba W; Valette H; Schollhorn-Peyronneau M-A; Coulon C; Ottaviani M; Chalon S; Dolle F; Emond P; Halldin C; Helfenbein J; Madelmont J-C; Deloye J-B; Guilloteau D; Bottlaender M
Article: PSYCHIATRY RESEARCH. 2006;148(2-3):165-173
Dopamine D₂ receptor binding in dirug-naive patients with schizophrenia examined with raclopride-C11 and positron emission tomography
Talvik M; Nordstrom A-L; Okubo Y; Olsson H; Borg J; Halldin C; Farde L
Article: PSYCHIATRY RESEARCH. 2006;148(2-3):185-193
A PET study of 5-HT_1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria
Jovanovic H; Cerin A; Karlsson P; Lundberg J; Halldin C; Nordstrom A-L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33(11):1374-1380
EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues
Borght TV; Asenbaum S; Bartenstein P; Halldin C; Kapucu O; Van Laere K; Varrone A; Tatsch K
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2006;49(11):1007-1019
Synthesis and PET evaluation of (R)-[S-methyl-¹¹C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters
Schou M; Pike VW; Varrone A; Gulyas B; Farde L; Halldin C
Article: NEUROIMAGE. 2006;32(4):1690-1708
A comparison of recent parametric neuroreceptor mapping approaches based on measurements with the high affinity PET radioligands [¹¹C]FLB 457 and [¹¹C]WAY 100635
Cselenyi Z; Olsson H; Halldin C; Gulyas B; Farde L
Article: SYNAPSE. 2006;60(3):256-263
Measurement of serotonin transporter binding with PET and [¹¹C]MADAM:: A test-retest reproducibility study
Lundberg J; Halldin C; Farde L
Article: PSYCHOPHARMACOLOGY. 2006;188(1):119-127
Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion:: a PET study in nonhuman primate brain using (S,S)-[¹⁸F]FMeNER-D₂
Seneca N; Gulyas B; Varrone A; Schou M; Airaksinen A; Tauscher J; Vandenhende F; Kielbasa W; Farde L; Innis RB; Halldin C
Article: BRAIN. 2006;129(Pt 8):2017-2028
Support for dopaminergic hypoactivity in restless legs syndrome:: a PET study on D2-receptor binding
Cervenka S; Palhagen SE; Comley RA; Panagiotidis G; Cselenyi Z; Matthews JC; Lai RY; Halldin C; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2006;49(8):687-698
Radiosynthesis of [¹⁸F]LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET
Dolle F; Hinnen F; Emond P; Mavel S; Mincheva Z; Saba W; Schollhorn-Peyronneau M-A; Valette H; Garreau L; Chalon S; Halldin C; Helfenbein J; Legaillard J; Madelmont J-C; Deloye J-B; Bottlaender M; Guilloteau D
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2006;16(12):3101-3104
Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors
Musachio JL; Hong J; Ichise M; Seneca N; Brown AK; Liow J-S; Halldin C; Innis RB; Pike VW; He R; Zhou J; Kozikowski AP
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33(6):657-668
Quantitative analyses of regional [¹¹C]PE2I binding to the dopamine transporter in the human brain:: a PET study
Jucaite A; Odano I; Olsson H; Pauli S; Halldin C; Farde L
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2006;14(11):3712-3720
Synthesis and structure-activity relationships (SARs) of 1,5-diarylpyrazole cannabinoid type-1 (CB₁) receptor ligands for potential use in molecular imaging
Donohue SR; Halldin C; Pike VW
Article: SYNAPSE. 2006;59(5):260-269
Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain:: A comparison of the agonist radioligand [^11C]MNPA and antagonist [¹¹C]raclopride
Seneca N; Finnema SJ; Farde L; Gulyás B; Wikström HV; Halldin C; Innis RB
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2006;317(1):147-152
Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter
Chalon S; Hall H; Saba W; Garreau L; Dollé F; Halldin C; Emond P; Bottlaender M; Deloye JB; Helfenbein J; Madelmont JC; Bodard S; Mincheva Z; Besnard JC; Guilloteau D
Article: PSYCHOPHARMACOLOGY. 2006;185(3):389-394
Search for correlations between serotonin 5-HT_1A receptor expression and cognitive functions -: a strategy in translational psychopharmacology
Borg J; Andrée B; Lundberg J; Halldin C; Farde L
Article: PSYCHOPHARMACOLOGY. 2006;185(1):29-35
Clozapine binds preferentially to cortical D₁-like dopamine receptors in the primate brain:: a PET study
Chou YH; Halldin C; Farde L
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2006;14(4):1115-1125
Synthesis, radiosynthesis and in vivo preliminary evaluation of [¹¹C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET
Dollé F; Emond P; Mavel S; Demphel S; Hinnen F; Mincheva Z; Saba W; Valette H; Chalon S; Halldin C; Helfenbein J; Legaillard J; Madelmont JC; Deloye JB; Bottlaender M; Guilloteau D
Article: MOLECULAR IMAGING AND BIOLOGY. 2006;8(1):1-8
Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands:: [C-11]desipramine, [C-11]talopram and [C-11]talsupram
Schou M; Sóvágó J; Pike VW; Gulyás B; Bogeso KP; Farde L; Halldin C
Article: SYNAPSE. 2005;58(3):173-183
[¹¹C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET
Halldin C; Lundberg J; Sóvágó J; Gulyás B; Guilloteau D; Vercouillie J; Emond P; Chalon S; Tarkiainen J; Hiltunen J; Farde L
Article: BRAIN RESEARCH BULLETIN. 2005;67(3):219-224
Lack of effect of reserpine-induced dopamine depletion on the binding of the dopamine-D3 selective radioligand, [¹¹C]RGH-1756
Sóvágó J; Farde L; Halldin C; Schukin E; Schou M; Laszlovszky I; Kiss B; Gulyás B
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15(5):517-520
Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[¹⁸F]FMeNER-D₂
Schou M; Halldin C; Pike VW; Mozley PD; Dobson D; Innis RB; Farde L; Hall H
Article: JOURNAL OF NUCLEAR MEDICINE. 2005;46(9):1505-1515
Quantification of ¹¹C-MADAM binding to the serotonin transporter in the human brain
Lundberg J; Odano I; Olsson H; Halldin C; Farde L
Article: NUCLEAR MEDICINE COMMUNICATIONS. 2005;26(8):695-700
Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[¹⁸F]FMeNER-D₂ in non-human primates
Seneca N; Andree B; Sjoholm N; Schou M; Pauli S; Mozley PD; Stubbs JB; Liow JS; Sovago J; Gulyás B; Innis R; Halldin C
Article: ARCHIVES OF NEUROLOGY. 2005;62(6):946-950
Regional reductions in serotonin 1A receptor binding in juvenile myoclonic epilepsy
Meschaks A; Lindstrom P; Halldin C; Farde L; Savic I
Article: SYNAPSE. 2005;56(2):100-104
Specific in vitro binding of (S,S)-[³H]MeNER to norepinephrine transporters
Ghose S; Fujita M; Morrison P; Uhl G; Murphy DL; Mozley PD; Schou M; Halldin C; Innis R
Article: MOLECULAR IMAGING AND BIOLOGY. 2005;7(3):209-219
Two C-methyl derivatives of [¹¹C]WAY-100635 -: Effects of an amido α-methyl group on metabolism and brain 5-HT_1A receptor radioligand behavior in monkey
McCarron JA; Marchais-Oberwinkler S; Pike VW; Tarkiainen J; Halldin C; Sóvagó J; Gulyas BZ; Wikström HV; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2005;32(4):353-360
A preliminary PET evaluation of the new dopamine D₂ receptor agonist [¹¹C]MNPA in cynomolgus monkey
Finnema SJ; Seneca N; Farde L; Shchukin E; Sóvágó J; Gulyás B; Wikström HV; Innis RB; Neumeyer JL; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2005;13(5):1811-1818
Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)-N-(2-[¹⁸F]fluoromethoxy-d₂-5-methoxybenzyl)acetamide:: a deuterium-substituted radioligand for peripheral benzodiazepine receptor
Zhang MR; Maeda J; Ito T; Okauchi T; Ogawa M; Noguchi J; Suhara T; Halldin C; Suzuki K
Article: NUCLEAR MEDICINE AND BIOLOGY. 2005;32(2):109-116
Preparation of highly specific radioactivity [¹⁸F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography
Ryzhikov NN; Seneca N; Krasikova RN; Gomzina NA; Shchukin E; Fedorova OS; Vassiliev DA; Gulyás B; Hall H; Savic I; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2005;13(3):883-893
N-Oxide analogs of WAY-100635:: new high affinity 5-HT_1A receptor antagonists
Marchais-Oberwinkler S; Nowicki B; Pike VW; Halldin C; Sandell J; Chou YH; Gulyas B; Brennum LT; Farde L; Wikström HV
Article: PSYCHIATRY RESEARCH. 2005;138(1):1-12
The role of the striatal dopamine transporter in cognitive aging
Erixon-Lindroth N; Farde L; Wahlin TBR; Sovago J; Halldin C; Bäckman L
Article: NEUROCHEMISTRY INTERNATIONAL. 2004;45(5):773-781
Joint explorative analysis of neuroreceptor subsystems in the human brain:: application to receptor-transporter correlation using PET data
Cselényi Z; Lundberg J; Halldin C; Farde L; Gulyás B
Article: NEUROCHEMISTRY INTERNATIONAL. 2004;45(5):609-617
Positron emission tomographic evaluation of the putative dopamine-D3 receptor ligand, [¹¹C]RGH-1756 in the monkey brain
Sóvágó J; Farde L; Halldin C; Langer O; Laszlovszky I; Kiss B; Gulyás B
Article: PSYCHOPHARMACOLOGY. 2004;175(2):148-153
A cross-validation study on the relationship between central D₂ receptor occupancy and serum perphenazine concentration
Talvik M; Nordström AL; Larsen NE; Jucaite A; Cervenka S; Halldin C; Farde L
Article: SYNAPSE. 2004;53(2):57-67
PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain
Schou M; Halldin C; Sóvágó J; Pike VW; Hall H; Gulyás B; Mozley PD; Dobson D; Shchukin E; Innis RB; Farde L
Article: NEUROIMAGE. 2004;22(2):794-803
Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET
Olsson H; Halldin C; Farde L
Article: NEUROLOGY. 2004;62(8):1343-1351
Limbic reductions of 5-HT_1A receptor binding in human temporal lobe epilepsy
Savic I; Lindström P; Gulyás B; Halldin C; Andrée B; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2004;31(3):327-336
New α₁-adrenoceptor antagonists derived from the antipsychotic sertindole-carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey
Balle T; Halldin C; Andersen L; Alifrangis LH; Badolo L; Jensen KG; Chou YW; Andersen K; Perregaard J; Farde L
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2004;141(6):1015-1023
Selectivity of ³H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice;: correlation with behavioural effects
Larsen AK; Brennum LT; Egebjerg J; Sánchez C; Halldin C; Andersen PH
Article: MOLECULAR IMAGING AND BIOLOGY. 2004;6(1):17-26
The pyridinyl-6 position of WAY-100635 as a site for radiofluorination-effect on 5-HT_1A receptor radioligand behavior in vivo
McCarron JA; Pike VW; Halldin C; Sandell J; Sóvagó J; Gulyas BS; Cselényi Z; Wikström HV; Marchais-Oberwinkler S; Nowicki B; Dollé F; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2004;31(1):103-110
A novel electrophilic synthesis and evaluation of medium specific radioactivity (1R,2S)-4-[¹⁸F]fluorometaraminol, a tracer for the assessment of cardiac sympathetic nerve integrity with PET
Eskola O; Grönroos T; Bergman J; Haaparanta M; Marjamäki P; Lehikoinen P; Forsback S; Langer O; Hinnen F; Dollé F; Halldin C; Solin O
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2003;6(4):361-370
Decreased thalamic D₂/D₃ receptor binding in drug-naive patients with schizophrenia:: a PET study with [¹¹C]FLB 457
Talvik M; Nordström AL; Olsson H; Halldin C; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2003;30(11):1520-1528
Radioiodinated SB 207710 as a radioligand in vivo:: imaging of brain 5-HT₄ receptors with SPET
Pike VW; Halldin C; Nobuhara K; Hiltunen J; Mulligan RS; Swahn CG; Karlsson P; Olsson H; Hume SP; Hirani E; Whalley J; Pilowsky LS; Larsson S; Schnell PO; Ell PJ; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2003;30(7):707-714
Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[¹¹C]MeNER
Schou M; Halldin C; Sóvágó J; Pike VW; Gulyás B; Mozley PD; Johnson DP; Hall H; Innis RB; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2003;30(9):1220-1230
[¹¹C]PE2I:: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain
Halldin C; Erixon-Lindroth N; Pauli S; Chou YH; Okubo Y; Karlsson P; Lundkvist C; Olsson H; Guilloteau D; Emond P; Farde L
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13(4):228-234
Distribution of 5-HT₄ receptors in the postmortem human brain -: an autoradiographic study using [¹²⁵I]SB 207710
Varnäs K; Halldin C; Pike VW; Hall H
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2003;11(13):2769-2782
Synthesis of a [6-pyridinyl-¹⁸F]-labelled fluoro derivative of WAY-100635 as a candidate radioligand for brain 5-HT_1A receptor imaging with PET
Karramkam M; Hinnen F; Berrehouma M; Hlavacek C; Vaufrey F; Halldin C; McCarron JA; Pike VW; Dollé F
Article: PSYCHOPHARMACOLOGY. 2003;167(1):37-45
Positron emission tomographic analysis of dose-dependent NAD-299 binding to 5-hydroxytryptamine-lA receptors in the human brain
Andrée B; Hedman A; Thorberg SO; Nilsson D; Halldin C; Farde L
Article: PSYCHOPHARMACOLOGY. 2003;166(3):234-240
Occupancy of 5-HT_1A receptors by clozapine in the primate brain:: a PET study
Chou YH; Halldin C; Farde L
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2003;304(1):81-87
Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity
Chalon S; Tarkiainen J; Garreau L; Hall H; Emond P; Vercouillie J; Farde L; Dasse P; Varnas K; Besnard JC; Halldin C; Guilloteau D
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2003;46(1):55-65
Preparation of 4-[¹¹C]methylmetaraminol, a potential PET tracer for assessment of myocardial sympathetic innervation
Langer O; Forngren T; Sandell J; Dollé F; Långström B; Någren K; Halldin C
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2002;12(24):3611-3613
Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter
Sandell J; Yu MX; Emond P; Garreau L; Chalon S; Någren K; Guilloteau D; Halldin C
Article: ACTA NEUROLOGICA SCANDINAVICA. 2002;106(6):325-332
PET studies on the brain uptake and regional distribution of [¹¹C] vinpocetine in human subjects
Gulyás B; Halldin C; Sandell J; Karlsson P; Sóvágó J; Kárpáti E; Kiss B; Vas A; Cselényi Z; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2002;29(7):753-759
Cerebral uptake of [ethyl-¹¹C]vinpocetine and 1-[¹¹C]ethanol in cynomolgous monkeys:: a comparative preclinical PET study
Gulyás B; Vas A; Halldin C; Sóvágó J; Sandell J; Olsson H; Fredriksson A; Stone-Elander S; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2002;29(6):651-656
PET examination of [¹¹C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter
Sandell J; Halldin C; Sovago J; Chou YH; Gulyás B; Yu MX; Emond P; Någren K; Guilloteau D; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2002;29(8):1031-1038
Drug distribution in man:: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine
Gulyás B; Halldin C; Sóvágó J; Sandell J; Cselényi Z; Vas A; Kiss B; Kárpáti E; Farde L
Article: PSYCHOPHARMACOLOGY. 2002;162(1):37-41
Low striatal and extra-striatal D₂ receptor occupancy during treatment with the atypical antipsychotic sertindole
Nyberg S; Olsson H; Nilsson U; Maehlum E; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2002;29(4):389-398
Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT_1A receptor and the alpha1-adrenergic receptor
Drews A; Pietzsch HJ; Syhre R; Seifert S; Varnäs K; Hall H; Halldin C; Kraus W; Karlsson P; Johnsson C; Spies H; Johannsen B
Article: NUCLEAR MEDICINE AND BIOLOGY. 2002;29(4):375-387
Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT_1A receptor and the alpha1-adrenergic receptor
Heimbold I; Drews A; Kretzschmar M; Varnäs K; Hall H; Halldin C; Syhre R; Kraus W; Pietzsch HJ; Seifert S; Brust P; Johannsen B
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2002;45(6):1253-1258
Substituted diphenyl sulfides as selective serotonin transporter ligands: Synthesis and in vitro evaluation
Emond P; Vercouillie J; Innis R; Chalon S; Mavel S; Frangin Y; Halldin C; Besnard JC; Guilloteau D
Article: JOURNAL OF NUCLEAR MEDICINE. 2002;43(3):292-303
The PET radioligand [carbonyl-¹¹C]desmethyl-WAY-100635 binds to 5-HT_1A receptors and provides a higher radioactive signal than [carbonyl-¹¹C]WAY-100635 in the human brain
Andrée B; Halldin C; Pike VW; Gunn RN; Olsson H; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2002;29(1):39-45
PET-examination and metabolite evaluation in monkey of [¹¹C]NAD-299, a radioligand for visualisation of the 5-HT_1A receptor
Sandell J; Halldin C; Chou YH; Swahn CG; Thorberg SO; Farde L
Article: ARCHIVES OF GENERAL PSYCHIATRY. 2002;59(1):25-30
Decreased dopamine D₂ receptor binding in the anterior cingulate cortex in schizophrenia
Suhara T; Okubo Y; Yasuno F; Sudo Y; Inoue M; Ichimiya T; Nakashima Y; Nakayama K; Tanada S; Suzuki K; Halldin C; Farde L
Article: BIOLOGIA FUTURA. 2002;53(1-2):59-66
Autoradiographic evaluation of [¹¹C]vinpocetine binding in the human postmortem brain
Hall H; Varnäs K; Sandell J; Halldin C; Farde L; Vas A; Kárpáti E; Gulyás B
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2001;44(14):1013-1023
Carbon-11 labelling of MADAM in two different positions: a highly selective PET radioligand for the serotonin transporter
Tarkiainen J; Vercouille J; Emond P; Sandell J; Hiltunen J; Frangin Y; Guilloteau D; Halldin C
Article: JOURNAL OF CLINICAL PHARMACOLOGY. 2001;41(S7):95S
Serotonin 5-HT_1A receptor imaging in the human brain with positron-emission tomography:: Coordination and the standardization and dissemination of methodology
Halldin C
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2001;158(6):926-930
No support for regional selectivity in clozapine-treated patients:: A PET study with [¹¹C]raclopride and [¹¹C]FLB 457
Talvik M; Nordström AL; Nyberg S; Olsson H; Halldin C; Farde L
Article: NEUROIMAGE. 2001;13(3):531-539
Error analysis for quantification of [¹¹C]FLB 457 binding to extrastriatal D₂ dopamine receptors in the human brain
Ito H; Sudo Y; Suhara T; Okubo Y; Halldin C; Farde L
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2001;9(3):695-702
Short and efficient syntheses of analogues of WAY-100635:: New and potent 5-HT_1A receptor antagonists
Marchais S; Nowicki B; Wikström H; Brennum LT; Halldin C; Pike VW
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2001;9(3):677-694
Synthesis of high-specific-radioactivity 4- and 6-[¹⁸F]fluorometaraminol- PET tracers for the adrenergic nervous system of the heart
Langer O; Dollé F; Valette H; Halldin C; Vaufrey F; Fuseau C; Coulon C; Ottaviani M; Någren K; Bottlaender M; Maziére B; Crouzel C
Article: INTERNATIONAL REVIEW OF PSYCHIATRY. 2001;13(1):12-17
Human brain imaging post-mortem - whole hemisphere technologies
Hall H; Hurd Y; Pauli S; Halldin C; Sedvall G
Article: NUCLEAR MEDICINE AND BIOLOGY. 2001;28(2):177-185
New halogenated [¹¹C]WAY analogues, [¹¹C]6FPWAY and [¹¹C]6BPWAY -: Radiosynthesis and assessment as radioligands for the study of brain 5-HT_1A receptors in living monkey
Sandell J; Halldin C; Pike VW; Chou YH; Varnäs K; Hall H; Marchais S; Nowicki B; Wikström HV; Swahn CG; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2001;44(2):113-120
Precursor synthesis and radiolabelling of [¹¹C]ADAM:: A potential radioligand for the serotonin transporter exploration by PET
Vercouillie J; Tarkiainen S; Halldin C; Emond P; Chalon S; Sandell J; Langer O; Guilloteau D
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2001;28(1):13-24
SPET imaging of central muscarinic acetylcholine receptors with iodine-123 labelled E-IQNP and Z-IQNP
Nobuhara K; Farde L; Halldin C; Karlsson P; Swahn CG; Olsson H; Bergström KA; Larsson SA; Schnell PO; McPherson DW; Savonen A; Hiltunen J; Sedvall G
Article: SYNAPSE. 2000;38(4):421-431
Autoradiographic localization of 5-HT_2A receptors in the human brain using L³H]M100907 and [¹¹C]M100907
Hall H; Farde L; Halldin C; Lundkvist C; Sedvall G
Article: SYNAPSE. 2000;38(2):138-143
Effect of amphetamine on extrastriatal D2 dopamine receptor binding in the primate brain: A PET study
Chou YH; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2000;27(8):707-714
Carbon-11 PB-12:: An attempt to visualize the dopamine D₄ receptor in the primate brain with positron emission tomography
Langer O; Halldin C; Chou YH; Sandell J; Swahn CG; Någren K; Perrone R; Berardi F; Leopoldo M; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(12):1235-1244
Preparation of [¹⁸F]β-CFT-FP and [¹¹C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)
Kämäräinen EL; Kyllönen T; Airaksinen A; Lundkvist C; Yu MX; Någren K; Sandell J; Langer O; Vepsäläinen J; Hiltunen J; Bergström K; Lötjönen S; Jaakkola T; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(11):1069-1074
Radiochemical labelling of the dopamine D₃ receptor ligand RGH-1756
Langer O; Gulyás B; Sandell J; Laszlovszky I; Kiss B; Domány G; Acs T; Farde L; Halldin C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2000;3(3):203-214
A PET study of [¹¹C]β-CIT-FE binding to the dopamine transporter in the monkey and human brain
Farde L; Ginovart N; Halldin C; Chou YH; Olsson H; Swahn CG
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(10):997-1004
Highly efficient synthesis of [¹¹C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET
Dolle F; Bottlaender M; Demphel S; Emond P; Fuseau C; Coulon C; Ottaviani M; Valette H; Loc'h C; Halldin C; Mauclaire L; Guilloteau D; Maziere B; Crouzel C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(10):1033-1046
Synthesis of [¹¹C]2β-carbomethoxy-3β-(3′-iodo-4′-methyl, -ethyl and isopropyl phenyl)nortropane as potential radiotracers for examination of the serotonin transporter with positron emission tomography
Sandell J; Halldin C; Helfenbein J; Chou YH; Vercouillie J; Emond P; Swahn CG; Guilloteau D; Farde L
Article: SYNAPSE. 2000;36(4):322-329
Dopamine D₂ receptor quantification in extrastriatal brain regions using [¹²³I]epidepride with bolus/infusion
Pinborg LH; Videbæk C; Knudsen GM; Swahn CG; Halldin C; Friberg L; Paulson OB; Lassen NA
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(6):613-621
A fast and convenient method for robotic preparation of [¹¹C]flumazenil avoiding HPLC purification
Krasikova R; Fedorova O; Korsakov M; Någren K; Maziere B; Halldin C
Journal article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(6):613-621
A fast and convenient method for robotic preparation of [11C]flumazenil avoiding HPLC purification
Krasikova R; Fedorova O; Korsakov M; Någren K; Maziere B; Halldin C
Article: NEUROLOGY. 2000;54(7):1482-1487
Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease
Kaasinen V; Någren K; Hietala J; Oikonen V; Vilkman H; Farde L; Halldin C; Rinne JO
Article: NUCLEAR MEDICINE AND BIOLOGY. 2000;27(3):233-238
High specific radioactivity (1R,2S)-4-[¹⁸F]fluorometaraminol:: A PET radiotracer for mapping sympathetic nerves of the heart
Langer O; Valette H; Dollé F; Halldin C; Loc'h C; Fuseau C; Coulon C; Ottaviani M; Bottlaender M; Mazière B; Crouzel C
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2000;157(4):635-637
Age-related cognitive deficits mediated by changes in the striatal dopamine system
Bäckman L; Ginovart N; Dixon RA; Wahlin TBR; Wahlin Å; Halldin C; Farde L
Article: NEUROPSYCHOPHARMACOLOGY. 2000;22(4):422-429
PET-determination of robalzotan (NAD-299) induced 5-HT_1A receptor occupancy in the monkey brain
Farde L; Andrée B; Ginovart N; Halldin C; Thorberg SO
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2000;43(4):331-338
Improved specific radioactivity of the PET radioligand [¹¹C]FLB 457 by use of the GE Medical Systems PETtrace MeI MicroLab
Sandell J; Langer O; Larsen P; Dolle F; Vaufrey F; Demphel S; Crouzel C; Halldin C
Article: PSYCHOPHARMACOLOGY. 2000;149(1):45-55
Z-IQNP:: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer's disease
Nobuhara K; Halldin C; Hall H; Karlsson P; Farde L; Hiltunen J; McPherson DW; Savonen A; Bergström KA; Pauli S; Swahn CG; Larsson SA; Schnell PO; Sedvall G
Article: PSYCHOPHARMACOLOGY. 2000;148(4):400-403
High 5HT_2A receptor occupancy in M100907-treated schizophrenic patients
Talvik-Lotfi M; Nyberg S; Nordström AL; Ito H; Halldin C; Brunner F; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2000;27(2):206-208
Metabolism of [¹²³I]epidepride may affect brain dopamine D₂ receptor imaging with single-photon emission tomography
Bergström KA; Yu MX; Kuikka JT; Åkerman KK; Hiltunen J; Lehtonen J; Halldin C; Tiihonen J
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2000;20(2):225-243
Measurement of striatal and extrastriatal dopamine D₁ receptor binding potential with [¹¹C]NNC 112 in humans:: Validation and reproducibility
Abi-Dargham A; Martinez D; Mawlawi O; Simpson N; Hwang DR; Slifstein M; Anjilvel S; Pidcock J; Guo NN; Lombardo I; Mann JJ; Van Heertum R; Foged C; Halldin C; Laruelle M
Article: SYNAPSE. 2000;35(1):39-44
Effects of chronic 17β-estradiol treatment on the serotonin 5-HT_1A receptor mRNA and binding levels in the rat brain
Österlund MK; Halldin C; Hurd YL
Article: NEUROIMAGE. 1999;10(6):666-674
PET mapping of extrastriatal D2-like dopamine receptors in the human brain using an anatomic standardization technique and [¹¹C]FLB 457
Okubo Y; Olsson H; Ito H; Lofti M; Suhara T; Halldin C; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1999;42(12):1183-1193
Precursor synthesis and radiolabelling of the dopamine D₂ receptor ligand [¹¹C]raclopride from [¹¹C]methyl triflate
Langer O; Någren K; Dolle F; Lundkvist C; Sandell J; Swahn CG; Vaufrey F; Crouzel C; Maziere B; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1999;26(11):1482-1485
Iodine-123 labelled Z-(R,R)-IQNP:: a potential radioligand for visualization of M₁ and M₂ muscarinic acetylcholine receptors in Alzheimer's disease
Bergström KA; Halldin C; Savonen A; Okubo Y; Hiltunen J; Nobuhara K; Swahn CG; Karlsson P; McPherson D; Knapp FF; Larsson S; Schnell PO; Farde L
Article: JOURNAL OF NEUROIMAGING. 1999;9(4):217-222
Brain uptake and plasma metabolism of [¹¹C]vinpocetine:: A preliminary PET study in a cynomolgus monkey
Gulyás B; Halldin C; Karlsson P; Chou YH; Swahn CG; Bönöck P; Paróczai M; Farde L
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 1999;19(10):1164-1173
Quantification of [¹¹C]FLB 457 binding to extrastriatal dopamine receptors in the human brain
Olsson H; Halldin C; Swahn CG; Farde L
Article: PSYCHOPHARMACOLOGY. 1999;146(2):220-227
A PET study of D₁-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain
Chou YH; Karlsson P; Halldin C; Olsson H; Farde L
Article: ORVOSI HETILAP. 1999;140(30):1687-1691
[Cerebral uptake and metabolism of (11C) Vinpocetine in monkeys: PET studies].
Gulyás B; Halldin C; Karlsson P; Chou YH; Swahn CG; Bönöczk P; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1999;26(5):509-518
Carbon-11 epidepride:: A suitable radioligand for PET investigation of striatal and extrastriatal dopamine D₂ receptors
Langer O; Halldin C; Dollé F; Swahn CG; Olsson H; Karlsson P; Hall H; Sandell J; Lundkvist C; Vaufrey F; Loc'h C; Crouzel C; Mazière B; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1999;26(5):501-507
Characterization of bromine-76-labelled 5-bromo-6-nitroquipazine for PET studies of the serotonin transporter
Lundkvist C; Loc'h C; Halldin C; Bottlaender M; Ottaviani M; Coulon C; Fuseau C; Mathis C; Farde L; Mazière B
Article: NUCLEAR MEDICINE AND BIOLOGY. 1999;26(5):491-499
PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter
Helfenbein J; Sandell J; Halldin C; Chalon S; Emond P; Okubo Y; Chou YH; Frangin Y; Douziech L; Gareau L; Swahn CG; Besnard JC; Farde L; Guilloteau D
Article: PSYCHOPHARMACOLOGY. 1999;144(3):303-305
Pindolol binding to 5-HT_1A receptors in the human brain confirmed with positron emission tomography
Andrée B; Thorberg SO; Halldin C; Farde L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 1999;2(2):73-82
Extrastriatal dopamine D2 receptor density and affinity in the human brain measured by 3D PET
Suhara T; Sudo Y; Okauchi T; Maeda J; Kawabe K; Suzuki K; Okubo Y; Nakashima Y; Ito H; Tanada S; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1999;26(4):343-350
Different brain radioactivity curves in a PET study with [¹¹C]β-CIT labelled in two different positions
Lundkvist C; Halldin C; Swahn CG; Ginovart N; Farde L
Article: SYNAPSE. 1999;32(2):93-109
PET studies of binding competition between endogenous dopamine and the D₁ radiotracer [¹¹C]NNC 756
Abi-Dargham A; Simpson N; Kegeles L; Parsey R; Hwang DR; Anjilvel S; Zea-Ponce Y; Lombardo I; Van Heertum R; Mann JJ; Foged C; Halldin C; Laruelle M
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1999;42(4):337-347
Synthesis and radiolabelling of 2β-carbomethoxy-3β-(3′-iodo-4′-isopropylphenyl) nortropane as a radioligand for the exploration of the serotonin transporter by SPET.
Helfenbein J; Emond P; Sandell J; Halldin C; Pereyre S; Frangin Y; Garreau L; Besnard JC; Guilloteau D; Chalon S
Article: NEUROIMAGE. 1999;9(2):235-242
Mapping of central D₂ dopamine receptors in man using [¹¹C]raclopride:: PET with anatomic standardization technique
Ito H; Okubo Y; Halldin C; Farde L
Article: SYNAPSE. 1999;31(2):154-162
Changes in striatal D₂-receptor density following chronic treatment with amphetamine as assessed with PET in nonhuman primates
Ginovart N; Farde L; Halldin C; Swahn CG
Article: NUCLEAR MEDICINE AND BIOLOGY. 1999;26(2):159-164
Radiosynthesis and autoradiographic evaluation of [¹¹C]NAD-299, a radioligand for visualization of the 5-HT_1A receptor
Sandell J; Halldin C; Hall H; Thorberg SO; Werner T; Sohn D; Sedvall G; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 1999;40(1):102-109
Localization of 5-HT_1A receptors in the living human brain using [carbonyl-¹¹C]WAY-100635:: PET with anatomic standardization technique
Ito H; Halldin C; Farde L
Article: NEUROIMAGE. 1999;9(1):108-116
Visualization of the dopamine transporter in the human brain postmortem with the new selective ligand [¹²⁵I]PE2I
Hall H; Halldin C; Guilloteau D; Chalon S; Emond P; Besnard JC; Farde L; Sedvall G
Article: JOURNAL OF NUCLEAR MEDICINE. 1998;39(12):2061-2068
Carbon-11-NNC 112:: A radioligand for PET examination of striatal and neocortical D₁-dopamine receptors
Halldin C; Foged C; Chou YH; Karlsson P; Swahn CG; Sandell J; Sedvall G; Farde L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 1998;1(2):95-101
D₂- and 5-HT₂ receptor occupancy in high-dose neuroleptic-treated patients
Nyberg S; Dencker SJ; Malm U; Dahl ML; Svenson JO; Halldin C; Naskashima Y; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 1998;39(11):1965-1971
Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man
Farde L; Ito H; Swahn CG; Pike VW; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 1998;18(9):941-950
Comparison of the transient equilibrium and continuous infusion method for quantitative PET analysis of [¹¹C]raclopride binding
Ito H; Hietala J; Blomqvist G; Halldin C; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1998;41(9):831-841
Methylation of amide and thiol functions with [¹¹C]methyl triflate, as exemplified by [¹¹C]NMSP, [¹¹C]flumazenil and [¹¹C]methionine
Nagren K; Halldin C
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 1998;18(4):317-323.
Positron emission tomographic analysis of dose-dependent MDL 100,907 binding to 5-hydroxytryptamine-2A receptors in the human brain
Andrée B; Nyberg S; Ito H; Ginovart N; Brunner F; Jaquet F; Halldin C; Farde L
Article: PSYCHIATRY RESEARCH. 1998;83(1):1-6
A PET study of D₂ dopamine receptor density at different phases of the menstrual cycle
Nordström AL; Olsson H; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 1998;25(5):503-508
[¹¹C]NNC 22-0215, a metabolically stable dopamine D₁ radioligand for PET
Foged C; Halldin C; Swahn CG; Ginovart N; Karlsson P; Lundkvist C; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1998;41(6):545-556
Improved syntheses of the PET radioligands, [¹¹C]FLB457, [¹¹C]MDL100907 and [¹¹C]β-CIT-FE, by the use of [¹¹C]methyl triflate
Lundkvist C; Sandell J; Nagren K; Pike VW; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1998;25(5):531-534
Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging
Kuikka JT; Baulieu JL; Hiltunen J; Halldin C; Bergström KA; Farde L; Emond P; Chalon S; Yu MX; Nikula T; Laitinen T; Karhu J; Tupala E; Hallikainen T; Kolehmainen V; Mauclaire L; Maziere B; Tiihonen J; Guilloteau D
Article: NUCLEAR MEDICINE AND BIOLOGY. 1998;25(4):405-409
Toxicity, mutagenicity, and behavioral effects of β-CIT, a ligand for dopamine transporter exploration by SPECT
Emond P; Farde L; Chalon S; Belzung C; Mauclaire V; Chiron JP; Halldin C; Besnard JC; Guilloteau D
Article: ACTA NEUROLOGICA SCANDINAVICA. 1998;97(5):279-286
Regional increases in [¹¹C]flumazenil binding after epilepsy surgery
Savic I; Blomqvist G; Halldin C; Litton JE; Gulyas B
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1998;25(4):338-346
[carbonyl-¹¹C]desmethyl-WAY-100635 (DWAY) is a potent and selective radioligand for central 5-HT_1A receptors in vitro and in vivo
Pike VW; Halldin C; McCarron JA; Lundkvist C; Hirani E; Olsson H; Hume SP; Karlsson P; Osman S; Swahn CG; Hall H; Wikström H; Mensonidas M; Poole KG; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1998;25(3):215-223
Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT_1A receptor radioligand, [carbonyl-¹¹C]WAY-100635 -: Explanation of high signal contrast in PET and an aid to biomathematical modelling
Osman S; Lundkvist C; Pike VW; Halldin C; McCarron JA; Swahn CG; Farde L; Ginovart N; Luthra SK; Gunn RN; Bench CJ; Sargent PA; Grasby PM
Article: NUCLEAR MEDICINE AND BIOLOGY. 1998;25(3):209-214
Evaluation and metabolite studies of ¹²⁵I- and ¹²³I-labelled E-(R,R)-IQNP:: Potential radioligands for visualization of M₁ muscarinic acetylcholine receptors in brain
Bergstrom KA; Halldin C; Hiltunen J; Swahn CG; Ito H; Ginovart N; Hall H; McPherson DW; Knapp FFR; Larsson S; Schnell PO; Farde L
Article: HUMAN PSYCHOPHARMACOLOGY. 1998;13(3):177-182
The metabolism of iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine (NNC13-8241) measured in human plasma is only minor
Akerman KK; Bergstrom KA; Halldin C; Lotjonen S; Yu MX; Nikula T; Hiltunen J; Foged C; Kuikka JT; Tiihonen J
Article: JOURNAL OF NUCLEAR MEDICINE. 1998;39(1):208-214
PET imaging of central 5-HT_2A receptors with carbon-11-MDL 100,907
Ito H; Nyberg S; Halldin C; Lundkvist C; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1997;25(1):19-23
Iodine-123 labeled nor-β-CIT as a potential tracer for serotonin transporter imaging in the human brain with single-photon emission tomography
Hiltunen J; Åkerman KK; Kuikka JT; Bergström KA; Halldin C; Nikula T; Räsänen P; Tiihonen J; Vauhkonen M; Karhu J; Kupila J; Länsimies E; Farde L
Article: PSYCHOPHARMACOLOGY. 1997;133(4):396-404
A PET study of [C-11]FLB 457 binding to extrastriatal D-2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients
Farde L; Suhara T; Nyberg S; Karlsson P; Nakashima Y; Hietala J; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1997;24(10):1261-1267
Bromine-76 and carbon-11 labelled NNC 13-8199, metabolically stable benzodiazepine receptor agonists as radioligands for positron emission tomography (PET)
Foged C; Halldin C; Loch C; Maziere B; Pauli S; Maziere M; Hansen HC; Suhara T; Swahn CG; Karlsson P; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1997;24(7):629-634
[I-125]beta-CIT-FE and [I-125]beta-CIT-FP are superior to [I-125]beta-CIT for dopamine transporter visualization: Autoradiographic evaluation in the human brain
Gunther I; Hall H; Halldin C; Swahn CG; Farde L; Sedvall G
Article: NUCLEAR MEDICINE AND BIOLOGY. 1997;24(7):621-627
[F-18]beta-CIT-FP is superior to [C-11]beta-CIT-FP for quantitation of the dopamine transporter
Lundkvist C; Halldin C; Ginovart N; Swahn CG; Farde L
Article: ARCHIVES OF GENERAL PSYCHIATRY. 1997;54(10):953-958
Delayed normalization of central D-2 dopamine receptor availability after discontinuation of haloperidol decanoate - Preliminary findings
Nyberg S; Farde L; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1997;39(10):803-816
Preparation of 4- and 6-[Br-76]bromometaraminol, two potential radiotracers for the study of the myocardial norepinephrine neuronal reuptake system with PET
Langer O; Dolle F; Loch C; Halldin C; Vaufrey F; Coulon C; Crouzel C; Nagren K; Maziere B
Article: PSYCHOPHARMACOLOGY. 1997;133(2):196-202
PET-characterization of [carbonyl-C-11]WAY-100635 binding to 5-HT1A receptors in the primate brain
Farde L; Ginovart N; Ito H; Lundkvist C; Pike VW; McCarron JA; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 1997;24(5):389-393
Autoradiographic comparison of [I-125]epidepride and [I-125]NCQ 298 binding to human brain extrastriated dopamine receptors
Hall H; Halldin C; Jerning E; Osterlund M; Farde L; Sedvall G
Article: PSYCHOPHARMACOLOGY. 1997;131(4):339-345
Central 5-HT2A and D-2 dopamine receptor occupancy after sublingual administration of ORG 5222 in healthy men
Andree B; Halldin C; VrijmoeddeVries M; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1997;24(6):596-601
In vitro and in vive characterisation of nor-beta-CIT: A potential radioligand for visualisation of the serotonin transporter in the brain
Bergstrom KA; Halldin C; Hall H; Lundkvist C; Ginovart N; Swahn CG; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1997;24(5):483-487
Striatal and extrastriatal imaging of dopamine D-2 receptors in the living human brain with [I-123]epidepride single-photon emission tomography
Kuikka JT; Akerman KK; Hiltunen J; Bergstrom KA; Rasanen P; Vanninen E; Halldin C; Tiihonen J
Article: SYNAPSE. 1997;25(4):321-325
Effect of reserpine-induced depletion of synaptic dopamine on [C-11]raclopride binding to D-2-dopamine receptors in the monkey brain
Ginovart N; Farde L; Halldin C; Swahn CG
Article: BRAIN. 1997;120:503-514
PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease
Ginovart N; Lundin A; Farde L; Halldin C; Backman L; Swahn CG; Pauli S; Sedvall G
Article: BRAIN RESEARCH. 1997;745(1-2):96-108
Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [H-3]WAY-100635 and [C-11]WAY-100635
Hall H; Lundkvist C; Halldin C; Farde L; Pike VW; McCarron JA; Fletcher A; Cliffe IA; Barf T; Wikstrom H; Sedvall G
Article: NEUROPSYCHOPHARMACOLOGY. 1997;16(1):1-7
A PET study of 5-HT2 and D-2 dopamine receptor occupancy induced by olanzapine in healthy subjects
Nyberg S; Farde L; Halldin C
Article: PSYCHOPHARMACOLOGY. 1996;128(3):240-247
Autoradiographic localisation of D-3-dopamine receptors in the human brain using the selective D-3-dopamine receptor agonist (+)-[H-3]PD 128907
Hall H; Halldin C; Dijkstra D; Wikstrom H; Wise LD; Pugsley TA; Sokoloff P; Pauli S; Farde L; Sedvall G
Article: HUMAN PSYCHOPHARMACOLOGY. 1996;11(6):483-490
Characterization of C-11 or I-123 labelled beta-CIT-FP and beta-CIT-FE metabolism measured in monkey and human plasma. Identification of two labelled metabolites with HPLC
Bergstrom KA; Halldin C; Lundkvist C; Swahn CG; Akerman KK; Kuikka JT; Hiltunen J; Tiihonen J; Lansimies E; Neumeyer JL; Farde L
Article: PSYCHIATRY RESEARCH. 1996;67(3):163-171
Test-retest reliability of central [C-11]raclopride binding at high D-2 receptor occupancy. A PET study in haloperidol-treated patients
Nyberg S; Farde L; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 1996;23(6):837-844
C-11- and Br-76-labelled NNC 22-0010, selective dopamine D-1 receptor radioligands for PET
Foged C; Halldin C; Loch C; Maziere B; Karlsson P; Maziere M; Swahn CG; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1996;23(6):813-819
Preparation of [Br-76]FLB 457 and [Br-76]FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET
Loch C; Halldin C; Bottlaender M; Swahn CG; Moresco RM; Maziere M; Farde L; Maziere B
Article: NUCLEAR MEDICINE AND BIOLOGY. 1996;23(5):627-634
Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-C-11]WAY-100635, in monkey and human plasma by HPLC: Comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET
Osman S; Lundkvist C; Pike VW; Halldin C; McCarron JA; Swahn CG; Ginovart N; Luthra SK; Bench CJ; Grasby PM; Wikstrom H; Barf T; Cliffe IA; Fletcher A; Farde L
Article: DEMENTIA. 1996;7(4):187-195
PET study of the M(1)-agonists [C-11]xanomeline and [C-11]butylthio-TZTP in monkey and man
Farde L; Suhara T; Halldin C; Nyback H; Nakashima Y; Swahn CG; Karlsson P; Ginovart N; Bymaster FP; Shannon HE; Foged C; Suzdak PD; Sauerberg P
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1996;23(7):798-803
Initial human studies with single-photon emission tomography using iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]-benzodiazepine (NNC 13-8241)
Kuikka JT; Hiltunen J; Foged C; Bergstrom KA; Halldin C; Akerman K; Tiihonen J; Farde L
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1996;38(7):675-685
Synthesis of unlabelled, H-3- and I-125-labelled beta-CIT and its omega-fluoroalkyl analogues beta-CIT-FE and beta-CIT-FP, including synthesis of precursors
Swahn CG; Halldin C; Gunther I; Patt J; Ametamey S
Article: SYNAPSE. 1996;23(2):115-123
Autoradiographic localization of extrastriatal D-2-dopamine receptors in the human brain using [I-125]epidepride
Hall H; Farde L; Halldin C; Hurd YL; Pauli S; Sedvall G
Article: SYNAPSE. 1996;22(4):386-390
[C-11] beta-CIT-FE, a radioligand for quantitation of the dopamine transporter in the living brain using positron emission tomography
Halldin C; Farde L; Lundkvist C; Ginovart N; Nakashima Y; Karlsson P; Swahn CG
Article: NUCLEAR MEDICINE AND BIOLOGY. 1996;23(3):221-227
[C-11]metaraminol, a false neurotransmitter: Preparation, metabolite studies and positron emission tomography examination in monkey
Nagren K; Halldin C; Swahn CG; Suhara T; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1996;23(3):201-209
Development of I-123-labelled NNC 13-8241 as a radioligand for SPECT visualization of benzodiazepine receptor binding
Foged C; Halldin C; Hiltunen J; Braestrup C; Thomsen C; Hansen HC; Suhara T; Pauli S; Swahn CG; Karlsson P; Larsson S; Farde L
Article: ANNALS OF NUCLEAR MEDICINE. 1996;10(1):85-88
Effects of cocaine on [11C]norepinephrine and [11C] beta-CIT uptake in the primate peripheral organs measured by PET.
Suhara T; Farde L; Halldin C; Någren K; Karlsson P
Article: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 1995;10(4):221-227
CENTRAL D-2 RECEPTOR OCCUPANCY AND EFFECTS OF ZUCLOPENTHIXOL ACETATE IN HUMANS
NYBERG S; FARDE L; BARTFAI A; HALLDIN C
Article: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):1053-1056
PET EXAMINATION OF THE MONKEY HEART WITH HIGH SPECIFIC RADIOACTIVITY [C-11] NOREPINEPHRINE AND [C-11] METARAMINOL
FARDE L; HALLDIN C; NAGREN K; KARLSSON P; SWAHN CG; SUHARA T
Article: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):1045-1048
AN HPLC-METHOD FOR DETERMINATION OF LIGAND METABOLISM DURING PET STUDIES WITH [C-11] METARAMINOL AND [C-11] NOREPINEPHRINE
SWAHN CG; HALLDIN C; NAGREN K; FARDE L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):1037-1043
SOME NEW METHODS FOR THE SYNTHESIS OF CARDIAC NEUROTRANSMISSION PET RADIOTRACERS
NAGREN K; HALLDIN C; SWAHN CG; SCHOEPS KO; LANGER O; MITTERHAUSER M; ZOLLE I
Article: AMERICAN JOURNAL OF PSYCHIATRY. 1995;152(10):1444-1449
D-1, D-2, AND 5-HT2 RECEPTOR OCCUPANCY IN RELATION TO CLOZAPINE SERUM CONCENTRATION - A PET STUDY OF SCHIZOPHRENIC-PATIENTS
NORDSTROM AL; FARDE L; NYBERG S; KARLSSON P; HALLDIN C; SEDVALL G
Article: PSYCHOPHARMACOLOGY. 1995;121(3):300-308
EVALUATION OF SCH-39166 AS PET LIGAND FOR CENTRAL D-1 DOPAMINE-RECEPTOR BINDING AND OCCUPANCY IN MAN
KARLSSON P; SEDVALL G; HALLDIN C; SWAHN CG; FARDE L
Article: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(7):905-913
[O-METHYL-C-11]BETA-CIT-FP, A POTENTIAL RADIOLIGAND FOR QUANTITATION OF THE DOPAMINE TRANSPORTER - PREPARATION, AUTORADIOGRAPHY, METABOLITE STUDIES, AND POSITRON EMISSION TOMOGRAPHY EXAMINATIONS
LUNDKVIST C; HALLDIN C; SWAHN CG; HALL H; KARLSSON P; NAKASHIMA Y; WANG SY; MILIUS RA; NEUMEYER JL; FARDE L
Article: PSYCHIATRY RESEARCH. 1995;61(2):67-83
NO ELEVATED D-2 DOPAMINE-RECEPTORS IN NEUROLEPTIC-NAIVE SCHIZOPHRENIC-PATIENTS REVEALED BY POSITRON EMISSION TOMOGRAPHY AND [C-11] N-METHYLSPIPERONE
NORDSTROM AL; FARDE L; ERIKSSON L; HALLDIN C
Article: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(6):711-717
SYNTHESIS AND BINDING-PROPERTIES OF [H-3]NNC-12-0781, A NEW RADIOLIGAND FOR THE DOPAMINE REUPTAKE SYSTEM
MULLER L; HALL H; HALLDIN C; FARDE L; HOHLWEG R; SUZDAK PD; NIELSEN EB; FOGED C
Article: SYNAPSE. 1995;20(3):200-208
VARIABILITY IN D-2-DOPAMINE RECEPTOR DENSITY AND AFFINITY - A PET STUDY WITH [C-11] RACLOPRIDE IN MAN
FARDE L; HALL H; PAULI S; HALLDIN C
Article: NEUROSCIENCE. 1995;67(1):37-48
DISTRIBUTION OF MESSENGER-RNAS FOR D-1 DOPAMINE-RECEPTORS AND DARPP-32 IN STRIATUM AND CEREBRAL-CORTEX OF THE CYNOMOLGUS MONKEY - RELATIONSHIP TO D-1 DOPAMINE-RECEPTORS
BRENE S; HALL H; LINDEFORS N; KARLSSON P; HALLDIN C; SEDVALL G
Article: JOURNAL OF NUCLEAR MEDICINE. 1995;36(7):1275-1281
CARBON-11-FLB-457 - A RADIOLIGAND FOR EXTRASTRIATAL D2 DOPAMINE-RECEPTORS
HALLDIN C; FARDE L; HOGBERG T; MOHELL N; HALL H; SUHARA T; KARLSSON P; NAKASHIMA Y; SWAHN CG
Article: PSYCHOPHARMACOLOGY. 1995;119(1):1-8
ORAL-ADMINISTRATION OF NNC-756 - A PLACEBO-CONTROLLED PET STUDY OF D-1-DOPAMINE RECEPTOR OCCUPANCY AND PHARMACODYNAMICS IN MAN
KARLSSON P; FARDE L; HALLDIN C; SEDVALL G; YNDDAL L; SLOTHNIELSEN M
Article: APPLIED RADIATION AND ISOTOPES. 1995;46(5):323-328
SYNTHESIS OF [F-18]NNC-12-0817 AND [F-18]NNC-12-0818 - 2 POTENTIAL RADIOLIGANDS FOR THE DOPAMINE TRANSPORTER
MULLER L; HALLDIN C; FOGED C; HOHLWEG R
Article: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 1995;36(4):385-392
SYNTHESIS OF 2-BETA-CARBOMETHOXY-3-BETA-(4-[BR-76]BROMOPHENYL)TROPANE ([BR-76]BETA-CBT), A PET TRACER FOR IN-VIVO IMAGING OF THE DOPAMINE UPTAKE SITES
LOCH C; MULLER L; OTTAVIANI M; HALLDIN C; FARDE L; MAZIERE B
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 1995;5(1):19-25
EFFECT OF CLOZAPINE AND RISPERIDONE ON 5-HT2 AND D-2-DOPAMINE RECEPTOR-BINDING IN THE POSTMORTEM HUMAN BRAIN - AN AUTORADIOGRAPHIC STUDY
HALL H; HALLDIN C; NYBERG S; FARDE L; SEDVALL G
Article: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(2):235-239
IMPROVED SYNTHESIS OF SOME COMMONLY USED PET RADIOLIGANDS BY THE USE OF [C-11] METHYL TRIFLATE
NAGREN K; MULLER L; HALLDIN C; SWAHN CG; LEHIKOINEN P
Article: CLINICAL NEUROSCIENCE. 1995;3(2):112-121
UTILIZATION OF RADIOLIGANDS IN SCHIZOPHRENIA RESEARCH
SEDVALL G; FARDE L; HALL H; HALLDIN C; KARLSSON P; NORDSTROM AL; NYBERG S; PAULI S
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In response to the letter "[¹¹C]raclopride and extrastriatal binding to D2/3 receptors"
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Sample preparation techniques for radiometabolite analysis of positron emission tomography radioligands; trends, progress, limitations and future prospects
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PET-MR and SPECT-MR multimodality probes: Development and challenges
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PET probes for imaging pancreatic islet cells
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New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals
Dahl K; Halldin C; Schou M
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Application of cross-species PET imaging to assess neurotransmitter release in brain
Finnema SJ; Scheinin M; Shahid M; Lehto J; Borroni E; Bang-Andersen B; Sallinen J; Wong E; Farde L; Halldin C; Grimwood S
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Factors That Limit Positron Emission Tomography Imaging of P-Glycoprotein Density at the Blood-Brain Barrier
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New PET radiopharmaceuticals beyond FDG for brain tumor imaging
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Current State of Agonist Radioligands for Imaging of Brain Dopamine D₂/D₃ Receptors In Vivo with Positron Emission Tomography
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Editorial comment: JOURNAL OF NUCLEAR MEDICINE. 2010;51(9):1331-1334
Molecular Imaging of the Dopamine Transporter
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Meeting abstract: NEUROIMAGE. 2010;52:S72
[11C]N-desmethyl-loperamide, a substrate that selectively images P-glycoprotein function, is trapped in lysosomes
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Confirmation of fenfluramine effect on 5-HT1B binding of [11C]AZ10419369 using an equilibrium approach
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Quantification of serotonin transporter availability with [11C]MADAM - A comparison between the ECAT HRRT and HR systems
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Synthesis of three F-18 labeled analogues of 1-deprenyl for PET Studies of monoamine oxidase B
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Quantification of [18F]LBT-999 binding to the dopamine transporter in the rhesus monkey brain with the HRRT system
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Quantification and wavelet-aided parametric imaging of cerebral amyloid using the HRRT PET-system and [18F]AZD4694
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[¹⁸F]AZD4694-A new PET radioligand for sensitive detection of β-amyloid deposits
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Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain
Finnema SJ; Varnas K; Stepanov V; Varrone A; Gulyas B; Arponen E; Helin S; Solin O; Haaparanta M; Sallinen J; Ingman K; Scheinin M; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S168
Kinetic analysis and quantification of the dopamine transporter in the non-human primate brain with [11C]PE2I and [18F]FE-PE2I
Varrone A; Toth M; Steiger C; Takano A; Guilloteau D; Ichise M; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S122
The novel mGluR5 radioligand [¹¹C]AZ11696415: Palladium mediated ¹¹C-cyanation and initial in vivo characterization in the cynomolgus monkey brain using positron emission tomography (PET)
Andersson J; Seneca N; Truong P; Wensbo D; McLeod D; Raboisson P; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S106
Clomipramine and the active metabolite, desmethylclomipramine, occupy NET in non-human primate measured by PET
Takano A; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S100
PET studies in cynomolgous monkeys and whole hemisphere post mortem autoradiographic studies in human brain slices with the dopamine D2/D3 receptor ligand 11C-cariprazine
Toth M; Varrone A; Jia Z; Horvath A; Laszlovszky I; Kiss B; Halldin C; Gulyas B
Meeting abstract: NEUROIMAGE. 2010;52:S95
Regional distribution of high and low affinity states of dopamine D2/3 receptor binding in humans: A PET study using [11C]MNPA and [11C]raclopride
Kodaka F; Ito H; Takano H; Takahashi H; Arakawa R; Fujie S; Sasaki T; Nakayama K; Halldin C; Farde L; Suhara T
Meeting abstract: NEUROIMAGE. 2010;52:S80
GSK588045 occupancy of brain 5-HT1A receptors examined using [11C]WAY100635 PET
van der Aart J; Comley R; Gulyas B; Garnier M; Petrone M; Iavarone L; Halldin C; Rabiner E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S299-S300
In vivo assessment of changes in serotonin release in the non-human primate brain using PET and [11C]AZ10419369
Finnema SJ; Varrone A; Hwang TJ; Farde L; Halldin C
Editorial comment: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(5):917-919
Approaches to quantify radioligands that wash out slowly from target organs
Hirvonen J; Terry GE; Halldin C; Pike VW; Innis RB
Meeting abstract: SCHIZOPHRENIA RESEARCH. 2010;117(2-3):258-259
BRAIN DISTRIBUTION AND BINDING OF [¹¹C]CARIPRAZINE: IN VIVO PET STUDIES IN NON-HUMAN PRIMATES AND WHOLE HEMISPHERE POSTMORTEM AUTORADIOGRAPHIC STUDIES IN HUMAN BRAIN SLICES
Gulyas B; Toth M; Varrone A; Horvath A; Laszlovszky I; Kiss B; Halldin C
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S69-S70
Effects of naltrexone on amphetamine-induced changes in the brain dopamine system
Jayaram-Lindstrom N; Haggkvist J; Halldin C; Schilstrom B; Nordstrom AL; Franck J
Published conference paper: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(10):1639-1650
Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT
Varrone A; Sjoholm N; Eriksson L; Gulyas B; Halldin C; Farde L
Other: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2009;86(4):368-377
Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications
Kannan P; John C; Zoghbi SS; Halldin C; Gottesman MM; Innis RB; Hall MD
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S7-S8
Limbic dopamine D2-receptor binding and social desirability
Cervenka S; Halldin C; Farde L
Review: ANNUAL REPORTS IN MEDICINAL CHEMISTRY. 2009;44:501-513
Discovery of Novel Positron Emission Tomography Tracers
McCarthy DJ; Halldin C; Andersson JD; Pierson ME
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S82-S83
Lower 5-HT1A receptor binding in patients with borderline personality disorder:: a PET study using [¹¹C]WAY100635
Jovanovic H; Andersson EE; Karlsson P; Halldin C; Nordstroem AL; Asberg M; Farde L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:s64
Molecular imaging of the 5-HTIA receptor and 5-HTT in relation to cognitive functions in man
Borg J; Lundberg J; Andree B; Kizling I; Halldin C; Fardel L
Meeting abstract: NEUROIMAGE. 2008;41:T38
Dopamine D_2/3 receptor occupancy of apomorphine in the non-human primate brain does not support the existence of two affinity states in vivo
Finnema SJ; Bang-Andersen B; Gulyas B; Bundgaard C; Wikstroem HV; Halldin C; Farde L
Meeting abstract: NEUROIMAGE. 2008;41:T19
[¹¹C]AZ10419369:: A selective 5-HT_1B receptor radioligand suitable for positron emission tomography (PET); Characterization in cynomolgus monkey brain
Andersson J; Pierson ME; Finnema S; Gulyas B; Medd AM; Powell ME; McCarthy DJ; Nyberg S; Heys R; Potts W; Seneca N; Mrzljak L; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T197
Evaluation of an inverse agonist with high affinity for the CB₁ receptor, [¹¹C]MePPEP, in rodents and humans
Terry GE; Liow J-S; Chernet E; Zoghbi SS; Phebus L; Lerner A; Felder CC; Tauscher J; Schaus JM; Pike VW; Halldin C; Innis RB
Meeting abstract: NEUROIMAGE. 2008;41:T140
Pharmacological characterization of the interactions of 2-methoxy-N-propylnorapomorphine (MNPA) with D₂ and D₃ dopamine receptors
Skinbjerg M; Narnkung Y; Halldin C; Innis RB; Sibley DR
Meeting abstract: NEUROIMAGE. 2008;41:T139
Kinetic brain analysis and whole-body imaging in monkey of [¹¹C]MNPA, a dopamine agonist radioligand
Seneca N; Skinbjerg M; Zoghbi SS; Liow JS; Gladding RL; Hong J; Kannan P; Tuan E; Sibley DR; Halldin C; Pike VW; Innis RB
Meeting abstract: NEUROIMAGE. 2008;41:T138
Occupancy of dopamine D₂/D₃ receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [¹¹C]MNPA
Seneca N; Zoghbi SS; Skinbjerg M; Liow JS; Hong J; Sibley DR; Pike VW; Halldin C; Innis RB
Meeting abstract: NEUROIMAGE. 2008;41:T134
Quantitative analysis of dopamine D2 receptor binding in human brain using PET with an agonist radioligand [¹¹C]MNPA
Otsuka T; Ito H; Takahashi H; Takano H; Arakawa R; Okumura M; Kodaka F; Miyoshi M; Sekine M; Seki C; Suhara T; Halldin C; Farde L
Meeting abstract: NEUROIMAGE. 2008;41:T102
Radiosynthesis of [¹¹C]MNPA from the precursor (R)-(-)-2-hydroxy-10,11-acetonide-NPA and a preliminary test-retest PET analysis in monkey brain
Steiger C; Finnema SJ; Wikstroem HV; Gulyas B; Nakao R; Suzuki K; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T91
COMT inhibition prevents the formation of lipophilic radiometabolites of catechols, -: An example with (S)-[¹¹C]N-methyl-NNC 01-0259
Finnema SJ; Bang-Andersen B; Jorgensen M; Gulyas B; Farde L; Wikstrom HV; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T90
Discovery and labeling of a homochiral high affinity 3,4-diarylpyrazoline as a candidate radioligand for in vivo imaging of cannabinoid type-1 receptors
Donohue SR; Finnema SJ; Truong P; Andersson J; Gulyas B; Pike VW; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T59
Quantitative analysis of norepinephrine transporter binding in human brain using PET with (S,S)-[¹¹F]FMeNER-D₂
Arakawa R; Okumura M; Ito H; Seki C; Takahashi H; Takano H; Nakao R; Suzuki K; Okubo Y; Suhara T; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T144
Autoradiography and in vivo evaluation in cynomolgus monkey of [¹⁸F]FE-PE2I, a new dopamine transporter PET radioligand
Varrone A; Schou M; Steiger C; Takano A; Finnema S; Guilloteau D; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T85
Advancement in PET quantification using 3D-OP-OSEM PSF reconstruction with the HRRT
Varrone A; Sjoholm N; Gulyas B; Halldin C; Farde L
Meeting abstract: NEUROIMAGE. 2008;41:T104
Quantitative analyses of [¹¹C]AZ10419369 binding to 5-HT_1B receptors in the human brain
Varnaes K; Nyberg S; Halldin C; Varrone A; Takano A; Karlsson P; McCarthy D; Smith M; Pierson ME; Soederstroem J; Farde L
Meeting abstract: NEUROIMAGE. 2008;41:T103
Mapping of the norepinephrine transporter in man using PET with (S,S)-[¹⁸F]FMeNER-D₂
Takano A; Varrone A; Gulyas B; Karlsson P; Tauscher J; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T77
Automated system for parametric image analysis in neuroreceptor binding studies with PET
Odano I; Sakaguchi K; Hosoya T; Varrone A; Savic I; Halldin C; Farde L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S289-S290
No changes in 5-HT1A receptor and serotonin transporter between phases of the menstrual cycle in healthy women
Jovanovic H; Karlsson P; Cerin A; Halldin C; Nordstrom AL
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S254-S255
PET-measured D2, 5-HT2, and norepinephrine transporter (NET) occupancy by quetiapine and N-desalkyl-quetiapine in non-human primates
Nyberg S; Takano A; Grimm S; Gulyas B; McCarthy D; Lee C; Goldstein J; Halldin C; Farde L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S186
Gender differences in the 5-HT1A receptor and serotonin transporter in the human brain: a PET study
Jovanovic H; Lundberg J; Karlsson P; Cerin A; Halldin C; Nordstrom AL
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2007;7(18):1806-1816
Development of radioligands for imaging of brain norepinephrine transporters In Vivo with positron emission tomography
Schou M; Pike VW; Halldin C
Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34(7):1133-1134
FDOPA PET has clinical utility in brain tumour imaging:: a proposal for a revision of the recent EANM guidelines -: Reply
Vander Borght T; Asenbaum S; Bartenstein P; Halldin C; Kapucu O; Van Laere K; Varrone A; Tatsch K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S82-S83
Gender differences in the 5-HT1A receptor and serotonin transporter in the human brain: a PET study
Jovanovic H; Lundberg J; Cerin A; Karlsson P; Halldin C; Nordstrom AL
Meeting abstract: NEUROIMAGE. 2006;31:T119
Imaging endogenous dopamine occupancy of the D2 receptor in rat brain with [11C]MNPA
Seneca N; Liow JS; Zoghbi S; Musachio JL; Hong J; Pike VW; Halldin C; Innis RB
Meeting abstract: NEUROIMAGE. 2006;31:T85
Increasing the accuracy of in vivo quantification of dopamine-D2/D3 receptor binding in the human brain by partial volume effect correction
Sovago J; Farde L; Cervenka S; Halldin C; Gulyas B
Meeting abstract: NEUROIMAGE. 2006;31:T44
In-target produced [¹¹C]methane meets the demands of increased specific radioactivity for neuroreceptor PET radioligands
Andersson J; Truong P; Halldin C
Meeting abstract: NEUROIMAGE. 2006;31:T15
A new PET radioligand [11C]cyclopropyl-FLB 457 for imaging extrastriatal dopamine D2 receptors:: Evaluation in monkey and comparison to [11C]FLB 457 and [11C]Fallypride
Airaksinen AJ; Finnema SJ; Nag S; Mukherjee J; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2006;31:T87
Dopamine transporter binding corrected for tissue heterogeneity and partial volume effect using [11C]PE2I and PET
Odano I; Jucaite A; Olsson H; Karlsson P; Pauli S; Halldin C; Farde L
Meeting abstract: NEUROIMAGE. 2006;31:T88
Comparisons of central benzodiazepine receptor mapping tracers, [18F]Flumazenil and [11C]Flumazenil presentation
Odano I; Farde L; Savic I; Ciumas C; Krasikova R; Airaksinen A; Karlsson P; Pauli S; Halldin C
Meeting abstract: NEUROIMAGE. 2006;31:T86
A comparison of recent parametric neuroreceptor mapping approaches based on measurements with the high affinity PET radioligands [11C]FLB 457 and [11C]WAY 100635
Cselenyi Z; Olsson H; Halldin C; Gulyas B; Farde L
Meeting abstract: NEUROIMAGE. 2006;31:T114
PET evaluation of the partial dopamine D1 receptor agonist radioligands R- and S-[11C]N-methyl-NNC 01-0259
Finnema S; Bang-Andersen B; Farde L; Jorgensen M; Gulyas B; Foged C; Wikstrom HV; Halldin C
Meeting abstract: NEUROIMAGE. 2006;31:T120
Dopamine D2/D3 receptor occupancy of apomorphine evaluated with the agonist radioligand [11C]MNPA and the antagonist radioligand [11C]Raclopride.: A PET evaluation in the non-human primate brain
Finnema S; Bang-Andersen B; Farde L; Gulyas B; Wikstrom HV; Halldin C
Meeting abstract: NEUROIMAGE. 2006;31:T50
Synthesis and in vivo evaluation of a new PET radioligand for imaging the cannabinoid type-1 (CB1) receptors
Donohue S; Halldin C; Finnema S; Gulyas B; Pike V
Meeting abstract: NEUROIMAGE. 2006;31:T48
Synthesis of ¹¹C-labeled (S,S)-CFMME and (R)-OHDMI and their evaluation as candidate radioligands for imaging norepinephrine transporters with PET
Schou M; Pike VW; Sovago J; Gulyas B; Gallagher P; Dobson D; Walter MW; Rudyk H; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2006;31:T28
Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion:: A PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
Seneca N; Gulyas B; Varrone A; Schou M; Tauscher J; Vandenhende F; Kielbasa W; Farde L; Innis RB; Halldin C
Published conference paper: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2005;229:219-223
[¹¹C]Vinpocetine:: a prospective peripheral benzodiazepine receptor ligand for primate PET studies
Gulyás B; Halldin C; Vas A; Banati RB; Shchukin E; Finnema S; Tarkainen J; Tihanyi K; Szilágyi G; Farde L
Published conference paper: BIOLOGICAL PSYCHIATRY. 2005;57(3):229-238
Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity
Jucaite A; Fernell E; Halldin C; Forssberg H; Farde L
Published conference paper: HUMAN BRAIN MAPPING. 2004;22(3):246-260
Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain
Varnäs K; Halldin C; Hall H
Review: ERNST SCHERING RESEARCH FOUNDATION WORKSHOP. 2004;(48):95-109
PET for drug development.
Halldin C; Gulyás B; Farde L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13:S330
PET examinations or thalamic D2 receptors in schizophrenic patients
Talvik M; Nordström AL; Olsson H; Halldin C; Farde L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13:S246-S247
A comparative study of serotonin transporter occupancy:: In vivo 5-HT reuptake inhibitory potency and serum concentrations of antidepressants in mice
Larsen AK; Brennum LT; Kreilgaard M; Sánchez C; Halldin C; Andersen PH
Published conference paper: AMERICAN JOURNAL OF PSYCHIATRY. 2002;159(5):761-767
PET study of D₁ dopamine receptor binding in neuroleptic-naive patients with schizophrenia
Karlsson P; Farde L; Halldin C; Sedvall G
Published conference paper: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2002;5(1):11-16
Saturation of striatal D₂ dopamine receptors by dozapine
Nyberg S; Chou YH; Halldin C
Review: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2002;29(3):416-434
PET and SPET tracers for mapping the cardiac nervous system
Langer O; Halldin C
Review: CURRENT PHARMACEUTICAL DESIGN. 2001;7(18):1907-1929
PET studies with carbon-11 radioligands in neuropsychopharmacological drug development
Halldin C; Gulyás B; Farde L
Review: QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2001;45(2):139-152
Brain radioligands -: State of the art and new trends
Halldin C; Gulyás B; Langer O; Farde L
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 2000;27(5):515-521
Use of PET and the radioligand [Carbonyl-¹¹C]WAY-100635 in psychotropic drug development
Andrée B; Halldin C; Thorberg SO; Sandell J; Farde L
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 2000;27(5):449-455
Radioligands for the study of brain 5-HT_1A receptors in vivo -: Development of some new analogues of WAY
Pike VW; Halldin C; Wikström H; Marchais S; McCarron JA; Sandell J; Nowicki B; Swahn CG; Osman S; Hume SP; Constantinou M; Andrée B; Farde L
Published conference paper: AMERICAN JOURNAL OF PSYCHIATRY. 1999;156(6):869-875
Suggested minimal effective dose of risperidone based on PET-measured D₂ and 5-HT_2A receptor occupancy in schizophrenic patients
Nyberg S; Eriksson B; Oxenstierna G; Halldin C; Farde L
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 1998;25(8):715-719
Whole hemisphere autoradiography of the postmortem human brain
Hall H; Halldin C; Farde L; Sedvall G
Published conference paper: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 1998;13:s15-s20
Implications of brain imaging for the management of schizophrenia
Nyberg S; Nilsson U; Okubo Y; Halldin C; Farde L
Published conference paper: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 1997;12:S3-S7
D-2 occupancy, extrapyramidal side effects and antipsychotic drug treatment: A pilot study with sertindole in healthy subjects
Farde L; Mack RJ; Nyberg S; Halldin C
Meeting abstract: SCHIZOPHRENIA RESEARCH. 1997;24(1-2):180
Neuro-receptor imaging in three-dimensions in vivo and in vitro: Application to dopamine and benzodiazepine receptors
Pauli S; Hall H; Halldin C; Sedvall G
Meeting abstract: SCHIZOPHRENIA RESEARCH. 1997;24(1-2):178-179
D-1-dopamine receptors in schizophrenia examined by PET
Karlsson P; Farde L; Halldin C; Sedvall G
Published conference paper: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 1996;168(29):40-44
Positron emission tomography of in-vivo binding characteristics of atypical antipsychotic drugs - Review of D-2 and 5-HT2 receptor occupancy studies and clinical response
Nyberg S; Nakashima Y; Nordstrom AL; Halldin C; Farde L
Published conference paper: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. 1996;206(1):133-144
Development of radioligands for the dopamine transporter
Muller L; Halldin C; Lundkvist C; Swahn CG; Foged C; Hall H; Karlsson P; Ginovart N; Nakashima Y; Suhara T; Farde L
Letter: LIFE SCIENCES. 1996;58(10):PL 187-92-192
[C-11]MDL 100907, a radioligand for selective imaging of 5-HT2A receptors with positron emission tomography
Lundkvist C; Halldin C; Ginovart N; Nyberg S; Swahn CG; Carr AA; Brunner F; Farde L
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):993-997
BR-76-BETA-CBT, A PET TRACER FOR INVESTIGATING DOPAMINE NEURONAL UPTAKE
MAZIERE B; LOCH C; MULLER L; HALLDIN C
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):971-976
THE METABOLITE PATTERN OF [I-123] BETA-CIT DETERMINED WITH A GRADIENT HPLC METHOD
BERGSTROM KA; HALLDIN C; KUIKKA JT; SWAHN CG; TIIHONEN J; HILTUNEN J; LANSIMIES E; FARDE L
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):965-979
COMPARISON OF [C-11] METHYL TRIFLATE AND [C-11] METHYL-IODIDE IN THE SYNTHESIS OF PET RADIOLIGANDS SUCH AS [C-11] BETA-CIT AND [C-11] BETA-CFT
NAGREN K; HALLDIN C; MULLER L; SWAHN CG; LEHIKOINEN P
Published conference paper: NUCLEAR MEDICINE AND BIOLOGY. 1995;22(8):959-964
SYNTHESIS OF NOR-BETA-CIT, BETA-CIT AND TRIMETHYLSTANNYL-BETA-CT
AMETAMEY SM; HALLDIN C; SWAHN CG; HALL H; SCHUBIGER PA; FARDE L
Published conference paper: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 1995;10:81-85
Positron emission tomography studies on D-2 dopamine receptor occupancy and plasma antipsychotic drug levels in man
Nyberg S; Nordstrom AL; Halldin C; Farde L
Other: PSYCHOPHARMACOLOGY. 1995;119(3):345-348
A PET STUDY OF D-2, AND 5-HT2, RECEPTOR OCCUPANCY INDUCED BY RISPERIDONE IN POOR METABOLIZERS OF DEBRISOQUIN AND RISPERIDONE
NYBERG S; DAHL ML; HALLDIN C
Other: SYNAPSE. 1995;19(4):297-300
LIPOPHILIC METABOLITE OF [I-123] BETA-CIT IN HUMAN PLASMA MAY OBSTRUCT QUANTITATION OF THE DOPAMINE TRANSPORTER
BERGSTROM KA; HALLDIN C; KUIKKA JT; SWAHN CG; TIIHONEN J; HILTUNEN J; LANSIMIES E; FARDE L
Meeting abstract: SCHIZOPHRENIA RESEARCH. 1995;15(1-2):86
DECREASED D-1-DOPAMINE RECEPTOR-BINDING IN DRUG-NAIVE SCHIZOPHRENIC-PATIENTS EXAMINED BY PET
KARLSSON P; FARDE L; HALLDIN C; SEDVALL G
Published conference paper: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 1995;15(1):19S-23S
POSITRON EMISSION TOMOGRAPHY STUDIES ON D-2 AND 5-HT2 RECEPTOR-BINDING IN RISPERIDONE-TREATED SCHIZOPHRENIC-PATIENTS
FARDE L; NYBERG S; OXENSTIERNA G; NAKASHIMA Y; HALLDIN C; ERICSSON B
Published conference paper: AMERICAN JOURNAL OF PSYCHIATRY. 1995;152(2):173-178
D-2 DOPAMINE-RECEPTOR OCCUPANCY DURING LOW-DOSE TREATMENT WITH HALOPERIDOL DECANOATE
NYBERG S; FARDE L; HALLDIN C; DAHL ML; BERTILSSON L
Published conference paper: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 1995;5:25-30
PET imaging of neuroreceptors in schizophrenia
Sedvall G; Pauli S; Karlsson P; Farde L; Nordstrom AL; Nyberg S; Halldin C
Published conference paper: CLINICAL NEUROPHARMACOLOGY. 1995;18:S121-S129
POSITRON EMISSION TOMOGRAPHY STUDIES ON DOPAMINE-RECEPTORS IN SCHIZOPHRENIA
FARDE L; NORDSTROM AL; KARLSSON P; HALLDIN C; SEDVALL G
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Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2000-2024

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Docent, Karolinska Institutet, 1989

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