Cecilia Österholm Corbascio

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CV
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Articles

Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2023;80(9):268
Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
Beusch CM; Simonson OE; Wedin JO; Sabatier P; Felldin U; Kadekar S; Osterholm C; Vegvari A; Zubarev RA; Fromell K; Nilson B; James S; Stahle E; Grinnemo K-H; Rodin S
Article: FRONTIERS IN ONCOLOGY. 2023;13:1097942
T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations
Vlachonikola E; Pechlivanis N; Karakatsoulis G; Sofou E; Gkoliou G; Jeromin S; Stavroyianni N; Ranghetti P; Scarfo L; Osterholm C; Mansouri L; Notopoulou S; Siorenta A; Anagnostopoulos A; Ghia P; Haferlach C; Rosenquist R; Psomopoulos F; Kouvatsi A; Baliakas P; Stamatopoulos K; Chatzidimitriou A
Article: NATURE COMMUNICATIONS. 2022;13(1):6226
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Herbst SA; Vesterlund M; Helmboldt AJ; Jafari R; Siavelis I; Stahl M; Schitter EC; Liebers N; Brinkmann BJ; Czernilofsky F; Roider T; Bruch P-M; Iskar M; Kittai A; Huang Y; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Osterholm C; Wahnschaffe L; Herling C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Anders S; Zapatka M; Del Poeta G; Zucchetto A; Bomben R; Gattei V; Dreger P; Woyach J; Herling M; Muller-Tidow C; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtioe J; Dietrich S
Article: METABOLISM OPEN. 2022;13:100167
Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells
Olesen K; Moruzzi N; Bulatovic I; Folmes C; Jeon R; Felldin U; Terzic A; Simonson OE; Le Blanc K; Osterholm C; Berggren P-O; Schiffer T; Rodin S; Tilevik A; Grinnemo K-H
Article: STEM CELLS. 2021;39(12):1751-1765
Spatiotemporal extracellular matrix modeling for in situ cell niche studies
Olesen K; Rodin S; Mak WC; Felldin U; Osterholm C; Tilevik A; Grinnemo K-H
Article: BIORESEARCH OPEN ACCESS. 2020;9(1):269-278
Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold
Granath C; Noren H; Bjorck H; Simon N; Olesen K; Rodin S; Grinnemol K-H; Osterholm C
Article: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY. 2020;159(6):2525-2537.e23
Synthetic tracheal grafts seeded with bone marrow cells fail to generate functional tracheae: First long-term follow-up study
Fux T; Osterholm C; Themudo R; Simonson O; Grinnemo K-H; Corbascio M
Article: CELL. 2019;179(7):1647-1660.e19
A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
Asp M; Giacomello S; Larsson L; Wu C; Furth D; Qian X; Wardell E; Custodio J; Reimegard J; Salmen F; Osterholm C; Stahl PL; Sundstrom E; Akesson E; Bergmann O; Bienko M; Mansson-Broberg A; Nilsson M; Sylven C; Lundeberg J
Article: STEM CELL RESEARCH & THERAPY. 2019;10(1):371
Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells
Grinnemo K-H; Lofling M; Nathanson L; Baumgartner R; Ketelhuth DFJ; Beljanski V; Davies LC; Osterholm C
Article: ATHEROSCLEROSIS. 2019;283:127-136
Dual roles of heparanase in human carotid plaque calcification
Aldi S; Eriksson L; Kronqvist M; Lengquist M; Lofling M; Folkersen L; Matic LP; Maegdefessel L; Grinnemo K-H; Li J-P; Osterholm C; Hedin U
Article: STEM CELLS AND DEVELOPMENT. 2019;28(5):310-318
Human Fetal Cardiac Mesenchymal Stromal Cells Differentiate In Vivo into Endothelial Cells and Contribute to Vasculogenesis in Immunocompetent Mice
Ljung K; Gronlund A; Felldin U; Rodin S; Corbascio M; Osterholm C; Grinnemo K-H
Article: SCIENTIFIC REPORTS. 2018;8(1):2777
Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve
Bjorck HM; Du L; Pulignani S; Paloschi V; Lundstromer K; Kostina AS; Osterholm C; Malashicheva A; Kostareva A; Evangelista A; Teixido-Tura G; Maleki S; Franco-Cereceda A; Eriksson P
Article: CIRCULATION RESEARCH. 2017;120(4):633-644
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
Eken SM; Jin H; Chernogubova E; Li Y; Simon N; Sun C; Korzunowicz G; Busch A; Backlund A; Osterholm C; Razuvaev A; Renne T; Eckstein HH; Pelisek J; Eriksson P; Diez MG; Matic LP; Schellinger IN; Raaz U; Leeper NJ; Hansson GK; Paulsson-Berne G; Hedin U; Maegdefessel L
Article: DIABETES. 2016;65(10):2888-2899
Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness
Strawbridge RJ; Hilding A; Silveira A; Osterholm C; Sennblad B; McLeod O; Tsikrika P; Foroogh F; Tremoli E; Baldassarre D; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Mannarino E; Grossi E; Syvanen A-C; Humphries SE; de Faire U; Ostenson C-G; Maegdefessel L; Hamsten A; Backlund A
Article: ONCOTARGET. 2016;7(26):39486-39496
Heparanase expression upregulates platelet adhesion activity and thrombogenicity
Cui H; Tan Y-X; Osterholm C; Zhang X; Hedin U; Vlodavsky I; Li J-P
Article: STEM CELL REPORTS. 2016;6(4):607-617
Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Mansson-Broberg A; Rodin S; Bulatovic I; Ibarra C; Lofling M; Genead R; Wardell E; Felldin U; Granath C; Alici E; Le Blanc K; Smith CIE; Salasova A; Westgren M; Sundstrom E; Uhlen P; Arenas E; Sylven C; Tryggvason K; Corbascio M; Simonson OE; Osterholm C; Grinnemo K-H
Article: PLOS ONE. 2015;10(3):e0120176
Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells
Bulatovic I; Ibarra C; Osterholm C; Wang H; Beltran-Rodriguez A; Varas-Godoy M; Mansson-Broberg A; Uhlen P; Simon A; Grinnemo K-H
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2014;3(12):1484-1494
Multipotent Mesenchymal Stromal Cells Synergize With Costimulation Blockade in the Inhibition of Immune Responses and the Induction of Foxpr Regulatory T Cells
Takahashi T; Tibell A; Ljung K; Saito Y; Gronlund A; Osterholm C; Holgersson J; Lundgren T; Ericzon B-G; Corbascio M; Kumagai-Braesch M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(10):2432-2443
Profiling of Atherosclerotic Lesions by Gene and Tissue Microarrays Reveals PCSK6 as a Novel Protease in Unstable Carotid Atherosclerosis
Perisic L; Hedin E; Razuvaev A; Lengquist M; Osterholm C; Folkersen L; Gillgren P; Paulsson-Berne G; Ponten F; Odeberg J; Hedin U
Article: ATHEROSCLEROSIS. 2013;226(1):67-73
Increased expression of heparanase in symptomatic carotid atherosclerosis
Osterholm C; Folkersen L; Lengquist M; Ponten F; Renne T; Li JP; Hedin U
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;302(11):L1159-L1166
Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia
Chang Y-T; Uggla AR; Osterholm C; Phan-Kiet T; Eklof A-C; Lengquist M; Hedin U; Tran-Lundmark K; Frenckner B
Article: PLOS ONE. 2012;7(7):e41334
Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids
Osterholm C; Lu N; Liden A; Karlsen TV; Gullberg D; Reed RK; Kusche-Gullberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(50):34935-34943
Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix
Oesterholm C; Barczyk MM; Busse M; Gronning M; Reed RK; Kusche-Gullberg M
Article: CELL AND TISSUE RESEARCH. 2008;334(1):93-102
Downregulation of tissue factor (TF) by RNA interference induces apoptosis and impairs cell survival of primary endothelium and tumor cells
Osterholm C; Li S; Ekberg H; Hedner U; Holgersson J
Article: TRANSPLANTATION. 2007;83(9):1259-1267
Anti-LFA-1 improves pig islet xenograft function in diabetic mice when long-term acceptance is induced by CTLA41g/anti-CD40L
Kumagai-Braesch M; Ekberg H; Wang F; Osterholm C; Ehrnfelt C; Sharma A; Lindeborg E; Holgersson J; Corbascio M
Article: TRANSPLANT IMMUNOLOGY. 2005;15(2):165-172
Differential expression of tissue factor (TF) in calcineurin inhibitor-induced nephrotoxicity and rejection-implications for development of a possible diagnostic marker
Österholm C; Veress B; Simanaitis M; Hedner U; Ekberg H
Article: TRANSPLANTATION. 2002;74(1):35-41
Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and vasculopathy in CD40 ligand-deficient mice
Corbascio M; Mahanty H; Österholm C; Qi ZQ; Pearson TC; Larsen CP; Freise CE; Ekberg H
Article: TRANSPLANT IMMUNOLOGY. 2002;10(1):55-61
CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely
Corbascio M; Ekstrand H; Österholm C; Qi ZQ; Simanaitis M; Larsen CP; Pearson TC; Riesbeck K; Ekberg H
Article: TRANSPLANTATION. 2002;73(2):293-297
CTLA4Ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice
Malm H; Corbascio M; Österholm C; Cowan S; Larsen CP; Pearson TC; Ekberg H
Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2001;1(1):29-37
Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants
Österholm C; Qi ZQ; Ekberg J; Veress B; Pyke C; Hedner U; Ekberg H
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All other publications

Review: FRONTIERS IN ONCOLOGY. 2023;13:1143811
Recent revelations and future directions using single-cell technologies in chronic lymphocytic leukemia
Oder B; Chatzidimitriou A; Langerak AW; Rosenquist R; Osterholm C
Review: CYTOTHERAPY. 2019;21(4):380-392
Pleiotropic roles of autophagy in stem cell-based therapies
Beljanski V; Grinnemo K-H; Osterholm C

Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2021

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