Cecilia Morgantini
About me
I am a clinical scientist dedicated to bridging the gap between the clinic and the lab. My work focuses on unraveling the complexities of diabetes complications and cardio-metabolic disorders through both basic and translational research.
Since January 2021: Principal Researcher/Team Leader at the Cardio Metabolic Unit
Since February 2019: Staff Physician in the Endocrinology Department at Karolinska University Hispital.
Education:
*Ph.D.* in Clinical Physiology Scuola Superiore Sant’Anna, Pisa, Italy/
Banting and Best Diabetes Center, University of Toronto, Canada (2014)
*MD* School of Medicine, University of Pisa, Italy (2005)
Research
Main research interest is to understand the complex role of immune cell activation in diabetes complications and cardio-metabolic disorders.
Teaching
Organizer of PhD Course - Lipid and Lipoprotein Metabolism: Basal Aspects and Clinical Significance
Co-supervisor of PhD students
Half-time review committee member
Articles
- Article: EMBO JOURNAL. 2023;42(23):e114086Krejcova G; Morgantini C; Zemanova H; Lauschke VM; Kovarova J; Kubasek J; Nedbalova P; Kamps-Hughes N; Moos M; Aouadi M; Dolezal T; Bajgar A
- Article: NATURE METABOLISM. 2023;5(7):1188-1203Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
- Journal article: JOURNAL OF HEPATOLOGY. 2022;77:S665-S666Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke V; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
- Journal article: JOURNAL OF HEPATOLOGY. 2022;77:s755-s756Fardellas A; Aouadi M; Nock S; Chen P; Morgantini C
- Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
- Article: IMMUNITY. 2021;54(9):2101-2116.e6Bleriot C; Barreby E; Dunsmore G; Ballaire R; Chakarov S; Ficht X; De Simone G; Andreata F; Fumagalli V; Guo W; Wan G; Gessain G; Khalilnezhad A; Zhang XM; Ang N; Chen P; Morgantini C; Azzimato V; Kong WT; Liu Z; Pai R; Lum J; Shihui F; Low I; Xu C; Malleret B; Kairi MFM; Balachander A; Cexus O; Larbi A; Lee B; Newell EW; Ng LG; Phoo WW; Sobota RM; Sharma A; Howland SW; Chen J; Bajenoff M; Yvan-Charvet L; Venteclef N; Iannacone M; Aouadi M; Ginhoux F
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M
- Article: METHODS IN MOLECULAR BIOLOGY. 2020;2164:11-13Morgantini C
- Journal article: DIABETES OBESITY & METABOLISM. 2019;21(11):2535-2541Xiao C; Stahel P; Morgantini C; Nahmias A; Dash S; Lewis GF
- Article: ELIFE. 2019;8:e47990Petkevicius K; Virtue S; Bidault G; Jenkins B; Cubuk C; Morgantini C; Aouadi M; Dopazo J; Serlie MJ; Koulman A; Vidal-Puig A
- Article: NATURE METABOLISM. 2019;1(4):445-459Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
- Article: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 2018;28(6):575-581Morgantini C; Trifiro S; Trico D; Meriwether D; Baldi S; Mengozzi A; Reddy ST; Natali A
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2018;103(2):622-631Trico D; Trifiro S; Mengozzi A; Morgantini C; Baldi S; Mari A; Natali A
- Article: METHODS IN MOLECULAR BIOLOGY. 2017;1639:161-171Aparicio-Vergara M; Tencerova M; Morgantini C; Barreby E; Aouadi M
- Article: DIABETES. 2016;65(7):1767-1778Xiao C; Dash S; Morgantini C; Hegele RA; Lewis GF
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(7):1457-1463Xiao C; Dash S; Morgantini C; Lewis GF
- Article: DIABETES. 2015;64(8):2939-2943Xiao C; Dash S; Morgantini C; Koulajian K; Lewis GF
- Article: DIABETES. 2015;64(7):2310-2318Xiao C; Dash S; Morgantini C; Adeli K; Lewis GF
- Article: DIABETES. 2015;64(3):766-774Dash S; Xiao C; Morgantini C; Koulajian K; Lewis GF
- Article: GASTROENTEROLOGY. 2014;147(6):1275-1284.e4Dash S; Xiao C; Morgantini C; Connelly PW; Patterson BW; Lewis GF
- Article: DIABETES. 2014;63(7):2394-2401Xiao C; Dash S; Morgantini C; Patterson BW; Lewis GF
- Article: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. 2014;24(6):594-599Morgantini C; Meriwether D; Baldi S; Venturi E; Pinnola S; Wagner AC; Fogelman AM; Ferrannini E; Natali A; Reddy ST
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2014;34(suppl_1)Xiao C; Dash S; Morgantini C; Patterson BW; Lewis GF
- Article: DIABETES CARE. 2013;36(12):4125-4131Baldi S; Bonnet F; Laville M; Morgantini C; Monti L; Hojlund K; Ferrannini E; Natali A
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(12):2895-2901Dash S; Xiao C; Morgantini C; Szeto L; Lewis GF
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(5):1056-1062Xiao C; Dash S; Morgantini C; Lewis GF
- Article: JOURNAL OF HYPERTENSION. 2012;30(4):720-724Morgantini C; Stea F; Boldrini B; Duranti E; Ghiadoni L; Natali A
- Article: DIABETES. 2011;60(10):2617-2623Morgantini C; Natali A; Boldrini B; Imaizumi S; Navab M; Fogelman AM; Ferrannini E; Reddy ST
- Article: DIABETES. 2010;59(12):3223-3228Morgantini C; Imaizumi S; Grijalva V; Navab M; Fogelman AM; Reddy ST
- Article: CLINICAL SCIENCE. 2010;119(1-2):37-44Di Marco S; Boldrini B; Conti U; Marcucci G; Morgantini C; Ferrannini E; Natali A
- Journal article: ARTERY RESEARCH. 2008;2(3):115Morgantini C; Stea F; Plantinga Y; Taddei S; Natali A; Ghiadoni L
- Journal article: HIGH BLOOD PRESSURE AND CARDIOVASCULAR PREVENTION. 2008;15(3):319Morgantini C; Stea F; Ghiadoni L; Duranti E; Taddei S; Natali A; Ferrannini E; Salvetti A
- Article: DIABETOLOGIA. 2008;51(5):862-871Natali A; Baldi S; Vittone F; Muscelli E; Casolaro A; Morgantini C; Palombo C; Ferrannini E
- Journal article:Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R AxisSulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
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All other publications
- Corrigendum: GASTROENTEROLOGY. 2022;163(4):1133Azzimato V; Chen P; Barreby E
- Conference publication: JOURNAL OF HEPATOLOGY. 2022;77:S756-S757Barreby E; Strunz B; Azzimato V; Shen JX; Naudet L; Sonnerborg I; Sulen A; Nock S; Levi L; Morgantini C; Fardellas A; Johansson H; Nowak G; Stal P; Ellis E; Naslund E; Lauschke V; Bjorkstrom N; Chen P; Aouadi M
- Conference publication: JOURNAL OF HEPATOLOGY. 2022;77:S755-S756Fardellas A; Aouadi M; Nock S; Chen P; Morgantini C
- Corrigendum: NATURE METABOLISM. 2021;3(2):287Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
- Preprint: SSRN ELECTRONIC JOURNAL. 2020Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
- Preprint: BIORXIV. 2019Petkevicius K; Virtue S; Bidault G; Jenkins B; Çubuk C; Morgantini C; Aouadi M; Dopazo J; Serlie M; Koulman A; Vidal-Puig A
- Corrigendum: NATURE METABOLISM. 2019;1(4):497Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:29Xiao C; Stahel P; Dash S; Morgantini C; Lewis GF
- Review: ANNUAL REVIEW OF NUTRITION. 2015;35:265-294Dash S; Xiao C; Morgantini C; Lewis GF
- Review: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(7):2525-2531Dash S; Xiao C; Morgantini C; Koulajian K; Lewis GF
- Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2014;17(4):355-359Morgantini C; Xiao C; Dash S; Lewis GF
- Review: ATHEROSCLEROSIS. 2014;233(2):608-615Xiao C; Dash S; Morgantini C; Lewis GF
- Conference publication: DIABETES. 2013;62:A108-A109Morgantini C; Meriwether D; Baldi S; Venturi E; Pinnola S; Fogelman AM; Ferrannini E; Natali A; Reddy ST
- Conference publication: DIABETES. 2012;61:A114Morgantini C; Boldrini B; Venturi E; Meriwether D; Lee YY; Baldi S; Natali A; Reddy ST
- Review: CIRCULATION JOURNAL. 2011;75(7):1533-1538Imaizumi S; Navab M; Morgantini C; Charles-Schoeman C; Su F; Gao F; Kwon M; Ganapathy E; Meriwether D; Farias-Eisner R; Fogelman AM; Reddy ST
- Conference publication: CIRCULATION. 2010;122(21)Morgantini C; Imaizumi S; Grijalva V; Navab M; Reddy ST; Fogelman AM
- Conference publication: DIABETES. 2010;59:A26Morgantini C; Grijalva V; Navab M; Fogelman AM; Reddy ST
- Conference publication: DIABETOLOGIA. 2008;51:S529-S530Morgantini C; Stea F; Boldrim B; Duranti E; Ghiadoni L; Ferrannini E; Natali A
Grants
- Swedish Research Council1 January 2023 - 31 December 2026Diabetic foot ulcer (DFU) requires frequent hospital visits, anti-biotic therapies, and surgical procedures. Not only this approach has debilitating consequences for patients and enormous costs for the health care system, but it is often not sufficient to prevent lower limb amputation. The immunological response in wound healing is mainly orchestrated by recruited monocytes and skin macrophages. The current hypothesis is that hyperglycaemia sustains an activated macrophages’ phenotype that inhibits wound healing. However, well controlled diabetes is not associated with better healing, and not all the diabetic patients develop chronic foot ulcers. In this project, we aim to characterize the immunological response of patients with DFU to discover new therapeutic targets for the treatment of chronic wounds. We suggest that an altered metabolic local environment can re-program monocytes/macrophages towards dysfunctional phenotypes unable to accomplish the healing process. Here, by using a longitudinal study cohort combined with clinical information, transcriptomic and proteomic analysis at single cell level, we will characterize the landscape of monocytes/macrophage populations involved in healing, and non-healing, foot ulcers. Functional validation will be performed in human skin organoids. My group´s unique access to patient material combined with cutting-edge methodologies provides an exceptional platform to identify genes and pathways involved in chronic DFU.