Cecilia Morgantini

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About me

I am a clinical scientist dedicated to bridging the gap between the clinic and the lab. My work focuses on unraveling the complexities of diabetes complications and cardio-metabolic disorders through both basic and translational research.
Since January 2021:
Principal Researcher/Team Leader at the Cardio Metabolic Unit
Since February 2019: Staff Physician in the Endocrinology Department at Karolinska University Hispital.
Education:
*Ph.D.* in Clinical Physiology Scuola Superiore Sant’Anna, Pisa, Italy/
Banting and Best Diabetes Center, University of Toronto, Canada (2014)
*MD* School of Medicine, University of Pisa, Italy (2005)

Research

Main research interest is to understand the complex role of immune cell activation in diabetes complications and cardio-metabolic disorders.

Teaching

Organizer of PhD Course - Lipid and Lipoprotein Metabolism: Basal Aspects
and Clinical Significance
Co-supervisor of PhD students
Half-time review committee member

Articles

Article: EMBO JOURNAL. 2023;42(23):e114086
Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection
Krejcova G; Morgantini C; Zemanova H; Lauschke VM; Kovarova J; Kubasek J; Nedbalova P; Kamps-Hughes N; Moos M; Aouadi M; Dolezal T; Bajgar A
Article: NATURE METABOLISM. 2023;5(7):1188-1203
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
Journal article: JOURNAL OF HEPATOLOGY. 2022;77:S665-S666
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke V; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Journal article: JOURNAL OF HEPATOLOGY. 2022;77:s755-s756
SAT195 Dissecting A-to-I RNA editome of liver macrophages in non-alcoholic fatty liver disease
Fardellas A; Aouadi M; Nock S; Chen P; Morgantini C
Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Article: IMMUNITY. 2021;54(9):2101-2116.e6
A subset of Kupffer cells regulates metabolism through the expression of CD36
Bleriot C; Barreby E; Dunsmore G; Ballaire R; Chakarov S; Ficht X; De Simone G; Andreata F; Fumagalli V; Guo W; Wan G; Gessain G; Khalilnezhad A; Zhang XM; Ang N; Chen P; Morgantini C; Azzimato V; Kong WT; Liu Z; Pai R; Lum J; Shihui F; Low I; Xu C; Malleret B; Kairi MFM; Balachander A; Cexus O; Larbi A; Lee B; Newell EW; Ng LG; Phoo WW; Sobota RM; Sharma A; Howland SW; Chen J; Bajenoff M; Yvan-Charvet L; Venteclef N; Iannacone M; Aouadi M; Ginhoux F
Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2164:11-13
Kupffer Cell Isolation from Human Biopsies.
Morgantini C
Journal article: DIABETES, OBESITY AND METABOLISM. 2019;21(11):2535-2541
Glucagon-like peptide-2 mobilizes lipids from the intestine by a systemic nitric oxide-independent mechanism.
Xiao C; Stahel P; Morgantini C; Nahmias A; Dash S; Lewis GF
Article: ELIFE. 2019;8:e47990
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
Petkevicius K; Virtue S; Bidault G; Jenkins B; Cubuk C; Morgantini C; Aouadi M; Dopazo J; Serlie MJ; Koulman A; Vidal-Puig A
Article: NATURE METABOLISM. 2019;1(4):445-459
Liver macrophages regulate systemic metabolism through non-inflammatory factors
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Article: NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES. 2018;28(6):575-581
A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects
Morgantini C; Trifiro S; Trico D; Meriwether D; Baldi S; Mengozzi A; Reddy ST; Natali A
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(2):622-631
Reducing Cholesterol and Fat Intake Improves Glucose Tolerance by Enhancing β Cell Function in Nondiabetic Subjects
Trico D; Trifiro S; Mengozzi A; Morgantini C; Baldi S; Mari A; Natali A
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1639:161-171
Isolation of Kupffer Cells and Hepatocytes from a Single Mouse Liver.
Aparicio-Vergara M; Tencerova M; Morgantini C; Barreby E; Aouadi M
Article: DIABETES. 2016;65(7):1767-1778
Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol
Xiao C; Dash S; Morgantini C; Hegele RA; Lewis GF
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2016;36(7):1457-1463
Intravenous Glucose Acutely Stimulates Intestinal Lipoprotein Secretion in Healthy Humans
Xiao C; Dash S; Morgantini C; Lewis GF
Article: DIABETES. 2015;64(8):2939-2943
Evaluation of the Effect of Enteral Lipid Sensing on Endogenous Glucose Production in Humans
Xiao C; Dash S; Morgantini C; Koulajian K; Lewis GF
Article: DIABETES. 2015;64(7):2310-2318
Gut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism
Xiao C; Dash S; Morgantini C; Adeli K; Lewis GF
Article: DIABETES. 2015;64(3):766-774
Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations
Dash S; Xiao C; Morgantini C; Koulajian K; Lewis GF
Article: GASTROENTEROLOGY. 2014;147(6):1275-1284.e4
Glucagon-Like Peptide-2 Regulates Release of Chylomicrons From the Intestine
Dash S; Xiao C; Morgantini C; Connelly PW; Patterson BW; Lewis GF
Article: DIABETES. 2014;63(7):2394-2401
Sitagliptin, a DPP-4 Inhibitor, Acutely Inhibits Intestinal Lipoprotein Particle Secretion in Healthy Humans
Xiao C; Dash S; Morgantini C; Patterson BW; Lewis GF
Article: NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES. 2014;24(6):594-599
HDL lipid composition is profoundly altered in patients with type 2 diabetes and atherosclerotic vascular disease
Morgantini C; Meriwether D; Baldi S; Venturi E; Pinnola S; Wagner AC; Fogelman AM; Ferrannini E; Natali A; Reddy ST
Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2014;34(suppl_1)
Abstract 247: Dipeptidyl Peptidase-4 Inhibition With Sitagliptin Acutely Inhibits Intestinal Lipoprotein Particle Secretion in Healthy Humans
Xiao C; Dash S; Morgantini C; Patterson BW; Lewis GF
Article: DIABETES CARE. 2013;36(12):4125-4131
Influence of Apolipoproteins on the Association Between Lipids and Insulin Sensitivity A cross-sectional analysis of the RISC Study
Baldi S; Bonnet F; Laville M; Morgantini C; Monti L; Hojlund K; Ferrannini E; Natali A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(12):2895-2901
High-Dose Resveratrol Treatment for 2 Weeks Inhibits Intestinal and Hepatic Lipoprotein Production in Overweight/Obese Men
Dash S; Xiao C; Morgantini C; Szeto L; Lewis GF
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(5):1056-1062
Novel Role of Enteral Monosaccharides in Intestinal Lipoprotein Production in Healthy Humans
Xiao C; Dash S; Morgantini C; Lewis GF
Article: JOURNAL OF HYPERTENSION. 2012;30(4):720-724
Effect of mild hyperisulinemia on conduit vessel endothelial function: role of noradrenergic activation
Morgantini C; Stea F; Boldrini B; Duranti E; Ghiadoni L; Natali A
Article: DIABETES. 2011;60(10):2617-2623
Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes
Morgantini C; Natali A; Boldrini B; Imaizumi S; Navab M; Fogelman AM; Ferrannini E; Reddy ST
Article: DIABETES. 2010;59(12):3223-3228
Apolipoprotein A-I Mimetic Peptides Prevent Atherosclerosis Development and Reduce Plaque Inflammation in a Marine Model of Diabetes
Morgantini C; Imaizumi S; Grijalva V; Navab M; Fogelman AM; Reddy ST
Article: CLINICAL SCIENCE. 2010;119(1-2):37-44
Effects of GIK (glucose-insulin-potassium) on stress-induced myocardial ischaemia
Di Marco S; Boldrini B; Conti U; Marcucci G; Morgantini C; Ferrannini E; Natali A
Journal article: ARTERY RESEARCH. 2008;2(3):115
P2.35 Role of Sympathetic Activation on Brachial Artery Endothelial Function During Hyperinsulinemia in Healthy Subjects
Morgantini C; Stea F; Plantinga Y; Taddei S; Natali A; Ghiadoni L
Journal article: HIGH BLOOD PRESSURE AND CARDIOVASCULAR PREVENTION. 2008;15(3):319
12.10 Role of Sympathetic Activation on Changes of Brachial Artery Endothelial Function During Hyperinsulinaemia in Healthy Subjects
Morgantini C; Stea F; Ghiadoni L; Duranti E; Taddei S; Natali A; Ferrannini E; Salvetti A
Article: DIABETOLOGIA. 2008;51(5):862-871
Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function
Natali A; Baldi S; Vittone F; Muscelli E; Casolaro A; Morgantini C; Palombo C; Ferrannini E
Journal article:
Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
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All other publications

Corrigendum: GASTROENTEROLOGY. 2022;163(4):1133
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Azzimato V; Chen P; Barreby E
Conference publication: JOURNAL OF HEPATOLOGY. 2022;77:S756-S757
Human resident liver macrophages protect against metabolic stress in obesity
Barreby E; Strunz B; Azzimato V; Shen JX; Naudet L; Sonnerborg I; Sulen A; Nock S; Levi L; Morgantini C; Fardellas A; Johansson H; Nowak G; Stal P; Ellis E; Naslund E; Lauschke V; Bjorkstrom N; Chen P; Aouadi M
Conference publication: JOURNAL OF HEPATOLOGY. 2022;77:S755-S756
Dissecting A-to-I RNA editome of liver macrophages in non-alcoholic fatty liver disease
Fardellas A; Aouadi M; Nock S; Chen P; Morgantini C
Corrigendum: NATURE METABOLISM. 2021;3(2):287
Liver macrophages regulate systemic metabolism through non-inflammatory factors (vol 1, pg 445, 2019)
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Preprint: SSRN ELECTRONIC JOURNAL. 2020
Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
Preprint: BIORXIV. 2019
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
Petkevicius K; Virtue S; Bidault G; Jenkins B; Çubuk C; Morgantini C; Aouadi M; Dopazo J; Serlie M; Koulman A; Vidal-Puig A
Corrigendum: NATURE METABOLISM. 2019;1(4):497
Liver macrophages regulate systemic metabolism through non-inflammatory factors (vol 1, 497, 2019)
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:29
INVESTIGATION OF THE ROLE OF ENTERIC BLOOD FLOW IN MEDIATING GLP-2 STIMULATION OF TRIGLYCERIDE MOBILIZATION AND CHYLOMICRON SECRETION IN THE HUMAN INTESTINE
Xiao C; Stahel P; Dash S; Morgantini C; Lewis GF
Review: ANNUAL REVIEW OF NUTRITION. 2015;35:265-294
New Insights into the Regulation of Chylomicron Production
Dash S; Xiao C; Morgantini C; Lewis GF
Review: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2015;100(7):2525-2531
Is Insulin Action in the Brain Relevant in Regulating Blood Glucose in Humans?
Dash S; Xiao C; Morgantini C; Koulajian K; Lewis GF
Review: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 2014;17(4):355-359
Dietary carbohydrates and intestinal lipoprotein production
Morgantini C; Xiao C; Dash S; Lewis GF
Review: ATHEROSCLEROSIS. 2014;233(2):608-615
New and emerging regulators of intestinal lipoprotein secretion
Xiao C; Dash S; Morgantini C; Lewis GF
Conference publication: DIABETES. 2013;62:A108-A109
HDL Composition Is Profoundly Altered in Patients With Type 2 Diabetes (T2D) and Atherosclerotic Vascular Disease
Morgantini C; Meriwether D; Baldi S; Venturi E; Pinnola S; Fogelman AM; Ferrannini E; Natali A; Reddy ST
Conference publication: DIABETES. 2012;61:A114
Macrovascular Complications in Patients With Type 2 Diabetes are Associated With Abnormal HDL Contents of Oxidized Fatty Acids and Haptoglobin
Morgantini C; Boldrini B; Venturi E; Meriwether D; Lee YY; Baldi S; Natali A; Reddy ST
Review: CIRCULATION JOURNAL. 2011;75(7):1533-1538
Dysfunctional High-Density Lipoprotein and the Potential of Apolipoprotein A-1 Mimetic Peptides to Normalize the Composition and Function of Lipoproteins
Imaizumi S; Navab M; Morgantini C; Charles-Schoeman C; Su F; Gao F; Kwon M; Ganapathy E; Meriwether D; Farias-Eisner R; Fogelman AM; Reddy ST
Conference publication: CIRCULATION. 2010;122(21)
ApoA-I Mimetic Peptide Prevents Atherosclerosis Development and Reduces Plaque Inflammation In A Mouse Model of Diabetes
Morgantini C; Imaizumi S; Grijalva V; Navab M; Reddy ST; Fogelman AM
Conference publication: DIABETES. 2010;59:A26
ApoA-I Mimetic Peptides Prevent Atherosclerosis Development in a Mouse Model of Diabetes
Morgantini C; Grijalva V; Navab M; Fogelman AM; Reddy ST
Conference publication: DIABETOLOGIA. 2008;51:S529-S530
Effects of mild hyperinsulinaemia on conduit vessel endothelial function: role of noradrenergic activation
Morgantini C; Stea F; Boldrim B; Duranti E; Ghiadoni L; Ferrannini E; Natali A

Grants

Characterise the immunological response of diabetic patients with chronic foot ulcers
Swedish Research Council
1 January 2023 - 31 December 2026

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