Cecilia Jylhä

About me
Publications
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About me

I defended my thesis on DNA repair at Stockholm University in 2011. With an
increased focus on cancer, I continued as a researcher in the DNA repair
field for a few years while moving to SciLifeLab in Solna. I spent 2014 at
the Institute of Cancer Research in London, where I came even closer to the
clinical setting in my aims to optimise radiotherapy for different tumors.
My progression from basic research towards patient care has since May 2017
taken me to the group of Katarina Le Blanc at KI, where we develop cell
therapies and produce mesenchymal stem cells intended for clinical use.
* M.Sc. in Cell- and Molecular Biology at Södertörn University College
* PhD in Molecular Genetics at Stockholm University

Articles

Article: CLINICAL CANCER RESEARCH. 2024;30(13):2764-2771
Cell-Free Human Papillomavirus DNA Is a Sensitive Biomarker for Prognosis and for Early Detection of Relapse in Locally Advanced Cervical Cancer
Sivars L; Jylha C; Crona Guterstam Y; Zupancic M; Lindqvist B; Nordenskjold M; Tham E; Hellman K
Article: ORAL ONCOLOGY. 2024;151:106749
Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
Zupancic M; Kostopoulou ON; Holzhauser S; Lukoseviciute M; Jylha C; Marklund L; Nasman A; Sivars L; Dalianis T
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):44
Liquid biopsy guides successful molecular targeted therapy of an inoperable pediatric brainstem neoplasm
Arthur C; Carlson L-M; Svoboda J; Sandvik U; Jylha C; Nordenskjold M; Holm S; Tham E
Article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae008
The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
Krynina O; de Stahl TD; Jylhae C; Arthur C; Giraud G; Nyman P; Fritzberg A; Sandgren J; Tham E; Sandvik U
Article: WORLD JOURNAL OF UROLOGY. 2023;41(12):3421-3427
Patient-specific targeted analysis of circulating tumour DNA in plasma is feasible and may be a potential biomarker in UTUC
Mu N; Jylha C; Axelsson T; Syden F; Brehmer M; Tham E
Article: CYTOTHERAPY. 2023;25(9):956-966
Lysis and phenotypic modulation of mesenchymal stromal cells upon blood contact triggers anti-inflammatory skewing of the peripheral innate immune repertoire
Davies LC; Queckborner S; Jylha CE; Andren AT; Forshell TZP; Le Blanc K
Article: CANCERS. 2023;15(7):1972
Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
Arthur C; Jylha C; de Stahl TD; Shamikh A; Sandgren J; Rosenquist R; Nordenskjold M; Harila A; Barbany G; Sandvik U; Tham E
Article: LEUKEMIA. 2023;37(2):339-347
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY
Mansouri L; Thorvaldsdottir B; Sutton L-A; Karakatsoulis G; Meggendorfer M; Parker H; Nadeu F; Brieghel C; Laidou S; Moia R; Rossi D; Catherwood M; Kotaskova J; Delgado J; Rodriguez-Vicente AE; Benito R; Rigolin GM; Bonfiglio S; Scarfo L; Mattsson M; Davis Z; Gogia A; Rani L; Baliakas P; Foroughi-Asl H; Jylha C; Skaftason A; Rapado I; Miras F; Martinez-Lopez J; de la Serna J; Rivas JMH; Thornton P; Larrayoz MJ; Calasanz MJ; Fesus V; Matrai Z; Bodor C; Smedby KE; Espinet B; Puiggros A; Gupta R; Bullinger L; Bosch F; Tazon-Vega B; Baran-Marszak F; Oscier D; N'Guyen-Khac F; Zenz T; Terol MJ; Cuneo A; Hernandez-Sanchez M; Pospisilova S; Mills K; Gaidano G; Niemann CU; Campo E; Strefford JC; Ghia P; Stamatopoulos K; Rosenquist R
Article: FRONTIERS IN ONCOLOGY. 2023;13:1176698
Whole-genome informed circulating tumor DNA analysis by multiplex digital PCR for disease monitoring in B-cell lymphomas: a proof-of-concept study
Haider Z; Wasterlid T; Spangberg LD; Rabbani L; Jylha C; Thorvaldsdottir B; Skaftason A; Awier HN; Krstic A; Gellerbring A; Lyander A; Hagglund M; Jeggari A; Rassidakis G; Sonnevi K; Sander B; Rosenquist R; Tham E; Smedby KE
Article: SCIENTIFIC REPORTS. 2021;11(1):7119
TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells.
Anbalagan S; Ström C; Downs JA; Jeggo PA; McBay D; Wilkins A; Rothkamm K; Harrington KJ; Yarnold JR; Somaiah N
Article: CANCER RESEARCH. 2020;80(17):3530-3541
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
Article: STEM CELLS AND DEVELOPMENT. 2019;28(17):1177-1190
Hyaluronan Hydrogels for the Local Delivery of Mesenchymal Stromal Cells to the Injured Vocal Fold
Hertegard S; Nagubothu SR; Malmstrom E; Strom CE; Tolf A; Davies LC; Le Blanc K
Article: NUCLEIC ACIDS RESEARCH (NAR). 2014;42(14):9108-9120
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
Luis Orta M; Hoglund A; Manuel Calderon-Montano J; Dominguez I; Burgos-Moron E; Visnes T; Pastor N; Strom C; Lopez-Iazaro M; Helleday T
Article: NATURE. 2014;508(7495):215-221
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: BIOMOLECULES. 2012;2(4):635-649
Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy.
Ström CE; Helleday T
Article: DNA REPAIR. 2011;10(9):961-969
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Strom CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T
Article: EMBO REPORTS. 2011;12(7):713-719
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
Segal-Raz H; Mass G; Baranes-Bachar K; Lerenthal Y; Wang S-Y; Chung YM; Ziv-Lehrman S; Strom CE; Helleday T; Hu MC-T; Chen DJ; Shiloh Y
Article: NUCLEIC ACIDS RESEARCH (NAR). 2011;39(8):3166-3175
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
Strom CE; Johansson F; Uhlen M; Szigyarto CA-K; Erixon K; Helleday T
Article: DNA REPAIR. 2010;9(7):835-841
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
Parsons JL; Dianova II; Finch D; Tait PS; Strom CE; Helleday T; Dianov GL

All other publications

Corrigendum: LEUKEMIA. 2023;37(2):504
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY (Dec, 10.1038/s41375-022-01802-y, 2022)
Mansouri L; Thorvaldsdottir B; Sutton L-A; Karakatsoulis G; Meggendorfer M; Parker H; Nadeu F; Brieghel C; Laidou S; Moia R; Rossi D; Catherwood M; Kotaskova J; Delgado J; Rodriguez-Vicente AE; Benito R; Rigolin GM; Bonfiglio S; Scarfo L; Mattsson M; Davis Z; Gogia A; Rani L; Baliakas P; Foroughi-Asl H; Jylha C; Skaftason A; Rapado I; Miras F; Martinez-Lopez J; de la Serna J; Rivas JMH; Thornton P; Larrayoz MJ; Calasanz MJ; Fesus V; Matrai Z; Bodor C; Smedby KE; Espinet B; Puiggros A; Gupta R; Bullinger L; Bosch F; Tazon-Vega B; Baran-Marszak F; Oscier D; Nguyen-Khac F; Zenz T; Terol MJ; Cuneo A; Hernandez-Sanchez M; Pospisilova S; Mills K; Gaidano G; Niemann CU; Campo E; Strefford JC; Ghia P; Stamatopoulos K; Rosenquist R
Meeting abstract: BLOOD. 2021;138:2617
Different Prognostic Impact of Recurrent Gene Mutations in IGHV-Mutated and IGHV-Unmutated Chronic Lymphocytic Leukemia: A Retrospective, Multi-Center Cohort Study By Eric, the European Research Initiative on CLL, in Harmony
Mansouri L; Thorvaldsdottir B; Sutton L-A; Meggendorfer M; Nadeu F; Brieghel C; Parker H; Laidou S; Moia R; Rossi D; Catherwood M; Kotaskova J; Delgado J; Rodriguez-Vicente AE; Benito R; Rigolin GM; Bonfiglio S; Scarfo L; Mattsson M; Davis Z; Gogia A; Rani L; Baliakas P; Jylha C; Skaftason A; Rapado I; Miras F; Martinez-Lopez J; de la Serna J; Hernandez Rivas JM; Thornton P; Jose Larrayoz M; Jose Calasanz M; Matrai Z; Bodor C; Smedby KE; Espinet B; Puiggros A; Gupta R; Bullinger L; Bosch F; Tazon B; Baran-Marszak F; Oscier D; Nguyen-Khac F; Zenz T; Jose Terol M; Cuneo A; Hernandez-Sanchez M; Pospisilova S; Mills KI; Gaidano G; Niemann CU; Campo E; Strefford JC; Ghia P; Stamatopoulos K; Rosenquist R
Meeting abstract: CANCER RESEARCH. 2019;79(13):105
MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Sanjiv K; Gad H; Rudd SG; Mortusewicz O; Stolz A; Amaral N; Brautigham L; Pudelko L; Kalderen C; Jemth A-S; Almlof I; Visnes T; Schultz N; Bostrom J; Montano JMC; Hagenkort A; Groth P; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Altun M; Strom C; Scobie M; Bastians H; Berglund UW; Helleday T
Meeting abstract: RADIOTHERAPY AND ONCOLOGY. 2018;127:s194
Cell cycle checkpoint modulates radiotherapy fraction size sensitivity in normal and malignant cells
Somaiah N; Anbalagan S; Strom C; Downs J; Jeggo P; Wilkins A; Boyle S; Rothkamm K; Yarnold J
Corrigendum: NATURE. 2017;544(7651):508
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T

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